scholarly journals Evaluation of Risk of Malignancy Index in the Preoperative Assessment of the Patients with Ovarian Mass

2020 ◽  
Vol 14 (4) ◽  
pp. 299-301
Keyword(s):  
Histopathological Examination ◽  
Preoperative Evaluation ◽  
Preoperative Assessment ◽  
Cross Sectional ◽  
Gynecological Disorders ◽  
Malignant Ovarian Tumor ◽  
Risk Of Malignancy ◽  
Risk Of Malignancy Index ◽  
The Mean ◽  
One Year

Background: Adnexal masses indicate a variety of gynecological and non-gynecological disorders, which may be benign or malignant. Early detection of malignancy is crucial to a proper planning of treatment and improvement of survival. Objective: The purpose of the study was to evaluate predictive value of risk of malignancy index (RMI) in differentiating between benign and malignant ovarian masses preoperatively. Study Design: Cross sectional (Validation) study. Settings: Obstetrics & Gynecology Department of Madinah Teaching Hospital affiliated with University Medical & Dental College Faisalabad Pakistan. Duration: One year from January 2018 to December 2018. Methodology: Total 86 patients were included in the study. Ultrasound was performed then staging laparotomy done followed by histopathological examination. Results: A total of 86 patients were included in the study. Out of which 50 patients (58.1%) were premenopausal and 36 patients (41.9%) were menopausal. The mean age of the patients was 55.79 years. According to histopathological examination of the specimens 44 were malignant and 42 were benign. The sensitivity of the RMI for malignant ovarian tumor is 70.45% and specificity is 69.05%. Conclusion: RMI was considered to have significant importance in preoperative evaluation and treatment of women with an adnexal mass, and was helpful in-patient referral to higher Centre for suitable and effective surgical intervention.

scholarly journals Role of human epididymis protein 4 for detection of ovarian carcinoma in adnexal masses: A pilot study

2016 ◽  
Author(s):  
Nidhi Bansal ◽  
A. Suneja ◽  
K. Guleria ◽  
N. B. Vaid ◽  
K. Mishra ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Cross Sectional Study ◽  
Ca 125 ◽  
Serum Samples ◽  
Cross Sectional ◽  
Adnexal Masses ◽  
Good Discriminator ◽  
Risk Of Malignancy ◽  
Risk Of Malignancy Index ◽  
Benign Tumours

Introduction: HE4 is a novel tumour biomarker used for early diagnosis of ovarian cancer. This study evaluated the diagnostic accuracy of HE4 alone and in combination with CA125, risk of malignancy index (RMI), risk of malignancy algorithm (ROMA). Methods: It was a cross sectional study conducted recruiting 88 women with adnexal masses who were planned for surgery. After baseline work up and ultrasound examination, serum samples were collected for estimation of CA 125 and HE4 levels. Serum HE4 levels were estimated using ELISA kit. RMI and ROMA score were calculated and diagnostic accuracy of HE4, CA 125, RMI, ROMA and their combination were compared. Cut off for HE4 and ROMA score were calculated using ROC curve. Results: Of 88 subjects, 66 were analyzed with 19 malignant (including 5 LMP) and 47 benign cases. The median value of HE4 among malignant cases was found to be significantly higher than among the benign cases. PPV and NPV of HE4 at a cut off 130.8 pMol/ml was 85.7% and 77.9% respectively. Highest PPV (88.9%) with acceptable NPV (80.7%) was found with ROMA followed by HE4 (PPV 85.7%; NPV 77.97%), RMI (PPV 76.92%; NPV 83%) and CA125 (PPV 52%; NPV 80.85%). Conclusion: HE4 levels were lower in Indian population both in malignant and benign tumours as compared to other studies. HE4 is a good discriminator and gives best accuracy when it is combined with CA125 in a logistic algorithm, ROMA.

scholarly journals External validation of the adapted Risk of Malignancy Index incorporating tumor size in the preoperative evaluation of adnexal masses

2011 ◽  
Vol 159 (2) ◽  
pp. 422-425 ◽  
Author(s):  
Petronella A.J. van den Akker ◽  
Petra L.M. Zusterzeel ◽  
Anette L. Aalders ◽  
Marc P.L.M. Snijders ◽  
Rahul A.K. Samlal ◽  
...  
Keyword(s):  
Tumor Size ◽  
Preoperative Evaluation ◽  
External Validation ◽  
Adnexal Masses ◽  
Risk Of Malignancy ◽  
Risk Of Malignancy Index

scholarly journals Evaluation of HE4, CA-125, Risk of Ovarian Malignancy Algorithm (ROMA) and Risk of Malignancy Index (RMI) in the Preoperative Assessment of Patients with Adnexal Mass

2016 ◽  
Vol 31 (5) ◽  
pp. 336-344 ◽  
Author(s):  
Khawla Al Musalhi ◽  
Manal Al Kindi ◽  
Faiza Al Aisary ◽  
Fatma Ramadhan ◽  
Thuraya Al Rawahi ◽  
...  
Keyword(s):  
Adnexal Mass ◽  
Preoperative Assessment ◽  
Ca 125 ◽  
Ovarian Malignancy ◽  
Risk Of Malignancy ◽  
Risk Of Malignancy Index

Risk of malignancy index in the preoperative evaluation of ovarian masses

2005 ◽  
Vol 16 (3) ◽  
pp. 200
Author(s):  
Ji Heum Paek ◽  
Hong Jue Lee ◽  
Dong Won Kim ◽  
Young Jae Kim ◽  
Sam Hyun Cho ◽  
...  
Keyword(s):  
Preoperative Evaluation ◽  
Risk Of Malignancy ◽  
Risk Of Malignancy Index ◽  
Ovarian Masses

Pediatric risk of malignancy index for preoperative evaluation of childhood ovarian tumors

2011 ◽  
Vol 28 (3) ◽  
pp. 259-266 ◽  
Author(s):  
Amos Hong Pheng Loh ◽  
Chiou Li Ong ◽  
Shu Lin Lam ◽  
Joyce Horng Yiing Chua ◽  
Chan Hon Chui
Keyword(s):  
Preoperative Evaluation ◽  
Ovarian Tumors ◽  
Risk Of Malignancy ◽  
Risk Of Malignancy Index

scholarly journals Prevalence and Management of Dysmenorrhea Among Secondary School Adolescents in Enugu State, Nigeria

2020 ◽  
Author(s):  
Amaka Onu ◽  
Deborah Aluh ◽  
Michael Ikehi
Keyword(s):  
Management Practices ◽  
Common Symptom ◽  
Management Options ◽  
Cross Sectional ◽  
Gynecological Disorders ◽  
Menstrual Symptoms ◽  
Significant Difference ◽  
The Mean ◽  
Enugu State ◽  
Descriptive Survey

Abstract Background: Dysmenorrhea is reported to be among the most common gynecological disorders worldwide. The current study aimed to determine the prevalence and management practices for dysmenorrhea among adolescent school girls in Nigeria. The study also aimed to determine the predictors for choosing a management option for dysmenorrhea.Methods: The study was a cross-sectional descriptive survey conducted in five conveniently selected secondary schools (high schools) in Enugu State. A 12-item questionnaire including a Visual Analog Scale was used to collect data. All data were analyzed using SPSS with significance set at p<0.05.Results: A total of 1,486 survey questionnaires were completed (88.45% response rate). The mean age of the study respondents was 15.26±1.517. The prevalence of dysmenorrhea was 51.1%. There was a significant difference (t =-6.299, p < 0.001) between the ages of the dysmenorrheic girls (15.50±1.466) and the ages of girls who were not dysmenorrheic (15.01±1.529). The mean age of Menarche was 12.64±1.450. Pain in the waist was the most common symptom reported among the respondents (57.4%, n = 853). More than one-third of the respondents reported that they take OTC medications for menstrual symptoms (31.8%, n = 472). Age and severity of dysmenorrhea significantly predicted the likelihood of taking a pharmacological agent for dysmenorrhea.Conclusion: Younger females were more likely to do nothing about menstrual pain. There is a need for adolescents to be educated on the safety and efficacy of different management options for dysmenorrhea early.

scholarly journals Menstruation: gap in knowledge, belief and practice among adolescent girls in an urban area of Belagavi

2017 ◽  
Vol 4 (10) ◽  
pp. 3640
Author(s):  
Suhasini Kanyadi ◽  
Chandra S. Metgud
Keyword(s):  
Urban Area ◽  
Adolescent Girls ◽  
External Genitalia ◽  
Cross Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Transition Into Adulthood ◽  
The Mean ◽  
Sanitary Pads ◽  
One Year

Background: The period of adolescence, beginning with the onset of puberty, is a crucial transition into adulthood. There is a substantial lacuna in the knowledge, belief and practice about menstruation. This study addresses the gap in knowledge, belief and practice regarding menstruation among adolescent girls. Methods: A community based cross sectional study was conducted over a period of one year, in an urban area of Belagavi among 625 adolescent girls in the age group of 16–19 years. Data was collected by house to house visit using a predesigned, pretested questionnaire. Results: The mean age (±SD) at menarche was found to be 12.8±1.73 years. Our study showed that as the knowledge increased, there was increase in the use of sanitary pad (p<0.001) and increase in the number of girls practicing cleaning of external genitalia during menstruation (p<0.01). However, it was found that 276 (50.5%) and 175 (37.7%) of the girls did not use sanitary pads and practice cleaning of external genitalia during menstruation even after having correct knowledge showing a gap in knowledge and practice. Similarly, among the 494 girls who knew that menstruation is a natural process, 93 (18.8%) girls wrongly believed she shouldn’t sleep in the same place as usual, 124 (25.1%) said she shouldn’t enter the kitchen, 186 (37.7%) believed that certain foods should be avoided and only 37 (7.5%) rightly believed that girls could go to place of worship during menstruation showing a gap in knowledge and belief. Conclusions: The study reported a gap in knowledge, belief and practice among adolescent girls. To bridge this gap causes have to be identified and addressed. 

scholarly journals Adverse Drug Reactions of Anti-Epileptic Drugs in Children with Epilepsy: A Cross-Sectional Study

2019 ◽  
Vol 14 (3) ◽  
pp. 217-224
Author(s):  
Sundeep Kaushik ◽  
Deepti Chopra ◽  
Suvasini Sharma ◽  
Satinder Aneja
Keyword(s):  
Antiepileptic Drugs ◽  
Adverse Drug Reactions ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Drug Reactions ◽  
Cross Sectional ◽  
Number Of Children ◽  
The Mean ◽  
One Year ◽  
Paediatric Epilepsy

Background: Adverse drug reactions (ADRs) due to antiepileptic drugs (AEDs) in children contribute to poorer patient outcomes. However, reliable data ragarding such ADRs is not available. Objectives: Thus, the aim of the present study was to determine the incidence and patterns of ADRs of antiepileptic drugs in children aged 2-17 years presenting to a tertiary care teaching hospital. Methods: An observational study was conducted in the Department of Pediatrics, Kalawati Saran Children’s Hospital for a period of one year. Two hundred consecutive eligible patients (aged 2-17 yrs with epilepsy on AED) with consenting parents were enrolled. ADRs were noted using Paediatric Epilepsy Side Effect Questionnaire (PESQ) at clinic visits and any other ADRs reported by parents were also recorded. Causality, severity and avoidability assessments were done. Results: The mean age was 10.5 ± 3.6 years. A total of 139 ADRs occurred in 97 patients. One hundred and nine ADRs were reported by use of PESQ, in addition, 30 ADRs were reported by parents. Poor school result (33.8%) was the commonest ADR. Valproate (61.9%) was the main drug causing ADRs. Valproate, when used in polytherapy, was associated with more number of children experiencing ADRs (72.2%). The most common add on drug was clobazam (42.3%). Children with poorly controlled epilepsy were associated with more ADRs. Causality assessment revealed that 91.3% of the ADRs were probable. Most (94.9%) ADRs were of ‘mild’ category and 95.7% were probably preventable. Treatment was discontinued only in 6 patients of phenytoin toxicity.R Conclusion: Cognitive and neurological problems were the most common ADRs seen in children with epilepsy. Polytherapy significantly increases the likelihood of ADRs in children.

scholarly journals Evaluation of risk of malignancy index in adnexal masses at a tertiary hospital: a prospective study

2020 ◽  
Vol 9 (3) ◽  
pp. 922
Author(s):  
Ritanjali Behera ◽  
Paramita Pradhan ◽  
Bharati Misra
Keyword(s):  
Prospective Study ◽  
Gold Standard ◽  
Surgical Planning ◽  
Tertiary Hospital ◽  
Adnexal Masses ◽  
Medical College ◽  
Risk Of Malignancy ◽  
Risk Of Malignancy Index ◽  
The Mean ◽  
A Prospective Study

Background: The discrimination between benign and malignant adnexal masses is important in deciding clinical management and optimal surgical planning. The aim of the study was to evaluate the effectiveness of risk of malignancy index (RMI) to identify cases with high potential of ovarian malignancy at a tertiary hospital.Methods: This prospective study was conducted over a period of two years from September 2017 to August 2019 at obstetrics and gynecology department of M. K. C. G. Medical College and Hospital, Berhampur. A total case of 130 patients with adnexal masses who underwent surgical treatment were included as histopathological report was taken as gold standard to calculate accuracy of RMI.Results: Of the total masses, 85 (65.4%) were benign and 45 (34.6%) were malignant. The mean age of patients was 41.03±14 years. The best cut off value for the RMI-3 was 225 with highest area under the ROC curve 87%, sensitivity of 75.55%, specificity of 98.82%, PPV of 97.14%, NPV of 88.42% and an accuracy of 90.76%.Conclusions: The present study demonstrated that RMI was a reliable method in detecting malignant ovarian tumors. The RMI is a simple and practically applicable tool in preoperative discrimination between benign and malignant adnexal masses in non-specialized gynecologic departments, particularly in developing countries.

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