MORPHOGENETIC MECHANISMS OF PATHOMORPHOLOGICAL CHANGES IN THE LIVER IN CHRONIC DRUG POISONING

2021 ◽  
Vol 2 (5) ◽  
pp. 34-39
Author(s):  
Sh.U. Babadjanova ◽  
◽  
M.Y. Ergasheva ◽  
Keyword(s):  
Liver Damage ◽  
Morphological Study ◽  
Liver Lesions ◽  
Drug Poisoning ◽  
Drug Intoxication ◽  
Morphological Criteria

This article presents the results of the morphogenetic and morphological study of the liver in chronic narcotic intoxication. Three groups of pathomorphological changes and their morphogenetic mechanisms are revealed: dystrophic, discirculatory and cholestatic.The role of drugs in pathogenesis and morphogenetic mechanisms of liver damage is still unclear. Meanwhile, peculiarities of pathomorphological changes at CVHrequire differentiation from structural liver lesions caused by narcotic intoxication based onthe development of morphogenetic and morphological criteria of liver lesions by drugs is possible and can be a basis for forensic histological diagnostics of CDI.Keywords: liver, drug intoxication, morphogenesis, morphology, chronic drug intoxication

Possible role of Arthrospira platensis in reversing oxidative stress-mediated liver damage in rats exposed to lead

2018 ◽  
Vol 97 ◽  
pp. 1259-1268 ◽  
Author(s):  
Samah R. Khalil ◽  
Walaa M. Elhady ◽  
Yaser H.A. Elewa ◽  
Noura E. Abd El-Hameed ◽  
Sozan A. Ali
Keyword(s):  
Oxidative Stress ◽  
Liver Damage ◽  
Arthrospira Platensis

Differential diagnosis of focal liver lesions: role of spin-echo and contrast-enhanced dynamic MR imaging.

Radiology ◽  
1994 ◽  
Vol 193 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Y Yamashita ◽  
Y Hatanaka ◽  
H Yamamoto ◽  
A Arakawa ◽  
T Matsukawa ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mr Imaging ◽  
Spin Echo ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Dynamic Mr Imaging ◽  
Contrast Enhanced ◽  
Dynamic Mr

scholarly journals Fibrosis in Chronic Hepatitis C: Correlation between Immunohistochemically-Assessed Virus Load with Steatosis and Cellular Iron Content

2016 ◽  
Vol 4 (4) ◽  
pp. 578-584
Author(s):  
Maha Akl ◽  
Ali EL Hindawi ◽  
Maha Mosaad ◽  
Ahmed Montasser ◽  
Ahmed El Ray ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Damage ◽  
Cellular Iron ◽  
Iron Load ◽  
Cirrhotic Group ◽  
Sirius Red

AIM: We aimed study impact of hepatocytic viral load, steatosis, and iron load on fibrosis in chronic hepatitis C and role of VEGF and VEGFR overexpression in cirrhotic cases in evolving HCC.MATERIAL AND METHODS: Total of 120 cases were included from TBRI and Beaujon Hospital as chronic hepatitis C (CHC), post-hepatitis C cirrhosis, and HCC. Cases of CHC were stained for Sirius red, Prussian blue and immunohistochemically (IHC) for HCV-NS3/NS4. HCC were stained IHC for VEGF and by FISH.RESULTS: Stage of fibrosis was significantly correlated with inflammation in CHC (P < 0.01). Noticed iron load did not correlate with fibrosis. Steatosis was associated with higher inflammation and fibrosis. The cellular viral load did not correlate with inflammation, steatosis or fibrosis. VEGF by IHC was significantly higher in cases of HCC when compared to cirrhotic group (P < 0.001). Amplification of VEGFR2 was confirmed in 40% of cases of HCC. Scoring of VEGF by IHC was the good indicator  of VEGFR2 amplification by FISH (P < 0.005).CONCLUSION: Grade of inflammation is the factor affecting fibrosis in CHC. The degree of liver damage is not related to cellular viral load or iron load. Steatosis is associated with higher inflammation and fibrosis. VEGF by IHC is correlated with overexpression of VEGFR2 by FISH.

Protective role of zinc in liver damage in experimental diabetes demonstrated via different biochemical parameters

2020 ◽  
Author(s):  
Ozlem Sacan ◽  
Ismet Burcu Turkyilmaz ◽  
Bertan Boran Bayrak ◽  
Ozgur Mutlu ◽  
Nuriye Akev ◽  
...  
Keyword(s):  
Liver Damage ◽  
Biochemical Parameters ◽  
Experimental Diabetes ◽  
Protective Role

scholarly journals Evaluation of Contrast-Enhanced Intraoperative Ultrasound in the Detection and Management of Liver Lesions in Patients with Hepatocellular Carcinoma

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Cristina Pace ◽  
Vittorio Nardone ◽  
Silvia Roma ◽  
Fabrizio Chegai ◽  
Luca Toti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Intraoperative Ultrasound ◽  
Preoperative Imaging ◽  
Liver Lesions ◽  
Therapy Decision ◽  
Contrast Enhanced ◽  
Regenerative Nodules ◽  
Malignant Liver

Aim. To evaluate the role of contrast-enhanced intraoperative ultrasound (CE-IOUS) during liver surgery in the detection and management of liver lesions in patients with hepatocellular carcinoma (HCC). Materials and Methods. From December 2016 to December 2017, 50 patients with HCC, who were candidates for liver resection, were evaluated with intraoperative ultrasound (IOUS). For all patients, MRI and/or CT were performed before surgery. During surgery, IOUS was performed after liver mobilization, and when nodules that had not been detected in the preoperative MRI and/or CT were observed, CE-IOUS scans were carried out with the dual purpose of better characterizing the unknown lesion and discovering new lesions. Results. In 12 patients, IOUS showed 14 nodules not detected by preoperative MRI and/or CT, before surgery. Out of the 12 lesions, five presented vascular features compatible with those of malignant HCC to the evaluation with CE-IOUS and four of these were simultaneously treated with intraoperative radiofrequency ablation (RFA). The fifth lesion was resected by the surgeon. The remaining nine lesions recognized by IOUS were evaluated as benign at CE-IOUS and considered regenerative nodules. The last diagnosis was confirmed during follow-up obtained by means of CT and/or MRI after 1, 3, 6, or 12 months. Conclusion. In our experience, CE-IOUS is a useful diagnostic tool in both benign pathologies, such as regenerative nodules, and malignant liver lesions. The advantage of this approach is the possibility of intraoperatively characterizing, based on vascularization patterns, lesions that could not be diagnosed by preoperative imaging, resulting in modification of the surgical therapy decision and expansion of the resection or intraoperative ablation.

scholarly journals Role of Ginger as Anti-inflammatory and Anti-apoptotic in Protection of Liver Damage Induced by Metalaxyl Fungicide in Male Albino Rats

2018 ◽  
Vol 08 (03) ◽  
Author(s):  
Marwa Fouad Hassa ◽  
Samy Hussein ◽  
Yakout El Senosi ◽  
Mogda Kamal Mansour ◽  
Aziza Amin
Keyword(s):  
Liver Damage ◽  
Albino Rats ◽  
Anti Inflammatory

scholarly journals Role of contrast enhanced ultrasound in characterization of focal liver lesions

2014 ◽  
Vol 45 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Shruti Thakur ◽  
Anupam Jhobta ◽  
D.S. Dhiman ◽  
R.G. Sood ◽  
Arun Chauhan ◽  
...  
Keyword(s):  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

scholarly journals Patterns of enhancement in the hepatobiliary phase of gadoxetic acid-enhanced MRI

2020 ◽  
Vol 93 (1112) ◽  
pp. 20190989
Author(s):  
Cathryn L Hui ◽  
Marcela Mautone
Keyword(s):  
Liver Parenchyma ◽  
Gadoxetic Acid ◽  
Hepatobiliary Phase ◽  
Liver Lesions ◽  
Enhanced Mri

A variety of patterns of enhancement of liver lesions and liver parenchyma is observed in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI. It is becoming increasingly apparent that many lesions may exhibit HBP enhancement. Much of the literature regarding the role of gadoxetic acid-enhanced MRI in characterising liver lesions is dichotomous, focusing on whether lesions are enhancing or non-enhancing in the HBP, rather than examining the patterns of enhancement. We provide a pattern-based description of HBP enhancement of liver parenchyma and of liver lesions. The role of OATP1B3 transporters, hepatocyte function and lesion composition in influencing patterns of HBP hyperintensity are discussed.

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