scholarly journals Improvement of transmucosal absorption of drugs in drug delivery system (DDS) 1. Improvement of intestinal and transmucosal absorption of poorly absorbable drugs: current status and future prospect

2005 ◽  
Vol 20 (4) ◽  
pp. 404-415 ◽  
Author(s):  
Akira Yamamoto
Author(s):  
Priyanka Yatham ◽  
Yogita Dahat ◽  
Arshad Khan ◽  
Rinku Baishya ◽  
Amit K. Srivastava ◽  
...  

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 847 ◽  
Author(s):  
Siyuan Deng ◽  
Maria Rosa Gigliobianco ◽  
Roberta Censi ◽  
Piera Di Martino

Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.


Author(s):  
Pooja Chawla ◽  
Monika Mis

This review article describes the current status and recent advances of polymeric drugs with regard to their application in drug delivery system. Essentially polymer-drug conjugation aims to achieve improved drug targeting, decrease drug toxicity and overcome mechanisms of drug resistance. First generation conjugates used linear monomethoxy PEGs and other linear polymers. Modern polymeric chemistry is increasingly producing new polymeric architectures such as dendrimers, hyper branched polymers and hybrid macromolecular structures (such as star polymers, linear graft and dendronized linear polymers and novel therapeutic siRNA. This undoubtedly can be employed for designing of second generation polymer therapeutics. Clinical approval of products such as Copaxone®, Renagel®, Vivagel® and Welchol® have been successful in developing interest in polymer therapeutics as a growing field of research and development. In conclusion, there is emerging data that polymer drug conjugation has become useful in a wide range of treatments from infectious to chronic diseases such as cancer. Polymer therapeutics holds promising future applications in the field of nanotherapeutics.  Polymeric Drugs: A Novel Approach to Drug Delivery System


2020 ◽  
Vol 13 (6) ◽  
pp. 2954
Author(s):  
R. Nagaraju ◽  
P. Subhash Chandra Bose ◽  
G. Ravi ◽  
Damineni Saritha ◽  
Valluru Ravi

2010 ◽  
Vol 30 (3) ◽  
pp. 321-328
Author(s):  
Bao-yue DING ◽  
lei AO ◽  
Xue-ying DING ◽  
Jing GAO ◽  
Wei FAN ◽  
...  

2021 ◽  
Vol 11 (4-S) ◽  
pp. 231-235
Author(s):  
Sabnam Gupta ◽  
Sudip Das ◽  
Abhay Singh ◽  
Suman Ghosh

The buccal region within the mucosal cavity of the mouth provides an alternative route over an oral drug administration for systemic as well as local drug delivery. As the buccal mucosa has an abundant blood supply and is relatively permeable, it can be considered as most accessible and desired location for both local and systemic drug delivery. The buccal method for medication delivery greatly helps in avoiding issues in the gastrointestinal environment, such as increased first-pass metabolism and medication degradation. Bucco-adhesive systems offer varieties of advantages such as convenience in administration and termination of therapy in case of emergency, higher patient compliance, better bioavailability, rapid absorption, etc. This current review highlights the bucco-adhesive drug delivery system, its advantages and limitations, mechanisms and theories of mucoadhesion, different bucco-adhesive dosage forms, and bioadhesive polymers. It also highlights the current status on mucoadhesive drug delivery methods for the buccal cavity or bucco-adhesive systems. Keywords: Bioadhesion, mucoadhesion, bucco-adhesive drug delivery system, oral mucosa, first-pass metabolism, bioadhesive polymers.


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