Hyperbaric Oxygen Therapy and Its Suitability as an Adjuvant for Treatment of Covid-19 Patients: A Review

2021 ◽  
Vol 12 (4) ◽  
pp. 2548-2556
Author(s):  
Sameera Dawar ◽  
Meena Jain
Keyword(s):  
Mechanical Ventilation ◽  
Oxygen Saturation ◽  
Hyperbaric Oxygen ◽  
Basic Principle ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Delivery ◽  
Atmospheric Pressure ◽  
Oxygen Therapy ◽  
Tissue Oxygenation ◽  
The Body

The outbreak of the SARS CoV2 ' pandemic' is believed to have originated in Wuhan in 2019 as a spread from bats to humans. It is a highly communicable infection-causing rapid human to human transmission of the virus by virtue of its infectious and nature. The virus has affected millions of people worldwide, with numbers still rising with each passing day. Depleting oxygen saturation levels is amongst the prime concerns in the majority of infected patients. Nasal prongs, face masks, mechanical ventilation and membrane (ECMO) are the commonly used modes of oxygen delivery in such patients. These methods though mostly successful, at times fail to restore the depleting oxygen levels to normal. oxygen therapy (HBOT) involves the administration of 100% O2 in a special chamber whose pressure is maintained at a level greater than 1 ATP. The main purpose for raising the pressure within the chamber is that as the atmospheric pressure increases, the saturation levels of oxygen in the blood also increase, which eventually result in increased overall tissue oxygenation. This article provides a systematic and wholesome review on the basic principle of oxygen therapy, its effects on the body at a microscopic and macroscopic level, its various uses and its suitability as an for the treatment of select COVID-19 infected patients.

Hyperbaric oxygen therapy in preventing mechanical ventilation in COVID-19 patients: a retrospective case series

2020 ◽  
Vol 29 (Sup5a) ◽  
pp. S4-S8 ◽  
Author(s):  
Kerry Thibodeaux ◽  
Marcus Speyrer ◽  
Amer Raza ◽  
Raphael Yaakov ◽  
Thomas E Serena
Keyword(s):  
Mechanical Ventilation ◽  
Oxygen Saturation ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Small Sample ◽  
World Health ◽  
Cardiac Complications ◽  
Dramatic Improvement ◽  
Increased Risk

Objective: A pandemic afflicts the entire world. The highly contagious SARS-CoV-2 virus originated in Wuhan, China in late 2019 and rapidly spread across the entire globe. According to the World Health Organization (WHO), the novel Coronavirus (COVID-19)has infected more than two million people worldwide, causing over 160,000 deaths. Patients with COVID-19 disease present with a wide array of symptoms, ranging from mild flu-like complaints to life threatening pulmonary and cardiac complications. Older people and patients with underlying disease have an increased risk of developing severe acute respiratory syndrome (SARS) requiring mechanical ventilation. Once intubated, mortality increases exponentially. A number of pharmacologic regimens, including hydroxychloroquine-azithromycin, antiviral therapy (eg, remdesevir), and anti-IL-6 agents (e.g., toclizumab), have been highlighted by investigators over the course of the pandemic, based on the therapy's potential to interrupt the viral life-cycle of SARS-CoV-2 or preventing cytokine storm. At present, there have been no conclusive series of reproducible randomised clinical trials demonstrating the efficacy of any one drug or therapy for COVID-19. Cases: COVID-19 positive patients (n=5) at a single institution received hyperbaric oxygen therapy (HBOT) between 13 and 20 April 2020. All the patients had tachypnoea and low oxygen saturation despite receiving high FiO2. HBOT was added to prevent the need for mechanical ventilation. A standard dive profile of 2.0ATA for 90 minutes was employed. Patients received between one and six treatments in one of two dedicated monoplace hyperbaric chambers. Results: All the patients recovered without the need for mechanical ventilation. Following HBOT, oxygen saturation increased, tachypnoea resolved and inflammatory markers fell. At the time of writing, three of the five patients have been discharged from the hospital and two remain in stable condition. Conclusion: This small sample of patients exhibited dramatic improvement with HBOT. Most importantly, HBOT potentially prevented the need for mechanical ventilation. Larger studies are likely to define the role of HBOT in the treatment of this novel disease.

Experience in Applying Hyperbaric Oxygen Therapy Using Portable Pressure Chambers for the Treatment of Patients with the Novel Coronavirus Infection COVID-19

Biomeditsina ◽  
2020 ◽  
pp. 39-46
Author(s):  
A. S. Samoilov ◽  
Yu. D. Udalov ◽  
M. V. Sheyanov ◽  
A. V. Gholinsky ◽  
A. B. Litvinenko
Keyword(s):  
Oxygen Saturation ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Capillary Blood ◽  
Blood Hemoglobin ◽  
Patient Groups ◽  
Radiological Changes ◽  
Coronavirus Infection ◽  
Novel Coronavirus

This communication presents the experience of using mobile pressure chambers in patients with the confi rmed novel coronavirus infection in hospital settings. The obtained preliminary results indicate positive antihypoxic effects of hyperbaric oxygen therapy (HBO) applied in the form of increased saturation. After a session of HBO, patients demonstrated an increase in the oxygen saturation of capillary blood hemoglobin at the average level of 3.71 points. Differences between SatO2 levels prior to and following HBO treatment were signifi cant in the CT2, CT3 and CT4 groups (p0.05). As expected, the effi cacy of HBO in terms of the oxygen saturation of capillary blood hemoglobin was the greatest in the patient groups showing pronounced clinical and radiological changes in the lungs.

scholarly journals Integrative Role of Hyperbaric Oxygen Therapy on Healthspan, Age-Related Vascular Cognitive Impairment, and Dementia

2021 ◽  
Vol 2 ◽  
Author(s):  
Priya Balasubramanian ◽  
Jordan Delfavero ◽  
Adam Nyul-Toth ◽  
Amber Tarantini ◽  
Rafal Gulej ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Vascular Cognitive Impairment ◽  
The Body ◽  
World Population ◽  
Age Related

Growing life expectancy will contribute to the on-going shift towards a world population increasingly comprised of elderly individuals. This demographic shift is associated with a rising prevalence of age-related diseases, among all age-related pathologies it has become crucial to understand the age-associated cognitive changes that remain a major risk factor for the development of vascular cognitive impairment and dementia (VCID). Furthermore, age-related Alzheimer’s disease and other neurogenerative diseases with vascular etiology are the most prominent contributing factors for the loss of cognitive function observed in aging. Hyperbaric Oxygen Therapy (HBOT) achieves physiologic effects by increasing oxygen tension (PO2), raising oxygen tissue levels, decreasing intracranial pressure and relieving cerebral edema. Many of the beneficial effects of HBOT exert their protective effects at the level of the microcirculation. Furthermore, the microcirculation’s exquisite pervasive presence across every tissue in the body, renders it uniquely able to influence the local environment of most tissues and organs, including the brain. As such, treatments aimed at restoring aging-induced functional and structural alterations of the cerebral microcirculation may potentially contribute to the amelioration of a range of age-related pathologies including vascular cognitive impairment, Alzheimer’s disease, and vascular dementias. Despite the presented evidence, the efficacy and safety of HBOT for the treatment of age-related vascular cognitive impairment and dementia remains understudied. The present review aims to examine the existing evidence indicative of a potential therapeutic role for HBOT-induced hyperoxia against age-related cerebromicrovascular pathologies contributing to cognitive impairment, dementia and decreased healthspan in the elderly.

scholarly journals Clinical Observation of Hyperbaric Oxygen Therapy in Patients with Craniocerebral Trauma

2014 ◽  
Vol 3 ◽  
pp. 14
Author(s):  
Shiqiang Wang
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Craniocerebral Trauma ◽  
The Body ◽  
Duration Of Treatment ◽  
The Difference ◽  
Gcs Score ◽  
Symptoms And Signs ◽  
Better Than

<p><strong>Objective: </strong>To review and analyze the clinical effect of hyperbaric oxygen therapy in the treatment of craniocerebral trauma, and to provide reference for the treatment of craniocerebral trauma. <strong>Method: </strong>From January 2009 to April 2014, we treated 287 cases of patients with craniocerebral trauma, on the basis of conventional treatment, the use of hyperbaric oxygen therapy and assessment for therapeutic effect. <strong>Results</strong><strong>: </strong>After hyperbaric oxygen therapy, patients with GCS score and GOS levels were significantly improved, compared with before treatment, the difference was statistically significant (<em>p</em> &lt; 0.05); effect of the treatment of patients with 2−3 courses of treatment was better than patients receive more than 3 courses of treatment (<em>p</em> &lt; 0.05). <strong>Conclusion: </strong>Hyperbaric oxygen in the treatment of craniocerebral trauma can effectively improve patient’s symptoms and signs, there are helpful in the recovery of the body function of patients. Hyperbaric oxygen treatment should be carry out as soon as possible with appropriate extending the duration of treatment, as well as reduce the severe disability, death and sequela.</p>

scholarly journals Parameters of the oxidative-reduction system of the homeostasis in female transplant patients with tumors of the reproductive system treated with hyperbaric oxygen therapy

2019 ◽  
Vol 11 (4) ◽  
pp. 290-300
Author(s):  
A. V. Babkina ◽  
M. Sh. Khubutiya ◽  
O. A. Levina ◽  
A. K. Evseev ◽  
A. K. Shabanov ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Postoperative Period ◽  
Reproductive System ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Hyperbaric Oxygenation ◽  
The Body ◽  
Antioxidant Systems ◽  
Complex Treatment ◽  
Transplant Patients

Introduction. Studies on the effects of hyperbaric oxygenation have often been represented as animal model experiments. Currently, the number of studies on the use of hyperbaric oxygen therapy in the post-transplant period in humans is growing. The need in investigating the efficacy of hyperbaric oxygen therapy in the postoperative period in female transplant patient with tumors of the reproductive system is dictated by time.The aim of the study was to evaluate the efficacy of hyperbaric oxygen therapy in the complex treatment of transplant patients at an early stage of the postoperative period.Material and methods. We have studied the course of an early postoperative period in 8 female transplant patients with reproductive system tumors treated in N.V. Sklifosovsky Research Institute for Emergency Medicine, using hyperbaric oxygenation. The hyperbaric oxygen therapy sessions were provided in a single-patient hyperbaric chamber at 1.2–1.6 ATA for 40 minutes. The status of the redox homeostasis system was assessed based on the data of the platinum electrode open circuit potential measured in blood plasma by using the potentiometric method; and the blood plasma antioxidant activity was assessed by cyclic voltammetry.Results. The analysis of the results showed that there was a direct relationship indicating the positive effect of hyperbaric oxygen therapy on the balance status of the pro- and antioxidant systems of the body, and on the improvement of blood counts.Conclusion. The early inclusion of hyperbaric oxygen therapy in the complex treatment of transplant patients with tumors of the reproductive system contributes to a more rapid recovery of pro- and antioxidant systems of the body, blood counts.

ARTERIAL INSUFFICIENCIES Hyperbaric Oxygen Therapy for Selected Problem Wounds

2020 ◽  
pp. 491-530
Keyword(s):  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Tissue Oxygenation ◽  
Minimum Level

There are sound fundamental reasons why additional oxygen may have benefits in the treatment of non-DFU wounds. It is easy to extrapolate that where there is a minimum level of tissue oxygenation required for wound healing, more oxygen in the form of HBO2 would improve healing even further. The challenge is determining whether there is evidence to support this extrapolation. Every wound that takes longer than expected to heal is a problem wound for that patient, so what makes HBO2 acceptable for the treatment of some wounds and not for others?

Hyperbaric oxygen therapy for COVID-19 patients with respiratory distress: treated cases versus propensity-matched controls

2020 ◽  
pp. 405-413 ◽  
Author(s):  
Scott A. Gorenstein ◽  
◽  
Michael L. Castellano ◽  
Eric S. Slone ◽  
Brian Gillette ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Distress ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Secondary Outcome ◽  
Inpatient Mortality ◽  
Oxygen Requirement ◽  
Subdistribution Hazard ◽  
Artery Disease

Objective: Given the high mortality and prolonged duration of mechanical ventilation of COVID-19 patients, we evaluated the safety and efficacy of hyperbaric oxygen for COVID-19 patients with respiratory distress. Methods: This is a single-center clinical trial of COVID-19 patients at NYU Winthrop Hospital from March 31 to April 28, 2020. Patients in this trial received hyperbaric oxygen therapy at 2.0 atmospheres of pressure in monoplace hyperbaric chambers for 90 minutes daily for a maximum of five total treatments. Controls were identified using propensity score matching among COVID-19 patients admitted during the same time period. Using competing-risks survival regression, we analyzed our primary outcome of inpatient mortality and secondary outcome of mechanical ventilation. Results: We treated 20 COVID-19 patients with hyperbaric oxygen. Ages ranged from 30 to 79 years with an oxygen requirement ranging from 2 to 15 liters on hospital days 0 to 14. Of these 20 patients, two (10%) were intubated and died, and none remain hospitalized. Among 60 propensity-matched controls based on age, sex, body mass index, coronary artery disease, troponin, D-dimer, hospital day, and oxygen requirement, 18 (30%) were intubated, 13 (22%) have died, and three (5%) remain hospitalized (with one still requiring mechanical ventilation). Assuming no further deaths among controls, we estimate that the adjusted subdistribution hazard ratios were 0.37 for inpatient mortality (p=0.14) and 0.26 for mechanical ventilation (p=0.046). Conclusions: Though limited by its study design, our results demonstrate the safety of hyperbaric oxygen among COVID-19 patients and strongly suggests the need for a well-designed, multi-center randomized control trial.

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