Biological markers of oxidative stress in exhaled air

AIM: To determine whether cigarette smoking, as a risk factor for CAD, affects oxidative stress.MATERIAL AND METHODS: The study included patients with CAD divided according to smoking status and number of cigarettes smoked during a whole day. In all subjects were examined biological markers of oxidative stress (concentration of oxidants and activity of antioxidant enzymes).RESULTS: The study included 300 patients with CAD, with an average age of 62.97 ± 11.18 years, with a predominance of males. Of the total, 34.0% were active smokers, and 43.0% were non-smokers. The number of the most active smokers smoked cigarettes 1-20/day. In terms of concentration of oxidants (MDA and HP) it has not proved a significant difference between smokers versus non-smokers. Over the activity of antioxidant enzymes (SOD, CAT and GPX) statistically significant difference was found in the activity of GPX and among active smokers with CAD and non-smokers with CAD (p = 0.039).CONCLUSION:Smoking as a risk factor for CAD is closely associated with increased oxidative stress and the number of cigarettes smoked plays an important role in increasing the level of oxidative damage and reduced antioxidant defence.AIM: To determine whether cigarette smoking, as a risk factor for CAD, affects (anti)oxidant status.MATERIAL AND METHODS: The study included patients with CAD, divided according to their smoking status and the number of cigarettes smoked during a day. Biological markers of oxidative stress (concentration of oxidants and activity of antioxidant enzymes) were measured in all subjects.RESULTS: The study included 300 patients with CAD, (average age of 63 ± 11 years), predominantly males. Of the total, 34.0% were active smokers, 23.0% were former smokers, and 43.0% were non-smokers. Most of the active smokers smoked 1-20 cigarettes/day. In terms of concentration of oxidants (MDA and HP) there was not a significant difference between smokers versus non-smokers. As for the activity of antioxidant enzymes (SOD, CAT and GPX), a statistically significant difference was found in the activity of GPX among the active smokers with CAD and the non-smokers with CAD (p = 0.039). CONCLUSION: Smoking as a risk factor for CAD is closely associated with increased oxidative stress, and the number of cigarettes smoked plays an important role in increasing the level of oxidative damage and reducing antioxidant defence.

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Biological Markers of Oxidative Stress in Cardiovascular Diseases: After so Many Studies, What do We Know?

Immunological Investigations ◽

10.1080/08820139.2018.1523925 ◽

2018 ◽

Vol 47 (8) ◽

pp. 823-843 ◽

Cited By ~ 7

Author(s):

Josef Fontana ◽

Michal Zima ◽

Vaclav Vetvicka

Keyword(s):

Oxidative Stress ◽

Cardiovascular Diseases ◽

Biological Markers ◽

Markers Of Oxidative Stress

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Biological markers of oxidative stress: Applications to cardiovascular research and practice

Redox Biology ◽

10.1016/j.redox.2013.07.006 ◽

2013 ◽

Vol 1 (1) ◽

pp. 483-491 ◽

Cited By ~ 355

Author(s):

Edwin Ho ◽

Keyvan Karimi Galougahi ◽

Chia-Chi Liu ◽

Ravi Bhindi ◽

Gemma A. Figtree

Keyword(s):

Oxidative Stress ◽

Biological Markers ◽

Cardiovascular Research ◽

Research And Practice ◽

Markers Of Oxidative Stress

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Faculty Opinions recommendation of Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1071147.524148 ◽

2007 ◽

Author(s):

Andreina Bruno

Keyword(s):

Oxidative Stress ◽

Calorie Restriction ◽

Clinical Findings ◽

Moderate Asthma ◽

Markers Of Oxidative Stress ◽

Overweight Adults

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Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study

Journal of Eating Disorders ◽

10.1186/s40337-021-00408-6 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Alexandra Gaál Kovalčíková ◽

Ľubica Tichá ◽

Katarína Šebeková ◽

Peter Celec ◽

Alžbeta Čagalová ◽

...

Keyword(s):

Oxidative Stress ◽

Anorexia Nervosa ◽

Redox Homeostasis ◽

Oxidative Status ◽

Carbonyl Stress ◽

Healthy Controls ◽

Psychosomatic Disorder ◽

Cross Sectional ◽

Wide Range ◽

Markers Of Oxidative Stress

Abstract Background Anorexia nervosa (AN) is a serious psychosomatic disorder with unclear pathomechanisms. Metabolic dysregulation is associated with disruption of redox homeostasis that might play a pivotal role in the development of AN. The aim of our study was to assess oxidative status and carbonyl stress in plasma, urine and saliva of patients with AN and healthy controls. Methods Plasma, spot urine, and saliva were collected from 111 girls with AN (aged from 10 to 18 years) and from 29 age-matched controls. Markers of oxidative stress and antioxidant status were measured using spectrophotometric and fluorometric methods. Results Plasma advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) were significantly higher in patients with AN than in healthy controls (by 96, and 82%, respectively). Accordingly, urinary concentrations of AOPP and fructosamines and salivary concentrations of AGEs were higher in girls with AN compared with controls (by 250, and 41% in urine; by 92% in saliva, respectively). Concentrations of thiobarbituric acid reactive substances (TBARS) in saliva were 3-times higher in the patients with AN than in the controls. Overall antioxidants were lower in plasma of girls with AN compared to the controls, as shown by total antioxidant capacity and ratio of reduced and oxidized glutathione (by 43, and 31%, respectively). Conclusions This is the first study assessing wide range of markers of oxidative status in plasma, urine and saliva of the patients with AN. We showed that both, higher levels of markers of oxidative stress and lower antioxidants play a role in redox disruption. Restoration of redox homeostasis might be of the clinical relevance

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