Under the excitation of large earthquake, structures enter into high nonlinear stage. Currently, Opensees, Perform-3d and Canny are used as the most popular nonlinear analysis procedures. The fiber model will be introduced firstly and the nonlinear analysis models in Canny are explained in detail. Then Canny2007 is used to conduct nonlinear time history analysis on a heavily damaged frame structure with interlayer in Dujiangyan during Wenchuan Earthquake. Analysis shows that the maximum inter-story drift appears between the interlayer and its upper layer, and the heavy damage agrees well with the results of damage investigation. By comparing the damage extent of frame structures with or without interlayer, it reveals that the seismic performance of RC frame structures without interlayer is obviously better than that of ones with interlayer.