scholarly journals Improvement of Advanced Assisted gastro retentive floating tablet using TRZ and S

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 194-200
Author(s):  
Venu Gopal Raju S ◽  
Viswanathan S ◽  
Nithya P
Keyword(s):  
Medical Care ◽  
Numerical Models ◽  
Discharge Medication ◽  
Medication Plan ◽  
Floating Tablet ◽  
Structure Measurement ◽  
Gastro Retentive ◽  
Trazodone Hydrochloride

Definition advancement is a significant piece of medication plan and improvement. Bioavailability and bioequivalence are absolutely reliant on definition improvement. Presently a-days detailing advancement is finished by following Quality through Design. Floating drug conveyance frameworks are the gastro retentive structures that absolutely control the delivery pace of target medication to a particular site which encourage a tremendous effect on medical care. This can be accomplished by utilization of different polymeric substances. Trazodone-Hydrochloride (TRZ), is a notable substance aggravate that is utilized as an energizer that has a place with a particular serotonin repeated inhibitors (SARI). The delivery information was fitted to different numerical models, for example, higuchi, Korsmeyer-Peppas (KP), 1st request &0 request to assess the energy and system of the medication discharge. Arranged coasting tablets of TRZ may end up being a possible possibility for sheltered and successful controlled medication conveyance over an all-encompassing timeframe for gastro retentive medication conveyance framework. The oral assisted medication architecture conveyance has been confounded through confined habitation time gastric. Also, rapid gastro-intestinal transmission might predict overall discharge medication in zone of retention and diminish the handled portion adequacy, as many of medications have been invested on small digestive upper piece system. Also, it handles structure measurement at assimilation site & in this way updates bio-availability as stated in.

scholarly journals Formulation and Pharmacokinetic Evaluation of Ritonavir Floating Tablets in the Management of AIDS

2018 ◽  
Vol 10 (6) ◽  
Author(s):  
R. Shireesh Kiran ◽  
B. Chandra Shekar ◽  
B. Nagendra Babu
Keyword(s):  
Drug Release ◽  
Sodium Bicarbonate ◽  
Controlled Drug Release ◽  
In Vitro Dissolution ◽  
Gastric Residence Time ◽  
Dissolution Studies ◽  
Floating Tablet ◽  
Gastro Retentive

In the current study, gastro-retentive tablets of Ritonavir was developed to increase its oral bioavailability using hydrophilic polymers HPMC K 4M, K 15M, and K 100M as release retarding agents. Polyox WSR 303 was chosen as resin, sodium bicarbonate was used as effervescent agents. The tablets were prepared by direct compression method and FTIR studies revealed that there is no interaction between the drug and polymers used for the formulation. Among all the formulations F21 containing HPMC K 100M, Crospovidone, Polyox WSR 303 and sodium bicarbonate, as gas generating agent was choosen as optimized formulation based on the evaluation parameters, floating lag time (33 sec) and total floating time (>24 h) and in vitro dissolution studies. From in vitro dissolution studies, the optimized formulation F21 and marketed product was shown 98.67% and 95.09 ± 5.01% of drug release respectively. From in vivo bioavailability studies, after oral administration of floating tablet containing 100 mg Ritonavir, the Cmax, Tmax, and AUC0–∞ of optimized gastroretentive formulation were found to be 30.11 ± 1.16μg/mL, 8.00±1.23 h and 173 ± 26.34μg*h/ml, respectively. Cmax and AUC values of optimized formulation were found to be significantly higher than of marketed product, where longer gastric residence time is an important condition for prolonged or controlled drug release and also for improved bioavailability.

scholarly journals Using Lean Six Sigma methodologies to reduce risk of warfarin medication omission at hospital discharge

2020 ◽  
Vol 9 (2) ◽  
pp. e000715
Author(s):  
Ashlie Kallal ◽  
David Griffen ◽  
Cassie Jaeger
Keyword(s):  
Electronic Health Record ◽  
Six Sigma ◽  
Warfarin Dose ◽  
Lean Six Sigma ◽  
Health Record ◽  
Discharge Medication ◽  
Medication Plan ◽  
Number Of Patients ◽  
Increased Risk ◽  
Electronic Health

Unintended omission of warfarin, an anticoagulant used to prevent and treat thromboembolic events, can lead to serious medical complications. These complications include increased medical costs, hospitalisations and significant patient harm, including increased risk of thrombosis and mortality. Chart review of discharged patients at our institution revealed an average of one patient/month with warfarin omitted from the discharge plan despite intention to continue therapy. Lean Six Sigma methodology was used to improve the process. A system alert was implemented in the electronic health record to alert providers of patients who received warfarin during admission, the discharge medication reconciliation was complete, and there was no prescription for warfarin. Date and time of last warfarin dose and international normalised ratio were included in the alert. Providers had the option to return to the chart to update the discharge medication plan and add the warfarin prescription or to choose an appropriate over-ride reason. The number of patients discharged without an intended warfarin prescription following alert implementation was reduced from 10.5% (4/38) to 0% (0/40) (two proportion test, p=0.03). Alert tracking enhanced the ability to identify patients at risk for warfarin omissions. Process sustainability has been achieved by embedding system alerts in the electronic health record to trigger process steps.

Evaluation of An Inpatient Pharmacy Consult on Discharge Medications in Bariatric Surgery Patients

2021 ◽  
pp. 089719002110302
Author(s):  
Amanda M. Van Prooyen ◽  
Jessica L. Hicks ◽  
Ed Lin ◽  
Scott S. Davis ◽  
Arvinpal Singh ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Medical Center ◽  
Academic Medical Center ◽  
Intervention Group ◽  
Pharmacist Intervention ◽  
Control Group ◽  
Medication History ◽  
Discharge Medication ◽  
Medication Plan ◽  
The Impact

Purpose: To evaluate the impact of an inpatient pharmacy consult on discharge medications following bariatric surgery. Methods: A pharmacy consult for discharge medication review for bariatric surgery patients was instituted at an academic medical center. The intervention included conducting a medication history, reviewing home medications for updates post-bariatric surgery, creating and documenting a discharge medication plan, and providing patient education. The impact of the intervention was evaluated by comparing medication classes, doses, and formulations prescribed during the intervention relative to a historical control group. Results: The study included 85 patients who received pharmacist intervention and 167 patients who did not receive pharmacist intervention following bariatric surgery. The prescription of an extended-release medication at discharge in the intervention group was reduced by 19.3% (28.7% vs. 9.4%, p = 0.0005). For patients on hypertension medications, 94.0% had their regimen reduced in the intervention group compared with 37.5% of patients in the control group (p < 0.001). Of patients on insulin at baseline, 87.5% of patients in the intervention group had dose reductions at discharge vs. 66.7% of patients in the control group (p = 0.37). No patients in the intervention group were discharged with oral antihyperglycemic medications or non-insulin injectable medications vs. 33.3% (p = 0.12) and 20.0% (p = 0.47), respectively, in the control group. Readmission rates at 30 days were insignificantly lower in the intervention group (3.5% vs. 4.2%, p = 1). Conclusions: Clinical pharmacist involvement in the discharge medication reconciliation process for bariatric surgery patients reduced prescribing of unadjusted medication classes, doses, and drug formulations.

scholarly journals Development and Evaluation of Gastro Retentive Floating Drug Delivery System of Ondansetron Hydrochloride

2021 ◽  
Vol 11 (6) ◽  
pp. 150-158
Author(s):  
Abadhesh Kumar Niranjan ◽  
Aditya Kumar
Keyword(s):  
Drug Release ◽  
Guar Gum ◽  
Uv Spectroscopy ◽  
Release Profile ◽  
Release Formulation ◽  
Weight Variation ◽  
Ondansetron Hydrochloride ◽  
Floating Tablet ◽  
Gastro Retentive

The Aim of the present study was to develop & evaluate Gastro-retentive floating Tablet of Ondansetron hydrochloride. The Objective was to calibrate and validate the UV- spectroscopy analytical method and to prepare and optimize the GR Floating tablets of Ondansetron hydrochloride in terms of dissolution release profile. The FDDS of the drug can minimize the fluctuation of drug plasma levels and result to associated adverse reactions, dosing frequency, and improved patient compliance. Conventionally, Ondansetron hydrochloride is taken up 2-3 times daily in the treatment of nausea and vomiting. Gastro retentive floating tablet of Ondansetron hydrochloride is better suited for treatment of postoperative nausea vomiting. In the present study, nine Gastro retentive Floating tablet formulations (F1, F2.....F9) of Ondansetron hydrochloride were prepared by the  method of direct compression and polymers HPMC K15 were used and Guargum and Chitosan, in different quantity to normalise their effect on the’ release profile of drug . Target release profile was >80% release of drug in 12 hours. Tablets were evaluated for various parameters namely: thickness, weight variation’, friability, hardness, assay, in-vitro buoyancy study & drug release. Formulation F8 containing Chitosan (26.66% w/w), Guargum (26.66% w/w) and Sod. Carbonate (25.83% w/w) had the desirable release profile. Keywords: Ondansetron hydrochloride; Gastro retentive floating tablet, Chitosan, Guar gum, Drug release

scholarly journals Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent

2012 ◽  
Vol 4 (5) ◽  
pp. 88 ◽  
Author(s):  
Ravikumar Ukawala ◽  
Gautam Singhvi ◽  
Suresh Jain ◽  
Vipin Shukla ◽  
Nilesh Yadav ◽  
...  
Keyword(s):  
Controlled Release ◽  
Psychotropic Agent ◽  
Floating Tablet ◽  
Gastro Retentive

scholarly journals FORMULATION AND EVALUATION OF GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF ZANAMIVIR USING DIFFERENT POLYMERS

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
V. Vijaya Kumar ◽  
B. Deekshi Gladiola ◽  
C. Madhusudhana Chetty ◽  
R. E. Ugandar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Guar Gum ◽  
Release Kinetics ◽  
Methyl Cellulose ◽  
Floating Tablets ◽  
Floating Tablet ◽  
Gastro Retentive

The objective of the present study is to develop gastro retentive drug delivery system of Zanamivir .Floating tablets of Zanamivir were developed with a gas generating agent NaHCO3 and in combination of different hydrophobic and hydrophilic polymers like xanthan gum, guar gum, HPMC and methyl cellulose .In the present work attempts have been made to prepare six formulations of Zanamivir in different ratios of drug and polymer to get a desired release profile by direct compression method .All the prepared tablets were evaluated in terms of pre compression and post compression parameters. FTIR studies revealed the absence of drug polymer interactions .Among all the formulations F5 Showed 97.4% of in vitro drug release for 10 hours and hence formulation F5 is selected as an optimized formulation. The optimized formulation F5 was found to follow Higuchi release kinetics and zero order. Further formulation F5 was subjected to accelerated stability studies for 3 months. It showed that the optimized formulation was intact without any interactions. Finally the optimized formulation F5 complying with all properties of floating tablets was found to be satisfactory Keywords: Zanamivir, floating tablet, natural gums, sodium bicarbonate, gastro retentive drug delivery systems

Exploring the Potentials of Corn Fiber Gum in Fabricating Mucoadhesive Floating Tablet of Poorly Gastro-retainable Drug

2020 ◽  
Vol 15 ◽  
Author(s):  
Bhumika Mangla ◽  
Anurekha Jain ◽  
Deepinder Singh Malik
Keyword(s):  
Drug Release ◽  
Polymer Concentration ◽  
Storage Conditions ◽  
Corn Fiber ◽  
Compression Technique ◽  
In Vitro Drug Release ◽  
Floating Tablets ◽  
Floating Tablet ◽  
Gastro Retentive

Aim:: To formulate and preliminary evaluated polysaccharide based mucoadhesive floating tablets of Cinnarizine. Background:: Gastro-retentive drug delivery systems has proved to be a successful approach to enhance the gastric residence with site specific targeting for achieving local or generalized effect. Various patents has also been filed globally employing gastro-retentive approach. Objective:: The study is designed to explore the mucoadhesive and low density characteristics of corn fibre gum (CFG) for preparation of gastro-retentive floating tablets of cinnarizine. Methods:: Floating tablets were prepared by direct compression technique using different concentrations of CFG (45, 50, 60% w/w). The formulated floating tablet batches were evaluated for their hardness, friability, drug content, floating duration/ lag time, swelling behavior, bioadhesive strength and in vitro drug release. Results:: Mucoadhesive strength was found to increase with an increment in the polysaccharide concentration. Swelling index was found to increase both with the increase in CFG concentration and with duration for which tablet remains in medium. The in vitro drug release studies indicated decrease in drug release (91% to 77%) with the increase in polymer concentration. The release data was further fitted to various kinetic models which revealed the drug release to be in accordance with Zero-order and Higuchi models, indicating polymer to exhibit the swellable matrix forming abilities. The value of n (between 0.458 and 0.997) from Korsemeyer Peppas model depicted the possibility of drug to follow more than one mechanism of release from the formulation i.e. diffusion and erosion. Stability studies revealed the preparations to retain their integrity and pharmaceutical characteristics at variable storage conditions. Conclusion:: Thus from the research findings, CFG could be concluded to possess potential binder, release retardant and mucoadhesive characteristics which could be successfully employed for the formulation of gastro-retentive floating tablets.

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