CONTRAST-INDUCED NEPHROPATHY;

Introduction: Contrast induced nephropathy (CIN) is a disorder characterizedby the onset of acute renal failure within 24 to 72 hours after the administration of iodinatedcontrast medium after coronary angiography. CIN is associated with prolonged hospitalizationand adverse clinical outcomes. The objective of this study is to determine the frequency ofcontrast induced nephropathy in patients of coronary artery disease undergoing coronaryangiography in local population. Setting: Department of Cardiology, Faisalabad Instituteof Cardiology. Period: 16-04-2016 to 15-10-2016. Subjects and Methods: 200 patients ofcoronary artery disease booked for coronary angiogram. Study design was Cross-sectional.Baseline characteristic and history of risk factors of coronary artery disease were noted. Serumcreatinine level was recorded at baseline and after 48 hours of angiography by sending bloodsample to the hospital pathology department and were noted. Contrast induced nephropathywas assessed. Results: Mean age of the patients was 53.61±12.48 year. Patients with agebetween 30-50 years were 76(38%) and patients with age 51-70 years were 124 (62%). Outof 200 patients, 130 (65%) were males while remaining 70 (35%) were females. In the studypopulation 14 (7%) developed contrast induced nephropathy (CIN). Mostly patients of 51-70years of age group developed CIN. CIN was reported in 9(6.92%) male patients and 5(7.1%)female patients. Among diabetic 4 (3.57%) patient developed CIN. Among hypertensive patients2 (2.77%) patient developed CIN. Similarly in patients presented with acute coronary syndrome8 (7.61%) patient developed CIN. Conclusion: In conclusion, contrast induced nephropathy inpatients with coronary artery disease undergoing coronary angiogram was found in 7%. CIN isa relative common finding following coronary angiography in patients especially in elderly andmale patients. More incidences of CIN were noted in patients presented with acute coronarysyndrome and in diabetic patients.

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CORONARY ARTERY DISEASE ON CT-CORONARY ANGIOGRAM – COMPARISON BETWEEN DIABETIC AND NON-DIABETIC POPULATION

Pakistan Heart Journal ◽

10.47144/phj.v54i1.2070 ◽

2021 ◽

Vol 54 (1) ◽

pp. 85-89

Author(s):

Muhammad Zubair Zaffar ◽

Ammar Akhtar ◽

Syed Naseem Iqbal Bukhari ◽

Rashid Minhas

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Positive Family History ◽

Invasive Technique ◽

Diabetic Patients ◽

Coronary Angiogram ◽

Obstructive Disease ◽

History Of ◽

Artery Disease ◽

Ct Coronary Angiogram

Objective: To evaluate the CT coronary angiograms of patients presenting with symptoms of coronary artery disease (CAD) as well as to compare the results between the diabetics and non-diabetics. Methodology: This descriptive cross-sectional study was carried out in Cardiology department of Chaudhary Pervaiz Elahi Institute of Cardiology, Multan. One hundred and fifty nine patients with history of symptoms of CAD and no previous history of myocardial infarction or revascularization were included in study. The conventional risk factors were noted and 64 slice multi detector CT coronary angiogram was done on all patients. Total calcium score and number of segments with disease, obstructive disease and non-obstructive disease were noted. Results were compared among diabetic and non-diabetic patients. Results: Mean age of the patients was 50.54±7.90 years. Out of 159 patients 118(74.2%) were males and 41 (25.8%) were females. Diabetic patients were 101(63.5%), 64 (40.3%) were hypertensive, 39(24.5%) were smokers, 24.5% (n=39) had positive family history, 18.2% (n=29) were obese and 13.8% (n=22) had dyslipidemia. There was no coronary artery disease in 40 (25.2%) patients while 91 (57.2%) patients had obstructive and 28 (17.6%) patients had non-obstructive disease. 83. 1% diabetics had obstructive CAD and 12.0% of non diabetic patients had obstructive CAD. Mean number of obstructive segments in diabetic patients are 2.36±1.23. Conclusion: CAD was more prevalent in diabetic patients and CAD is easily predicted by non-invasive technique of CT coronary angiography.

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Cost-utility of ticagrelor plus aspirin in diabetic patients with stable coronary artery disease

European Heart Journal - Cardiovascular Pharmacotherapy ◽

10.1093/ehjcvp/pvaa082 ◽

2020 ◽

Author(s):

Bin Wu ◽

Lizheng Shi

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Incremental Cost ◽

Stable Coronary Artery Disease ◽

Bleeding Risk ◽

Cost Utility ◽

Diabetic Patients ◽

Clinical Benefits ◽

History Of ◽

Artery Disease

Abstract Aims Ticagrelor plus aspirin could reduce the risks of major adverse cardiac events in diabetic patients with stable coronary artery disease (SCD), and yet it also increases bleeding risk. This study would compare the cost and effectiveness of aspirin and ticagrelor plus aspirin therapies in diabetic patients with SCD from a US healthcare sector perspective. Methods and results A state-transition Markov model was developed to project probabilities of myocardial infarction, ischaemic stroke, bleeding, and death with and without ticagrelor among all diabetic patients with SCD as the overall population, and those with a history of previous percutaneous coronary intervention (PCI) as a sub-population. Model inputs were extracted from published sources. Lifetime costs and quality-adjusted life-years (QALYs) were measured. The clinical benefits and bleeding risk of ticagrelor added to aspirin were translated into additional 0.08 QALYs at incremental costs of $19 580 in the overall population, yielding an incremental cost-utility ratio (ICUR) of $260 032/QALY. In the sub-population with an additional 0.43 QALYs at an incremental cost of $20 189, the ICUR was $46 426/QALY. Two-way sensitivity showed the clinical benefits of ticagrelor plus aspirin was counterbalanced by its risk of major bleeding. One-way sensitivity and probabilistic sensitivity analysis demonstrated that the results were generally robust except the all-cause death reduction. Conclusion The results indicated that ticagrelor plus aspirin is likely to be a cost-effective option in the diabetic patients with a history of PCI. Diabetes management can be improved by carefully prescribing ticagrelor to individuals with low risk of bleeding and high risk of ischaemic events.

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Correlation between Atherogenic index and the severity of coronary artery disease in diabetic patients undergoing elective coronary angiography using Gensini score

QJM ◽

10.1093/qjmed/hcaa041.002 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

A S Elyamani ◽

M A Elnozahi ◽

A M Abdelmoteleb

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Angiography ◽

Significant Positive Correlation ◽

Atherogenic Index ◽

Diabetic Patients ◽

Gensini Score ◽

Atherogenic Index Of Plasma ◽

Positive Correlation ◽

Artery Disease

Abstract Background Dyslipidemia is one of the most important factors for CAD. Atherogenic index of plasma (AIP) is a new indicator involved in dyslipidemia. However, its relation with CAD severity in diabetic patients is not well established yet. Aim of the Study To study the relationship between atherogenic index of plasma and severity of coronary artery disease (CAD) in the diabetic patients. Methods Our study was conducted on 150 diabetic patient with stable CAD undergoing elective coronary angiography in Al-Agoza Hospital from april 2016 to august 2018. Atherogenic index was calculated from the logarithmically transformed ratio of concentrations of TGs to HDL-C obtained from the patient’s lipid profile. correlation of the AIP and the severity of CAD according to Gensini scoring system was done. Results AIP had a statistically significant positive relation with IDDM (p = 0.033), NIDDM (p = 0.033), HTN (p = 0.024), dyslipedemia (p = 0.042). And a highly significant positive correlation with FBS (p < 0.001, r = 0.479) and HbA1c (p < 0.001, r = 0.538), proximal LAD lesions (p = 0.002), LCX (p < 0.001), and the number of vessls affected (p = 0.005). AIP Also had a highly significant positive correlation with severity of CAD in terms of Gensini score (p < 0.001, r = 0.692). Conclusion AIP is considered a good predictor of CAD severity and multivessel affection in diabetic patients.

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Unique angiographic findings in a patient with myocardial ischemia and immunoglobulin G4-related disease

SAGE Open Medical Case Reports ◽

10.1177/2050313x17728010 ◽

2017 ◽

Vol 5 ◽

pp. 2050313X1772801

Author(s):

Yusuke Kanzaki ◽

Takashi Miura ◽

Naoto Hashizume ◽

Tatsuya Saigusa ◽

Soichiro Ebisawa ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Angiography ◽

Intravascular Ultrasound ◽

Plasma Cells ◽

Immunoglobulin G4 ◽

Related Disease ◽

Multiple Organs ◽

History Of ◽

Artery Disease

Immunoglobulin G4-related disease characteristically involves multiple organs including the heart and coronary arteries. Immunoglobulin G4-related coronary artery disease is thought to be due to periarteritis and histopathologically is characterized by marked thickening of the adventitia and periarterial fat with infiltration of immunoglobulin G4-positive plasma cells. Although comprehensive diagnostic criteria require a biopsy for a definite or probable diagnosis of immunoglobulin G4-related disease, obtaining a coronary artery biopsy is difficult and risky. However, imaging findings including coronary angiography and intravascular ultrasound might be useful tools to establish a diagnosis of immunoglobulin G4-related coronary artery disease. We report a case of a 63-year-old man with a history of immunoglobulin G4-related disease who presented with exertional chest pain. We found unique angiographic and intravascular ultrasound features of immunoglobulin G4-related coronary artery disease that distinguished it from those of arteriosclerotic coronary artery disease and suggest that coronary angiography and intravascular ultrasound might be useful tools in the diagnosis of immunoglobulin G4-related coronary artery disease.

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Association of classical risk factors and coronary artery disease in type 2 diabetic patients submitted to coronary angiography

Diabetology & Metabolic Syndrome ◽

10.1186/1758-5996-6-46 ◽

2014 ◽

Vol 6 (1) ◽

pp. 46 ◽

Cited By ~ 10

Author(s):

Célia Bittencourt ◽

Valdecira M Piveta ◽

Carolina SV Oliveira ◽

Felipe Crispim ◽

Deyse Meira ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Angiography ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Artery Disease ◽

Type 2 Diabetic

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Coronary Artery Dominance in Western Maharashtra Population by Angiographic Method

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl4.4410 ◽

2020 ◽

Vol 11 (SPL4) ◽

pp. 1998-2002

Author(s):

Sheela D. Kadam ◽

Abhijeet Shelke ◽

Priya P Roy ◽

Megha A Doshi ◽

Shruti P Mohite

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Angiography ◽

X Ray ◽

Invasive Angiography ◽

The World ◽

History Of ◽

Artery Disease ◽

Angiographic Method ◽

Day By Day

Coronary artery disease (CAD) is going to become a significant cause of death in the world. The CAD is increasing day by day because of the changing lifestyle of people. The responsible factors for CAD are diabetes, hypertension, addiction and heredity also. So, the present work is undertaken to study the dominant pattern of coronary artery in the Maharashtra population. The present study was a hospital-based, prospective and observational study of 360 patients who have coronary artery disease undergoing coronary angiography. This study carried out from May 2018-November 2019 of both genders of 25 years of age and above [Male-215(59.72%) and female was 145(40.27 %)]. Out of that, the youngest patient below 40 years male was 30(73.17%), and the female was 11(26. 82%). While above 40 years males were 185(57.99%) and females was 134(42%). The patients with a history of by-pass surgery and angioplasty were excluded. Invasive angiography was performed by either femoral or radial artery using radio-opaque dye (OMNIPCK-50ml) that is visible by an x-ray machine (GE. INNOVA). The socio-demographic Proforma of patients, the pattern of coronary arterial dominance were recorded. Right coronary artery was dominant in 273(75.83%) patients observed in this study. While LCx was dominant in 49(13.6%) and co-dominant in 38 (10.55%) patients. Knowledge of study can be helpful to cardiologists for anatomical assessment of coronary arteries for diagnostic purposes and invasive studies.

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P0142CONTRAST INDUCED NEPHROPATHY AFTER CORONARY ANGIOGRAPHY

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0142 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Durdona Saipova ◽

Shavkat Muminov ◽

Baxodir Nigmanov ◽

Kamila Olimxanova

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Angiography ◽

Serum Creatinine ◽

Functional State ◽

Negative Relationship ◽

Serum Creatinine Concentration ◽

Contrast Induced Nephropathy ◽

Creatinine Concentration ◽

Artery Disease

Abstract Background and Aims Determination of markers of kidney damage in patients with coronary artery disease after coronary angiography. HYPERLINK “https://www.healthline.com/health/coronary-angiography” Method The study included 303 patients with coronary artery disease who were planned coronary angiography. The initial examination of patients included an assessment of the structural and functional state of the kidneys, metabolic profile and the functional state of the cardiovascular system. Renal filtration function was assessed by the clearance of creatinine and cystatin C with the calculation of glomerular filtration rate (eGFRcr and eGFRcis) All coronary artery disease patients included in the study underwent coronary angiography using a contrast drug unigexole. If there is necessity, stenting of the coronary arteries was performed. On the 2nd day after coronary angiography, a serum creatinine concentration was determined to isolate patients in whom coronary angiography was complicated by CIN. Contrast induced nephropathy was defined as an increase in serum creatinine concentration by 25% 24 hours after coronarography. According to the study, patients were divided into 2 groups - 67.99% of patients with an uncomplicated postoperative period of caranoroangiography; CIN (-) group and CIN (+) group 32.01% of patients who developed contrast-induced nephropathy. Subsequently, the CIN + and CIN- groups were retrospectively compared according to the initial hemodynamic parameters, structural and functional state of the kidneys, and metabolic characteristics. Results The results of the study showed that eGFRcr did not significantly differ in the CIN(+) and CIN(-) groups, although it turned out to be lower in both groups. (p <0.05). While eGFRcis in the CIN(+) group was significantly lower than in patients with uncomplicated coronary angiography. Correlation analysis showed a reliable positive average relationship between the values of eGFRcr and eGFRcis in the CIN(+) group (r = 0.32, p <0.001). Correlation revealed a reliable average negative relationship between eGFRcis and the relative density of urine (r = -0.46, p <0.001), indicating a combined violation of the glomerular and canalicular function of the kidneys, which indicates that in these patients, despite the preserved eGFRcr, pathogenetic markers of impaired renal function are detected. The Resistance Index (RI), which characterizes the resistance of the microvasculature of the kidneys in all patients with coronary artery disease significantly exceeded the control values. The selected groups according to the value of RI were arranged as follows: the minimum value of RI is in the CIN(–) without diabetes mellites group, and the maximum value is in patients with СIN(+) and diabetes mellitus. Conclusion In patients with coronary artery disease undergoing endovascular procedures, eGFRcis is a more accurate indicator of latent impaired renal filtration function than eGFRcr. Decrease in eGFRcis below 89ml / min in patients with coronary artery disease at risk of developing contrast-induced nephropathy during caranoroangiography. An increase in RI of segmental arteries of the kidneys is associated with a decrease in the filtration function of the kidneys and patients with maximum RI have the greatest risk of developing glomerular dysfunction under conditions of exposure to contrast.

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