scholarly journals Elevated Plasma Factor VIII in Non-Pyogenic Cerebral Venous Thrombosis after Head Trauma without Skull Fracture

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Kipyoung Jeon ◽  
◽  
Jean Hee Kim ◽  
Kijeong Lee ◽  
Kyu-Nam Park ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Factor Viii ◽  
Head Trauma ◽  
Cerebral Venous Thrombosis ◽  
Skull Fracture ◽  
Hemorrhagic Transformation ◽  
Venous Infarction ◽  
Sagittal Sinus ◽  
Plasma Factor ◽  
Post Traumatic

Cerebral Venous Thrombosis (CVT) is a relatively uncommon but important cause of stroke that tends to affect young adults, especially women. Head trauma with or without skull fracture was reported to be triggering factors for CVT, but the underlying pathophysiology was not well elucidated. Endothelial injury and coexistent hypercoagulability were supposed to contribute to CVT after head trauma without skull fracture. We report a 49-year-old female patient who presented with headache with vomiting after head trauma and was initially diagnosed as post-traumatic Intracerebral Hemorrhage (ICH), but subsequently, progressed to CVT that resulted in cerebral venous infarction with hemorrhagic transformation. Magnetic Resonance brain Venography (MRV) confirmed CVT in superior sagittal sinus as well as right transverse and sigmoid sinuses. She was treated with endovascular mechanical thrombectomy followed by anticoagulation. The coagulopathy panel was checked both in hospital and in outpatient clinic for evaluating the etiology underlying post-traumatic nonpyogenic CVT. Persistently elevated level of plasma Factor VIII was identified. We should consider that patients with recent head trauma history without skull fracture and coexistent hypercoagulability could develop CVT resulting in cerebral venous infarction with hemorrhagic transformation even when the patient showed no definite focal neurologic deficit or the patient’s initial CT scan revealed no intracranial hemorrhage.

scholarly journals Recurrent Cerebral Venous Thrombosis Associated with Elevated Factor VIII

2006 ◽  
Vol 2 (4) ◽  
pp. 286 ◽  
Author(s):  
Mi Jung Kim ◽  
A-Hyun Cho ◽  
Young-Joo No ◽  
Hee-Young Kim ◽  
Jong S. Kim
Keyword(s):  
Venous Thrombosis ◽  
Factor Viii ◽  
Cerebral Venous Thrombosis

A Case of Cerebral Venous Thrombosis and Deep Venous Thrombosis Due to Hyperthyroidism with Increased Factor VIII Activity

2019 ◽  
Vol 28 (11) ◽  
pp. 104364 ◽  
Author(s):  
Mutsumi Yokoyama ◽  
Ryotaro Yamashita ◽  
Masayuki Furuya ◽  
Maiko Yamazaki ◽  
Kazuo Koyama ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Factor Viii ◽  
Deep Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Factor Viii Activity

scholarly journals Cerebral venous thrombosis with a catch

2021 ◽  
Vol 12 ◽  
pp. 590
Author(s):  
Raj Swaroop Lavadi ◽  
B. V. Sandeep ◽  
Manpreet Singh Banga ◽  
Sangamesh Halhalli ◽  
Anantha Kishan
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Head Injuries ◽  
Skull Fracture ◽  
Wound Debridement ◽  
Postoperative Mri ◽  
Depressed Fracture ◽  
Traumatic Head ◽  
High Index Of Suspicion ◽  
Plan Management

Background: Cerebral venous thrombosis (CVT) is a rare entity typically occurring in patients in hypercoagulable states. They can also occur in cases of trauma. The symptoms are nonspecific. Case Description: A 28-year-old male presented to the emergency department with a head injury. During the necessary imaging, it was found that he had a depressed skull fracture and other signs of traumatic brain injury. Unbeknownst to the patient and the patient party, it was also revealed that the patient only had one kidney. Wound debridement and excision of the depressed fracture were performed. A postoperative MRI revealed that the patient had CVT. Conclusion: There should be a high index of suspicion for CVT in case of traumatic head injuries. The surgeon should plan management according to the patient’s comorbidities.

scholarly journals Specific Polymorphism 4G/5G Gene for PAI-1 as a Possible Cause of Cerebral Venous Thrombosis: A Case Report

2017 ◽  
Vol 18 (2) ◽  
pp. 169-173
Author(s):  
Tatjana Boskovic Matic ◽  
Aleksandar Gavrilovic ◽  
Snezana Simovic ◽  
Dejan Aleksic ◽  
Katarina Vesic ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Plasminogen Activator ◽  
Cerebral Venous Thrombosis ◽  
Sinus Thrombosis ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Sagittal Sinus ◽  
Clinical Center ◽  
The Impact ◽  
Activator Inhibitor

AbstractThrombosis of veins and venous sinus (CVT) is the rare cerebral vascular disorder which makes less than 1% of all strokes. Thrombosis of veins and venous sinuses is picturesquely called “мајоr neurological forger” since it is characterized by very varied clinical picture. Among the various causes of CVT, which can be of infective or non-infective nature, the congenital hyper coagulations especially stand out, diagnosis is based on highly sophisticated diagnostic tests.We present the case of a female patient, 36 years old, who was hospitalized at the Clinic for Neurology in Clinical Center because of the diffuse headache she had for the last few days, with milder right-sided hemiparesis and one generalized tonic-clonic epileptic seizure. With nuclear magnetic resonance (MR/2D venography) the thrombosis of the upper and lower sagittal sinuses is confirmed. By appropriate laboratory tests, as well as by confirmatory immunological and genetic analyses, the impact of the most of the factors is excluded which can contribute to the occurrence of venous thrombosis. The only pathological findings which indicated the possible congenital thrombophilia as the cause of the sagittal sinus thrombosis was the determination of the specific polymorphism of the 4G/5G gene for plasminogen activator inhibitor 1.According to our knowledge, this is the first decribed case of the possible impact of the specific polymorphism of the 4G/5G gene for plasminogen activator inhibitor of 1 on the development of cerebral venous thrombosis.

scholarly journals Cerebral Venous Air Embolism due to a Hidden Skull Fracture Secondary to Head Trauma

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Ai Hosaka ◽  
Tetsuto Yamaguchi ◽  
Fumiko Yamamoto ◽  
Yasuro Shibagaki
Keyword(s):  
Head Trauma ◽  
Superior Sagittal Sinus ◽  
Skull Fracture ◽  
Air Embolism ◽  
Skull Fractures ◽  
Venous Air Embolism ◽  
Sagittal Sinus ◽  
The Right ◽  
Head Computed Tomography

Cerebral venous air embolism is sometimes caused by head trauma. One of the paths of air entry is considered a skull fracture. We report a case of cerebral venous air embolism following head trauma. The patient was a 55-year-old man who fell and hit his head. A head computed tomography (CT) scan showed the air in the superior sagittal sinus; however, no skull fractures were detected. Follow-up CT revealed a fracture line in the right temporal bone. Cerebral venous air embolism following head trauma might have occult skull fractures even if CT could not show the skull fractures.

scholarly journals Combined Hypertrophic Pachymeningitis and Cerebral Venous Thrombosis in a Case of Granulomatosis with Polyangiitis

2019 ◽  
Vol 11 (2) ◽  
pp. 252-255
Author(s):  
Tadahiro Kuribayashi ◽  
Yasuhiro Manabe ◽  
Shunya Fujiwara ◽  
Yoshio Omote ◽  
Hisashi Narai ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Granulomatosis With Polyangiitis ◽  
Laboratory Data ◽  
Brain Magnetic Resonance Imaging ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Hypertrophic Pachymeningitis ◽  
Left Frontal Lobe ◽  
Sagittal Sinus

We report a rare case of hypertrophic pachymeningitis (HP) and cerebral venous thrombosis associated with proteinase-3-antineutrophil cytoplasmic antibody (PR3-ANCA)-positive granulomatosis with polyangiitis (GPA). A 58-year-old male developed left headache after exudative otitis media. The laboratory data were positive for PR3-ANCA. Brain magnetic resonance imaging revealed bilateral paranasal sinusitis, left frontal lobe edema, and a thick dura mater with abnormal enhancement in the frontotemporal lobe. Magnetic resonance venography detected stenosis of the superior sagittal sinus. The patient was successfully treated with glucocorticoid, cyclophosphamide, and apixaban. Contrast neuroimaging should be performed for patients who present with unexplained headache, especially with middle ear and paranasal inflammation. These symptoms should be considered as GPA-related HP and cerebral venous thrombosis.

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