Experience of using antioxidants to improve semen parameters in males with idiopathic infertility

Background. It is known that a multitude of factors may lead to male factor infertility, but still, in the majority of cases, the cause remains largely idiopathic, reflecting poor understanding of the basic process of spermatogenesis and the mechanisms involved. Resveratrol is a polyphenol compound that displays several cellular aspects mainly associated with SIRT1-pathway activation and promotion of mitochondrial enhancer activities. In several animal models, resveratrol has shown positive effects on mitochondria and membrane potential. This could explain effects on sperm concentration and motility. The aim of this study is to evaluate the effects on the semen parameters of GENANTE®, a multivitamin supplement containing 150 mg of resveratrol/day, in patients with idiopathic infertility. Methods. This was a prospective single center clinical study. Twenty patients took a multivitamin supplement based on 150 mg of resveratrol (GENANTE®), in the form of an oral tablet every 12 h, and were followed up at 1, 3, and 6 months after treatment. Pre- and post-treatment evaluation included history, clinical examination, semen analysis, hormonal determinations, and scrotal and prostatic ultrasound. Results. Our preliminary pilot study demonstrated that the multivitamin supplement based on resveratrol improves sperm motility (48.3% ± 13.8 vs. 59.0% ± 12.8, p = 0.0001) and concentration (22.6 × 106/mL ± 9.5 vs. 25.7 × 106/mL ± 8.1, p = 0.0001) after 3 and 6 months of treatment in men with idiopathic infertility. Conclusion. Our data suggest that targeting the metabolic and energetic pathways involved in spermatogenesis and mitochondrial activity could lead to potential effects and counteract subfertility/infertility in men through a mitochondria dynamics mechanism. Trial registration number: ClinicalTrials.gov registration identifier: NCT03864198, registered on 1 January 2019.

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Benefits of Empiric Nutritional and Medical Therapy for Semen Parameters and Pregnancy and Live Birth Rates in Couples with Idiopathic Infertility: A Systematic Review and Meta-analysis

European Urology ◽

10.1016/j.eururo.2018.12.022 ◽

2019 ◽

Vol 75 (4) ◽

pp. 615-625 ◽

Cited By ~ 7

Author(s):

Muhammad Imran Omar ◽

Raj Prasenjit Pal ◽

Brian D. Kelly ◽

Harman Maxim Bruins ◽

Yuhong Yuan ◽

...

Keyword(s):

Systematic Review ◽

Medical Therapy ◽

Live Birth ◽

Meta Analysis ◽

Semen Parameters ◽

Birth Rates ◽

Live Birth Rates ◽

Idiopathic Infertility

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Effect of Dietary Intake of Supplement Fertylor15 Containing Astaxanthin and Other Compounds on Human Sperm: In Vivo and In Vitro Study

Medical & Clinical Research ◽

10.33140/mcr.05.07.03 ◽

2020 ◽

Vol 5 (7) ◽

Keyword(s):

Dietary Intake ◽

Sperm Quality ◽

Daily Intake ◽

In Vitro Study ◽

Vitro Study ◽

Semen Parameters ◽

Endocrine Disorders ◽

Sperm Dna Fragmentation ◽

Idiopathic Infertility

Chronic stress and endocrine disorders that result from environmental pollution, reactive oxygen species (ROS), and genetic abnormalities, are responsible of the idiopathic infertility. The aim of this study was to investigate the effect of a daily intake of supplement containing astaxanthin (Asta), known to ameliorate sperm viability in in vitro conditions, and other elements, on semen quality. Sperm from 34 volunteers were analyzed before (T0 ) and after (T1 ) 30 days of intake of supplement containing Asta, zinc, selenium, arginine, vitamins C and E, Coenzyme Q10 and folic acid. Semen parameters (sperm concentration, motility, morphology) and biochemical properties (rafts shifting, tyrosine phosphorylation (Tyr-P) and acrosome reaction (AR)) were evaluated. In additional 18 volunteers, Asta, all other components or both were analyzed also in in vitro conditions. Results show an improvement of sperm quality with a decrease of membrane-bound IgG. The percentages of cells achieving capacitation and AR were increased (28±8 to 52±10%, p<0.0001, and 24±5 to 46±7%, p<0.0001, respectively). The in vitro study assessed that Asta and other compounds had a synergistic positive effect on all the biochemical parameters, with no sperm DNA fragmentation. In conclusion, this dietary intake would be helpful in the treatment of no-complicated idiopathic infertility.

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