Study of prevalence and determinants of peripheral neuropathy in patients with type 2 diabetes mellitus

2021 ◽  
Vol 18 (3) ◽  
pp. 10-14
Author(s):  
S Bethiun ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Age Group ◽  
Duration Of Diabetes ◽  
History Of

Background: India is witnessing a depressing situation due to escalating incidence and prevalence of type 2 diabetes mellitus (T2DM) and its inevitable outcomes of cardiovascular diseases (CVD), diabetic neuropathy, nephropathy and retinopathy. Present study was aimed to investigate peripheral neuropathy in adult patients with type 2 diabetes. Material and Methods: Present study was hospital based, prospective, observational study conducted in subjects recruited from the diabetes OPD of both gender ≥ 30 years, known case of type 2 diabetes mellitus. The screening for DPN was conducted using the Michigan Neuropathy Screening Instrument (MNSI). Results: In present study, 256 subjects satisfying study criteria were considered for study. Most of patients were from 51-65 years age group (39.8%) followed by 31-50 years age group (37.1%). Male subjects (54.3%) were more than females (45.7%). Mean duration of type 2 diabetes mellites was 10.6 ± 6.3 years. Mean HbA1c was 9.3 ± 2.8% and 65.6% had HbA1c≥7%. Common high risk factors were hypertension (52.3%), alcoholic > 60 mg/day (30.5%), BMI > 30kg/m2 (26.6%), smoking habits >1 pack/day (18.0 %), history of peripheral artery disease (12.5 %) and history of prior ulcer (12.1%). Prevalence of peripheral neuropathy in subjects with type 2 diabetes mellitus in present study was 35.2%, calculated as per reduced perception/absent monofilament test. Vibration perception test was absent in 22.7 % subjects and ankle reflex was absent in 13.3 % subjects. Age, duration of diabetes, fasting blood sugar, BMI, HbA1c ≥ 7 % and alcoholic (> 60 mg/day) were statistically significant in subjects of type 2 diabetes mellitus with peripheral neuropathy and difference was statistically significant. Conclusion: Diabetic peripheral neuropathy was significantly and positively associated with age, duration of diabetes, fasting blood sugar, BMI, HbA1c ≥ 7 % and alcoholic (> 60 mg/day). Regular screening of patients with diabetes mellitus for peripheral neuropathy may be recommended for early diagnosis and treatment.

scholarly journals Pengaruh Pelayanan Kefarmasian di Rumah pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Wilayah Kota Yogyakarta

2020 ◽  
Vol 10 (2) ◽  
pp. 126
Author(s):  
Nur Rasdianah ◽  
Suwaldi Martodiharjo ◽  
Tri Murti Andayani ◽  
Lukman Hakim
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medication Adherence ◽  
Glycemic Control ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Level Of Knowledge ◽  
Sugar Levels

The increasing prevalence of diabetes mellitus (DM) in Indonesia requires participation of all parties including pharmacists. This study aims to determine the impact of the implementation of home pharmacy service guidelines for patients with type 2 diabetes mellitus on the level of knowledge, medication adherence, therapeurical satisfaction and glycemic control. This study used a quasi-experimental design with one group pre-test and post-test design involving 37 patients with type 2 diabetes mellitus who met the requirements of inclusion and exclusion criterias. The Diabetes Knowledge Questionnaire (DKQ-24) and the Diabetes Medication Satisfaction Tool (DMSAT) were used for collecting the data. Patient adherence was measured using a pillcount method and fasting blood sugar levels (FSB) data were obtained from the laboratory results. The study was conducted in two community health centers and patient’s home in the Yogyakarta Municipality area. The data were analysed using Wilcoxon and Spearman test. The results showed the change of the level of knowledge, medication adherence, therapeutic satisfaction and glycemic control before and after intervention of pharmacy services at home. The average decreasing of fasting blood sugar levels 17.09 mg/dL ± 1.43

scholarly journals Assessing the Prevalence and Predicting Factors of an Abnormal Gated Myocardial Perfusion SPECT in Asymptomatic Patients with Type 2 Diabetes

2021 ◽  
Author(s):  
Elinaz Hosseinzadeh ◽  
Mohammadali Ghodsirad ◽  
Toktam Alirezaei ◽  
Maryam Arefnia ◽  
Mahasti Amoui ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Male Gender ◽  
Silent Myocardial Ischemia ◽  
Duration Of Diabetes ◽  
Predicting Factors ◽  
Asymptomatic Patients ◽  
History Of

Abstract IntroductionConsidering the significant prevalence of silent myocardial ischemia and its related morbidity and mortality in asymptomatic type two diabetic patients, it is not well known whether early screening with MPI is cost-effective. However, predicting factors are not elucidated. Materials and MethodsThis was a cross-sectional study including 63 asymptomatic patients with type 2 diabetes mellitus (T2DM), with normal ECG and ejection fraction. Patients with any history of documented valvular, congestive or ischemic heart disease, renal or hepatic failure were excluded. At first all patients were interviewed and checked for risk factors and then patients underwent a two-day rest/stress 99mTc-MIBI gated MPI SPECT. Data was assessed by QPS/QGS and 4DM software and evaluated by a nuclear medicine specialist with summed stress score (SSS) of more than 4 defined as CAD. ResultsThere were 42 females (67%) and 21 males (33%), with a mean age of 61.33 ± 6.98 years and 7.97 ± 4.86 years history of T2DM. CAD was detected in 26 (41.3%) patients and was significantly associated with male gender, smoking, requiring insulin therapy and EF (P-value = 0.019, 0.046, 0.05, 0.033, respectively). A significant association was found between the duration of diabetes, especially when >15y, and the probability of having CAD.. Multivariable logistic regression revealed that smoking; male gender and diabetes duration were the strongest independent predictors of abnormal MPI results.ConclusionWe found a high (46%) prevalence of abnormal stress MPI SPECT in patients with type 2 diabetes mellitus, despite being asymptomatic. Asymptomatic patients with a history of smoking, long duration of diabetes, being under insulin treatment and male gender might benefit from MPI for early detection of silent ischemia.

scholarly journals Detection of Anti-Helicopacter pylori IgG Antibody, Anti-GAD antibody, Anti-Beta islets cell in a sample of serum with type-2 Diabetes mellitus patients

2013 ◽  
Vol 10 (4) ◽  
pp. 1157-1161
Author(s):  
Baghdad Science Journal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Igg Antibody ◽  
H Pylori

We have investigated twenty five patients with type-2 diabetes mellitus aged (35-60) years and fifteen healthy persons as control group to detect Anti-Helicobacter pylori IgG antibody. All studied groups were carried out to measure fasting blood sugar, anti- Glutamic acid decarboxylase (GAD), anti-? islets cells antibody by IFAT, Anti-H. pylori IgG antibody by ELISA technique. There was significant elevation in the concentration of fasting blood sugar than in control group (P < 0.05), the patients had negative results for anti-GAD antibody and anti- ? islets cells antibody, there were significant differences (P < 0.05) of anti-H. pylori IgG antibody in 28 % of patients had type-2 diabetes than control group. This lead to suggestion that type -2 diabetes mellitus patients are more susceptible to H. pylori .

scholarly journals Falls among Older Adults with Type 2 Diabetes Mellitus with Peripheral Neuropathy

2021 ◽  
Vol 72 (2) ◽  
pp. 92-98
Author(s):  
Mantana Vongsirinavarat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Muscle Strength ◽  
Clinical Test ◽  
Balance Performance ◽  
Functional Reach Test ◽  
History Of

Objective: The high incidence and prevalence of falls among older people with type 2 diabetes mellitus (ODM) have been documented. The risk factors of falls among ODM were identified as poor diabetic control, diabetic peripheral neuropathy (DPN) and balance impairment. This study aimed to investigate the contribution of DPN to history of falls. The differences of balance performance and lower limb muscle strength among ODM with and without DPN were also explored. Methods: This cross-sectional study interviewed 112 ODM for their falls occurrences within the previous 6 months. DPN was determined by the score of the Michigan Neuropathy Screening Instrument. Balance performance tests included Clinical Test of Sensory Interaction and Balance (mCTSIB), Functional Reach Test (FRT) and Timed Up and Go Test (TUG). Leg muscle strength was also measured. The logistic regression analysis was performed. Results: The history of falls was reported 30.6% of ODM with DPN and 10.4% of ODM without DPN. Presenting of DPN influenced falls with odds ratio of 3.46 among ODM. Differences were found of mCTSIB in the condition of eyes closed on firm and foam surfaces, FRT, and TUG between those with and without DPN. Knee extensor strength differed between those with and without DPN. Conclusion: DPN was more prominent among fallers. Balance performance and leg strength were lower in ones with DPN. Falls prevention programs including balance training and therapeutic exercise to improve balance performance and muscle strength should be emphasized among ODM, especially before the onset of DPN.

scholarly journals Prevalence of depression in patients with type 2 diabetes mellitus and its association with fasting blood sugar levels, in an urban area of Kancheepuram district, Tamil Nadu

2017 ◽  
Vol 4 (9) ◽  
pp. 3399 ◽  
Author(s):  
Anantha Eashwar V. M ◽  
Gopalakrishnan S. ◽  
Umadevi R.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Poor Prognosis ◽  
Severe Depression ◽  
Fasting Blood Sugar ◽  
Prevalence Of Depression ◽  
Sugar Levels

Background: Type 2 diabetes mellitus (T2DM) and depressive disorders are among the major health problems in our community. Chronic medical conditions, like diabetes are affectively stressful for patients and may influence pathophysiologic mechanisms as well as mood. This can lead to depression and poor prognosis of T2DM. This study was done to assess the prevalence of depression among T2DM patients and its association with glycemic control.Methods: This descriptive cross sectional study was carried out among 300 T2DM patients attending Urban Health Training Center (UHTC), Anakaputhur, which belongs to the urban field practice area of our institution. Fasting Blood Sugar levels (FBS) were assessed retrospectively from their medical records; and they were screened for depression by administering the nine items, “Patient Health Questionnaire - 9”.Results: Of the 300 T2DM patients, 54% were females. The mean age of the participants was 53±9.7 years. 31% of the study participants had fasting blood sugar (FBS) levels above 125 mg/dl. Depression was present in 39.7% of the individuals, among which, 17.3% had mild depression, 13% had moderate depression, 6.7% had moderately severe depression and 2.7% had severe depression. Depression was found to be significantly associated with increasing fasting blood sugar levels, diabetic complications, female gender and diabetic treatment.Conclusions: This study shows that depression is highly prevalent among T2DM patients and is associated with poor prognosis, as reflected by poor glycemic control (FBS) and the occurrence of diabetic complications. So screening and counselling for depression among T2DM patients have to be carried out for optimum control and treatment of T2DM.

scholarly journals Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Dijana J. Miric ◽  
Bojana M. Kisic ◽  
Snezana Filipovic-Danic ◽  
Rade Grbic ◽  
Ilija Dragojevic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Xanthine Oxidase ◽  
Diabetic Peripheral Neuropathy ◽  
Atherogenic Index ◽  
Multivariable Logistic Regression Model ◽  
Duration Of Diabetes

This study investigated the relationship between serum xanthine oxidase (XOD) activity and the occurrence of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. Serum XOD activity, ischemia-modified albumin (IMA), uric acid (UA), albumin, glycated hemoglobin (HbA1c), advanced glycation end products (AGE), total free thiols, atherogenic index of plasma (AIP), and body mass index (BMI) were measured in 80 T2DM patients (29 with and 51 without DPN), and 30 nondiabetic control subjects. Duration of diabetes, hypertension, medication, and microalbuminuria was recorded. Serum XOD activities in controls, non-DPN, and DPN were5.7±2.4 U/L,20.3±8.6 U/L, and27.5±10.6 U/L (p<0.01), respectively. XOD activity was directly correlated to IMA, UA, BMI, HbA1c, and AGE, while inversely correlated to serum total free thiols. A multivariable logistic regression model, which included duration of diabetes, hypertension, AIP, HbA1c, UA, and XOD activity, revealed HbA1c [OR = 1.03 (1.00–1.05);p=0.034] and XOD activity [OR = 1.07 (1.00–1.14);p=0.036] as independent predictors of DPN. Serum XOD activity was well correlated to several other risk factors. These results indicate the role of XOD in the development of DPN among T2DM patients.

scholarly journals The Influence of Peripheral Neuropathy, Gender, and Obesity on the Postural Stability of Patients with Type 2 Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Aline Herrera-Rangel ◽  
Catalina Aranda-Moreno ◽  
Teresa Mantilla-Ochoa ◽  
Lylia Zainos-Saucedo ◽  
Kathrine Jáuregui-Renaud
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Postural Stability ◽  
Static Posturography ◽  
Gender And Age ◽  
Soft Surface ◽  
History Of

Aim.To assess the influence of peripheral neuropathy, gender, and obesity on the postural stability of patients with type 2 diabetes mellitus.Methods.151 patients with no history of otology, neurology, or orthopaedic or balance disorders accepted to participate in the study. After a clinical interview and neuropathy assessment, postural stability was evaluated by static posturography (eyes open/closed on hard/soft surface) and the “Up & Go” test.Results.During static posturography, on hard surface, the length of sway was related to peripheral neuropathy, gender, age, and obesity; on soft surface, the length of sway was related to peripheral neuropathy, gender, and age, the influence of neuropathy was larger in males than in females, and closing the eyes increased further the difference between genders. The mean time to perform the “Up & Go” test was 11.6 ± 2.2 sec, with influence of peripheral neuropathy, gender, and age.Conclusion.In order to preserve the control of static upright posture during conditions with deficient sensory input, male patients with type 2 diabetes mellitus with no history of balance disorders may be more vulnerable than females, and obesity may decrease the static postural control in both males and females.

Improvement in fasting blood sugar, anthropometric measurement and hs-CRP after consumption of epigallocatechin-3-gallate (EGCG) in patients with type 2 diabetes mellitus

2019 ◽  
Vol 50 (2) ◽  
pp. 348-359 ◽  
Author(s):  
Said Hadi ◽  
Meysam Alipour ◽  
Vahideh Aghamohammadi ◽  
Sahar Shahemi ◽  
Fatemeh Ghafouri-Taleghani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Anthropometric Measurement ◽  
Model Assessment ◽  
Content Type ◽  
Hs Crp

Purpose The epigallocatechin gallate (EGCG) effect in diabetes has been investigated in animal studies, but results of clinical trials are inconsistent. Thus, this study aims to evaluate the effects of EGCG supplementation in patients with type 2 diabetes mellitus (T2DM). Design/methodology/approach A total of 50 patients with T2DM were recruited in a double-blind, randomized, placebo-controlled trial. The eligible participants were randomly allocated to EGCG (n = 25) and placebo (n = 25) groups. The EGCG group received two capsules of EGCG (each capsule contained 150 mg; Shari Made®, Iran) and placebo group was administered two capsules of placebo (starch) for eight weeks. A three-day 24-h dietary recall and anthropometric and laboratory measurements were carried out at the beginning and the end of the study. Findings At the end of the trial, weight and body mass index (BMI) were decreased significantly in both groups, but the reduction was not statistically significant between the two groups. Fasting blood sugar decreased significantly in EGCG group. No significant between-group and within-group differences were found in insulin, homeostatic model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index values. The high-sensitive C-reactive protein (hs-CRP) was significantly reduced in the EGCG group (4.13 ± 0.48-3.93 ± 0.50, p = 0.003) compared to baseline. Originality/value This study showed that consuming 300 mg/day of EGCG for eight weeks in patients with T2DM caused a significant decrease in fasting blood glucose, body weight, BMI and hs-CRP compared to baseline. Therefore, the EGCG supplementation may improve glycemic control, anthropometric and inflammation status in T2DM.

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