LIPOSOMES AS DRUG DELIVERY SYSTEM IN THE TREATMENT OF INFECTIOUS DISEASES

1989 ◽  
Vol 8 (7) ◽  
pp. 482
Author(s):  
A. Coune
2002 ◽  
Vol 8 (6) ◽  
pp. 455-465 ◽  
Author(s):  
Yoko Shoji ◽  
Jingoro Shimada ◽  
Yutaka Mizushima

2019 ◽  
Vol 11 (483) ◽  
pp. eaau6267 ◽  
Author(s):  
Malvika Verma ◽  
Karan Vishwanath ◽  
Feyisope Eweje ◽  
Niclas Roxhed ◽  
Tyler Grant ◽  
...  

Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.


2020 ◽  
Vol 27 ◽  
Author(s):  
Daniele Fernanda Renzi ◽  
Laís de Almeida Campos ◽  
Eduardo Hösel Miranda ◽  
Rubiana Mara Mainardes ◽  
Wolf-Rainer Abraham ◽  
...  

: The Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery. In this sense, the objective of the present study was to evaluate the contributions of newly developed nanoparticles to the treatment of fungal infections. Studies have shown that nanoparticles generally improve the biopharmaceutical and pharmacokinetic characteristics of antifungals, which is reflected in a greater pharmacodynamic potential and lower toxicity, as well as the possibility of prolonged action. It also offers the proposition of new routes of administration. Nanotechnology is known to contribute to a new drug delivery system, not only for the control of infectious diseases, but for various other diseases as well. In recent years, several studies have emphasized its application in infectious diseases, presenting better alternatives for the treatment of fungal infections.


Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi

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