Pregelatinized glutinous rice starch as a sustained release agent for tablet preparations

The effect of grinding on the pharmaceutical properties of matrix tablets consisting of ground glutinous rice starch (GRS) and theophylline (TH) was predicted by near infrared (NIR) spectroscopy. Ground GRS samples were prepared by grinding GRS in a planetary ball mill for 0-120 min, measured by X-ray diffractometry (XRD) and NIR, and then evaluated for crystallinity (%XRD) based on XRD profiles. Tablets containing TH (5 w/w%), ground GRS (94 w/w%), and magnesium stearate (1 w/w%) were formed by compression. Gel-forming and drug-release processes of the tablets were measured using a dissolution instrument with X-ray computed tomography (XCT). Swelling ratio (SWE) and mean drug-release time (MDT) were evaluated based on XCT and drug-release profiles, respectively. Calibration models for predicting percent %XRD, MDT, and SWE were constructed based on the NIR of ground GRS using partial least-squares. The results indicated the possibility of controlling the pharmaceutical properties of matrix tablets by altering the pre-gelatinization of GRS based on changes in their NIR spectra during the milling process.

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CHEMICAL MODIFICATION, CHARACTERIZATION AND EVALUATION OF MUCOADHESIVE POTENTIALITY OF ASSAM BORA RICE STARCH

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i9.20108 ◽

2017 ◽

Vol 9 (9) ◽

pp. 132 ◽

Cited By ~ 1

Author(s):

Abdul Baquee Ahmed ◽

Iman Bhaduri

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Sustained Release ◽

Chemical Modification ◽

Ex Vivo ◽

Rice Starch ◽

Modified Starch ◽

Native Starch ◽

Ft Ir

Objective: The objective of the present study was to chemical modification, characterization and evaluation of mucoadhesive potentiality of Assam bora rice starch as potential excipients in the sustained release drug delivery system. Methods: The starch was isolated from Assam bora rice and esterified using thioglycolic acid and characterized by Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and Nuclear magnetic resonance (NMR). The 10% w/v gel formulation based on modified bora rice starch loaded with irinotecan (0.6%) was prepared and evaluated for various rheological properties, ex-vivo mucoadhesion using goat intestine and in vitro drug release study in phosphate buffer pH 6.8.Results: The chemical modification was confirmed by FT-IR and NMR studies with the presence of the peak at 2626.74 cm-1 and a singlet at 2.51 respectively due to–SH group. Ex-vivo mucoadhesion studies showed 6.6 fold increases in mucoadhesion of the modified starch with compared to native starch (46.3±6.79g for native starch; 308.7±95.31g for modified starch). In vitro study showed 89.12±0.84 % of drug release after 6 h in phosphate buffer pH 6.8 and the release kinetics followed Non-Fickian diffusion.Conclusion: The modified Assam bora rice starch enhanced a mucoadhesive property of the native starch and thus, can be explored in future as a potential excipient for the sustained release mucoadhesive drug delivery system.

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Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug

Carbohydrate Polymers ◽

10.1016/j.carbpol.2020.116556 ◽

2020 ◽

Vol 245 ◽

pp. 116556 ◽

Cited By ~ 2

Author(s):

May Thu Soe ◽

Thaned Pongjanyakul ◽

Ekapol Limpongsa ◽

Napaphak Jaipakdee

Keyword(s):

Composite Films ◽

Rice Starch ◽

Buccal Delivery ◽

Glutinous Rice ◽

Hydrophilic Drug ◽

Chitosan Composite

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Double attack on patent for Wellbutrin sustained-release agent

Nature Reviews Drug Discovery ◽

10.1038/nrd1336 ◽

2004 ◽

Vol 3 (3) ◽

pp. 196-196

Keyword(s):

Sustained Release ◽

Release Agent

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Preparation of Glutinous Rice Starch Nanofibers by Electrospinning

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.506.230 ◽

2012 ◽

Vol 506 ◽

pp. 230-233 ◽

Cited By ~ 4

Author(s):

P. Jaiturong ◽

Krit Sutjarittangtham ◽

Sukum Eitssayeam ◽

Jakkapan Sirithunyalug

Keyword(s):

Chemical Structure ◽

Chemical Properties ◽

Rice Starch ◽

High Porosity ◽

High Voltage Power Supply ◽

Electrospinning Technique ◽

Physical Chemical ◽

Glutinous Rice ◽

Ft Ir ◽

Basic Characteristics

Glutinous rice starch (GRS) is produced from glutinous rice which is commonly cultivated in the Northeast of Thailand. GRS contains two types of glucose polymers which are amylose and amylopectin. Glutinous rice starch nanofibers (GNF) can be produced by an electrospinning technique. This is not a complicated method but needs a high voltage power supply. The aim of this study was to understand the production of GNF and physical-chemical properties of GNF. The morphology of GNF was examined by scanning electron microscopy. The characteristics of GNF are high porosity, flake multi-layers and a high swelling power. The Electrospinning technique did not change the chemical structure of GRS based on an FT-IR evaluation. This research revealed the basic characteristics of electrospun glutinous starch for use in various applications in the future.

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