scholarly journals Radiomics imaging biomarkers from the perspective of tumor biology

2022 ◽  
Author(s):  
Sebastian Sanduleanu
Keyword(s):  
Tumor Biology ◽  
Imaging Biomarkers

scholarly journals Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant Glioma

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1633 ◽  
Author(s):  
Victor Ruiz-Rodado ◽  
Tomohiro Seki ◽  
Tyrone Dowdy ◽  
Adrian Lita ◽  
Meili Zhang ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Mouse Model ◽  
Tumor Biology ◽  
Central Carbon Metabolism ◽  
Idh1 Mutation ◽  
Genetically Engineered ◽  
Metabolic Reprogramming ◽  
Imaging Biomarkers ◽  
Isocitrate Dehydrogenase 1 ◽  
Genetically Engineered Mouse Model

Understanding the metabolic reprogramming of aggressive brain tumors has potential applications for therapeutics as well as imaging biomarkers. However, little is known about the nutrient requirements of isocitrate dehydrogenase 1 (IDH1) mutant gliomas. The IDH1 mutation involves the acquisition of a neomorphic enzymatic activity which generates D-2-hydroxyglutarate from α-ketoglutarate. In order to gain insight into the metabolism of these malignant brain tumors, we conducted metabolic profiling of the orthotopic tumor and the contralateral regions for the mouse model of IDH1 mutant glioma; as well as to examine the utilization of glucose and glutamine in supplying major metabolic pathways such as glycolysis and tricarboxylic acid (TCA). We also revealed that the main substrate of 2-hydroxyglutarate is glutamine in this model, and how this re-routing impairs its utilization in the TCA. Our 13C tracing analysis, along with hyperpolarized magnetic resonance experiments, revealed an active glycolytic pathway similar in both regions (tumor and contralateral) of the brain. Therefore, we describe the reprogramming of the central carbon metabolism associated with the IDH1 mutation in a genetically engineered mouse model which reflects the tumor biology encountered in glioma patients.

Tumor biology driven treatment selection in primary ovarian cancer

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
F Arnold ◽  
D Margraf ◽  
O Hoffmann ◽  
K von Dehn-Rotfelser ◽  
I Funke ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Biology ◽  
Treatment Selection ◽  
Primary Ovarian Cancer

Towards novel imaging Biomarkers for PD: characterising the dynamic pattern of regional metabolism in idiopathic REM-Sleep-Behaviour-Disorders

2019 ◽  
Author(s):  
I Alberts ◽  
W Ping ◽  
H Xianhua ◽  
I Yakushev ◽  
J Wang ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Imaging Biomarkers ◽  
Dynamic Pattern ◽  
Sleep Behaviour ◽  
Regional Metabolism

Association between tumor biology and occult lymph node metastases before and after primary neoadjuvant therapy (NAT) for patients with early breast cancer

2019 ◽  
Author(s):  
HC Kolberg ◽  
C Kolberg-Liedtke ◽  
M Krajewska ◽  
I Bauerfeind ◽  
TN Fehm ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Neoadjuvant Therapy ◽  
Early Breast Cancer ◽  
Lymph Node Metastases ◽  
Tumor Biology ◽  
Before And After ◽  
Node Metastases

Tumor biology and classification of NET

2013 ◽  
Author(s):  
Aldo Scarpa
Keyword(s):  
Tumor Biology

Role of TWEAK and Fn14 in tumor biology

10.2741/2270 ◽  
2007 ◽  
Vol 12 (1) ◽  
pp. 2761 ◽  
Author(s):  
Jeffrey, A. Winkles
Keyword(s):  
Tumor Biology
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