scholarly journals Comparative studying of biochemical indices of the blood in experimental acute biliary pancreatitis and obstructive cholestasis

2020 ◽  
Vol 87 (1-2) ◽  
pp. 70-73
Author(s):  
I. N. Mamontov
Keyword(s):  
Alkaline Phosphatase ◽  
Laboratory Animals ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis ◽  
Blood Indices ◽  
The Third ◽  
Urea Content ◽  
Obstructive Cholestasis ◽  
Biochemical Indices ◽  
Severe Hyperbilirubinemia

Objective. Comparative studying of levels of some biochemical indices in experimental acute biliary pancreatitis and obstructive cholestasis. Materials and methods. An acute biliary pancreatitis was simulated on 32 rats and obstructive cholestasis – on 23. On the first, third and 7th days after the blood indices of general bilirubin, albumin and the urea, as well as activity of alaninaminotranspherase, aspartataminotranspherase, alkaline phosphatase and amylase were studied. Results. In the acute biliary pancreatitis on the second day of the experiment 10 (31.3%) rats have deceased, and in obstructive cholestasis - 1 (4.3%) rat (p < 0.01). In both groups of laboratory animals the signs of cholestasis were determined, and in the acute biliary pancreatitis – signs of pancreatitis. On the first day in acute biliary pancreatitis in comparison with acute cholestasis there were noted the enhanced values of the amylase activity (p < 0.001) and the urea content (p < 0.05); on the third day – the lower values of the general bilirubin content (p < 0.001), higher values of the alaninaminotranspherase activity (p < 0.05), the urea content (p < 0.01) and activity of amylase (p < 0.05); on the 7-th day – lower values of general bilirubin (p < 0.05), higher values of activity of alkaline phosphatase and aspartataminotranspherase (p < 0.05). Conclusion. More severe hyperbilirubinemia is observed in obstructive cholestasis. In the acute biliary pancreatitis the trustworthy enhanced values of the alaninaminotranspherase (on the third day) and aspartataminotranspherase (on the 7-th day) activities, the urea content (on the third day), as well as activity of alkaline phosphatase (on the 7th day) are noted.

scholarly journals The Predictivity of Serum Biochemical Markers in Acute Biliary Pancreatitis

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Bülent Güngör ◽  
Kasım Çağlayan ◽  
Cafer Polat ◽  
Deniz Şeren ◽  
Kenan Erzurumlu ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Biochemical Markers ◽  
Total Bilirubin ◽  
Direct Bilirubin ◽  
Gamma Glutamyl Transferase ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis ◽  
Glutamyl Transferase

Background and Aim. There are no accurate methods of differentiating acute biliary pancreatitis. Obstructions of biliary ducts, idiopathic pancreatitis may be related with biliary origin which needs identification for acute treatment. We searched for the predictivity of biochemical markers in early acute biliary pancreatitis. Patients and Methods. Serum levels of AST (Aspartate Transaminase),ALT (Alanine Transaminase), ALP (Alkaline Phosphatase), GGT (Gamma Glutamyl Transferase), total bilirubin, direct bilirubin, LDH (Lactate Dehydrogenase), amylase, lipase, CRP (C-Reactive Protein) and WBC (White Blood Cell) were measured in 157 patients with acute pancreatitis. Biliary and nonbiliary pancreatitis were differentiated by Magnetic Resonance Cholangiopancreatography (MRCP), Endoscopic Retrograde Cholangiopancreatography (ERCP), Intraoperative Cholangiopancreatography (IOC). Cut-off points of admission biochemical markers with sensitivity, specifity, positive predictive value and negative predictive value were determined after identification of significant variables. Receiver Operator Curves were plotted for each biochemical marker. Results. Serum Alkaline Phosphatase, total bilirubin, direct bilirubin, amylase and lipase levels were significantly higher in biliary pancreatitis with a positive predictive value of 80.8%, 83.9%, 81.6%, 78.8%, 79.7%. Conclusion. Increased Alkaline Phosphatase,total bilirubin, direct bilirubin, amylase and lipase levels may be used in prediction of biliary pancreatitis.

Urgent ERCP reduce complications in acute biliary pancreatitis

2009 ◽  
Vol 47 (05) ◽  
Author(s):  
J Pozsár ◽  
P Sahin ◽  
I Brandhuber ◽  
Z Kövesdi ◽  
L Topa
Keyword(s):  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis

The roles of intraductal US in acute biliary pancreatitis patients without choledocholithiasis on ERCP

Endoscopy ◽  
2006 ◽  
Vol 39 (S 1) ◽  
Author(s):  
JH Moon ◽  
YK Cheon ◽  
YD Cho ◽  
JO Kim ◽  
JS Lee ◽  
...  
Keyword(s):  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis

Bile Infection and Bile Acids Concentration in Bile in Acute Biliary Pancreatitis

2009 ◽  
Vol 81 (12) ◽  
Author(s):  
Jakub Zasada ◽  
Józefa Panek ◽  
Mirosław Dolecki ◽  
Zbigniew Biesiada ◽  
Marcin Dembiński
Keyword(s):  
Bile Acids ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis

REPEATED LONG-TERM SPACE FLIGHTS: PROTEOMIC INVESTIGATIONS OF COSMONAUTS' BLOOD

2020 ◽  
Vol 54 (5) ◽  
pp. 15-22
Author(s):  
I.M. Larina ◽  
◽  
D.N. Kashirina ◽  
K.S. Kireev ◽  
A.I. Grigoriev ◽  
...  
Keyword(s):  
Bone Structure ◽  
Space Station ◽  
The Body ◽  
Coagulation Cascade ◽  
Chemical Components ◽  
Blood Proteins ◽  
Blood Indices ◽  
Before And After ◽  
Biochemical Indices

We performed the first ever comparative analysis of modifications in the proteome, ionogram and some other blood plasma biochemical indices of 18 male cosmonauts (44 ± 6 years of age) before and after maiden or repeated long-term missions to the Russian segment of the International space station (ISS RS). Levels of proteins, substrates and ions as well as chemical components were measured using the LC-MS-based proteomics and routine biochemical techniques. A total of 256 to 281 indices were investigated with the methods of descriptive statistic, regression analysis, and access to bioinformatics resources. It was shown that blood indices recovery from the maiden and repeated missions reflects changes in the body systems and goes at a various speed. The results of measurements made prior to launch and on day 7 after landing are dependent on the number of missions. The bioinformatics techniques showed that after maiden missions both the mediator proteins of alkaline phosphatase (AP) and blood proteins with reliably changing concentrations are associated with the bio-processes including stress, metabolism and DNA reparation, apoptosis, catabolism and proteolysis. During early re-adaptation from repeated missions the AP level was affected by bone remodeling, phosphorylation, angiogenesis and coagulation cascade suggesting a distinct and urgent trigger of the processes of bone structure and mineralization.

Complete resolution of acute pancreatitis-induced chylous ascites following transhepatic portal vein stenting

2020 ◽  
Vol 13 (12) ◽  
pp. e235986
Author(s):  
Alexander Tindale ◽  
James Jackson ◽  
Darina Kohoutova ◽  
Panagiotis Vlavianos
Keyword(s):  
Portal Vein ◽  
Complete Resolution ◽  
Chylous Ascites ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis ◽  
Portal Vein Stenosis ◽  
First Case ◽  
Vein Stenosis ◽  
Inflammatory Changes

We introduce a case of a 73-year-old man who developed intractable chylous ascites due to portal vein compression as a result of peripancreatic inflammatory changes after acute biliary pancreatitis. After stenting the portal vein stenosis, the chylous ascites improved from requiring weekly paracentesis to requiring no drainage within 4 months of the procedure and at the 15-month follow-up. To our knowledge, it is the first case reported in the literature where portal vein stenting has successfully been used to treat pancreatitis-induced chylous ascites.

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