scholarly journals Pathological Effects of Cypermethrin on the Testes and Accessory Sexual Glands of Yankasa Rams

2017 ◽  
Vol 2 (1) ◽  
pp. 006-012
Author(s):  
Simon U
Keyword(s):  
2021 ◽  
Vol 22 (9) ◽  
pp. 4368
Author(s):  
Heriberto Rodriguez-Martinez ◽  
Emilio A. Martinez ◽  
Juan J. Calvete ◽  
Fernando J. Peña Vega ◽  
Jordi Roca

Seminal plasma (SP), the non-cellular component of semen, is a heterogeneous composite fluid built by secretions of the testis, the epididymis and the accessory sexual glands. Its composition, despite species-specific anatomical peculiarities, consistently contains inorganic ions, specific hormones, proteins and peptides, including cytokines and enzymes, cholesterol, DNA and RNA—the latter often protected within epididymis- or prostate-derived extracellular vesicles. It is beyond question that the SP participates in diverse aspects of sperm function pre-fertilization events. The SP also interacts with the various compartments of the tubular genital tract, triggering changes in gene function that prepares for an eventual successful pregnancy; thus, it ultimately modulates fertility. Despite these concepts, it is imperative to remember that SP-free spermatozoa (epididymal or washed ejaculated) are still fertile, so this review shall focus on the differences between the in vivo roles of the SP following semen deposition in the female and those regarding additions of SP on spermatozoa handled for artificial reproduction, including cryopreservation, from artificial insemination to in vitro fertilization. This review attempts, including our own results on model animal species, to critically summarize the current knowledge of the reproductive roles played by SP components, particularly in our own species, which is increasingly affected by infertility. The ultimate goal is to reconcile the delicate balance between the SP molecular concentration and their concerted effects after temporal exposure in vivo. We aim to appraise the functions of the SP components, their relevance as diagnostic biomarkers and their value as eventual additives to refine reproductive strategies, including biotechnologies, in livestock models and humans.


Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1302
Author(s):  
Hossam G. Tohamy ◽  
Sara E. El-Kazaz ◽  
Saqer S. Alotaibi ◽  
Hawary S. Ibrahiem ◽  
Mustafa Shukry ◽  
...  

The study investigated the ability of boswellic acid (BA) to alleviate the testicular and oxidative injury FPN insecticide intoxication in the male rat model. Rats were randomly assigned to six equivalent groups (six rats each) as the following: control rats orally administered with 2 mL physiological saline/kg of body weight (bwt); boswellic acid (BA1) rats orally administered 250 mg BA/kg bwt; boswellic acid (BA2) rats orally administered 500 mg BA/kg bwt; fipronil (FPN) rats orally administered 20 mg FPN/kg bwt; (FPN + BA1) rats orally administered 20 mg FPN/kg bwt plus 250 mg BA/kg bwt, and (FPN + BA2) rats orally administered 20 mg FPN/kg bwt plus 500 mg BA/kg bwt. After 60 days, semen viability percentage and live spermatozoa percentage were decreased, and a considerably increased abnormality of the sperm cells in FPN-administered rats improved substantially with the co-administration of BA. BA had refinement of the histological architecture of testes and sexual glands. Quantitative analysis recorded a noticeable decline in the nuclear cell-proliferating antigen (PCNA) percentage area. FPN triggered cell damage, which was suggested by elevated malondialdehyde and interleukin 6, tumor necrosis factors alpha, and decreased glutathione level. Proapoptotic factor overexpression is mediated by FPN administration, while it decreased the antiapoptotic protein expression. Similarly, BA has shown significant upregulation in steroidogenic and fertility-related gene expression concerning the FPN group. Pathophysiological damages induced by FPN could be alleviated by BA’s antioxidant ability and antiapoptotic factor alongside the upregulation of steroidogenic and fertility-related genes and regimented the detrimental effects of FPN on antioxidant and pro-inflammatory biomarkers.


1996 ◽  
Vol 42 (2) ◽  
pp. 37-41
Author(s):  
N. D. Goncharova ◽  
L. A. Mkhitarova

The levels of bioactive LH, major sex and adrenal steroid hormones and their precursors in the system of biosynthesis were measured in the peripheral blood of 37 male Papio hamadryas of different age under baseline conditions and after injection of ACTH, LH releasing hormone, and human chorionic gonadotropin. The measurements were carried out in adult animals with the optimal reproductive characteristics (group 1, aged 6 to 9, and group 2, aged 10 to 15 years) and in aging males (group 3, aged 20 to 26 years). The levels of hydrocortisone and its immediate precursor in the biosynthesis chain of 11-deoxyhydrocortisone virtually did not change with age, whereas the concentrations of ∆5-precursors (pregnenolone and 17-hydroxypregnenolone) gradually reduced with aging. The levels of the major adrenal androgens dehydroepiandrosterone and dehydroepiandrosterone sulfate also appreciably decreased with age. The levels of sex hormones did not change between 6 and 15 years of age; but in animals aged 20 to 26 the concentration of testosterone showed a trend to reduction, and that of LH to increase. In group 3 the peaks of LH and testosterone secretion in response to LH releasing factor were delayed. On the other hand, the amplitude and duration of the increment of both LH and testosterone in response to LH releasing factor was virtually unchanged at all ages and was largely determined by the basal level of LH. The detected age-specific changes in the hormonal function of adrenals and sex glands of Papio hamadryas are much similar to those in humans.


1943 ◽  
Vol 118 (6) ◽  
pp. 1077
Author(s):  
LEON HERMAN
Keyword(s):  

2017 ◽  
Vol 42 (2) ◽  
pp. 375-394 ◽  
Author(s):  
N. Cañas-Hoyos ◽  
T. Lobo-Echeverri ◽  
C. I. Saldamando-Benjumea

Tetrahedron ◽  
2005 ◽  
Vol 61 (45) ◽  
pp. 10699-10704 ◽  
Author(s):  
Miloš Buděšínský ◽  
Irena Valterová ◽  
Etienne Sémon ◽  
Eliana Cancello ◽  
Christian Bordereau

1860 ◽  
Vol 10 ◽  
pp. 192-196

A memoir upon the aquiferous system and the oviducts of Lamellibranchiate Mollusks by Messrs. Rolleston and Robertson, was read before the Royal Society at the Meeting on the 3rd of February, 1859. The abstract of this memoir, contained in the ‘Annals and Magazine of Natural History,’ reached me in the month of July; and I was not a little surprised to find that a structure which I had so elaborately stu­died in the course of my various journeys to the sea-shore, and which I had carefully described in a number of species, was something quite different from what I had imagined it to be. "Without entering into minute anatomical details, which would not tend to elucidate the question, I find that Messrs. Rolleston and Robertson consider that the organs, the ducts, and the orifices supposed to be the ovaries or their excretory ducts, are, in fact, nothing but an aquiferous appa­ratus, and that the openings placed on each side of the foot are the excretory orifices of this system. They discover elsewhere the ducts whose office is to convey away the products of the genital glands. The enunciation of an opinion so opposed to what I, in common with many other authors, had maintained, seemed to require a recur­rence to direct observation. But on repeating my examination of Cardium edule , Tellina solidula , Mactra stultorum and Donax anatina , I have precisely verified my previous conclusions. On throwing injections into the genital orifices, the sexual glands have become turgid; and on examining fragments of such injected genital glands microscopically, the injected substance was seen mixed with the ova or spermatozoa. These facts may be observed with especial ease in Cardium edule .


2015 ◽  
Vol 61 (1) ◽  
pp. 31-35
Author(s):  
D A Morozov ◽  
N Yu Raygorodskaya ◽  
N V Bolotova ◽  
E S Pimenova ◽  
G N Maslyakova ◽  
...  

The objective of the present study was differential diagnostics between ovotestis and gonadal dysgenesis, the choice of the gender and the surgical strategy for the treatment of abnormal sexual glands. Diagnostics of the disturbances of gonadal differentiation (DGD) requires morphological verification. The ovotesticular gonad is characterized by the presence of a mature ovarian tissue and a dysgenetic testicular component. The authors describe the surgical separation of the ovotestis with preservation of the segments represented by the mature ovarian tissue. The presence of immature ovarian elements in the testicular gonad is one of the signs of its dysgenesis. Such cases need to be treated by the surgical removal of dysgenetic gonads.


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