scholarly journals Improving Printability of a Thermoresponsive Hydrogel Biomaterial Ink by Nanoclay Addition

2020 ◽  
Author(s):  
Chen Hu ◽  
Lukas Hahn ◽  
Mengshi Yang ◽  
Alexander Altmann ◽  
Philipp Stahlhut ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Viscoelastic Properties ◽  
Critical Properties ◽  
Stimuli Responsive ◽  
Hybrid Hydrogel ◽  
Thermoresponsive Hydrogel ◽  
Enhanced Resolution ◽  
Copolymer Poly ◽  
Significant Attention ◽  
Made In

As a promising biofabrication technology, extrusion-based bioprinting has gained significant attention in the last decade and major advances have been made in the development of bioinks. However suitable synthetic and stimuli-responsive bioinks are underrepresented in this context. <a>In this work, we described a hybrid system of nanoclay Laponite XLG and thermoresponsive block copolymer poly(2-methyl-2-oxazoline)-<i>b</i>-poly(2-<i>n</i>-propyl-2-oxazine) (PMeOx-<i>b</i>-PnPrOzi) as a novel biomaterial ink, and discussed its critical properties relevant for extrusion-based bioprinting, including viscoelastic properties and printability.</a> <a>The hybrid hydrogel retains the thermogelling properties but is strengthened by the added clay (over 5 kPa of storage modulus, and 240 Pa of yield stress). Importantly, the shear-thinning character is further enhanced, which, in combination with very rapid viscosity recovery (~1 s) and structure recovery (~10 s) is highly beneficial for extrusion-based 3D printing. Accordingly, various 3D patterns could be printed with markedly enhanced resolution and shape fidelity compared to the biomaterial ink without added clay.</a>

scholarly journals Improving printability of a thermoresponsive hydrogel biomaterial ink by nanoclay addition

2020 ◽  
Vol 56 (1) ◽  
pp. 691-705 ◽  
Author(s):  
Chen Hu ◽  
Lukas Hahn ◽  
Mengshi Yang ◽  
Alexander Altmann ◽  
Philipp Stahlhut ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Viscoelastic Properties ◽  
Critical Properties ◽  
Stimuli Responsive ◽  
Hybrid Hydrogel ◽  
Thermoresponsive Hydrogel ◽  
Enhanced Resolution ◽  
Copolymer Poly ◽  
Significant Attention ◽  
Made In

Abstract As a promising biofabrication technology, extrusion-based bioprinting has gained significant attention in the last decade and major advances have been made in the development of bioinks. However, suitable synthetic and stimuli-responsive bioinks are underrepresented in this context. In this work, we described a hybrid system of nanoclay Laponite XLG and thermoresponsive block copolymer poly(2-methyl-2-oxazoline)-b-poly(2-n-propyl-2-oxazine) (PMeOx-b-PnPrOzi) as a novel biomaterial ink and discussed its critical properties relevant for extrusion-based bioprinting, including viscoelastic properties and printability. The hybrid hydrogel retains the thermogelling properties but is strengthened by the added clay (over 5 kPa of storage modulus and 240 Pa of yield stress). Importantly, the shear-thinning character is further enhanced, which, in combination with very rapid viscosity recovery (~ 1 s) and structure recovery (~ 10 s), is highly beneficial for extrusion-based 3D printing. Accordingly, various 3D patterns could be printed with markedly enhanced resolution and shape fidelity compared to the biomaterial ink without added clay. Graphic abstract

scholarly journals Improving Printability of a Thermoresponsive Hydrogel Biomaterial Ink by Nanoclay Addition

2020 ◽  
Author(s):  
Chen Hu ◽  
Lukas Hahn ◽  
Mengshi Yang ◽  
Alexander Altmann ◽  
Philipp Stahlhut ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Viscoelastic Properties ◽  
Critical Properties ◽  
Stimuli Responsive ◽  
Hybrid Hydrogel ◽  
Thermoresponsive Hydrogel ◽  
Enhanced Resolution ◽  
Copolymer Poly ◽  
Significant Attention ◽  
Made In

As a promising biofabrication technology, extrusion-based bioprinting has gained significant attention in the last decade and major advances have been made in the development of bioinks. However suitable synthetic and stimuli-responsive bioinks are underrepresented in this context. <a>In this work, we described a hybrid system of nanoclay Laponite XLG and thermoresponsive block copolymer poly(2-methyl-2-oxazoline)-<i>b</i>-poly(2-<i>n</i>-propyl-2-oxazine) (PMeOx-<i>b</i>-PnPrOzi) as a novel biomaterial ink, and discussed its critical properties relevant for extrusion-based bioprinting, including viscoelastic properties and printability.</a> <a>The hybrid hydrogel retains the thermogelling properties but is strengthened by the added clay (over 5 kPa of storage modulus, and 240 Pa of yield stress). Importantly, the shear-thinning character is further enhanced, which, in combination with very rapid viscosity recovery (~1 s) and structure recovery (~10 s) is highly beneficial for extrusion-based 3D printing. Accordingly, various 3D patterns could be printed with markedly enhanced resolution and shape fidelity compared to the biomaterial ink without added clay.</a>

Photo- and Thermo-Dual-Responsive Organic/Inorganic Hybrid Materials

2013 ◽  
Vol 538 ◽  
pp. 181-184 ◽  
Author(s):  
Xin De Tang ◽  
Ye Chen ◽  
Fa Qi Yu ◽  
Mei Shan Pei
Keyword(s):  
Block Copolymer ◽  
Hybrid Materials ◽  
Self Assembly ◽  
Polymeric Materials ◽  
Stimuli Responsive ◽  
Inorganic Hybrid ◽  
Dual Responsive ◽  
Hexyl Methacrylate ◽  
Poly Ethylene ◽  
Copolymer Poly

Organic/inorganic hybrid materials based upon stimuli-responsive copolymers have attracted an inceasing attention. Compared with the polymeric materials, these hybrid materials can form aggregates in aqueous solution with much more stable shape-persistance due to the inorganic structure, which facilitate the mass delivery and long-term life. A novel hybrid material based on a new reactive block copolymer, poly(ethylene oxide)-block-poly{3-(trimethoxysilyl)propyl methacrylate-co-N-isopropylacrylamide-co-6-[4-(4-methoxyphenylazo)phenoxy]hexyl methacrylate} [PEO-P(TMSPMA-NIPAM-AzoMA)] was synthesized via atom transfer radical polymerization (ATRP). The vesicles were obtained by self-assembly of the resulting block copolymer in a selective solvent, and then the PTMSPMA block was subjected to hydrolysis and polycondensation reaction to fix vesicle wall in the presence of triethylamine as a catalyst. The photo- and thermo- dual-responsive properties of the vesicles were investigated.

Sticky ends in a self-assembling ABA triblock copolymer: the role of ureas in stimuli-responsive hydrogels

2019 ◽  
Vol 4 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Ryan T. Shafranek ◽  
Joel D. Leger ◽  
Song Zhang ◽  
Munira Khalil ◽  
Xiaodan Gu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Viscoelastic Properties ◽  
Triblock Copolymer ◽  
Thermal Response ◽  
Stimuli Responsive ◽  
Self Assembling ◽  
Polymeric Hydrogels ◽  
Aba Triblock Copolymer ◽  
Responsive Hydrogels

Directed self-assembly in polymeric hydrogels allows tunability of thermal response and viscoelastic properties.

Modular polymerized ionic liquid block copolymer membranes for CO2/N2 separation

2014 ◽  
Vol 2 (21) ◽  
pp. 7967-7972 ◽  
Author(s):  
Brian J. Adzima ◽  
Surendar R. Venna ◽  
Steven S. Klara ◽  
Hongkun He ◽  
Mingjiang Zhong ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Block Copolymer ◽  
Polymerized Ionic Liquid ◽  
Copolymer Poly ◽  
Poly Ionic Liquid

A robust and orthogonal approach to access modular block-copolymer poly(ionic liquid)s.

Self-Association of the Thermosensitive Block Copolymer Poly(2-isopropyl-2-oxazoline)-b-poly(N-isopropylacrylamide) in Water–Methanol Mixtures

2014 ◽  
Vol 47 (19) ◽  
pp. 6900-6910 ◽  
Author(s):  
Rintaro Takahashi ◽  
Xing-Ping Qiu ◽  
Na Xue ◽  
Takahiro Sato ◽  
Ken Terao ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Self Association ◽  
Copolymer Poly

scholarly journals Isolation of Circulating Biomarkers for Liquid Biopsy using Immunoaffinity‐Based Stimuli‐Responsive Hybrid Hydrogel Beads

2021 ◽  
Author(s):  
Yoon-Tae Kang ◽  
Young Jun Kim ◽  
Brittany Rupp ◽  
Emma Purcell ◽  
Thomas Hadlock ◽  
...  
Keyword(s):  
Liquid Biopsy ◽  
Stimuli Responsive ◽  
Circulating Biomarkers ◽  
Hybrid Hydrogel ◽  
Hydrogel Beads

Polylactic acid block copolymer grafted temozolomide targeted nano delivery in the treatment of glioma

2021 ◽  
Vol 11 (5) ◽  
pp. 627-633
Author(s):  
Maokai Wang ◽  
Rongyan Kuang ◽  
Baoqing Huang ◽  
Defeng Ji
Keyword(s):  
Central Nervous System ◽  
Block Copolymer ◽  
Tumor Recurrence ◽  
Poly Lactic Acid ◽  
First Line ◽  
Kunitz Domain ◽  
The Central Nervous System ◽  
Modified Block ◽  
Copolymer Poly ◽  
Line Chemotherapy

Gliomas are tumors of the central nervous system; they can be invasive and are commonly treated by surgical resection, chemo, and radiotherapy. Removal of a glioma is dangerous and not always successful. Temozolomide (TMZ), the first-line chemotherapy drug for gliomas, inhibit tumor recurrence, and metastasis to some extent. TMZ is often accompanied by side effects such as anemia, fever, constipation, and more. Here using a double-targeted Kunitz domain Angiopep-2 (ANG) modified block copolymer poly(lactic acid)-polyethylene glycol (PEG-PLA) coated with TMZ, we constructed a nano-delivery system (ANG@PLA-PEG/TMZ) that crosses the blood-brain barrier (BBB) to treat gliomas.

Viscoelastic Properties of Aligned Block Copolymer Lamellae

2001 ◽  
Vol 34 (25) ◽  
pp. 8701-8709 ◽  
Author(s):  
Hyeok Hahn ◽  
Joon H. Lee ◽  
Nitash P. Balsara ◽  
Bruce A. Garetz ◽  
Hiroshi Watanabe
Keyword(s):  
Block Copolymer ◽  
Viscoelastic Properties
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