EFFICIENCY OF COMBINED USE OF METFORMIN AND INTRANASAL INSULIN FOR CORRECTION OF HYPOTHALAMIC SIGNALING AND THE INSULIN, LEPTIN AND INCRETIN LEVELS IN RATS WITH METABOLIC SYNDROME

Objective. To evaluate the effect of the chronic use of combined oral contraceptives (COCs: ethinyl estradiol and levonorgestrel) on the indices of metabolic syndrome in adult female Wistar rats and possible therapeutic management. Materials and Methods. 64 female Wistar rats received either distilled water, norethindrone (NOR), COC, intranasal insulin (INI), metformin (MET), saxagliptin (SAX), INI+MET, and INI+SAX. After 8 weeks of exposure to COC, the animals were sorted into the therapeutic groups. Several parameters were assayed for, such as body weight changes, fasting blood glucose (FBG) level, insulin levels, inflammatory cytokines, and glycated hemoglobin (Hb1Ac). Results. The levels of FBG, insulin, and Hb1Ac were increased consequent upon COC treatment. Treatment with INI+SAX and INI+MET reduced significantly the levels of FBG and Hb1Ac; in addition, the level of insulin was significantly increased in the INI+MET groups ( p ≤ 0.05 ). Serum lipid profile analysis showed a statistical reduction in high-density lipoprotein (HDL) level; this reduction was also significantly reversed in the INI+SAX group. Reduced catalase activity observed in the COC group was reversed in the INI+MET group ( p ≤ 0.05 ). A nonsignificant increase in the level of TNF-α as a result of COC treatment was reversed by INI and INI+MET treatment. Liver GLUT4 and G-6-phosphate levels were significantly increased by COC treatment, and this effect was reversed by INI+SAX in both assays, respectively ( p ≤ 0.01 ). Conclusions. The use of MET and SAX in combination with INI has been shown to reverse some indices of MetS. This study proposes a clinical phase to backup and ascertain these preclinical findings.

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The dynamics of indicators of peroxide metabolism in patients with cicatricial skin deformations in combination with metabolic syndrome in complex use of physiotherapeutic treatment methods and drinking mineral waters

Fizioterapevt (Physiotherapist) ◽

10.33920/med-14-2104-06 ◽

2021 ◽

pp. 45-55

Author(s):

K.V. Kazatseva ◽

S.N. Nagornev ◽

V.K. Frolkov ◽

E.V. Gusakova

Keyword(s):

Metabolic Syndrome ◽

Lipid Peroxidation ◽

Antioxidant Enzymes ◽

Mineral Water ◽

Effective Means ◽

Mineral Waters ◽

Combined Use ◽

Pathogenetic Therapy ◽

Peroxidation Processes

The article analyzes the role of lipid peroxidation processes in the pathogenesis of cicatricial skin changes, including in patients with metabolic syndrome. Baseline indices of LPO processes and antioxidant enzymes in patients with metabolic syndrome indicate the development of oxidative stress and accumulation of cytotoxic carbonyl products. The course use of a combination of fermenkol phonophoresis, fractional photothermolysis and mineral water «Essentuki №17» in patients with cicatricial changes in the skin and metabolic syndrome is accompanied by a decrease in the severity of insulin resistance and lipid peroxidation processes. The use of a complex of physiotherapeutic factors and drinking mineral water contributes to an increase in the coefficient of antioxidant protection by 54%. The revealed dynamics of the assessed parameters is realized due to the elimination of molecular inhibitors of antioxidant enzymes in conditions of an increase in the receptor sensitivity of tissues to insulin and a decrease in the level of glycemia. The manifestation of antioxidant activity in the combined use of physiotherapeutic methods and mineral waters for drinking purposes allows this technology to be considered as an effective means of pathogenetic therapy of cicatricial deformities of the skin in combination with metabolic syndrome.

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The Clinical Efficacy of Combined Use of the Metformin and the Atorvastatin in Patients with Osteoarthritis and Metabolic Syndrome

Journal of New Medical Technologies ◽

10.12737/13307 ◽

2015 ◽

Vol 22 (3) ◽

pp. 93-98

Author(s):

Васильева ◽

L. Vasileva ◽

Лахин ◽

D. Lakhin

Keyword(s):

Metabolic Syndrome ◽

Clinical Efficacy ◽

Analogue Scale ◽

Control Group ◽

Side Reactions ◽

Anthropometric Data ◽

The Metabolic Syndrome ◽

Combined Use ◽

Hypertensive Therapy ◽

Lipid Spectrum

The purpose was to evaluate the effectiveness of combined use of the Metformin and the Atorvastatin for the correction of the metabolic syndrome in patients with osteoarthritis. The study included 70 patients with osteoarthri-tis and metabolic syndrome, who were divided into 2 groups: control and basic. In the control group, the patients received only pathogenetic treatment of osteoarthritis and anti-hypertensive therapy. Patients of the main group also received the Metformin 500 mg x 2 times and the Atorvastatin 10 mg/day. The authors monitored biochemical, anthropo-metric indicators, assessed the severity of articular syndrome by calculation of the number of tender joints and swollen joints according to the index Richie. The intensity of articular syndrome was evaluated by the visual analogue scale, the authors determined the index WOMAC and Lequesne in both groups of patients 1-3, 7-10 days, 3, 6, and 12 months. On the background of combined use of these drugs has been able to achieve significantly positive changes in the characteristics of carbohydrate metabolism, lipid spectrum of blood, anthropometric data, as well as reducing the severity of pain and the number of swollen joints in the absence of side reactions. These results confirm the clinical efficacy of combined use of the Metformin and Atorvastatin not only for the metabolic syndrome, but for the articular status in osteoarthritis.

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Correction of small bowel function as a new direction for treating patients with metabolic syndrome

Terapevticheskii arkhiv ◽

10.17116/terarkh201789843-49 ◽

2017 ◽

Vol 89 (8) ◽

pp. 43-49

Author(s):

Ya M Vakhrushev ◽

M V Lyapina

Keyword(s):

Metabolic Syndrome ◽

Small Bowel ◽

Positive Impact ◽

Bowel Function ◽

Research Society ◽

Pancreatic Enzymes ◽

Blood Levels ◽

Functional Studies ◽

Combined Use ◽

Small Bowel Function

Aim. To provide a rationale for and to evaluate the therapeutic efficiency of the combined use of pancreatic enzymes and actovegin in the combination therapy of patients with metabolic syndrome (MS) on the basis of comprehensive clinical and functional studies of the small bowel (SB). Subjects and methods. In the course of treatment, 120 patients with MS (verified using the diagnostic criteria elaborated by the All-Russian Research Society of Cardiology (2009)) underwent a comprehensive study of SB function: an isolated study of resorptive processes; evaluation of parietal and cavitary digestion, motor-evacuation function. The peripheral blood levels of gastrin, insulin, cortisol, thyroxine and thyrotropin were determined. Results. The combined use of pancreatic enzymes and actovegin has a positive impact on the clinical and functional state of SB, which was manifested as restoration of its hydrolysis and absorption, as well as motor-evacuation function in the patients with MS. The treatment resulted in reductions in the levels of triglycerides from 2.85±0.34 to 1.53±0.18 mmol/l (p

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Polytherapy in schizophrenia in light of the literature data

Pharmacotherapy in Psychiatry and Neurology ◽

10.33450/fpn.2019.12.004 ◽

2020 ◽

Vol 35 (3-4) ◽

pp. 193-199

Author(s):

Jan Jaracz

Keyword(s):

Metabolic Syndrome ◽

Pharmacological Treatment ◽

Antipsychotic Drugs ◽

Meta Analysis ◽

Combined Use

The use of several drugs is quite common in the treatment of diseases, such as hypertension and epilepsy. Since the 1990s, there has been a tendency to use simultaneously two or more antipsychotic drugs to treat schizophrenia patients. It is estimated that 30–40% of patients are treated with two or more antipsychotic drugs. This was also confirmed by research carried out in Poland. This is despite the fact that the standards of pharmacological treatment of schizophrenia consistently recommend the use of monotherapy. There are also doubts about the safety of polytherapy. So far, it has not been clearly shown whether this is more effective than monotherapy. A recently published meta-analysis showed that only the combined use of clozapine and aripiprazole is more effective than other monotherapy and polytherapy. It has not yet been confirmed that the combined use of two antipsychotic drugs was associated with a higher risk of metabolic syndrome symptoms and QTc segment prolongation. The paper presents data on the scale of the phenomenon of polytherapy as well as publications on the effectiveness and safety of such proceedings as compared to monotherapy. Due to the ambiguity of the results, it is difficult to make clear recommendations regarding the management of monotherapy ineffectiveness. The work ends with a few questions that concern doubts about how to treat patients with schizophrenia to make the treatment rational.

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Adiponectin and Leptin Adipocytokines in Metabolic Syndrome: What Is Its Importance?

Dubai Diabetes and Endocrinology Journal ◽

10.1159/000510521 ◽

2020 ◽

Vol 26 (3) ◽

pp. 93-102

Author(s):

María Luz Gunturiz Albarracín ◽

Ana Yibby Forero Torres

Keyword(s):

Diabetes Mellitus ◽

Metabolic Syndrome ◽

Adipose Tissue ◽

Caloric Intake ◽

Subclinical Inflammation ◽

Regulatory Activity ◽

Obesity Epidemic ◽

Combined Use ◽

Bone Physiology

The global obesity epidemic has motivated a large number of investigations related to adipose tissue. Within the advances in this area, a variety of factors secreted by adipose tissue and with regulatory activity on caloric intake, energy expenditure, reproduction, locomotor activity, glycidic and lipid metabolism, immune response, and bone physiology have been described. Among these adipocyte hormones, collectively called “adipokines” or “adipocytokines,” leptin (LEP) and adiponectin are addressed in this review. The regulation of adipocytokines is altered in diseases such as obesity, atherosclerosis, type 2 diabetes mellitus, and metabolic syndrome (MS) due to the increase in the mass of white adipose tissue. LEP and adiponectin have a broad spectrum of functions in regulating metabolism and are an important link between obesity and MS. Because these adipocytokines have opposite effects on subclinical inflammation and insulin resistance, it has been suggested that the combined use of these 2 adipocytokines may work as a better biomarker in the diagnosis of MS than using them individually. In this review, we address the characteristics and main functions of adipocytokines derived from adipose tissue such as adiponectin and LEP, which in the Colombian context could give good guidance for the management of MS, especially in populations of children and adolescents.

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Analysis of the mechanisms of synergistic effect in the combined use of physiotherapy factors

Fizioterapevt (Physiotherapist) ◽

10.33920/med-14-2112-08 ◽

2021 ◽

pp. 70-79

Author(s):

A. A. Benkov ◽

S. N. Nagornev ◽

V. K. Frolkov ◽

E. V. Gusakova ◽

M. S. Nagorneva

Keyword(s):

Metabolic Syndrome ◽

Synergistic Effect ◽

Magnetic Stimulation ◽

Biological Effects ◽

Low Frequency ◽

Evidence Base ◽

Molecular Evidence ◽

Physical Factors ◽

Combined Use ◽

Tissue System

The study is devoted to the analysis of the internal mechanisms of the realization of biological effects of the combined use of a low-frequency alternating electrostatic field and transcranial magnetic stimulation with a running magnetic field in patients with metabolic syndrome. The results obtained allow concluding that the simultaneous course effect of these physiotherapeutic factors is accompanied by the development of a synergistic effect, objectively assessed by a set of parameters characterizing the state of the microcirculatory-tissue system, metabolic processes and peroxide metabolism. The quantitative assessment carried out using the synergy factor allowed classifying the type of interaction of physical factors as potentiation. The analysis of the internal mechanisms of supraadditive interaction made it possible to establish that this phenomenon can be most accurately explained from the standpoint of epigenetic regulation, which is a change in gene expression with the preservation of the DNA sequence and which determines the phenomenon of functional cumulation during the course of physiotherapeutic factors. The epigenetic model of the realization of synergy acts as a molecular evidence base for the sanogenetic effects observed in patients with metabolic syndrome under the systemotropic effect of physiotherapeutic factors.

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W09.247 Carotid intima-media thickness and outward carotid enlargement in women with metabolic syndrome

Atherosclerosis ◽

10.1016/s0021-9150(04)90246-8 ◽

2004 ◽

Vol 5 (1) ◽

pp. 57

Author(s):

P PAUCIULLO

Keyword(s):

Metabolic Syndrome ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Media Thickness

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