Effects of Time and Dietary Selenium Concentration as Sodium Selenite on Tissue Selenium Uptake by Sheep

1988 ◽  
Vol 66 (9) ◽  
pp. 2299 ◽  
Author(s):  
M. G. Echevarria ◽  
P. R. Henry ◽  
C. B. Ammerman ◽  
P. V. Rao
Keyword(s):  
Sodium Selenite ◽  
Selenium Concentration ◽  
Dietary Selenium ◽  
Selenium Uptake ◽  
Tissue Selenium

scholarly journals Effects of barley-bound organic selenium compared with inorganic selenite on selenium concentration and structure of tissues in pig

1984 ◽  
Vol 56 (1) ◽  
pp. 61-72
Author(s):  
P. Kurkela ◽  
E. Kääntee
Keyword(s):  
Sodium Selenite ◽  
Selenium Concentration ◽  
Growing Pigs ◽  
Selenium Level ◽  
Histological Structure ◽  
Muscle Dystrophy ◽  
Pork Production ◽  
Organic Selenium ◽  
Tissue Selenium ◽  
Porcine Tissues

A study was made of the effects of barley feeds containing varying levels of natural grain selenium derived from fertilizer and of the effects of sodium selenite on selenium concentrations in the tissues of growing pigs and on the histological structure of myocardium and longissimus muscle. The results indicated that organic grain selenium affects the selenium levels of porcine tissues significantly more than sodium selenite supplementation of the same amount. The organic selenium concentrations of feed and organs were found to be linearly correlated. Spleen, lung and heart were the most reliable indicators of tissue selenium level in pigs. The selenium concentration of muscles of pigs fed on naturally seleniferous feed (270 µg Se/kg DM) was at the internationally level (500 µg Se/kg DM in meat), whereas the same amount of selenite in feed increased the selenium level of muscle only slightly (to 200/µg Se/kg DM). The histological structures of heart and muscle of pigs fed on naturally seleniferous feed were normal, whereas in the selenite group there were signs of muscle dystrophy when the selenium level was below 200 µg Se/kg DM. In addition, the pigs given selenite were subsequently placed in a lower, fat-containing carcass class. Feed with a natural organic selenium level of 150—200 µg Se/kg DM is preferred to selenite selenium supplement in pork production.

scholarly journals Knockout of Selenoprotein V Affects Regulation of Selenoprotein Expression by Dietary Selenium and Fat Intakes in Mice

2019 ◽  
Vol 150 (3) ◽  
pp. 483-491 ◽  
Author(s):  
Ling-Li Chen ◽  
Jia-Qiang Huang ◽  
Yao Xiao ◽  
Yuan-Yuan Wu ◽  
Fa-Zheng Ren ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Thioredoxin Reductase ◽  
Selenium Concentration ◽  
Basal Diet ◽  
Functional Expression ◽  
Dietary Selenium ◽  
Thioredoxin Reductase 1 ◽  
Tissue Selenium ◽  
Selenoprotein V ◽  
Genotype A

ABSTRACT Background The metabolic function of selenoprotein V (SELENOV) remains unknown. Objectives Two experiments were conducted to determine effects of the Selenov knockout (KO) on selenium concentration and mRNA, protein, and/or activity of 4 major selenoproteins [glutathione peroxidase (GPX) 1, GPX4, thioredoxin reductase-1 (TXNRD1), and selenoprotein P (SELENOP)] in the serum, liver, testis, and/or white adipose tissue (WAT) of mice fed different dietary selenium and fat concentrations. Methods In Experiment (Expt) 1, 40 KO and 40 wild-type (WT) mice (males, 8 wk old) were fed (n = 10/genotype) a casein-sucrose basal diet plus 0, 0.3, 1, or 3 mg Se/kg (as sodium selenite) for 32 wk . In Expt 2, 20 KO and 20 WT mice (males, 8 wk old) were fed (n  = 10/genotype) a normal-fat diet (NF; 10% calories from fat) or a high-fat diet (HF; 60% calories from fat) for 19 wk. Results In Expt 1, the KO caused consistent or substantial decreases (P < 0.05) of mRNA amounts of Gpx1, Txnrd1, and Selenop in the testis (≤52%), but selenium concentrations (19–29%) and GPX activities (≤ 50%) were decreased in the liver across different dietary selenium concentrations . Hepatic and testis GPX1 protein was elevated (≤31%) and decreased (≤45%) by the KO, respectively. In Expt 2, the genotype and dietary fat intake exerted interaction effects ( P < 0.05) on Gpx1 mRNA amounts in the WAT; Gpx1, Txnrd1, and Selenop mRNA amounts and TXNRD activities in the testis; and selenium concentrations in the serum and liver. However, these 2 treatments produced largely independent or additive effects (P < 0.05) on the GPX1 and SELENOP protein amounts in the liver and testis (up to ± 50% changes). Conclusions The KO-mediated changes in the tissue selenium concentrations and functional expression of 3 major selenoproteins implied potential for SELENOV in regulating body selenium metabolism in the mouse.

Exploring the effect of selenium forms on final body weight, slaughtercharacteristics and tissue selenium concentration in Aseel cockerels

2016 ◽  
Author(s):  
Waseem Muhammad Zia ◽  
Anjum Khalique ◽  
Saima Naveed ◽  
Jibran Hussain ◽  
Imran Muhammad ◽  
...  
Keyword(s):  
Body Weight ◽  
Sodium Selenite ◽  
Control Diet ◽  
Selenium Concentration ◽  
Control Group ◽  
Final Body Weight ◽  
Treatment Groups ◽  
Group A ◽  
Tissue Selenium ◽  
Group B

A study to investigate the influence of selenium on final body weight and slaughter traits of Aseel was conducted. Three-weeks-old 120 cockerels from Lakha, Mushki, Peshaweri and Mianwali varieties of Aseel were randomly selected and distributed into four groups, 30 cockerels each, subdivided into 3 treatment groups A, B (experimental groups), and C (control group) with 10 cockerels in each treatment. Birds were assigned three experimental diets. The diet for the birds of group A incorporated 0.3 mg/kg Se-enriched yeast and group B included 0.3 mg/kg sodium selenite, while C was fed the diet without Se (control diet). Final body weight, dressed weight, dressing%, eviscerated weight, eviscerated%; chest, thigh and giblets weight; selenium content in chest and thigh in Se-yeast fed birds were significantly increased than those got sodium selenite or control diet. The study concluded that Se-enriched yeast is more effective in improving body weight and slaughtering characteristics of Aseel.

Effect of selenium supplementation on survival, liveweight and wool weight of young sheep on Kangaroo Island, South Australia

1979 ◽  
Vol 19 (101) ◽  
pp. 689 ◽  
Author(s):  
SK Walker ◽  
GP Hall ◽  
DH Smith ◽  
RW Ponzoni ◽  
GJ Judson
Keyword(s):  
Total Dose ◽  
Whole Blood ◽  
Sodium Selenite ◽  
South Australia ◽  
Selenium Concentration ◽  
Mortality Rates ◽  
Selenium Supplementation ◽  
First Year ◽  
Weaning Weight ◽  
Fleece Weight

The responses in liveweight, wool weight and survival, to selenium supplementation, were studied in young sheep from weaning to yearling age. The experiment was conducted over three years. In the first year, one sodium selenite supplementation rate was used (total dose 46.5 mg). During the following two years two supplementation rates were administered (total doses 46.5 mg and 93 mg). Mean concentrations of selenium in whole blood in unsupplemented sheep varied from 0.19-0.56 pmol l-l and from 0.20-0.44 pmol l-1 in the two years in which concentrations were measured. Supplementation, which commenced at lamb marking, increased the selenium concentration in sheep at weaning and thereafter. Selenium supplementation improved the break-of-season weight (P < 0.01) and yearling weight (P < 0.01 ) but not weaning weight (0.05 < P < 0.1 ). Hogget fleece weight was improved (P < 0.01 ) and mortality reduced (P < 0.01) by selenium supplementation. There was a treatment x year interaction in mortality rates (P < 0.01 ). There were no significant differences between the two supplementation rates

scholarly journals Selenium speciation and biological characteristics of selenium-rich Bailing mushroom, Pleurotus tuoliensis

2018 ◽  
pp. 704
Author(s):  
Yajie Zou, Fang Du, Haijun Zhang, Qingxiu Hu
Keyword(s):  
Fruiting Body ◽  
Sodium Selenite ◽  
Selenium Concentration ◽  
Biological Characteristics ◽  
Selenium Speciation ◽  
Fruiting Bodies ◽  
Good Tolerance ◽  
Icp Ms ◽  
Mycelia Growth

Nowadays the study of selenium-rich mushrooms is very popular. In the present study, selenium speciation in fruiting body of Pleurotus tuoliensis was investigated in cultivation substrates with different concentrations of sodium selenite, as well as mycelia growth and mushroom development. The results showed that the P. tuoliensis mycelia appeared good tolerance to selenium at all test concentrations. A selenium concentration of 10 mg/kg promoted fruiting of P. tuoliensis; the fruiting bodies were of good quality and had a low malformation rate. HPLC–ICP-MS determined that organic seleniums enriched in stipes and caps existed mainly in the form of selenoCystine and selenoMethionine at selenium concentrations of 10-100 mg/kg. These findings suggest that P. tuoliensis could be developed as a selenium-rich mushroom product for use as a novel dietary source of bioavailable supplemental selenium.

scholarly journals PSIII-24 Selenium requirement of turkeys based on tissue selenium concentration and selenoprotein activity and transcript expression

2019 ◽  
Vol 97 (Supplement_2) ◽  
pp. 177-178
Author(s):  
Rachel M Taylor ◽  
Roger A Sunde
Keyword(s):  
Selenium Concentration ◽  
Transcript Expression ◽  
Life Stages ◽  
Growth Data ◽  
Turkey Poults ◽  
Liver And Kidney ◽  
Tissue Selenium ◽  
Se Deficiency ◽  
Commercial Turkey ◽  
Se Status

Abstract Selenium (Se) is an essential and toxic trace mineral in animal diets. The current NRC turkey Se requirement is 0.2 µg Se/g diet for all life stages, higher than the published rat and mouse requirements. The studies that form the basis for the turkey requirement were performed over 50 years ago and based on prevention of Se-deficiency disease. With the genetic improvement of commercial turkey flocks and emerging new Se status biomarkers, we fed day-old male poults a Se-deficient (0.005 µg/g), vitamin E-adequate torula-based diet supplemented with graded levels of Se, from 0 to 5 µg/g, for 28 days. Poults supplemented with <0.05 µg/g had reduced growth, but there was no effect of high Se on growth. Se biomarkers responded hyperbolically to increasing dietary Se and reached plateaus at or before 0.4 µg/g. In deficiency, liver and kidney Se fell to <10% of Se-adequate levels. Activities of plasma GPX3; liver, kidney, pancreas and muscle GPX1; and liver, kidney, muscle and gizzard GPX4 all decreased to <10% in Se deficiency and reached plateau levels by 0.4 µg/g. In the same tissues, ≤6 out of 24 selenoprotein transcripts were downregulated to 2X Se-adequate levels in poults fed up to 5 µg/g diet. Liver Se increased to 5.6X Se-adequate levels with 5 µg/g diet. We conclude that the dietary Se level to maximize Se status biomarkers in growing turkey poults is 0.4 µg Se/g diet, double the current NRC requirement. Transcript expression is maximized at lower dietary Se levels than enzyme activities of the corresponding selenoproteins. Lastly, based on growth data, the turkey appears resistant to excess dietary Se, suggesting FDA Se supplementation limits can be safely raised. (Funded by USDA Hatch 1013496)

scholarly journals Effect of a long-term peroral supplementation with sodium selenite and selenium lactate-protein complex on selenium status in goats and their kids

2009 ◽  
Vol 54 (No. 7) ◽  
pp. 324-332 ◽  
Author(s):  
L. Misurova ◽  
L. Pavlata ◽  
A. Pechova ◽  
R. Dvorak
Keyword(s):  
Glutathione Peroxidase ◽  
Protein Complex ◽  
Sodium Selenite ◽  
Selenium Concentration ◽  
Selenium Supplementation ◽  
Control Group ◽  
Glutathione Peroxidase Activity ◽  
Significant Difference ◽  
Average Activity

The aim of this study was to evaluate the effect of a long-term peroral selenium supplementation in the form of sodium selenite and selenium lactate-protein complex by comparing selenium concentrations and glutathione peroxidase activity in blood of goats and their kids as well as comparing selenium concentrations in goat colostrums. For the study, a total of 27 clinically healthy pregnant white shorthair goats were used. They were divided to three groups, i.e., the control group (C) without any selenium supplementation, sodium selenite group (E1) and selenium lactate-protein complex group (E2). For four months, experimental goats received 0.43 mg of selenium per animal per day in diet; goats from the control group were given 0.15 mg of selenium per animal per day. At the beginning of the experiment, goats of all groups showed an average selenium concentration of 96 &mu;g/l in whole blood. On the parturition day, samples of first colostrum from goats and heparinized blood from goats and kids were taken. In the control group (C), average blood selenium concentrations of 111.4 ± 33.5 &mu;g/l were observed on the parturition day. In both experimental groups, selenium concentrations were significantly higher (<I>P</I> < 0.05). Average selenium concentration in the sodium selenite group (E1) was 177.2 ± 34.8 &mu;g/l and in the group supplemented with selenium lactate-protein complex (E2) 159.0 ± 28.5 &mu;g/l. Average glutathione peroxidase (GSH-Px) activity in blood of control goats (C) was 581.9 ± 99.2 &mu;kat/l, in group E1 1 154.6 ± 156.2 &mu;kat/l and in group E2 1 011.6 ± 153.6 &mu;kat/l. GSH-Px activity in experimental groups was significantly higher (<I>P</I> < 0.05) as compared with the control group. Average selenium concentrations in colostrum was in the control group 40.1 ± 12.8 &mu;g/l, in E1 99.0 ± 29.9 &mu;g/l and in group E2 79.0 ± 17.7 &mu;g/l. Colostral selenium concentrations in experimental groups were significantly higher (<I>P</I> < 0.05) as compared with the control group. No significant difference in the monitored parameters was found between experimental groups. In kids of control mothers (kC), average selenium concentrations in blood on the parturition day were 62.4 ± 22.9 &mu;g/l; kids of mothers supplemented with sodium selenite (kE1) showed average selenium levels of 100.0 ± 31.2 &mu;g/l, and the average selenium concentration in kids of mothers receiving lactate-protein complex was 83.4 ± 20.1 &mu;g/l (kE2). Average GSH-Px activity in control kids (kC) was 402.1 ± 153.9 &mu;kat/l. Kids from kE1 showed average activity of GSH-Px 806.1 ± 254.9 &mu;kat/l and kids from group kE2 529.9 ± 119.8 &mu;kat/l. Statistically significant difference (<I>P</I> < 0.05) was found only between kC and kE1 which showed significantly higher selenium concentration and GSH-Px activity. The results of this study confirm that both forms of selenium administered in experimental groups (i.e., sodium selenite and selenium lactate-protein complex) had similar biological effect in goats. However, results obtained in kids indicate a better effect of supplementation with sodium selenite.

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