Gymnanthemum coloratum: Review of its Medicinal uses, Phytochemistry and Pharmacological Properties -

2020 ◽  
Vol 10 (5) ◽  
pp. 196-204
Author(s):  
Alfred Maroyi

Gymnanthemum coloratum is a shrub or a small tree widely used as traditional medicine throughout its distributional range in tropical Africa. The current study is aimed at reviewing the phytochemistry, pharmacological properties and medicinal uses of G. coloratum. Literature on pharmacological properties, phytochemistry and medicinal uses of G. coloratum was obtained from numerous internet sources such as Scopus, Elsevier, SciFinder, Google Scholar, Pubmed, ScienceDirect, BMC and Web of Science. Other sources of information included pre-electronic sources such as journal articles, theses, book chapters, books and other scientific publications obtained from the university library. The articles published between 1964 and 2020 were used in this study. The current study showed that G. coloratum is used as an anthelmintic, and traditional medicine for reproductive problems, schistosomiasis, liver diseases, sexually transmitted infections, diabetes, sores and wounds, respiratory problems, malaria, skin diseases, fever and gastro-intestinal problems. Ethnopharmacological research identified glaucolides, lactones, amino acids, essential oils, alkaloids, anthocyanins, cardenolids, coumarins, flavonoids, glycosides, leucoanthocyanins, phenols, quinones, reducing sugars, saponins, steroids, tannins, terpenoids and triterpenes from the aerial parts, leaves, roots and stems of G. coloratum. The aerial parts, leaves, roots and whole plant parts of G. coloratum and compounds isolated from the species exhibited anthelmintic, antimicrobial, anti-Blastocystis, anti-inflammatory, anti-sickling, insecticidal and larvicidal, antiplasmodial, antimalarial, antioxidant, antiproliferative, anti-Toxoplasma, hypoglycaemic and antidiabetic and cytotoxicity activities. Gymnanthemum coloratum should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.

Author(s):  
Alfred Maroyi

Hilliardiellia aristata is a herbaceous plant species used as traditional medicine in southern Africa. The current investigation is aimed at reviewing the phytochemistry, pharmacological properties and medicinal uses of H. aristata. Results of the current study are based on literature search on pharmacological properties, phytochemistry and medicinal uses of H. aristata using information obtained from several internet sources such as Scopus, Elsevier, SciFinder, Google Scholar, Pubmed, ScienceDirect, BMC and Web of Science. Other sources of information included pre-electronic sources such as journal articles, theses, book chapters, books and other scientific publications obtained from the University library. The current study showed that H. aristata is used as a protective charm, traditional medicine for kidney problems, fever, headache, respiratory infections and malaria. Ethnopharmacological research identified glaucolides, lactones, alkaloids, phenols, tannins, glycosides, terpenoids, saponins, flavonoids and steroids from the aerial parts and leaves of H. aristata. The aerial parts, leaves, roots and whole plant parts of H. aristata exhibited anti-inflammatory, antibacterial, antifungal, antiplasmodial, antiprotozoal, larvicidal and cytotoxicity activities. Hilliardiella aristata should be subjected to detailed phytochemical, pharmacological and toxicological studies.


2020 ◽  
Vol 10 (5) ◽  
pp. 213-222
Author(s):  
Alfred Maroyi

Cissampelos mucronata A. Rich. is a perennial climber widely used as traditional medicine in tropical Africa. This study is aimed at providing a critical review of medicinal uses, phytochemical and pharmacological properties of C. mucronata. Documented information on medicinal uses, phytochemical and pharmacological properties of C. mucronata was collected from several online sources such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the University library. The articles published between 1962 and 2020 were used in this study. This study revealed that leaves, rhizome, roots and stems, and whole plant parts of C. mucronata are mainly used as traditional medicines for sexually transmitted infections, fever, swellings, headache, respiratory problems, snakebite, malaria, pregnancy problems and gastro-intestinal problems. Phytochemical compounds identified from the species include alkaloids, anthraquinones, flavonoids, glycerine, glycosides, phenolics, reducing sugars, resin, saponins, steroids, tannins and triterpenes. Pharmacological research revealed that C. mucronata extracts and alkaloids isolated from the species have antibacterial, anti-mycobacterial, antifungal, antiplasmodial, antitrypanosomal, anti-ulcer, anti-androgenic, anti-steroidogenic, enzyme tyrosine kinase p56 inhibitory, hypoglycemic, larvicidal, molluscicidal, sedative, tocolytic, uterine relaxant and cytotoxicity activities. There is need for extensive toxicological evaluations of crude extracts and compounds isolated from the species since C. mucronata contains potentially toxic compounds


2020 ◽  
Vol 11 (4) ◽  
pp. 5948-5955
Author(s):  
Alfred Maroyi

Cissampelos capensis L.f. is a perennial climber widely used as a traditional medicine in South Africa. This study was aimed at providing a critical review of medicinal uses, phytochemical and pharmacological properties of C. capensis. Documented information on the pharmacological properties, phytochemistry and medicinal uses of C. capensis was collected from several online sources such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. This study revealed that leaf, rhizome and root infusions and decoctions of C. capensis are mainly used as a blood purifier, and traditional medicines for respiratory problems, ulcers, sores and wounds, skin and stomach cancers, snakebite, sexually transmitted infections, skin diseases, diabetes and gastrointestinal problems. Phytochemical compounds identified from the species include alkaloids, essential oils, flavonoids, phenolics, saponins and tannins. Pharmacological research revealed that C. capensis extracts and compounds isolated from the species have anthelmintic, antibacterial, antifungal, antidiabetic, antimalarial, hepatotoxicity, spermatozoa and cytotoxicity activities. Documentation of the medicinal uses, phytochemistry and pharmacological properties of C. capensis is vital as this information provides baseline data required for future research and development of health-promoting and pharmaceutical products. There is a need for extensive toxicological evaluations of crude extracts and compounds isolated from the species since C. capensis contains potentially toxic compounds.


2020 ◽  
Vol 11 (4) ◽  
pp. 5460-5466
Author(s):  
Alfred Maroyi

Schefflera umbellifera (Sond.) Baill. is an evergreen tree widely used as traditional medicine throughout its distributional range in southern Africa. Schefflera umbellifera is indigenous to Eswatini, Malawi, Mozambique, South Africa and Zimbabwe. This study was aimed at providing a critical review of medicinal uses, phytochemical and pharmacological properties of S. umbellifera. Documented information on medicinal uses, phytochemical and pharmacological properties of S. umbellifera was collected from several online sources such as Scopus, Google Scholar, PubMed, Francis and Taylor and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the University library. This study revealed that the bark, leaf and root decoction or infusion of S. umbellifera are mainly used as diuretic, laxative, colic and protective charm, and traditional medicine for stomach ulcers, weaning infants, insanity, inflammation, rheumatism and malaria. Phytochemical compounds identified from the species include 3-hydroxy-20(29)-lupen-28-ol, 7-hydroxy-6-methoxycoumarin, betulin, ent-kaur-16-en-19-oic acid and oleanolic acid. Pharmacological research revealed that S. umbellifera extracts and compounds isolated from the species have antibacterial, anti-HIV, anti-inflammatory, antimalarial, antiprotozoal, larvicidal and cytotoxicity activities. Schefflera umbellifera should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.


2020 ◽  
Vol 10 (5) ◽  
pp. 264-273
Author(s):  
Alfred Maroyi

Volkameria glabra (E. Mey.) Mabb. & Y.W. Yuan is a deciduous shrub or a small tree widely used as traditional medicine throughout its distributional range in tropical Africa. This study is aimed at providing a critical review of pharmacological properties, phytochemistry, and medicinal uses of V. glabra. Documented information on pharmacological properties, phytochemistry and medicinal uses of V. glabra was collected from several online sources such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. This study revealed that the bark, leaf and root infusion and/or decoction of V. glabra are mainly used as immune booster, protective charm, anthelmintic and ethnoveterinary medicine, and traditional medicine for convulsions, fractured bones, fever, wounds, gastro-intestinal problems, snake bite and respiratory diseases. Phytochemical compounds identified from the species include aliphatic glycosides, anthraquinones, cardiac glycosides, flavonoids, iridoid, phenols, saponins, steroids, tannins and triterpenoids. The V. glabra and compounds isolated from the species exhibited acaricidal, anthelmintic, antibacterial, antifungal, antimycobacterial, anti-collagenase, antidiabetic, anti-elastase, anti-inflammatory, antileishmanial, antioxidant, antiplasmodial, antipyretic, cholinesterase enzyme inhibition, immune-stimulant and cytotoxicity activities. Volkameria glabra should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.


2020 ◽  
Vol 10 (5) ◽  
pp. 247-256
Author(s):  
Alfred Maroyi

Maerua angolensis DC. is collected from the wild for its edible leaves and fruits, and is also used as a traditional medicine. This study is aimed at evaluating the ethnomedicinal uses, phytochemistry and pharmacological properties of M. angolensis. Results of the current study are based on data derived from several online databases such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as scientific publications, books, dissertations, book chapters and journal articles. The articles published between 1960 and 2020 were used in this study. This study revealed that the aerial parts, bark, leaves, roots and stem bark infusion and/or decoction of M. angolensis are mainly used as a protective charm and ethnoveterinary medicine, and a traditional medicine for pain, cancer, fever, malaria, sores, wounds and gastro-intestinal problems. Phytochemical compounds identified from the species include alkaloids, amino acids, anthraquinones, betaines, cardiac glycosides, cyanidin, esters, fatty acids, flavonoids, glucosinolates, phenols, saponins, sterols, steroids, tannins and triperpenoids. Ethnopharmacological research revealed that M. angolensis extracts have acaricidal, anthelmintic, antibacterial, antifungal, antidiarrhoeal, anticonvulsant, anti-diabetic, antidepressant, anti-inflammatory, antioxidant, antinociceptive, anxiolytic, anti-urolithiatic, antiprotozoal, molluscicidal and nematicidal activities. There is need for extensive toxicological evaluations of crude extracts and compounds isolated from the species since M. angolensis contains potentially toxic compounds


2020 ◽  
Vol 10 (5) ◽  
pp. 205-212
Author(s):  
Alfred Maroyi

Baccharoides lasiopus is a woody shrub widely used as traditional medicine throughout its distributional range in tropical Africa. This study is aimed at providing a critical review of the pharmacological properties, phytochemistry, and medicinal uses of B. lasiopus. Documented information on the pharmacological properties, phytochemistry, and medicinal uses of B. lasiopus was collected from several online sources, which included Scopus, Google Scholar, PubMed and Science, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. The articles published between 1971 and 2020 were used in this study. This study showed that the leaves, roots, stems, whole plant parts, root and stem bark of B. lasiopus are widely used as galactagogue, purgative and anthelmintic, and traditional medicine for headache, liver diseases, skin diseases, respiratory infections, malaria, augment labour, convulsions, epilepsy, fainting, female reproductive problems, and gastro-intestinal problems. Phytochemical compounds identified from the species include elemanolide type sesquiterpene lactones, alkaloids, anthraquinones, cardiac glycosides, coumarins, flavonoids, phenolics, reducing sugars, saponins, steroids, tannins, terpenoids, and xanthines. Pharmacological research revealed that B. lasiopus extracts and compounds isolated from the species have anthelmintic, antibacterial, antifungal, antiviral, antihyperglycemic, antiplasmodial, antimalarial, antiprotozoal, haematological, hepatoprotective, hepatotoxicity, larvicidal, and cytotoxicity activities. Future research on B. lasiopus should focus on the possible biochemical mechanisms of action of both the crude extracts and identified phytochemical compounds including toxicological, in vivo, and clinical studies to corroborate the traditional medical applications of the species.


2020 ◽  
Vol 11 (4) ◽  
pp. 6196-6202
Author(s):  
Alfred Maroyi

Maerua triphylla A. Rich. is a shrub or small tree collected from the wild for its edible leaves and also used as traditional medicine. This study is aimed at evaluating the ethnomedicinal and ethnobotanical uses of M. triphylla. Results of the current study are based on data derived from several online databases such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as scientific publications, books, dissertations, book chapters and journal articles. This study revealed that the fruit, leaf, root, stem bark and twig infusion and/or decoction of M. triphylla  are mainly used as ethnoveterinary medicine, aphrodisiac and antidote for poisoning, and traditional medicine for rheumatism, boils, cancer, respiratory problems, snakebite, headache, migraine and gastro-intestinal problems. Phytochemical compounds identified from dried aerial parts and branches of M. triphylla include betaines and quaternary ammonium compounds such as 3-hydroxyprolinebetaine, glycine betaine, proline betaine and 3-hydroxy-1,1-dimethyl pyridinium.  Preliminary ethnopharmacological research revealed that M. triphylla leaf extracts have acaricidal and cytotoxicity activities. Documentation of the medicinal uses, phytochemistry and pharmacological properties of M. triphylla is important as this information provides baseline data required for future research focusing on ethnopharmacological properties of the species. Maerua triphylla should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological properties"


2020 ◽  
Vol 10 (5) ◽  
pp. 175-181
Author(s):  
Alfred Maroyi

Gardenia volkensii K. Schum. is a shrub or small tree widely used as traditional medicine throughout its distributional range in tropical Africa. This study is aimed at providing a critical review of the medicinal uses, phytochemistry and biological activities of G. volkensii. Documented information on the medicinal uses, phytochemistry and biological activities of G. volkensii was collected from several online sources, which included Scopus, Google Scholar, PubMed and Science Direct. Additional information was gathered from pre-electronic sources such as book chapters, books, journal articles and scientific publications sourced from the university library. The articles published between 1972 and 2020 were used in this study. This study showed that the species is widely used as emetic and protective charm, and as traditional medicine for infertility, sore eyes, sexually transmitted infections, headache, gastro-intestinal infections, earache, convulsions, epilepsy and respiratory infections. Phytochemical compounds identified from the species include aldehydes, benzenoids, cinnamates, coumarins, essential oils, fatty acids, flavonoids, iridoids, phenolics, phytosterols and triterpenoids. Pharmacological research revealed that G. volkensii extracts and compounds isolated from the species have antibacterial, antifungal, antioxidant, mutagenic and antimutagenic and cytotoxicity activities. Future research on G. volkensii should focus on detailed phytochemical evaluations including toxicological, in vivo and clinical studies to corroborate the traditional medical applications of the species.


2020 ◽  
Vol 10 (5) ◽  
pp. 182-189
Author(s):  
Alfred Maroyi

Maerua crassifolia Forssk. is an evergreen tree widely used as traditional medicine throughout its distributional range in the Sahel region, peninsular Arabia east to Pakistan, east and west Africa. This study is aimed at providing a critical review of medicinal uses, phytochemical and pharmacological properties of M. crassifolia. Documented information on medicinal uses, phytochemical and pharmacological properties of M. crassifolia was collected from several online sources such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. The articles published between 1964 and 2020 were used in this study. This study revealed that the bark, fruit, leaf and twig infusion and/or decoction of M. crassifolia are mainly used as ethnoveterinary medicine, and traditional medicine for cephalalgia, headache, fever, malaria, wounds, skin infections, toothache and gastro-intestinal problems. Phytochemical compounds identified from the species include alkaloids, amino acids, betaines, cardiac glycosides, fatty acids, flavonoids, lignan glucosides, phenolics, quaternary ammonium compounds, saponins, steroids, tannins and terpenoids. The M. crassifolia extracts exhibited antibacterial, anti-diarrhoeal, analgesic, anti-inflammatory, antioxidant, antiplasmodial, antiprotozoal, antitrypanosomal, antipyretic and cytotoxicity activities. Maerua crassifolia should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.


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