scholarly journals Features of the recovery period of hypoxic lesion to the central nervous system in children of the first year of life with congenital heart disease

2020 ◽  
Vol 35 (3) ◽  
pp. 53-58
Author(s):  
V. A. Zhelev ◽  
A. S. Pogudina ◽  
E. V. Mikhalev ◽  
A. O. Okorokov ◽  
T. S. Krivonogova ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Congenital Heart Disease ◽  
Nervous System ◽  
Heart Disease ◽  
Congenital Heart ◽  
Recovery Period ◽  
First Year ◽  
Resistance Level ◽  
The Central Nervous System ◽  
First Year Of Life

Aim. To study the features of recovery period of hypoxic lesion to the central nervous system (CNS) in children of the first year of life in the presence of congenital heart disease (CHD).Material and Methods. The study involved 80 children born full-term and premature with gestational status of 35–37 weeks with hypoxic damage to the CNS. The main observation group comprised 50 children with CHD (interventricular and atrial septal defects, open ductus arteriosus). All children underwent a comprehensive health assessment, standard echocardiography, and neurosonography at ages of five to seven days and one, three, and six months. Biochemical analysis included assessment of serum neurospecific enolase (NSE), succinate dehydrogenase (SDG), and α-glycerophosphate dehydrogenase (α-GPDH). The control group included 20 full-term newborns without CHD and CNS lesions.Results. The main manifestations in newborns with CHD and hypoxic damage to the CNS were the suppression syndrome, agitation, and hypertension-hydrocephalic syndrome. At the age of six months, a delay in motor development indicators persisted in 35% of children in the main group. The high NSE level in newborns with concomitant septal heart defects was associated with a decrease in the quantitative indicators of neuropsychic development (g = –0.6, p < 0.05). The children with CHD and hypoxic damage to the CNS in the first year of life were significantly more often (p < 0.05) deficient in weight and height. A decrease in the resistance level in the first year of life was observed in 40% of children from the main group, which significantly differed compared with group of children without CHD (p < 0.001). The newborns with hypoxic CNS and CHD lesions had a decrease in the activity of α-GPDH and SDG at the age of five to seven days; the low activity of SDG persisted at the ages of one and six months; the enzyme activity in children of the comparison group was normal (p < 0.05).Conclusion. Children with CHD had the features of clinical course of perinatal damage to the CNS in the acute and recovery periods, a slowdown in the rate of physical and neuropsychic development, a decrease in the resistance level, and impaired functional state of the body. The decreases in the activities of SDG and α-GPDH in children with hypoxic lesions to the CNS in the presence of CHD implied the disturbances in cellular bioenergetics and resulted in inadequate response to external factors.

CENTRAL NERVOUS SYSTEM COMPLICATIONS FOLLOWING BLALOCK-TAUSSIG OPERATION

PEDIATRICS ◽  
1967 ◽  
Vol 39 (1) ◽  
pp. 18-23
Author(s):  
Patricia M. Clarkson ◽  
Manuel R. Gomez ◽  
Robert B. Wallace ◽  
William H. Weidman
Keyword(s):  
Central Nervous System ◽  
Congenital Heart Disease ◽  
Nervous System ◽  
Heart Disease ◽  
Congenital Heart ◽  
Cyanotic Congenital Heart Disease ◽  
Arterial System ◽  
Neurologic Complications ◽  
The Central Nervous System ◽  
Low Incidence

Two cases of severe neurologic symptoms after a Blalock-Taussig anastomosis are presented in detail. The histories of 116 patients with cyanotic congenital heart disease who had such an anastomotic operation at the Mayo Clinic were reviewed. There was a low incidence (less than 1%) of postoperative neurologic complications in patients without evidence of focal dysfunction of the central nervous system prior to operation. The review suggested an increased incidence of complications in those patients with a cerebrovascular abnormality before surgery. It is likely that these complications are related to alterations in the vertebrobasilar arterial system associated with this procedure.

THE WOLFF-PARKINSON-WHITE SYNDROME IN INFANTS AND CHILDREN

PEDIATRICS ◽  
1959 ◽  
Vol 24 (4) ◽  
pp. 585-603
Author(s):  
Gerold L. Schiebler ◽  
Paul Adams ◽  
Ray C. Anderson
Keyword(s):  
Central Nervous System ◽  
Congenital Heart Disease ◽  
Nervous System ◽  
Heart Disease ◽  
Congenital Heart ◽  
Infants And Children ◽  
White Syndrome ◽  
The Central Nervous System ◽  
Wolff Parkinson White Syndrome ◽  
In Infants And Children

It is the belief of the authors that the Wolff-Parkinson-White syndrome, although frequently misinterpreted, is not an uncommon finding in infants and children. This electrocardiographic pattern occurred approximately once among every 200 children (0.5%) referred for cardiac evaluation. Twenty-eight infants and children with the Wolff-Parkinson-White syndrome, 19 (68%) of whom were males, were arbitrarily classified into five general groups: 1) "traditional—9 cases; and those associated with 2) congenital heart disease–13 cases; 3) rheumatic heart disease–1 case; 4) familial cardiomegaiy–2 cases; and 5) disease of the central nervous system–5 cases. Only two patients were placed in more than one category. The small number in the "traditional" group (9 of 28 cases) is striking. About half of the cases studied had associated congenital heart disease, particularly Ebstein's anomaly of the tricuspid valve. A review of reported cases with the Wolff-Parkinson-White syndrome and congenital heart disease appears to show that this syndrome may be associated with many congenital malformations of the heart, but particularly with dextrocardia and anomalies of the tricuspid valve (Ebstein's malformation and tricuspid atresia). The association of the Wolff-Parkinson-White syndrome with diseases of the central nervous system and with congenital anomalies in other areas of the body is noted. Fourteen of the patients (50%) had episodes of tachycardia, and paroxysms of tachycardia were suspected in two others. Digitalis preparations have proved to be efficacious in terminating the bouts of tachycardia in children. The prognosis in those individuals without any other congenital anomaly is usually good. On the basis of this study, the authors consider that every child with this electrocardiographic pattern should be investigated for additional abnormalities.

scholarly journals Parental experience of the neuromotor development of children with congenital heart disease: an exploratory qualitative study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Elena Mitteregger ◽  
Martina Wehrli ◽  
Manuela Theiler ◽  
Jana Logoteta ◽  
Irina Nast ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Qualitative Study ◽  
Motor Development ◽  
Congenital Heart ◽  
Healthcare Professionals ◽  
Qualitative Content Analysis ◽  
First Year ◽  
First Year Of Life ◽  
Neuromotor Development

Abstract Background Children with severe congenital heart disease (CHD) are a group of children at risk for neurodevelopmental impairments. Motor development is the first domain to show a delay during the first year of life and may significantly contribute to parental concerns, stress, and difficulties in early child-parent attachment. Thus, the aim of the study was to better understand the wishes and concerns of parents of children with CHD and explore their experience of their children’s neuromotor development in the first year of life. Methods In this qualitative study, fourteen families were recruited. Their children were aged 1–3 years and had undergone open heart surgery within the first 6 months of life. Semi-structured interviews were audio-recorded and transcribed. The data was explored within an expert group, and a qualitative content analysis was conducted using VERBI MAXQDA software 2020. The study was conducted in accordance with the COREQ checklist. Results Parents of children with CHD reported several burdens and needs. Parental burdens concerned the child’s motor development, their own physical and psychological strain, and difficulties in communication with healthcare professionals. The needs, parents reported included supporting their child’s motor development, a medical coordinator, and better communication between healthcare professionals and parents. During the first phase of their children’s illness, parents underwent a dynamic transitional phase and expressed the need to rely on themselves, to trust their children’s abilities, and to regain self-determination in order to strengthen their self-confidence. Conclusions It is essential to involve parents of children with CHD at an early stage of decision-making. Parents are experts in their children and appreciate medical information provided by healthcare professionals. Interprofessional teamwork, partnering with parents, and continuous support are crucial to providing the best possible care for children and their families. Family-centred early motor intervention for CHD children might counteract the effect of parental overprotection and improve children’s motor development and thus strengthen child-parent interaction. In future work, we aim to evaluate a family-centred early motor intervention for children with CHD developed on the basis of this qualitative study. Trial registration Not applicable.

scholarly journals Updates in Congenital Heart Disease: Can Outcomes Improve?

2019 ◽  
Vol 36 (S 02) ◽  
pp. S22-S28
Author(s):  
Gerard R. Martin ◽  
Russell R. Cross ◽  
Lisa A. Hom ◽  
Darren Klugman
Keyword(s):  
Intensive Care Unit ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
First Year ◽  
Cardiac Intensive Care Unit ◽  
Cardiac Intensive Care ◽  
First Year Of Life ◽  
Pulse Oximetry Screening

AbstractDespite numerous advances in medical and surgical management, congenital heart disease (CHD) remains the number one cause of death in the first year of life from congenital malformations. The current strategies used to approach improving outcomes in CHD are varied. This article will discuss the recent impact of pulse oximetry screening for critical CHD, describe the contributions of advanced cardiac imaging in the neonate with CHD, and highlight the growing importance of quality improvement and safety programs in the cardiac intensive care unit.

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