scholarly journals Fish oil enhanced the efficacy of low-dose cyclophosphamide regimen for proliferative lupus nephritis: a randomized controlled double-blind trial

2021 ◽  
Author(s):  
Chi Zhang ◽  
Chang Ge ◽  
Junsheng Wang ◽  
Dong Sun
Keyword(s):  
Urinary Tract Infection ◽  
Placebo Group ◽  
Urinary Tract ◽  
Tract Infection ◽  
Lupus Nephritis ◽  
Fish Oil ◽  
Lupus Erythematosus ◽  
Low Dose ◽  
Activity Index ◽  
Number Of Patients

Background: Lupus nephritis (LN) is one of the most severe organ that damages the systemic lupus erythematosus (SLE). Cyclophosphamide is one of the main drugs used in the treatment of LN. Fish oil is a general term of all the oily substances in fish, whose main component is omega-3 fatty acid. This study aimed to investigate whether fish oil could be used as an adjunct to low-dose cyclophosphamide in proliferative LN treatment. Methods: A total of 237 patients with proliferative LN were recruited and randomized into two groups: cyclophosphamide + placebo group and cyclophosphamide + fish oil group. In the cyclophosphamide + placebo group, participants received prednisone + cyclophosphamide + placebo. In the cyclophosphamide + fish oil group, participants received prednisone + cyclophosphamide + fish oil. Before and after treatment, the clinical parameters of the patients in both groups were evaluated. Results: In the cyclophosphamide + fish oil group, the number of patients achieving complete remission (n = 45, 46.9%) was significantly higher than the cyclophosphamide + placebo group (n = 31, 32.6%). The number of patients achieving no response in the cyclophosphamide + fish oil group (n = 8, 8.3%) was significantly lower than the cyclophosphamide + placebo group (n = 22, 23.2%). Hematuria (P = 0.036), urine protein-creatinine ratio (uPCR) (P = 0.014), estimated glomerular filtration rate (eGFR) (P = 0.027), and renal SLE disease activity index (SLEDAI) (P = 0.009) improved more significantly in the cyclophosphamide + fish oil group. The number of patients with infection (P = 0.04) or urinary tract infection (P = 0.04) in the cyclophosphamide + fish oil group was lower than the cyclophosphamide + placebo group. Conclusion: In conclusion, the treatment of fish oil in LN patients enhances the efficiency of cyclophosphamide, alleviates nephritis-related parameters, and inhibits infection and urinary tract infection during the treatment. Thus, fish oil may serve as a potential adjuvant drug in the treatment of LN.

scholarly journals EVALUATION OF THE MICROBIAL PROFILE AND ANTIBIOTIC RESISTANCE OF BACTERIA CAUSING URINARY TRACT INFECTION IN THE CHILDREN OF KYIV REGION

2016 ◽  
pp. 43-49
Author(s):  
О. Lavrenchuk ◽  
І. Bagdasarova
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Acquired Resistance ◽  
High Sensitivity ◽  
E Coli ◽  
Microbial Profile ◽  
Number Of Patients ◽  
Causative Agents ◽  
Resistance To Penicillin

The rapid growth of the acquired resistance of bacteria to antibacterial agents requires a revision of the selection ofempirical antimicrobial therapy in children with urinary tract infection (UTI). The aim of this work was to investigate the etiological structure of uropathogen flora and its sensitivity to nitrofurantoin and antibacterial drugs ofother classes in children with UTI in Kyiv and region. Materials and methods. Were examined in 95 children aged 3 to 17years in the aediatric Nephrology Department of, Institute of Nephrology NAMS of Ukraine” on the basis of clinical hospital №7 Kyiv city in 2015-2016. The disease duration ofthepatients rangedfrom 3 months to 4years. Results.The microbial spectrum of the urine depended on theform of pyelonephritis, but all patients were dominated by enterobacteria E. coli and Kl. pneumoniae. The greatest number of patients was resistant to ampicillin, co-trimoxazol and cefuroxime – 10.5% of patients with acute and 17.2% with chronic pyelonephritis. The highest sensitivity was preserved in all patients before medications meronem and gentamicin – 100% and 94.7%, respectively. Most children in Kyiv and Kyiv region showed a high sensitivity to nitrofurantoin:furamag – 78.9-75.8%,furagin - 63.8-65.5%. Comparative analysis of therapeutic efficiency of drugsfuramag and co-trimoxazol, demonstrated greater therapeutic efficacy of nitro- furans in the absence of recurrences, compared with co-trimoxazol (Oto 1.68withp=0.021). Conclusions. Among the causative agents of UTI in children of the city of Kyiv and Kyiv region was dominated by gram-negativeflora - E. coli and Kl. pneumoniae. High sensitivity to nitrofurantoin drugs, especiallyfuramag, cephalosporins, and gentamicin and meronem was documented. High rates of resistance to penicillin and co-trimoxazol was revealed. The use of the drugfuramag contributed to a more rapid, complete andpersistent normalization ofclinical and laboratory parameters in children with UTI.

scholarly journals Long-term low-dose co-trimoxazole in prophylaxis of childhood urinary tract infection: bacteriological aspects.

BMJ ◽  
1976 ◽  
Vol 2 (6029) ◽  
pp. 206-208 ◽  
Author(s):  
R N Gruneberg ◽  
J M Smellie ◽  
A Leakey ◽  
W S Atkin
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Low Dose

PREVENTION OF URINARY-TRACT INFECTION WITH LOW-DOSE NITROFURANTOIN

The Lancet ◽  
1971 ◽  
Vol 298 (7734) ◽  
pp. 1112-1114 ◽  
Author(s):  
R.R. Bailey ◽  
P.E. Gower ◽  
A.P. Roberts ◽  
H.E. De Wardener
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Low Dose

Efficacy of Five Years of Continuous, Low-Dose Trimethoprim-Sulfamethoxazole Prophylaxis for Urinary Tract Infection

1988 ◽  
Vol 157 (6) ◽  
pp. 1239-1242 ◽  
Author(s):  
L. E. Nicolle ◽  
G. K. M. Harding ◽  
M. Thomson ◽  
J. Kennedy ◽  
B. Urias ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Low Dose

scholarly journals Pattern of Bacterial Pathogens Causing Urinary Tract Infection and Their Antibiotic Sensitivity: A Tertiary Care Hospital Experience

2016 ◽  
Vol 5 (1) ◽  
pp. 20-23
Author(s):  
Raziur Rahman ◽  
Muhammad Abdur Rahim ◽  
Samira Rahat Afroze ◽  
Palash Mitra ◽  
Tabassum Samad ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
E Coli ◽  
Number Of Patients

Background and Aims: Urinary tract infection (UTI) is a common illness. The spectrum of bacteria causing UTI and their antibiotic sensitivity is not uniform. This study was designed to describe the bacteriological spectrum causing UTI and their antibiotic sensitivity.Methods: This cross-sectional study was done in the Department of Internal Medicine, BIRDEM General Hospital from January to June, 2013.Results: Total number of patients was 103 with females predominance (F:M ratio 2:1). Mean age was 57.5 years. Most (91.3%) of the study population were diabetic with poor glycaemic control (mean HbA1c 9.9%). Common symptoms were fever, dysuria, increased urinary frequency, suprapubic pain, vomiting and loin pain. Neutrophilic leukocytosis was common (94.2%). E. coli (79.6%) was the commonest aetiological agent followed by Klebsiella (9.7%), Citrobacter (3.9%), Acinetobacter (1.9%), Enterobacter (1.9%), Enterococcus (1.9%) and Pseudomonas (0.9%). Imipenem (100%), aminoglycosides e.g. amikacin and gentamycin and nitrofurantoin were among the most sensitive antibiotics.Conclusion: E. coli is the commonest organism causing UTI and imipenem, amikacin and nitrofurantoin are the most sensitive antibiotics.Birdem Med J 2015; 5(1): 20-23

scholarly journals Natural history of uncomplicated urinary tract infection without antibiotics: a systematic review

2020 ◽  
Vol 70 (699) ◽  
pp. e714-e722
Author(s):  
Tammy Hoffmann ◽  
Ruwani Peiris ◽  
Chris Del Mar ◽  
Gina Cleo ◽  
Paul Glasziou
Keyword(s):  
Systematic Review ◽  
Urinary Tract Infection ◽  
Placebo Group ◽  
Urinary Tract ◽  
Natural History ◽  
Tract Infection ◽  
Risk Of Bias ◽  
Uncomplicated Urinary Tract Infection ◽  
Randomised Trials ◽  
History Of

BackgroundAlthough uncomplicated urinary tract infection (UTI) is commonly treated with antibiotics, the duration of symptoms without their use is not established; this hampers informed decision making about antibiotic use.AimTo determine the natural history of uncomplicated UTI in adults.Design and settingSystematic review.MethodPubMed was searched for articles published until November 2019, along with reference lists of articles identified in the search. Eligible studies were those involving adults with UTIs in either the placebo group of randomised trials or in single-group prognostic studies that did not use antibiotics and measured symptom duration. A modified version of a risk of bias assessment for prognostic studies was used. Outcomes were the percentage of patients who, at any time point, were symptom free, had symptom improvement, or had worsening symptoms (failed to improve). Adverse event data were also extracted.ResultsThree randomised trials (346 placebo group participants) were identified, all of which specified women only in their inclusion criteria. The risk of bias was generally low, but incomplete reporting of some details limited assessment. Over the first 9 days, the percentage of participants who were symptom free or reported improved symptoms was reported as rising to 42%. At 6 weeks, the percentage of such participants was 36%; up to 39% of participants failed to improve by 6 weeks. The rate of adverse effects was low and, in two trials, progression to pyelonephritis was reported in one placebo participant.ConclusionAlthough some uncertainty around the natural history of uncomplicated UTIs remains, some women appear to improve or become symptom free spontaneously, and most improvement occurs in the first 9 days. Other women either failed to improve or became worse over a variable timespan, although the rate of serious complications was low.

Phytotherapy is a component of the clinical decision in the tactics of delayed administration of antibacterial therapy to children with urological symptoms at the outpatient stage

2020 ◽  
pp. 30-37
Author(s):  
T.V. Budnik ◽  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antibacterial Therapy ◽  
Urine Analysis ◽  
Herbal Remedy ◽  
Dipstick Test ◽  
Early Date ◽  
Number Of Patients ◽  
Urological Symptoms

Prevalence of a patient with urologic symptoms at an outpatient doctor, pediatric nephrologist contributes to the hyperdiagnosis of urinary tract infection in children (UTI). At the same time, the lack of a clear patient stratification algorithm for the use of antibacterial drugs (ABD) leads to abuse and serious consequences. The objective: study of the efficacy and safety of the use of standardized herbal medicine Canephron® N in children with urological symptoms without signs of systemic inflammatory reaction with the possibility of delayed administration of antibacterial therapy at the outpatient stage. Materials and methods. The study included 50 children aged 12 to 18 years with characteristic urological symptoms without any signs of systemic inflammation (lack of hyperthermia and/or leukocytosis). The study was conducted with the informed consent of children and parents in accordance with the Declaration of Human Rights in Helsinki. Verification of diagnoses was performed according to the unified clinical protocol of the Ministry of Health of Ukraine No. 627 dated November 3, 2008. The delayed tactics for the appointment of ABD are based on the provisions of the national British guidance NICE, 2018 by urine analysis using a dipstick test. Results. In 97% ± 2.8 (35/36) cases, the clinical and laboratory efficacy of the herbal remedy Canephron® N was confirmed. On the 7th day of therapy, 100% of patients (p<0.05) showed a regression of dysuria, pain, and leukocyturia. The number of patients with bacteriuria was reduced by 1.8 times (40% ± 20.77 (14/36) vs 22% ± 30.99 (8/36); p<0.05). The powerful crystallolytic action of the drug was noted at an early date (the crystalluria level increased by 2.8 times at day 7 of therapy, p<0.05), however, it required the prolongation of the use of the drug Canephron® N under the control of saline and ultrasound indicators. The likelihood of delayed involvement in ABD phytotherapy was low and was OR=0.049±0.553 [0.017; 0.146]; p<0.05. The likelihood of recurrent UTI in the next 3 months after the 7-day course with Canephron® N was minimal and was OR=0.001±1.434 at 95% CI [0.000; 0.014]; p<0.05. Conclusions. The delayed tactics of ABD under the guise of the herbal remedy Canephron® N was justified for girls aged 12–18 years with the stratification of the patient by dipstick test (88% ± 5.17 (44/50) showed negative nitrite test). The further prospect of such research in children is urgent and valid. Key words: urological symptoms, urinary tract infection, children, phytotherapy, Canephron® N.

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