Analysis of the mechanisms of synergistic effect in the combined use of physiotherapy factors

2021 ◽  
pp. 70-79
Author(s):  
A. A. Benkov ◽  
S. N. Nagornev ◽  
V. K. Frolkov ◽  
E. V. Gusakova ◽  
M. S. Nagorneva
Keyword(s):  
Metabolic Syndrome ◽  
Synergistic Effect ◽  
Magnetic Stimulation ◽  
Biological Effects ◽  
Low Frequency ◽  
Evidence Base ◽  
Molecular Evidence ◽  
Physical Factors ◽  
Combined Use ◽  
Tissue System

The study is devoted to the analysis of the internal mechanisms of the realization of biological effects of the combined use of a low-frequency alternating electrostatic field and transcranial magnetic stimulation with a running magnetic field in patients with metabolic syndrome. The results obtained allow concluding that the simultaneous course effect of these physiotherapeutic factors is accompanied by the development of a synergistic effect, objectively assessed by a set of parameters characterizing the state of the microcirculatory-tissue system, metabolic processes and peroxide metabolism. The quantitative assessment carried out using the synergy factor allowed classifying the type of interaction of physical factors as potentiation. The analysis of the internal mechanisms of supraadditive interaction made it possible to establish that this phenomenon can be most accurately explained from the standpoint of epigenetic regulation, which is a change in gene expression with the preservation of the DNA sequence and which determines the phenomenon of functional cumulation during the course of physiotherapeutic factors. The epigenetic model of the realization of synergy acts as a molecular evidence base for the sanogenetic effects observed in patients with metabolic syndrome under the systemotropic effect of physiotherapeutic factors.

scholarly journals Results of the Preformed Physical Factors Application in the Rehabilitation Treatment of Corneal Ulcerative Defects

2021 ◽  
Vol 20 (4) ◽  
pp. 126-132
Author(s):  
Olga V. Yurova ◽  
Yaroslav A. Soloviev ◽  
Tatiana V. Konchugova
Keyword(s):  
Visual Acuity ◽  
Drug Therapy ◽  
Low Frequency ◽  
Pain Syndrome ◽  
Control Group ◽  
Physical Factors ◽  
Standard Drug ◽  
Corneal Ulcers ◽  
Combined Use

Currently, an infectious corneal ulcer, a defect in the corneal epithelium, remains one of the main causes of monocular blindness,which necessitates the development of new effective methods of treatment. Aim. To develop and evaluate the effectiveness of the technique for the complex application of preformed physical factors of local andsegmental action in patients with corneal ulcers. Material and methods. The study involved 85 patients with corneal ulcers aged 18 to 60 years divided into three groups. Patients ofthe control group (29 people) received the standard drug therapy, the comparison group (29 people) underwent a course of magnetophoresiswith solcoseryl on closed eyelids against the background of standard drug therapy, patients of the main group (27 people)received standard drug therapy, magnetophoresis and low-frequency electrostatic fields on the collar area. All patients were evaluatedfor visual acuity, the size of the ulcer and the area of stromal infiltration. The subjective severity of pain syndrome (VAS scale),psychoemotional state (SAN test) were assessed. Statistical analysis of the data was performed using SPSS Statistics v.25. Results. Immediately after treatment, the use of preformed physical factors made it possible to shorten the period of the ulcer epithelializationand suppression of the inflammatory reaction in the cornea, which significantly improved the clinical and functionalparameters of the eye, as well as considerably reduced the severity of pain syndrome in comparison with standard drug treatment. Conclusion. In the long-term period, the use of preformed physical factors contributed to a significant decrease in the size of thecorneal infiltration area (residual opacities) and an improvement in the quality of life of patients according to the General MentalWellbeing scale, which exceeded the effectiveness of standard drug therapy, while the combined use of a low-frequency electrostaticfield and magnetophoresis allowed to noticeably improve the indicators of visual acuity in comparison with standard drug therapyand isolated use of magnetophoresis.

scholarly journals The role of low-frequency repetitive transcranial magnetic stimulation in major depression: A call to increase the evidence base

2020 ◽  
Vol 13 (5) ◽  
pp. 1296-1297 ◽  
Author(s):  
Jean-Philippe Miron ◽  
Jack Sheen ◽  
Farrokh Mansouri ◽  
Daniel M. Blumberger ◽  
Zafiris J. Daskalakis ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Major Depression ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Evidence Base

Prebiotics from energy cane bagasse

2020 ◽  
pp. 488-494
Author(s):  
Giovanna M. Aita ◽  
Young Hwan Moon
Keyword(s):  
Biological Effects ◽  
Caloric Content ◽  
Gut Health ◽  
Activated Carbon Adsorption ◽  
Bifidobacterium Adolescentis ◽  
Great Opportunity ◽  
Energy Cane ◽  
Carbon Adsorption ◽  
Combined Use ◽  
Crude Sample

Xylooligosaccharides (XOS) is a group of emerging prebiotics that selectively stimulate the growth of advantageous gastrointestinal bacteria benefitting the host’s gut health and functionality. XOS can achieve positive biological effects at low daily doses and low caloric content, properties that are the same or more desirable than the already established prebiotics. XOS are present in plants in very low amounts so there is a great opportunity to isolate XOS with varying degrees of polymerization from the hemicellulose (xylan) fraction of lignocellulosic materials (e.g., bagasse), a source that offers both economic and environmental advantages. In this study, the recovery of XOS by the combined use of activated carbon adsorption, water washing and ethanol desorption from diluted acid pretreated energy cane bagasse hydrolysates was evaluated. The recovered XOS was tested for its prebiotic activity on Bifidobacterium adolescentis ATCC 15703. The final product of extracted XOS from energy cane bagasse (XOS EC Bagasse crude sample) had a purity of 93%, which was comparable to the purities observed with two commercially available XOS prebiotics, CPA (89%) and CPB (93%). XOS EC Bagasse crude sample exhibited prebiotic properties by stimulating the growth of B. adolescentis ATCC 15703 and by producing lactic acid, which were comparable to those observed with the commercial prebiotics.

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy through regulation of gut microbiota and bile acid metabolism

2021 ◽  
Author(s):  
Ming-zhi Zhu ◽  
Fang Zhou ◽  
Jian Ouyang ◽  
Qi-ye Wang ◽  
Yi-long Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Synergistic Effect ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Low Doses ◽  
Combined Use

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy. The synergistic effect may be attributed to regulation of gut microbiota and BA metabolism.

scholarly journals Repetitive transcranial magnetic stimulation as a prophylactic treatment in migraine

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Azza B. Hammad ◽  
Rasha E. Elsharkawy ◽  
Ghada S. Abdel Azim
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Serum Level ◽  
Pain Intensity ◽  
Magnetic Stimulation ◽  
Prophylactic Treatment ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Control Group ◽  
Neurokinin A ◽  
Abortive Treatment

Abstract Background Clinical applications of transcranial magnetic stimulation (TMS) have shown promising results in the treatment of headache disorders, with migraine being one of the most encountered. Objective To assess the role of low-frequency repetitive transcranial magnetic stimulation as a preventive treatment of migraine (with and without aura) and correlate the results with the serum level of the inflammatory biomarker (neurokinin A). Methods Forty patients, with age ranging from 15 to 55 years, diagnosed with migraine (30 migraine without aura and 10 with aura) and 20 apparently healthy individuals, who were age and sex matched with the patient group, were included in this study. A low-frequency (1 Hz) rTMS protocol was applied for all patients for five consecutive days interictally. Assessment of pain intensity using visual analogue scale and frequency and duration of attacks as well as number of pills taken by patients as an abortive treatment according to the Basic Diagnostic Headache Diary for 4 weeks before and 4 weeks after TMS sessions was done. In addition, the Migraine Disability Assessment scale (MIDAS) was applied to assess the severity and degree of disability caused by migraine. Measurement of neurokinin A serum level was done by using ELISA for all patients before and after TMS and for control group once. Results There was a significant reduction in pain intensity, frequency and duration of migraine attacks, migraine disability scores, and number of pills taken as abortive treatment for attacks after rTMS (P < 0.001). Also, serum level of neurokinin A in the patients was significantly reduced after rTMS (P < 0.001). Conclusion Low-frequency rTMS is an effective prophylactic treatment for migraine with and without aura.

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