scholarly journals "Novel applications of DDS on infectious diseases and future prospect" Drug delivery system responding to cellular signals in infected cells

2006 ◽  
Vol 21 (5) ◽  
pp. 505-515
Author(s):  
Yoko Shoji ◽  
Kouta Kodama ◽  
Daisuke Asai ◽  
Yoshiki Katayama ◽  
Hideki Nakashima
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Drug Delivery System ◽  
Delivery System ◽  
Future Prospect ◽  
Infected Cells ◽  
Novel Applications

Cell derived liposomes expressing CCR5 as a new targeted drug-delivery system for HIV infected cells

2011 ◽  
Vol 151 (2) ◽  
pp. 139-148 ◽  
Author(s):  
Tomer Bronshtein ◽  
Naama Toledano ◽  
Dganit Danino ◽  
Shimon Pollack ◽  
Marcelle Machluf
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Infected Cells ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Drug Delivery System to Control Infectious Diseases

2002 ◽  
Vol 8 (6) ◽  
pp. 455-465 ◽  
Author(s):  
Yoko Shoji ◽  
Jingoro Shimada ◽  
Yutaka Mizushima
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Drug Delivery System ◽  
Delivery System

scholarly journals A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment

2019 ◽  
Vol 11 (483) ◽  
pp. eaau6267 ◽  
Author(s):  
Malvika Verma ◽  
Karan Vishwanath ◽  
Feyisope Eweje ◽  
Niclas Roxhed ◽  
Tyler Grant ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Infectious Diseases ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tuberculosis Treatment ◽  
Swine Model ◽  
Drug Dosing ◽  
Preclinical Safety

Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.

scholarly journals NANOPARTICLES AS A TOOL FOR BROADENING ANTIFUNGAL ACTIVITIES

2020 ◽  
Vol 27 ◽  
Author(s):  
Daniele Fernanda Renzi ◽  
Laís de Almeida Campos ◽  
Eduardo Hösel Miranda ◽  
Rubiana Mara Mainardes ◽  
Wolf-Rainer Abraham ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fungal Infections ◽  
Infection Rates ◽  
Prolonged Action ◽  
Lower Toxicity ◽  
Routes Of Administration ◽  
Therapeutic Alternatives

: The Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery. In this sense, the objective of the present study was to evaluate the contributions of newly developed nanoparticles to the treatment of fungal infections. Studies have shown that nanoparticles generally improve the biopharmaceutical and pharmacokinetic characteristics of antifungals, which is reflected in a greater pharmacodynamic potential and lower toxicity, as well as the possibility of prolonged action. It also offers the proposition of new routes of administration. Nanotechnology is known to contribute to a new drug delivery system, not only for the control of infectious diseases, but for various other diseases as well. In recent years, several studies have emphasized its application in infectious diseases, presenting better alternatives for the treatment of fungal infections.

Sign in / Sign up

Export Citation Format

Share Document