Artificial Intelligence Recognizes β-Lapachone as an Allosteric 5- Lipoxygenase Inhibitor

2018 ◽  
Author(s):  
Gonçalo Bernardes ◽  
Tiago Rodrigues ◽  
Markus Werner ◽  
Jakob Roth ◽  
Eduardo H. G. da Cruz ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Drug Discovery ◽  
Natural Product ◽  
Systems Pharmacology ◽  
Lipoxygenase Inhibitor ◽  
Machine Learning Methods ◽  
Biochemical Assays ◽  
Viable Approach ◽  
Chemical Matter

<div> <div> <div> <p>Chemical matter with often-discarded moieties entails opportunities for drug discovery. Relying on orthogonal ligand-centric machine learning methods, targets were consensually identified as potential counterparts for the fragment-like natural product β-lapachone. Resorting to a comprehensive range of biophysical and biochemical assays, the natural product was validated as a potent, ligand efficient, allosteric and reversible modulator of 5-lipoxygenase (5-LO). Moreover, we provide a rationale for 5-LO-inhibiting chemotypes inspired in the β-lapachone scaffold through a focused analogue library. This work demonstrates the power of artificial intelligence technologies to deconvolute complex phenotypic readouts of clinically relevant chemical matter, leverage natural product-based drug discovery, as an alternative and/or complement to chemoproteomics and as a viable approach for systems pharmacology studies. </p> </div> </div> </div>

Artificial Intelligence Recognizes β-Lapachone as an Allosteric 5- Lipoxygenase Inhibitor

2018 ◽  
Author(s):  
Gonçalo Bernardes ◽  
Tiago Rodrigues ◽  
Markus Werner ◽  
Jakob Roth ◽  
Eduardo H. G. da Cruz ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Drug Discovery ◽  
Natural Product ◽  
Systems Pharmacology ◽  
Lipoxygenase Inhibitor ◽  
Machine Learning Methods ◽  
Biochemical Assays ◽  
Viable Approach ◽  
Chemical Matter

<div> <div> <div> <p>Chemical matter with often-discarded moieties entails opportunities for drug discovery. Relying on orthogonal ligand-centric machine learning methods, targets were consensually identified as potential counterparts for the fragment-like natural product β-lapachone. Resorting to a comprehensive range of biophysical and biochemical assays, the natural product was validated as a potent, ligand efficient, allosteric and reversible modulator of 5-lipoxygenase (5-LO). Moreover, we provide a rationale for 5-LO-inhibiting chemotypes inspired in the β-lapachone scaffold through a focused analogue library. This work demonstrates the power of artificial intelligence technologies to deconvolute complex phenotypic readouts of clinically relevant chemical matter, leverage natural product-based drug discovery, as an alternative and/or complement to chemoproteomics and as a viable approach for systems pharmacology studies. </p> </div> </div> </div>

Clinical Trials and Machine Learning: Regulatory Approach Review

2021 ◽  
Vol 16 ◽  
Author(s):  
Diego Alejandro Dri ◽  
Maurizio Massella ◽  
Donatella Gramaglia ◽  
Carlotta Marianecci ◽  
Sandra Petraglia
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Clinical Trials ◽  
Patient Safety ◽  
Drug Discovery ◽  
Clinical Applications ◽  
Clinical Development ◽  
Regulatory Approach ◽  
National Competent Authorities ◽  
Review Current

: Machine Learning, a fast-growing technology, is an application of Artificial Intelligence that has significantly contributed to drug discovery and clinical development. In the last few years, the number of clinical applications based on Machine Learning has constantly been growing. Moreover, it is now also impacting National Competent Authorities during the assessment of most recently submitted Clinical Trials that are designed, managed, or generating data deriving from the use of Machine Learning or Artificial Intelligence technologies. We review current information available on the regulatory approach to Clinical Trials and Machine Learning. We also provide inputs for further reasoning and potential indications, including six actionable proposals for regulators to proactively drive the upcoming evolution of Clinical Trials within a strong regulatory framework, focusing on patient safety, health protection, and fostering immediate access to effective treatments.

scholarly journals Modelling of Traffic Flows and Supply Chains Based on Geospatial Knowledge

2021 ◽  
Vol 2068 (1) ◽  
pp. 012042
Author(s):  
A Kolesnikov ◽  
P Kikin ◽  
E Panidi
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Supply Chains ◽  
Inventory Management ◽  
Traffic Flows ◽  
Machine Learning Methods ◽  
Customer Interaction ◽  
Long Term Impact ◽  
Artificial Intelligence Systems

Abstract The field of logistics and transport operates with large amounts of data. The transformation of such arrays into knowledge and processing using machine learning methods will help to find additional reserves for optimizing transport and logistics processes and supply chains. This article analyses the possibilities and prospects for the application of machine learning and geospatial knowledge in the field of logistics and transport using specific examples. The long-term impact of geospatial-based artificial intelligence systems on such processes as procurement, delivery, inventory management, maintenance, customer interaction is considered.

RESEARCHING METHODS FOR PROCESSING TEXT INFORMATION AND REVIEWING THE STAGES OF AN ARTIFICIAL INTELLIGENCE MODEL CREATION AT PRODUCING CHATBOTS

2021 ◽  
Vol 2021 (2) ◽  
pp. 19-23
Author(s):  
Anastasiya Ivanova ◽  
Aleksandr Kuz'menko ◽  
Rodion Filippov ◽  
Lyudmila Filippova ◽  
Anna Sazonova ◽  
...  
Keyword(s):  
Neural Network ◽  
Artificial Intelligence ◽  
Machine Learning ◽  
Text Processing ◽  
Text Format ◽  
Machine Learning Methods ◽  
Methods And Techniques ◽  
Text Information ◽  
Processing Techniques ◽  
Machine Processing

The task of producing a chatbot based on a neural network supposes machine processing of the text, which in turn involves using various methods and techniques for analyzing phrases and sentences. The article considers the most popular solutions and models for data analysis in the text format: methods of lemmatization, vectorization, as well as machine learning methods. Particular attention is paid to the text processing techniques, after their analyzing the best method was identified and tested.

An artificial intelligence-enabled industry classification and its interpretation

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Daejin Kim ◽  
Hyoung-Goo Kang ◽  
Kyounghun Bae ◽  
Seongmin Jeon
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Classification System ◽  
Standard Industrial Classification ◽  
American Industry ◽  
Content Type ◽  
Global Industry ◽  
Machine Learning Methods ◽  
Industry Classification ◽  
Traditional Industry

PurposeTo overcome the shortcomings of traditional industry classification systems such as the Standard Industrial Classification Standard Industrial Classification, North American Industry Classification System North American Industry Classification System, and Global Industry Classification Standard Global Industry Classification Standard, the authors explore industry classifications using machine learning methods as an application of interpretable artificial intelligence (AI).Design/methodology/approachThe authors propose a text-based industry classification combined with a machine learning technique by extracting distinguishable features from business descriptions in financial reports. The proposed method can reduce the dimensions of word vectors to avoid the curse of dimensionality when measuring the similarities of firms.FindingsUsing the proposed method, the sample firms form clusters of distinctive industries, thus overcoming the limitations of existing classifications. The method also clarifies industry boundaries based on lower-dimensional information. The graphical closeness between industries can reflect the industry-level relationship as well as the closeness between individual firms.Originality/valueThe authors’ work contributes to the industry classification literature by empirically investigating the effectiveness of machine learning methods. The text mining method resolves issues concerning the timeliness of traditional industry classifications by capturing new information in annual reports. In addition, the authors’ approach can solve the computing concerns of high dimensionality.

The Usage Analysis of Machine Learning Methods for Intrusion Detection in Software-Defined Networks

2021 ◽  
pp. 959-975
Author(s):  
Derya Yiltas-Kaplan
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Intrusion Detection ◽  
Network Architectures ◽  
Software Defined Networks ◽  
Learning Approaches ◽  
Advantages And Disadvantages ◽  
Machine Learning Methods ◽  
Network Problems ◽  
Usage Analysis

This chapter focuses on the process of the machine learning with considering the architecture of software-defined networks (SDNs) and their security mechanisms. In general, machine learning has been studied widely in traditional network problems, but recently there have been a limited number of studies in the literature that connect SDN security and machine learning approaches. The main reason of this situation is that the structure of SDN has emerged newly and become different from the traditional networks. These structural variances are also summarized and compared in this chapter. After the main properties of the network architectures, several intrusion detection studies on SDN are introduced and analyzed according to their advantages and disadvantages. Upon this schedule, this chapter also aims to be the first organized guide that presents the referenced studies on the SDN security and artificial intelligence together.

scholarly journals WAYS TO USE NEURAL NETWORKS AND MACHINE LEARNING IN COMPUTER GAMES

2021 ◽  
Vol 295 (2) ◽  
pp. 97-100
Author(s):  
K. Seniva ◽  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Neural Networks ◽  
Computer Games ◽  
Real Life ◽  
Gaming Industry ◽  
Game Development ◽  
Machine Learning Methods ◽  
Long Time ◽  
And Behavior

This article discusses the main ways of using neural networks and machine learning methods of various types in computer games. Machine learning and neural networks are hot topics in many technology fields. One of them is the creation of computer games, where new tools are used to make games more interesting. Remastered and modified games with neural networks have become a new trend. One of the most popular ways to implement artificial intelligence is neural networks. They are used in everything from medicine to the entertainment industry. But one of the most promising areas for their development is games. The game world is an ideal platform for testing artificial intelligence without the danger of harming nature or people. Making bots more complex is just a small part of what neural networks can do. They are also actively used in game development, and in some areas they already make people feel uncomfortable. Research is ongoing on color and light correction, real-time character animation and behavior control. The main types of neural networks that can learn such functions are considered. Neural networks learn (and self-learn) very quickly. The more primitive the task, the faster the person will become unnecessary. This is already noticeable in the gaming industry, but will soon spread to other areas of life, because games are just a convenient platform for experimenting with artificial intelligence before its implementation in real life. The main problem faced by scientists is that it is difficult for neural networks to copy the mechanics of the game. There are some achievements in this direction, but research continues. Therefore, in the future, real specialists will be required for the development of games for a long time, although AI is already coping with some tasks.

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