Secang (Caesalpinia Sappan) : Telaah Aktifitas Biologis Dan Potensi Pemanfaatannya

2016 ◽  
Vol 1 (2) ◽  
pp. 14-23 ◽  
Author(s):  
Irawan W Kusuma
Keyword(s):  
Biological Activities ◽  
Scientific Basis ◽  
Plant Resources ◽  
Caesalpinia Sappan ◽  
High Possibility ◽  
Huge Variety ◽  
Traditional Manner ◽  
Active Substances ◽  
Agricultural Food ◽  
Biological Active Substances

Plant resources serve abundant useful biological active substances. Secang, a local name of Caesalpinia sappan (Leguminosae), promise high possibility for a  broad-ranging purposes due to its biological activities. In traditional manner, the wood of secang is used for coloring agent for beverages, foods and cosmetics. Several  phytochemicals were isolated from the secang extract, including brazilin, brezilein, protosappanin, 4-0-methy/ sappanol, caesalpin, kampesterol and b-sitosterol. Secang extract and the compounds thereformhave been reported to possess a huge variety of  biological activities such asantioxidant, antibacterial, antifungal, anticancer, natural contraceptive and xanthine oxidase (XO) inhibitor.The biological  activities of the extracts andph vtochemicals ftrom secang may give scientific basis for their application in agricultural, food processing, medical and other industries.

Biological active substances of Origanum vulgare L.

2016 ◽  
Vol 48 (1) ◽  
pp. 20-25 ◽  
Author(s):  
L.A. Kotyuk ◽  
◽  
D.B. Rakhmetov ◽  
Keyword(s):  
Origanum Vulgare ◽  
Active Substances ◽  
Biological Active Substances

scholarly journals Study in phytochemical composition biological active substances (antioxidant) some species of sage brush (Artemisia L).

2016 ◽  
Vol 4 (4) ◽  
pp. 4-10
Author(s):  
Gerelmaa Adiya ◽  
◽  
Ariunaa Jugder ◽  
Tserennadmid Byambasuren ◽  
◽  
...  
Keyword(s):  
Phytochemical Composition ◽  
Active Substances ◽  
Biological Active Substances

scholarly journals Biological Activity of Bicyclic and Tricyclic Diterpenoids from Salvia Species of Immediate Pharmacological and Pharmaceutical Interest

2011 ◽  
Vol 6 (8) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Maria Carmela Bonito ◽  
Carla Cicala ◽  
Maria Carla Marcotullio ◽  
Francesco Maione ◽  
Nicola Mascolo
Keyword(s):  
Biological Activities ◽  
Folk Medicine ◽  
Plant Defence ◽  
Experimental Studies ◽  
Scientific Basis ◽  
Chemical Structures ◽  
Wide Range ◽  
Real Value ◽  
Antimicrobic Activity ◽  
Cyclic Compounds

Diterpenoids are a class of compounds that derive from the condensation of four isoprene units that leads to a wide variety of complex chemical structures, including acyclic bi-, tri-and tetra-cyclic compounds; in Salvia species, only bi-, tri-and tetra-cyclic compounds have been found. This review covers a wide range of biological activities and mode of action of diterpenoids isolated from Salvia species that might raise some pharmacological and pharmaceutical interest. We have produced a synoptic table where the biological activities of the main active principles are summarized. Our analysis emphasizes that diterpenoids from Salvia species continue to be a plant defence system since their antimicrobic activity. Experimental studies show that most of diterpenoids considered have cytotoxic and / or antiproliferative activity. Some of them have also cardiovascular and central effects. In a less extended manner, diterpenoids from Salvia species show gastrointestinal, urinary, antinflammatory, antidiabetic, ipolipidemic and antiaggregating effects. In the last decade, several clinical trials have been developed in order to investigate the real value of Salvia extracts treatment; results obtained are promising and confer scientific basis in the use of medicinal plants from folk medicine.

scholarly journals PHYTOCHEMICAL AND CYTOTOXIC INVESTIGATIONS OF THE HEARTWOOD OF CAESALPINIA SAPPAN LINN

2018 ◽  
Vol 11 (2) ◽  
pp. 336 ◽  
Author(s):  
Chuleeporn Ngernnak ◽  
Pawaret Panyajai ◽  
Songyot Anuchapreeda ◽  
Weerah Wongkham ◽  
Aroonchai Saiai
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Biological Activities ◽  
Leukemia Cell ◽  
Leukemia Cells ◽  
Cytotoxic Effects ◽  
Caesalpinia Sappan ◽  
Ms Analysis ◽  
Human Acute Myeloid Leukemia ◽  
Acute Myeloid

  Objective: The purpose of this study was to identify the chemical constituents in the dichloromethane extract by gas chromatography–mass spectrometry (GC–MS) analysis and evaluate the cytotoxic effects on leukemia cells of isolated compounds from Caesalpinia sappan Linn.Methods: Dichloromethane extract obtained from the heartwood of C. sappan was investigated by GC–MS and column chromatography. Cytotoxic effects on leukemia cells of the isolated compounds were examined using MTT assay.Results: The GC–MS analysis of dichloromethane extract from C. sappan revealed the presence of 14 compounds. Linoleic acid and β-sitosterol were found to be the major compounds presenting in 14% and 13%, respectively. The separation of the dichloromethane extract led to the isolation of brazilin (1) as a major compound, together with lupeol (2), and a mixture of β-sitosterol (3), and stigmasterol (4). Their structures were elucidated based on spectroscopic methods. Brazilin (1) showed a cytotoxic effect on human acute myeloid leukemia cell (KG1) and human acute myeloid leukemia stem cell (KG1a) with inhibitory concentration at 50% growth (IC50) values of 13.30 ± 0.49 and 12.24 ± 1.08 μg/ml, respectively. Conclusion: Many groups of phytochemical compounds in the dichloromethane extract of C. sappan were detected by GC–MS analysis. Some of them have been reported to possess various biological activities. Moreover, brazilin (1) isolated compound from C. sappan shows cytotoxicity on leukemia cells, which could be a potential anticancer property.

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