scholarly journals DIABETIC RETINOPATHY;

2019 ◽  
Vol 26 (04) ◽  
Author(s):  
Jamal ud Din ◽  
Zahidullah Khan ◽  
Inamullah Khan

Objectives: The prime objective of the study was to determine the prevalence of Diabetic Retinopathy in recently diagnosed type 2 diabetic patients with duration up to one year. Study Design: Single center, descriptive, observational study. Setting: Department of Medicine, Khyber Teaching Hospital, Peshawar. Period:  August, 2017 to March, 2018. Material and Methods: A total of 196 patients who were either newly diagnosed or diagnosed within last 12 months were included in the study. Patients with type 1 diabetes or diagnosed later than 12 months were excluded from the study. Patients with retinopathy due to some other cause were also excluded from the study. Both out door patients and admitted patients were included in the study. After detailed history, proper fundoscopic examination of both eyes was performed and findings were recorded on preformed proforma. Results: A total of 196 patients were enrolled in the study. One hundred and ten were male and 86 were female in a ratio of 1.3:1 respectively. Age distribution amongst study population ranged between 30-60 years. Mean age of the population was 49.18 ± 7.62 SD years with median age 48 years and mode age 45 years. Out of 196 patients, 32 (16.3%) patients had diabetic retinopathy on proper fundoscopic examination. Conclusion: Diabetic retinopathy is a well known microvascular complication of diabetes mellitus and any one with this complication must be referred to specialist ophthalmologist for further necessary investigation and management to prevent further complications.

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Satu Vavuli ◽  
Tuire Salonurmi ◽  
Sirpa Loukovaara ◽  
Antti E. Nissinen ◽  
Markku J. Savolainen ◽  
...  

Aims. This study investigated the association of autoantibodies binding to oxidized low-density lipoproteins (oxLDL) in diabetic retinopathy (DR). Methods. Plasma from 229 types 1 and 2 patients with DR including diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) was analysed with ELISA-based assay to determine IgA, IgG, and IgM autoantibody levels binding to oxLDL. The controls were 106 diabetic patients without retinopathy (NoDR) and 139 nondiabetic controls (C). Results. PDR group had significantly higher IgA autoantibody levels than DME or NoDR: mean 94.9 (SD 54.7) for PDR, 75.5 (41.8) for DME (p=0.001), and 76.1 (48.2) for NoDR (p=0.008). There were no differences in IgG, IgM, or IgA that would be specific for DR or for DME. Type 2 diabetic patients had higher levels of IgA autoantibodies than type 1 diabetic patients (86.0 and 65.5, resp., p=0.004) and the highest levels in IgA were found in type 2 diabetic patients with PDR (119.1, p>0.001). Conclusions. IgA autoantibodies were increased in PDR, especially in type 2 diabetes. The high levels of IgA in PDR, and especially in type 2 PDR patients, reflect the inflammatory process and enlighten the role of oxLDL and its autoantibodies in PDR.


Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 599-P ◽  
Author(s):  
SARA CHERCHI ◽  
ALFONSO GIGANTE ◽  
PIERPAOLO CONTINI ◽  
DANILA PISTIS ◽  
ROSANGELA M. PILOSU ◽  
...  

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