scholarly journals Premarital counselling: an experience from Bahrain

1997 ◽  
Vol 3 (3) ◽  
pp. 415-419
Author(s):  
Shaikha Salim Al Arrayed ◽  
Nada Hafadh ◽  
Samera Al Serafi
Keyword(s):  
At Risk ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Dehydrogenase Deficiency ◽  
Sickle Cell Trait ◽  
Cell Disease ◽  
Beta Thalassaemia ◽  
Thalassaemia Trait ◽  
Analyse Data ◽  
Glucose 6 Phosphate Dehydrogenase

The present study was conducted to analyse data of the first 500 clients who voluntarily attended premarital counselling during 1993-1994. It was found that 74.1% of clients were not related to their partner, 23.2% were first cousins and 1.5% were second cousins;the rest were distant relatives. Sickle-cell disease was found in 1.6% of clients, sickle-cell trait in 13.0%, beta-thalassaemia trait in 2.0% and glucose-6-phosphate dehydrogenase deficiency in 26.0%. Of the couples attending counselling, 8.1% were found to be at risk of having affected offspring. The consanguinity rate among the couples at risk was 15.4%

Cell Free Fetal and Total DNA Levels in Pregnancies at Risk of Sickle Cell Disease and Significant Ethnic Variation.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3791-3791
Author(s):  
Ageliki Gerovassili ◽  
Kypros H. Nicolaides ◽  
Swee Lay Thein ◽  
David Rees
Keyword(s):  
At Risk ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Globin Gene ◽  
Cell Disease ◽  
Maternal Weight ◽  
Chromosome 11 ◽  
Significant Difference ◽  
African Caribbean

Abstract Cell free (cf) DNA in maternal circulation is increasingly investigated in pregnancy. We aimed to determine if sickle cell trait women had quantitative differences of cfDNA with controls and if there was an ethnic difference between the cfDNA levels of Northern European and African/African-Caribbean populations. Non-invasive prenatal diagnosis through quantification of fetal and total cfDNA was tested in 33 pregnant women at risk of carrying a fetus affected with sickle cell disease and 124 control pregnancies. Fetal cfDNA assays were based on two Y chromosome specific markers (SRY and DYS14) and total cfDNA was based on the β-globin gene on chromosome 11. Maternal age (MA), gestation age (GA), fetal sex, storage time prior to extraction, maternal weight and body mass index (BMI) before pregnancy were compared to the fetal and total cfDNA levels. No significant difference in the fetal or total cfDNA levels was found between any of the control pregnancies and the sickle cell trait mothers carrying HbAA, HbAS and HbSS fetuses. However, higher levels of total cfDNA, but lower fetal cfDNA levels were observed in the African/African-Caribbean population compared with the Nothern Europeans. A significant variation in cfDNA was found between ethnic groups, which should be taken under consideration in future studies measuring cfDNA.

scholarly journals Student screening for inherited blood disorders in Bahrain

2021 ◽  
Vol 9 (3) ◽  
pp. 344-352
Author(s):  
S. Al Arrayed ◽  
N. Hafadh ◽  
S. Amin ◽  
H. Al Mukhareq ◽  
H. Sanad
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
G6pd Deficiency ◽  
High Performance ◽  
Sickle Cell Trait ◽  
Disease Incidence ◽  
Cell Disease ◽  
Blood Disorders ◽  
Inherited Disorders ◽  
Beta Thalassaemia

In Bahrain and neighbouring countries inherited disorders of haemoglobin, i. e. sickle-cell disease, thalassaemias and glucose-6-phosphate dehydrogenase [G6PD] deficiency, are common. As part of the National Student Screening Project to determine the prevalence of genetic blood disorders and raise awareness among young Bahrainis, we screened 11th-grade students from 38 schools [5685 students], organized lectures and distributed information about these disorders. Haemoglobin electrophoresis, high performance liquid chromatography, blood grouping and G6PD deficiency testing were performed. Prevalences were: 1.2% sickle-cell disease; 13.8% sickle-cell trait; 0.09% beta-thalassaemia; 2.9% beta-thalassaemia trait; 23.2% G6PD deficiency; 1.9% G6PD deficiency carrier. Health education, carrier screening and premarital counselling remain the best ways to reduce disease incidence with potentially significant financial savings and social and health benefits

scholarly journals Epidemiology of hereditary anemias in Saudi Arabia

2021 ◽  
Author(s):  
Shada Murshed Alharbi ◽  
Jawad Hussain Alshaiti ◽  
Jamila Mofareh Ghazwani ◽  
Afia Mofareh Ghazwani ◽  
Nawaf Mohammed Abushelwah ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Dehydrogenase Deficiency ◽  
Epidemiological Studies ◽  
Cell Disease ◽  
The Past ◽  
Prevalence Trends ◽  
High Prevalence ◽  
Glucose 6 Phosphate Dehydrogenase

The prevalence rates of hereditary anemias in Saudi Arabia are remarkably high when compared to other countries. For instance, estimates show that the prevalence of thalassemia constitutes one of the highest rates globally. Furthermore, it has been demonstrated that epidemiology significantly differs between the different regions across the Kingdom. Therefore, many epidemiological investigations were conducted. In this context, it has been demonstrated that the prevalence of thalassemia ranges from 0.4% to 5.9% in the Northern and Eastern regions, respectively. In the present literature review, we have discussed the different findings of epidemiological studies that studied the epidemiology of hereditary anemias in Saudi Arabia. We mainly discussed the epidemiology of glucose-6-phosphate dehydrogenase deficiency (G6PD), sickle cell disease, and thalassemia. Recent evidence indicates that the trends of β-thalassemia are significantly decreasing over the past years. On the other hand, it has been demonstrated that the prevalence trends of sickle cell disease is constant over the past years. G6PD is also highly prevalent in Saudi Arabia. However, recent evidence is lacking in the literature and needs to be updated by future investigations. Consanguineous marriage has been reported to be an important risk factor for the high prevalence of β-thalassemia and sickle cell disease across the Kingdom.

scholarly journals Glucose-6-phosphate dehydrogenase deficiency in sickle cell disease by DNA analysis [letter]

Blood ◽  
1995 ◽  
Vol 85 (2) ◽  
pp. 601-602
Author(s):  
ST Saad ◽  
FF Costa ◽  
TS Salles ◽  
MF Sonatti ◽  
MS Figueiredo
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Dna Analysis ◽  
Dehydrogenase Deficiency ◽  
Cell Disease ◽  
Glucose 6 Phosphate Dehydrogenase

Neonatal Screening for Sickle Cell Disease, Glucose-6-Phosphate Dehydrogenase Deficiency and α-Thalassemia in Qatif and Al Hasa

1998 ◽  
Vol 18 (4) ◽  
pp. 289-292 ◽  
Author(s):  
Zaki Nasserullah ◽  
Abdulaziz Al Jame ◽  
Hussain Abu Srair ◽  
Ghazi Al Qatari ◽  
Saad Al Naim ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Neonatal Screening ◽  
Dehydrogenase Deficiency ◽  
Cell Disease ◽  
Glucose 6 Phosphate Dehydrogenase

The clinical impact of glucose-6-phosphate dehydrogenase deficiency in patients with sickle cell disease

2018 ◽  
Vol 25 (6) ◽  
pp. 494-499 ◽  
Author(s):  
Matthew S. Karafin ◽  
Xiaoyun Fu ◽  
Angelo D’Alessandro ◽  
Tiffany Thomas ◽  
Eldad A. Hod ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Dehydrogenase Deficiency ◽  
Clinical Impact ◽  
Cell Disease ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Frequency of haemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in Basra

2003 ◽  
Vol 9 (1-2) ◽  
pp. 45-54
Author(s):  
M. K. Hassan ◽  
J. Y. Taha ◽  
L. M. Al Naama ◽  
N. M. Widad ◽  
S. N. Jasim
Keyword(s):  
Public Health ◽  
Sickle Cell ◽  
G6pd Deficiency ◽  
Sickle Cell Trait ◽  
Public Health Education ◽  
Management Plan ◽  
Beta Globin ◽  
Beta Thalassaemia ◽  
Thalassaemia Trait ◽  
Glucose 6 Phosphate Dehydrogenase

Basra, southern Iraq, was mapped for haemoglobinopathies and glucose-6-phosphate dehydrogenase [G6PD] deficiency. Of 1064 couples aged 14-60 years recruited from the Public Health Laboratory, 49 had beta-thalassaemia trait, 69 had sickle-cell trait, 2 had haemoglobin D trait, 2 had haemoglobin C trait and 1 had high persistent fetal haemoglobin. Carriers of major beta-globin disorders comprised 11.48%. G6PD deficiency was detected in 133 individuals [12.5%]. Only 10 couples [0.94%] were at risk of having children affected with either sickle-cell disease or beta-thalassaemia major. These defects constitute a real health problem and necessitate a management plan and public health education for early diagnosis and therapy

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