scholarly journals Influence of Thyroid Disorders on Liver Function Tests in –Diyala Governorate

2021 ◽  
Vol 21 (1) ◽  
pp. 13-19
Author(s):  
Noor Ibrahem Jalil ◽  
◽  
Raya S Baban ◽  
Alaa A Mahmoud
Keyword(s):  
Liver Function ◽  
Alanine Aminotransferase ◽  
Biochemical Parameters ◽  
Significant Positive Correlation ◽  
Liver Function Tests ◽  
Thyroid Disorder ◽  
Mean Values ◽  
Function Tests ◽  
Healthy Control ◽  
Age Range

Background: Thyroid diseases may disturb liver function; liver disease modulates thyroid hormone metabolism, and a range of systemic diseases disturb both organs. There are clinical and laboratory relations between thyroid and liver diseases. Patients with chronic liver disease may have thyroiditis, hyperthyroidism, or hypothyroidism.aPatients with subacute thyroiditis or hyperthyroidism may have abnormalities in liver function tests, which return to normal as the thyroid disorder improves. Objective: The present study is designed to investigate the effects of thyroid disorders on liver function tests. Patients and Methods: In this study sixty patients were employed and categorized into two groups, thirty patients with hyperthyroidism (13 male and 17female) with age range of 25-45years, (mean 33.38) and thirty patients with hypothyroidism (11male and 19 female) with age range 25-45 years (mean 36.78),while 30 normal healthy individuals were chosen as a control group (15male and 15 female) in the same age range (mean 34.44) were taken for comparison. Blood samples were collected from the patients at Baqubah Teaching Hospital , between April 2020 to July 2020. Basic serum biochemical parameters including, thyroid stimulation hormone (TSH), triiodothyronine(T3) and thyroxin (T4)were assayed for patients and control groups by Cobas e 411 autoanalyzer within eight weeks. Serum normal values for alanine aminotransferase (ALT). ALT (Alanine Aminotransferase), Aspartate aminotransferase (AST), alkaline phosphatase test (ALP), direct bilirubin (DB) and total bilirubin( TSB) were assayed within four days by Cobas integra 400 plus autoanalyzer. Results: The mean value of ALT, AST, ALP,TSB, and DB in patients with hyperthyroidism, and hypothyroidism was significantly increased when compared with their mean values of healthy control (p <0.05).A significant difference was also found in mean values of T3,T4,TSH in hyperthyroidism and hypothyroidism when compared with their mean values of healthy control(p <0.05). Results of this work revealed a significant negative correlation of TSH with ALP and TSB (p<0.05). Further, T4 showed a significant positive correlation with ALP (P<0.05).The same results revealed that there was a significant positive correlation between T3 and ALP with (p<0.05).There was no significant correlations between ALT,AST,DB with TSH,T3,T4.Further,no significant correlations between TSB and T3,T4 (p >0.05). Conclusion: The current study shows that thyroid disorder might cause significant effect on the metabolism of hepatocytes reflected by an increase in biochemical parameters of liver function test AST, ALT ALP,TSB and DB in both hyperthyroidism and hypothyroidism subjects. Keywords: Thyroid diseases ,Alanine aminotransferase , hyperthyroidism, Tetraiodothyronin ,Thyroid stimulating hormone,hypothyroidism

scholarly journals Effect of Ramadan Fasting on Body Composition, Biochemical Profile, and Antioxidant Status in a Sample of Healthy Individuals

2020 ◽  
Vol 18 (4) ◽  
Author(s):  
Asna Urooj ◽  
Namratha Pai Kotebagilu ◽  
Lohith Mysuru Shivanna ◽  
Satish Anandan ◽  
Akshatha Nagaraja Thantry ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Liver Function ◽  
Biochemical Parameters ◽  
Liver Function Tests ◽  
Free Living ◽  
Ramadan Fasting ◽  
Random Blood Sugar ◽  
Function Tests ◽  
Function Test

Background: Muslims fast during the month of Ramadan by abstinence from food and drink every day from dawn to sunset. Studies have reported contradictory results with respect to the changes in body weight and biochemical parameters. No study has been conducted on the association between fasting and body weight and biochemical parameters in the Indian setting on healthy Muslim subjects. Objectives: To assess the effect of fasting during Ramadan on biochemical parameters such as lipid profile, liver function test, renal function test, antioxidant status, random blood sugar, hemoglobin, body composition, and blood pressure in a sample of healthy individuals. Methods: In this study, 52 healthy free-living participants (25 males, 27 females, 21-64 years) who met the inclusion and exclusion criteria and completed both follow-ups (before and after Ramadan) were studied. Participants were fasting 12 hours a day for at least 21 days, including menstruating women. It was a free-living study with no dietary restrictions. Anthropometry, lipid profile, liver and renal function tests were measured by standard methods. Body composition was analyzed by bioelectrical impedance. Results: Significant beneficial changes in albumin, alanine aminotransferase, creatinine, and high-density lipoprotein (HDL) were observed, while total cholesterol, random blood sugar, aspartate aminotransferase, and alkaline phosphatase enzymes remained unchanged after Ramadan. Fasting did bring in some changes in body composition; among both men and women, mean weight loss ranged from 0.81 - 1.4 kg in majority of the subjects, which was due to loss in muscle mass. Moderate changes in intra- and extracellular water content was observed after fasting. Conclusions: Significant improvements were observed in HDL levels and liver function tests, which can be attributed to the loss of body weight. Improvement in liver function tests may be related to the changes in cytokines and alteration in sleep patterns. Ramadan-like fasting, along with the nutritional education prior to fasting, may be beneficial and effective in the spiritual and overall well-being.

scholarly journals Aminotransferase Levels in Relation to Short-Term use of Acetaminophen Four Grams Daily in Postoperative Cardiothoracic Patients in the Intensive Care Unit

2011 ◽  
Vol 39 (6) ◽  
pp. 1056-1063 ◽  
Author(s):  
S. J. G. M. Ahlers ◽  
L. van Gulik ◽  
E. P. A. van Dongen ◽  
P. Bruins ◽  
D. Tibboel ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Cardiac Surgery ◽  
Intensive Care ◽  
Liver Function ◽  
Alanine Aminotransferase ◽  
Liver Function Tests ◽  
Analgesic Agent ◽  
Short Term ◽  
Function Tests ◽  
Volunteer Study

A volunteer study suggested that taking paracetamol 4 g daily could result in elevated alanine aminotransferase plasma levels in a substantial proportion of healthy volunteers. The safety of this dose of paracetamol for acute postoperative pain remains controversial. This study aimed to examine the incidence of alanine aminotransferase elevations after short-term use of paracetamol 4 g daily, as part of the standard pain management protocol, for 93 consecutive patients after cardiothoracic surgery. Alanine aminotransferase levels and other liver function tests were measured preoperatively as baseline and once daily after surgery during the intensive care unit stay. Preoperative alanine aminotransferase levels of more than one time the upper limit of normal (ULN, >40 U/l) was observed in 11% (n=10) of the patients but none of these baseline alanine aminotransferase levels exceeded three times the ULN (>3×ULN). The average daily dose of paracetamol administered was 50 mg/kg (SD=16) after surgery. Postoperative alanine aminotransferase levels of >1×ULN was observed in 17% (n=16), and 4% (n=4) exceeded >3×ULN. The other liver function tests of the latter four patients, including aspartate aminotransferase (range 173 to 5590 U/l), γ-glutamyltransferase (range 56 to 103 U/l), lactate dehydrogenase (range 376 to 3518 U/l) and the International Normalised Ratio (range 2.0 to 6.6), were all abnormal. These four patients all had right ventricular failure or cardiogenic shock during the postoperative period which could explain the significant rises in alanine aminotransferase after surgery. In conclusion, the incidence of significant alanine aminotransferase elevations after using daily paracetamol as an analgesic agent for cardiac surgery, at a dose of 4 g per day, was low and mostly due to complications after surgery. Our results, albeit still very limited, provided some reassurance about the safety of paracetamol 4 g daily, as a supplementary analgesic agent for adult patients undergoing cardiac surgery.

scholarly journals Correlation between Aminotransferase Ratio (AST/ALT) and Other Biochemical Parameters in Chronic Liver Disease of Viral Origin

2015 ◽  
Vol 3 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Shah Md Fazlul Karim ◽  
Md Rezwanur Rahman ◽  
Shahana Shermin ◽  
Razia Sultana
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Serum Albumin ◽  
Prothrombin Time ◽  
Chronic Liver Disease ◽  
Biochemical Parameters ◽  
Significant Positive Correlation ◽  
Liver Function Tests ◽  
Viral Origin ◽  
Correlation Test

Background: In recent years the ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) in patients of chronic liver disease (CLD) of various origins has gained much attention. This variable is readily available, easy to interpret, and inexpensive and the clinical utility of the AST/ALT ratio in the diagnostic workup of patients with CLD is quite promising. Objective: The present study was designed to find out the link between aminotransferase (AST/ALT) ratio with commonly measured biochemical parameters of liver function tests in CLD of viral origin. Materials and method: This cross sectional study was carried out in the department of Biochemistry, Sir Salimullah Medical College, Dhaka, Bangladesh. Forty four biopsy proven diagnosed subjects of chronic viral hepatitis without cirrhosis of both sex were selected purposively. With aseptic precaution 5 mL venous blood was collected from each subject and common liver function tests (serum AST, ALT, AST/ALT ratio, alkaline phosphatase, total bilirubin, serum total protein, serum albumin, serum globulin, serum albumin/globulin ratio, prothrombin time) and viral serology (HBsAg, Anti HDV antibody, Anti HCV antibody) were performed. Data were analyzed by SPSS version 19 for Windows. Pearson’s correlation test was done to determine association between AST/ALT with other biochemical parameters. Results: Mean(±SD) age of the study subjects was 32.55±10.55 years (range 20-50 years) with 48 (77.7%) male and 14 (22.6%) female subjects. Pearson’s correlation test was done between AST to ALT ratio with other biochemical parameters and prothrombin time showed significant positive correlation (p <0.01). Conclusion: In our study we found significant positive correlation between AST/ALT with prothrombin time in CLD subjects without cirrhosis. DOI: http://dx.doi.org/10.3329/dmcj.v3i1.22234 Delta Med Col J. Jan 2015; 3(1): 13-17

scholarly journals Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity

1999 ◽  
Vol 82 (4) ◽  
pp. 257-262 ◽  
Author(s):  
Isabelle Leclercq ◽  
Yves Horsmans ◽  
Jean-Pierre Desager ◽  
Stanislas Pauwels ◽  
André P. Geubel
Keyword(s):  
Cytochrome P450 ◽  
Liver Function ◽  
Dietary Intake ◽  
Fatty Liver ◽  
Alanine Aminotransferase ◽  
Liver Volume ◽  
Liver Function Tests ◽  
Function Tests ◽  
Dietary Sugar ◽  
Cyp2e1 Activity

Dietary habits are often considered as a pathogenic factor for fatty liver. The impact of dietary intake and steatosis on drug metabolism remains poorly investigated. Our aim was to assess the effect of dietary intake on in vivo cytochrome P450 (CYP) activities in eleven patients with abnormal liver function tests potentially due to fatty liver and associated with a high-sugar diet. Liver function tests, liver volume, aminopyrine breath test (ABT) and chlorzoxazone (CZ) pharmacokinetics (area under the curve, AUC) which are known to reflect CYP2E1 activity were evaluated before and after 2 months restriction of dietary sugar intake. Features at inclusion were an increased BMI (30·3 (sd 3·2) kg/m2), high hepatic volume (1·96 (sd 0·48) litres), hyperechogenic liver parenchyma, elevated liver enzyme activities (alanine aminotransferase (EC 2.6.1.2) 58·6 (sd 17·4) IU/l with alanine aminotransferase : aspartate aminotransferase (EC 2.6.1.1) ratio > 1), together with a normal ABT value (0·68 (sd 0·21) % specific activity of administered dose of [14C]aminopyrine in breath after 1 h) and a high CYP2E1 activity (CZ AUC 20·3 (sd 7·1) μg/ml per h). A dietary sugar restriction was prescribed. On the basis of repeated interviews by the same dietitian, unaware of any clinical and biochemical data, six patients remained compliant to the diet and exhibited reductions in BMI (P < 0·001), serum alanine aminotransferase (P = 0·008), liver volume (P = 0·002) and CYP2E1 activity (P = 0·007), a significant increase in ABT (P < 0·001) together with the disappearance of liver hyperechogenicity at ultrasound. In contrast, the five non-compliant patients did not show any significant change in any of these variables. In conclusion, CYP2E1 activity is induced in patients with perturbations of liver function tests potentially due to fatty liver. In these patients, effective dietary sugar restriction is associated with a reduction in liver volume, a reduction in CYP2E1 activity and an increased aminopyrine metabolism rate.

scholarly journals Liver Function Tests Values in Albino Wistar Rats Administered with Isolated Nigeria Achatina achatina Snail Lectin.

2021 ◽  
Vol 15 (02) ◽  
pp. 092-102
Author(s):  
Odiegwu C.N.C. ◽  
Chianella I. ◽  
Azubike N.C. ◽  
Odiegwu U.O . ◽  
Ogbuowelu O.S.
Keyword(s):  
Liver Function ◽  
Wistar Rats ◽  
Nutritive Value ◽  
Affinity Purification ◽  
Liver Function Tests ◽  
Mean Values ◽  
Ammonium Sulphate Precipitation ◽  
Function Tests ◽  
Complete Purification ◽  
Animal House

Achatina achatina snail specie are considered by many people in Nigeria, Ghana and other parts of West Africa to be the most prized snail for eating. In general, lectins bind to sugar moieties in cell walls or membrane, thereby change the physiology of the membrane to cause agglutination, mitosis or other biochemical changes in the cell. It has been deduced that lectins could be toxic and can as well be used as potent administrations that could be used or serve as substitutes for routine treatment or management of many disorders. Based on these, the toxicity of the Achatina achatina snail lectin in animals was investigated with a view to determining the nutritional value of the snail as food stuffs by carrying out tests to determine the blood values of Liver Function Tests (LFT) parameters in Albino Wistar Rats administered with the lectin. A total of 120 samples of the Nigeria Achatina achatina snail specie were collected, authenticated at the Zoology Department of the University of Nigeria, Nsukka and 80mls of pooled crude Lectin extract was obtained. Purifications were performed on 20mls of the crude extract in three steps viz, Ammonium sulphate precipitation and Dialysis (Partial purifications), Con A Sepharose 4B affinity Chromatography column (Complete purification). The affinity purified lectin was used for all the tests conducted in this research. The crude, partially and complete/affinity purified Lectin extracts were subjected to Haemagglutination tests. The Lectin was further assessed to determine its effects on Liver Function Tests (LFT) parameters viz, Total bilirubin (TB), Conjugate bilirubin (CB), Alkaline phosphatase (ALP), Aspartate transaminase (AST) and Alanine transaminase (ALT) as follows: A total of Thirty-five (35) male Albino Wistar Rats weighing 101-180g and aged 2-3 months obtained from the Animal house of University of Nigeria, Nsukka, were used in this research. The animals were Grouped into 5 (A-E) and allowed for 2 weeks acclimatization. Graded doses of 0.04ml, 0.05ml and 0.06ml of the Affinity purified Lectin were administered intra-peritoneally to each of the rats in Groups A-D (test groups) according to their body weights at intervals of 2 days for 1 week. Group E served as the control. Two (2) mls of blood was collected from each of the rats before and 24 hours after the last day of lectin administration for the following tests: TB, CB, ALP, AST and ALT (performed by means of Roche Cobas C111 automated chemistry analyser). The results of the research showed as follows: On complete/affinity purification, 15mls of pure sample containing only the high molecular weight lectin was obtained. The respective haemagglutination tests on the crude, partially and affinity purified Lectin showed on standardization preferential agglutinations with Blood group A type. Bar charts statistics show that there was Post lectin administration mean increase in TB, CB and AST when the Post administrations values were compared with the Pre values. The Bar charts statistics show that there was Post lectin administration mean decrease in ALP and ALT. However, the differences in the Pre and Post administration mean values of these parameters were further subjected to one way analysis of variance (ANOVA) test statistics aimed at determining whether the mean increases or decreases in these assessed parameters were statistically significant. The ANOVA statistics show that the effects of the lectin on all the assessed LFT parameters viz, TB, CB, ALP, AST and ALT were statistically insignificant (P > 0.05). The results obtained in this research has succeeded in demonstrating that the A. achatina snail lectin is non-toxic, non-carcinogenic and therefore point to its nutritive value as food stuff, hence supports the snail eating education.

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