FORMULASI DAN KARAKTERISASI NANOSUSPENSI MORIN DENGAN METODE SONOPRESIPITASI

Muhammad Dzakwan

doi:10.29313/jiff.v3i2.6062

FORMULASI DAN KARAKTERISASI NANOSUSPENSI MORIN DENGAN METODE SONOPRESIPITASI

Jurnal Ilmiah Farmasi Farmasyifa ◽

10.29313/jiff.v3i2.6062 ◽

2020 ◽

Vol 3 (2) ◽

pp. 121-131

Author(s):

Muhammad Dzakwan

Keyword(s):

Pluronic F68

Pendahuluan : Morin (3,5,7, 2,4’- pentahidroksiflavone) adalah senyawa flavonoid golongan flavonol yang poten sebagai antioksidan, antikanker, antiinflamasi dan sebagai antidiabetes. Morin bersifat lipofil, tidak larut dalam air sehingga ketersediaan hayati dan aplikasi klinis menjadi terbatas. Nanosuspensi adalah sistem dispersi koloidal, 100% mengandung bahan obat dengan ukuran 10-1000 nm, tidak mengandung bahan pembawa apapun kecuali sebagai bahan penstabil. Tujuan : Penelitian ini bertujuan membuat nanosuspensi morin yang stabil dengan metode sonopresipitasi. Karakterisasi nanosuspensi meliputi ukuran partikel, indeks polidispersitas, zeta potensial, morfologi nanosuspensi dan aktivitas antioksidan. Metode : Nanosuspensi morin dibuat dengan metode sonopresipitasi dengan frekuensi 50 kHz selama 8 menit dengan variasi bahan penstabil jenis surfaktan, polimer dan kombinasi keduanya. Karakterisasi nanosuspensi meliputi ukuran partikel, indeks polidispersitas, zeta potensial, morfologi partikel (TEM), stabilitas fisik dan aktivitas antioksidan. Kesimpulan : Morin berhasil dikembangkan menjadi nanosuspensi dengan metode sonopresipitasi. Formula 7 dengan stabilizer SLS-Pluronic F68 (0,5:1) merupakan formula terpilih dengan ukuran partikel terkecil sebesar 182,7 nm, ukuran partikel seragam (PI : 0,210), stabil setelah penyimpanan 8 minggu dengan nilai zeta potensial -37,8 mV. Aktivitas antioksidan nanosuspensi morin meningkat sebesar 2-3 kali

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Surface and bulk properties of aqueous binary mixtures of Pluronic F68 and low-molecular-weight cationic surfactants: 2. Wetting and modifying effects of mixed solutions

Colloid Journal ◽

10.1134/s1061933x0802004x ◽

2008 ◽

Vol 70 (2) ◽

pp. 144-147 ◽

Cited By ~ 4

Author(s):

Yu. G. Bogdanova ◽

V. D. Dolzhikova

Keyword(s):

Molecular Weight ◽

Binary Mixtures ◽

Cationic Surfactants ◽

Low Molecular Weight ◽

Pluronic F68 ◽

Bulk Properties ◽

Mixed Solutions ◽

Aqueous Binary Mixtures

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Influence of pluronic F68 on oxygen mass transfer

Biotechnology Progress ◽

10.1002/btpr.1770 ◽

2013 ◽

Vol 29 (5) ◽

pp. 1278-1288 ◽

Cited By ~ 19

Author(s):

Christian Sieblist ◽

Marco Jenzsch ◽

Michael Pohlscheidt

Keyword(s):

Mass Transfer ◽

Oxygen Mass Transfer ◽

Pluronic F68

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NANOEMULSIONS BASED ON LIPOIC ACID DERIVATIVES WITH VARIOUS ALCOHOLS: PRODUCTION AND INFLUENCE ON FUNCTIONAL ACTIVITY OF PLATELETS

BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES ◽

10.37747/2312-640x-2020-18-461-464 ◽

2020 ◽

pp. 461-464

Author(s):

A. Sinebryukhova ◽

A. Shipelova ◽

E. Darnotuk ◽

A. Chekanov ◽

O. Baranova ◽

...

Keyword(s):

Particle Size ◽

Arachidonic Acid ◽

Lipoic Acid ◽

Encapsulation Efficiency ◽

Room Temperature ◽

Optimal Conditions ◽

Pluronic F68 ◽

Long Term Storage ◽

Term Storage

The optimal conditions were selected for obtaining homogeneous nanoemulsions (NE) of lipoic acid conjugates (LA-conjugates) based on Pluronic F68 (1,8%) with a particle size not exceeding 400 nm, characterized by 97±2% encapsulation efficiency of substances in nanoparticles (NP). A heterogeneous NE (polydispersity index, PDI>0,3) with the derivative of LA and myo-inositol based on phosphatidylcholine (PC, C = 3 mg/ml) was also obtained consisting of 2 particle fractions: 20–70 nm (27%) and 122–212 nm (73%). The obtained NEs with LA-conjugates based on Pluronic F68 and PC were stable during long-term storage (more than 12 months) at room temperature. The effect of the obtained NEs of LA-conjugates on platelet aggregation (Pt) caused by arachidonic acid (AA) was determined, and a mechanism of their action was proposed.

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Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy

Pharmaceutics ◽

10.3390/pharmaceutics12111039 ◽

2020 ◽

Vol 12 (11) ◽

pp. 1039

Author(s):

Teresa del Castillo-Santaella ◽

Yan Yang ◽

Inmaculada Martínez-González ◽

María José Gálvez-Ruiz ◽

Miguel Ángel Cabrerizo-Vílchez ◽

...

Keyword(s):

Hyaluronic Acid ◽

Delivery System ◽

Surface Characterization ◽

Positive Impact ◽

Foam Stability ◽

Surface Elasticity ◽

Foam Sclerotherapy ◽

Pluronic F68 ◽

Surface Active ◽

Bioactive Agents

The use of foams to deliver bioactive agents and drugs is increasing in pharmaceutics. One example is the use of foam as a delivery system for polidocanol (POL) in sclerotherapy, with the addition of bioactive compounds to improve the delivery system being a current subject of study. This work shows the influence of two bioactive additives on the structure and stability of POL foam: hyaluronic acid (HA) and Pluronic-F68 (F68). HA is a natural non-surface-active biopolymer present in the extracellular matrix while F68 is a surface-active poloxamer that is biocompatible with plasma-derived fluids. Both additives increase the bulk viscosity of the sample, improving foam stability. However, HA doubled and F68 quadruplicated the foam half lifetime of POL. HA reduced the size and polydispersity of the bubble size distribution and increased the surface elasticity with respect to POL. Both facts have a positive impact in terms of foam stability. F68 also altered bubble structure and increased surface elasticity, again contributing to the enhancement of foam stability. The surface characterization of these systems is important, as in foam sclerotherapy it is crucial to assure the presence of POL at the surface of the bubbles in order to deliver the sclerosant agent in the target vein.

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