scholarly journals Profile of Tissue Selenium Concentration In A Cohort Of Nigerian Men With Prostate Cancer

2021 ◽  
Vol 05 (04) ◽  
Author(s):  
Igbokwe MC ◽  
Badmus TA ◽  
Salako AA ◽  
Obiajunwa EI ◽  
Olasehinde O ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Selenium Concentration ◽  
Nigerian Men ◽  
Tissue Selenium

scholarly journals PSIII-24 Selenium requirement of turkeys based on tissue selenium concentration and selenoprotein activity and transcript expression

2019 ◽  
Vol 97 (Supplement_2) ◽  
pp. 177-178
Author(s):  
Rachel M Taylor ◽  
Roger A Sunde
Keyword(s):  
Selenium Concentration ◽  
Transcript Expression ◽  
Life Stages ◽  
Growth Data ◽  
Turkey Poults ◽  
Liver And Kidney ◽  
Tissue Selenium ◽  
Se Deficiency ◽  
Commercial Turkey ◽  
Se Status

Abstract Selenium (Se) is an essential and toxic trace mineral in animal diets. The current NRC turkey Se requirement is 0.2 µg Se/g diet for all life stages, higher than the published rat and mouse requirements. The studies that form the basis for the turkey requirement were performed over 50 years ago and based on prevention of Se-deficiency disease. With the genetic improvement of commercial turkey flocks and emerging new Se status biomarkers, we fed day-old male poults a Se-deficient (0.005 µg/g), vitamin E-adequate torula-based diet supplemented with graded levels of Se, from 0 to 5 µg/g, for 28 days. Poults supplemented with <0.05 µg/g had reduced growth, but there was no effect of high Se on growth. Se biomarkers responded hyperbolically to increasing dietary Se and reached plateaus at or before 0.4 µg/g. In deficiency, liver and kidney Se fell to <10% of Se-adequate levels. Activities of plasma GPX3; liver, kidney, pancreas and muscle GPX1; and liver, kidney, muscle and gizzard GPX4 all decreased to <10% in Se deficiency and reached plateau levels by 0.4 µg/g. In the same tissues, ≤6 out of 24 selenoprotein transcripts were downregulated to 2X Se-adequate levels in poults fed up to 5 µg/g diet. Liver Se increased to 5.6X Se-adequate levels with 5 µg/g diet. We conclude that the dietary Se level to maximize Se status biomarkers in growing turkey poults is 0.4 µg Se/g diet, double the current NRC requirement. Transcript expression is maximized at lower dietary Se levels than enzyme activities of the corresponding selenoproteins. Lastly, based on growth data, the turkey appears resistant to excess dietary Se, suggesting FDA Se supplementation limits can be safely raised. (Funded by USDA Hatch 1013496)

Correlation of serum PSA and Gleason score in Nigerian men with prostate cancer

2008 ◽  
Vol 14 (1) ◽  
pp. 15-22 ◽  
Author(s):  
C. A. Okolo ◽  
O. M. Akinosun ◽  
O. B. Shittu ◽  
E. O. Olapade-Olaopa ◽  
L. I. Okeke ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Nigerian Men

scholarly journals Effects of barley-bound organic selenium compared with inorganic selenite on selenium concentration and structure of tissues in pig

1984 ◽  
Vol 56 (1) ◽  
pp. 61-72
Author(s):  
P. Kurkela ◽  
E. Kääntee
Keyword(s):  
Sodium Selenite ◽  
Selenium Concentration ◽  
Growing Pigs ◽  
Selenium Level ◽  
Histological Structure ◽  
Muscle Dystrophy ◽  
Pork Production ◽  
Organic Selenium ◽  
Tissue Selenium ◽  
Porcine Tissues

A study was made of the effects of barley feeds containing varying levels of natural grain selenium derived from fertilizer and of the effects of sodium selenite on selenium concentrations in the tissues of growing pigs and on the histological structure of myocardium and longissimus muscle. The results indicated that organic grain selenium affects the selenium levels of porcine tissues significantly more than sodium selenite supplementation of the same amount. The organic selenium concentrations of feed and organs were found to be linearly correlated. Spleen, lung and heart were the most reliable indicators of tissue selenium level in pigs. The selenium concentration of muscles of pigs fed on naturally seleniferous feed (270 µg Se/kg DM) was at the internationally level (500 µg Se/kg DM in meat), whereas the same amount of selenite in feed increased the selenium level of muscle only slightly (to 200/µg Se/kg DM). The histological structures of heart and muscle of pigs fed on naturally seleniferous feed were normal, whereas in the selenite group there were signs of muscle dystrophy when the selenium level was below 200 µg Se/kg DM. In addition, the pigs given selenite were subsequently placed in a lower, fat-containing carcass class. Feed with a natural organic selenium level of 150—200 µg Se/kg DM is preferred to selenite selenium supplement in pork production.

scholarly journals Effects of Selenium Auricularia cornea Culture Supplementation on Growth Performance, Antioxidant Status, Tissue Selenium Concentration and Meat Quality in Growing-Finishing Pigs

Animals ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2701
Author(s):  
Ying Ju ◽  
Mingzhi Liu ◽  
Liling Huang ◽  
Yanglan Luo ◽  
Liangliang Qi ◽  
...  
Keyword(s):  
Oxidative Stability ◽  
Growth Performance ◽  
Meat Quality ◽  
Antioxidant Status ◽  
Control Diet ◽  
Selenium Concentration ◽  
Control Group ◽  
Finishing Pigs ◽  
Fresh Meat ◽  
Tissue Selenium

Selenium Auricularia cornea culture (SAC) is a new source of organic selenium. Two experiments were conducted to determine the available energy of SAC fed to pigs and to evaluate the effects of dietary SAC supplementation on growth performance, serum biochemical profiles, fecal short chain fatty acids (SCFA), meat quality, tissue selenium concentration, and oxidative stability of fresh meat in growing-finishing pigs. In Experiment (Exp.) 1, 12 barrows with average body weight (BW) of 42.40 ± 5.30 kg were randomly allotted to two groups and fed the basal diet and SAC-supplemented diet, individually. In Exp. 2, 96 growing-finishing pigs (BW: 91.96 ± 7.55 kg) were grouped into four dietary treatments; each treatment contained six replicates with four pigs per replicate. The four treatments fed a control diet and three experimental diets supplemented with 0.6%, 1.2%, and 2.4% SAC, respectively. The trial lasted for 45 days. The results revealed that digestible energy (DE) of SAC was 11.21 MJ/kg. The average daily gain (ADG) was improved in pigs fed 1.2% and 2.4% SAC during day 24 to 45 and the overall period. Dietary 1.2% and 2.4% SAC supplementation had a lower F/G (p < 0.05) than the control diet during different stages. Dietary SAC supplementation increased fecal butyrate contents (p < 0.05), and pigs fed 1.2% and 2.4% SAC diets had a higher MCT1 mRNA expression (p = 0.04) in the colon. Pigs fed 2.4% SAC had higher GSH-Px contents (p < 0.05) in serum, liver, and longissimus dorsi muscle (LDM) than those in the control group. The 2.4% SAC-supplemented group revealed a higher Se content (p < 0.05) in LDM and a lower MDA concentration (p < 0.05) in fresh meat during the simulated retail display on day six. In conclusion, this study suggested that SAC was more effective in improving growth, enhancing the antioxidant status, depositing Se in muscle, and increasing meat oxidative stability of pigs.

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