scholarly journals Evaluation of heart rate variability in patients with different forms of pulmonary hypertension

2021 ◽  
Vol 18 (3) ◽  
pp. 147-152
Author(s):  
Nasiba Kh. Qurbonbekova ◽  
Anna M. Kasparova ◽  
Elena Sh. Kozhemyakina ◽  
Alexander V. Sobolev ◽  
Tamila V. Martynyuk
Keyword(s):  
Heart Rate ◽  
Pulmonary Hypertension ◽  
Heart Rate Variability ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Functional Status ◽  
Cardiovascular System ◽  
The Body ◽  
Increased Risk ◽  
Pulmonary Arterial

Pulmonary hypertension (PH) is a severe pathology of the cardiovascular system with extremely poor prognosis, if unreated. Early diagnosis of PH is difficult, due to the absence pathognomonic symptoms, and at the initial stage the disease may be asymptomatic. An increase in pulmonary vascular resistance and pressure in the pulmonary artery cause severe dysfunction of the right ventricle, which affects the functional status of patients. The assessment of heart rate variability (HRV) parameters is used to predict the increased risk of sudden death in various diseases of the cardiovascular system and the functional status of the body. HRV is mainly regulated by the sympathetic and parasympathetic divisions of the autonomic nervous system. It is noted that pulmonary arterial hypertension is associated with increasing of sympathetic activity. The review, based on the analysis of the pathophysiological mechanisms of pulmonary arterial hypertension and chronic thromboembolic PH, presents the results of studies assessing the time and spectral parameters of HRV in patients with PH of various etiologies.

Heart rate variability predicts outcome in children with pulmonary arterial hypertension

2010 ◽  
Vol 142 (2) ◽  
pp. 159-165 ◽  
Author(s):  
Astrid E. Lammers ◽  
Elizabeth Munnery ◽  
Alison A. Hislop ◽  
Sheila G. Haworth
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Pulmonary Arterial

scholarly journals Decreased Heart Rate Variability in Sickle Cell Anemia as Effect of Pulmonary Arterial Hypertension

Kardiologiia ◽  
2019 ◽  
Vol 59 (4) ◽  
pp. 39-44 ◽  
Author(s):  
F. Akgul ◽  
T. A. Batyraliev ◽  
D. V. Fettser ◽  
E. Seyfeli ◽  
A. G. Arystan ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Mortality Risk ◽  
Healthy Subjects ◽  
Pulmonary Arterial ◽  
Frequency Power

Decreased heart rate variability (HRV) is associated with increased mortality risk in various diseases. Theobjective of this investigation:to study HRV in patients with sickle cell anemia (SCA) and to assess the effect of pulmonary arterial hypertension (PAH) on HRV in these patients.Materials and methods. HRV registration and Doppler echocardiographic assessment of systolic pulmonary arterial pressure (PAP) was carried out in 61 stable patients with SCA and 24 healthy subjects.Results. Low frequency power (LFP) and high frequency power (HFP) were decreased in SCA patients compared to healthy subjects. Among SCA patients, PAH patients had lower  LFP and HFP than patients without PAH. In SCA patients, systolic PAP showed significant negative correlation with LFP and HFP. Conclusion.HRV is significantly decreased in SCA patients, especially in those with PAH. HRV may be particularly useful in early detection of PAH patients who may have worse prognosis and higher mortality risk.

Neural control of ANF release in hypoxia and pulmonary hypertension

1990 ◽  
Vol 259 (3) ◽  
pp. H735-H744 ◽  
Author(s):  
A. J. Baertschi ◽  
J. H. Jiao ◽  
D. E. Carlson ◽  
R. W. Campbell ◽  
W. G. Teague ◽  
...  
Keyword(s):  
Heart Rate ◽  
Pulmonary Hypertension ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Neural Control ◽  
Venous Pressure ◽  
Electrical Conductance ◽  
Neural Pathways ◽  
Control Series ◽  
Pulmonary Arterial

Hypoxia causes the release of atrial natriuretic factor (ANF), but the mechanisms are not yet understood. This study examined the relative contribution of pulmonary arterial hypertension, neural pathways, increased heart rate, or increased atrial size to the ANF response. Alveolar hypoxia [fractional concentration of O2 in inspired gas (FIo2) = 0.1] or pulmonary arterial hypertension (25-45 mmHg) was induced for 10 min in four series (n = 4-12 each) of anesthetized, mechanically ventilated pigs. During hypoxia, plasma ANF concentrations increased by 129 +/- 52 (SE) pg/ml (or 271 +/- 105%) over baseline (35 +/- 7 pg/ml; P less than 0.01) (series 1). There was also a significant increase of pulmonary arterial pressure, heart rate, central venous pressure, and pulmonary capillary wedge pressure. Repeated pulmonary hypertension induced by intravenous air infusion caused a repeated and reversible 125 +/- 14% increase (P less than 0.001) of plasma ANF, and this response was totally abolished by lesion of the cervical vagosympathetic trunks (series 2). Lesion of these nerves 1 h before hypoxia also decreased the ANF response to hypoxia by 45-58% (P less than 0.01), whereas responses of heart rate and atrial pressures were unchanged (series 3). The ANF response to hypoxia, expressed in percent of baseline, was not affected by 0.2 mg/kg propranolol (PR) (no PR: 145 +/- 63%; PR: 151 +/- 82%; not significantly different from series 1 and control, series 3), although the increase in heart rate (no PR: 61 +/- 15 beats/min) was almost abolished (PR: 17 +/- 5 beats/min) (series 4). Hypoxia caused no significant changes in right and left atrial peak volume regardless of propranolol, as measured with an electrical conductance catheter. The results indicate that a new neural reflex of probably pulmonary arterial origin mediates approximately 50% of the ANF response to hypoxia. The remaining ANF response remains to be explored further and cannot be explained by conventional release mechanisms such as atrial stretch and pulsatility alone.

Pulmonary Arterial Hypertension: Epidemiology and Registries

2014 ◽  
Vol 13 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Michael D. McGoon ◽  
Marc Humbert
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Task Force ◽  
The World ◽  
Important Means ◽  
Pulmonary Arterial

Registries of pulmonary arterial hypertension (PAH) are important means by which to characterize the presentation and outcome of patients and to provide a basis for predicting the course of the disease. This article summarizes the published conclusions of the World Symposium of Pulmonary Hypertension task force that addressed registries and epidemiology of PAH.

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