scholarly journals Comparative Study of Compartmental Modeling of Sustained Release Oral Dosage Forms and Intramuscular Injection

2019 ◽  
Vol 22 (3) ◽  
pp. 222-226
Author(s):  
Khawla H. Rasheed
Keyword(s):  
Sustained Release ◽  
Kinetic Parameters ◽  
Correlation Coefficient ◽  
Intramuscular Injection ◽  
High Performance ◽  
Diclofenac Sodium ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Compartmental Modeling ◽  
Oral Dosage Forms

This study has been performed to compare the compartmental modeling of two types of extravascular routes, sustained-release (SR) oral dosage forms and intramuscular (IM) injection. Twenty healthy volunteers received a single dose of 100 mg Diclofenac Sodium (DS) sustained-release tablet, then 75 mg DS Intramuscular injection after two weeks washout period. The concentrations of DS in plasma were measured using reverse-phase high-performance liquid chromatography (HPLC). The data analyzed using compartmental modeling, with single time-variant input and output. Primary kinetic parameters for both formulations, ( , , ) and other kinetic parameters were evaluated. The result shows that the IM injection needs a shorter time to reach the maximum concentration with convergent bioavailability to SR oral dosage forms, in another hand the data of IM injection fitted to single-compartment model with a correlation coefficient of 0.93 and the data of SR tablet fitted to two-compartment models with a correlation coefficient of 0.97.

A new polymer-excipient for ethanol-resistant, sustained-release oral dosage forms

2021 ◽  
Author(s):  
Thomas Endres ◽  
Christian Meier ◽  
Jan Hendrik Schattka ◽  
Claas Gronewold ◽  
Christian Moers
Keyword(s):  
Sustained Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Oral Dosage Forms

scholarly journals Recent Patents on Modified Release Oral Dosage Forms

2021 ◽  
Vol 11 (4-S) ◽  
pp. 195-211
Author(s):  
Atul Pund ◽  
Atishkumar Mundada ◽  
Manoj Magar ◽  
Abhijeet Kadam
Keyword(s):  
Controlled Release ◽  
Sustained Release ◽  
Extended Release ◽  
Dosage Forms ◽  
Delivery Systems ◽  
The Body ◽  
Oral Dosage ◽  
Modified Release ◽  
Delayed Release ◽  
Oral Dosage Forms

Background: Conventional oral dosage forms have limited bioavailability and frequent dosing of the drug is needed to maintain the effective therapeutic concentration in the body. This results in poor patient compliance and fluctuations in the plasma drug levels, especially in the chronic diseases and disorders. Objective: To overcome such problems and to enhance the efficiency and bioavailability of the drug, modified drug delivery systems such as extended release delivery systems (controlled release; sustained release) and delayed release delivery systems are developed which can prolong the release and hence action of the drug in the body. Methods: Through this review, we throw the light on recent patents and patent applications on modified release systems pertaining to oral dosage forms.  The various free patent search databases were used to collect and analyze the information on modified release delivery systems. Results: Modified release systems such as extended release and delayed release delivery systems have been found to be of great significance due to their advantages over immediate release dosage forms. These systems are formulated using various approaches, different types of release controlling polymers such as natural, semisynthetic and synthetic polymers and found to avoid the limitations of conventional oral dosage forms. Conclusion: Modified drug release systems have potential especially, in case of the chronic diseases, mental health disorders and lifestyle diseases and disorders. These systems have unique commercial advantages which will sustain the interest of both the researchers and the pharmaceutical companies. Keywords: Modified release systems, extended release systems, controlled release systems, sustained release systems, delayed release systems, oral dosage forms, multilayer dosage form, multilayered tablets

scholarly journals Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Diclofenac Sodium and Diclofenac Potassium

2009 ◽  
Vol 98 (4) ◽  
pp. 1206-1219 ◽  
Author(s):  
B.Chuasuwan ◽  
V. Binjesoh ◽  
J.E. Polli ◽  
H. Zhang ◽  
G.L. Amidon ◽  
...  
Keyword(s):  
Diclofenac Sodium ◽  
Immediate Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms
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