scholarly journals Association between MATN-3 Gene Polymorphism and Primary Knee Osteoarthritis in Indian Population: A Community-Based Case-Control Study

2020 ◽  
Vol 02 (01) ◽  
Author(s):  
Vikas Trivedi ◽  
Ruchit Shah ◽  
Shakeel Qidwai ◽  
Mishra AN
Keyword(s):  
Gene Polymorphism ◽  
Knee Osteoarthritis ◽  
Indian Population ◽  
Case Control Study ◽  
Case Control ◽  
Community Based ◽  
Control Study

scholarly journals MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jiaao Gu ◽  
Jiesheng Rong ◽  
Fulin Guan ◽  
Liying Jiang ◽  
Shuqing Tao ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Knee Osteoarthritis ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Restriction Enzyme Digestion ◽  
Chinese Han ◽  
Community Based ◽  
Han Population ◽  
Control Study

Background. The matrilin, especially matrilin-3 (MATN3), are reported to play important roles in the pathophysiology of osteoarthritis (OA). To explore the relationship between MATN3 SNP6 (rs8176070) and primary OA, we conducted a community-based case-control study.Methods. A total of 732 community residents aged 40–84 years participated in the community-based study in Northeast China. After taking physical and radiographic examinations, 420 of the residents were diagnosed OA (216 women and 204 men). The other 312 individuals without any symptoms of osteoarthritis or signs in the radiographs (156 women and 156 men) were considered as healthy controls. After obtaining the DNA of case and control groups, genotypes of the MATN3 SNP6 were determined by polymerase chain reaction followed by restriction enzyme digestion. The numbers of patients with different OA subtypes were also calculated.Results. The distribution of genotypes and alleles of the MATN3 SNP6 between OA patients and controls was different significantly. The BB carrier tends to be associated with the increased osteoarthritis (P= 0.025, OR = 1.724, 95% CI = 1.071–2.77), especially the knee osteoarthritis (P= 0.021, OR = 2.402, 95% CI = 1.141–5.060) and lumber osteoarthritis (P= 0.020, OR = 1.880, 95% CI = 1.103–3.204). Bb carrier increased hand osteoarthritis risk (P= 0.002, OR = 5.380, 95% CI = 1.828–15.835). The B allele might have an effect on the increased knee osteoarthritis (P= 0.000, OR = 3.143, 95% CI = 2.283–4.328).Conclusion. These findings suggest that the MATN3 gene polymorphism might be associated with osteoarthritis in the Chinese Han population.

Inflammatory system gene polymorphism and the risk of stroke: A case–control study in an Indian population

2008 ◽  
Vol 75 (1) ◽  
pp. 158-165 ◽  
Author(s):  
Indranil Banerjee ◽  
Veena Gupta ◽  
Tanveer Ahmed ◽  
Mohammad Faizaan ◽  
Puneet Agarwal ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Indian Population ◽  
Case Control Study ◽  
Case Control ◽  
Control Study ◽  
Inflammatory System

Folate supplementation, MTHFR gene polymorphism and neural tube defects: a community based case control study in North India

2011 ◽  
Vol 26 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Roumi Deb ◽  
Jyoti Arora ◽  
Sanjenbam Yaiphaba Meitei ◽  
Sangeeta Gupta ◽  
Vanita Verma ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Neural Tube ◽  
Case Control Study ◽  
Case Control ◽  
Mthfr Gene ◽  
North India ◽  
Community Based ◽  
Folate Supplementation ◽  
Mthfr Gene Polymorphism ◽  
Control Study

scholarly journals The Decisive Case-Control Study Elaborates the Null Association between ADAMTS5 rs226794 and Osteoarthritis in Asians: A Case-Control Study and Meta-Analysis

Genes ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1916
Author(s):  
Chung-Cheng Kao ◽  
Hsiang-En Hsu ◽  
Yi-Chou Chen ◽  
Ming-Yu Tu ◽  
Su-Wen Chuang ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Knee Osteoarthritis ◽  
Case Control Study ◽  
Meta Analysis ◽  
Gene Sequencing ◽  
Case Control ◽  
Knee Oa ◽  
The Relationship ◽  
Allele Model ◽  
Control Study

Background: Osteoarthritis is an important health issue for the elderly. Many studies indicate that genetics is an important risk factor for osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is one gene that is most frequently implicated. Many recent studies have examined the relationship between a polymorphism in the ADAMTS5 gene (rs226794) and the risk for developing osteoarthritis without definitive results. Objective: In this case-control study, we examined the correlation between the ADAMTS5 gene polymorphism, rs226794, and knee osteoarthritis. We used a meta-analysis and trial sequential analysis to determine whether ADAMTS5 rs226794 expression increases susceptibility to osteoarthritis. Methods: This study consisted of two parts: a case-control study and a meta-analysis. The case-control study included subjects who underwent knee radiography at the Health Examination Center of the Tri Service General Hospital from 2015 to 2019. The Kellgren–Lawrence (KL) grading system was used as diagnostic criteria. Patients with unsuccessful gene sequencing were excluded. There were 606 subjects in the knee osteoarthritis group (KL ≥ 2) and 564 in the control group (KL < 2). Gene sequencing was performed using iPLEX Gold to determine the association between the gene polymorphism of ADAMTS5 rs226794 and knee osteoarthritis. For the meta-analysis, databases such as PubMed, Embase, and Cochrane were queried to identify studies that examined the relationship between ADAMTS5 rs226794 and osteoarthritis. Next, the findings of the meta-analysis were incorporated with the results of the case-control study and samples from the published studies to estimate the association between the genetic polymorphism and osteoarthritis using an odds ratio and a 95% confidence interval. Results: We found a non-significant association between the G allele and knee OA (crude-OR: 0.93 (95% CI: 0.79–1.10) and adjusted-OR: 1.02 (95% CI: 0.76–1.36) in the allele model) in the present study, and the analysis of other genetic models revealed a similar trend. After including five published studies and our case-control study, the results with 2866 Asians indicated a conclusively null association between ADAMTS5 rs226794 and knee OA) OR: 1.09 (95% CI: 0.93–1.26). The results for Caucasians also revealed a null association (OR: 1.21 (95% CI: 0.81–1.82)). Conclusions: This study indicates that the gene polymorphism, ADAMTS5 rs226794, is not significantly associated with knee osteoarthritis. Additionally, assuming that the cumulative sample size in the allele model is sufficient, we confirmed that the G allele is not a risk factor for osteoarthritis. This study integrated all available evidence to arrive at this conclusion, and it suggests that no additional studies are necessary.

scholarly journals Association of matrix Gla protein polymorphism and knee osteoarthritis in a chinese population

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Wenpeng Hui ◽  
Zhong Cao ◽  
Xiao Wang ◽  
Junfeng Zhu
Keyword(s):  
Gene Polymorphism ◽  
Knee Osteoarthritis ◽  
Case Control Study ◽  
Case Control ◽  
Matrix Gla Protein ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Knee Oa ◽  
Control Study

Abstract Several studies have explored the association between matrix Gla protein (MGP) gene polymorphism and knee osteoarthritis (OA) risk; however, they obtained conflicting findings. The present study aims to explore the association of MGP gene polymorphism and OA risk in a Chinese Han population. A total of 256 patients with radiographic knee OA and 327 control subjects were recruited in this case–control study. The genotypes of MGP gene rs1800802 polymorphism was determined by standard PCR and restriction fragment length polymorphism (PCR-RLFP). In this case–control study, we observed that MGP gene rs1800802 polymorphism increased the risk of knee OA. Subgroup analyses also found that rs1800802 polymorphism was related to the elevated risk for knee OA among the female, smoker, drinker, and body mass index (BMI) ≥25 kg/m2 groups. In conclusion, this study shows that MGP gene rs1800802 polymorphism is associated with increased risk for knee OA in Chinese Han population and the rs1800802 polymorphism may be a diagnostic marker of radiographic knee OA.

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