Comparing the patient experience between a novel 360° gamma camera (VERITON-CT) and a conventional dual head gamma camera.

51Cr-bleomycin was used for the scintigraphic detection of tumours and the assessment of the spread of the disease in 20 patients with various malignances: 7 with Hodgkins Lymphoma, 5 with other malignant lymphomas, 4 cases of cervix carcinoma and 4 other tumours. The scintigraphy was performed using a Toshiba GC 401 gamma camera coupled to an MDSI computer Trinary. Active foci were scored using a semiquantitative scale of 0 to 5. Results of these studies were compared with those of tests similarly carried out with 57Co-bleomycin (in 9 of the cases) and 67Ga-citrate (11 cases); they demonstrated that the properties of 51Cr-bleomycin for scintigraphic detection of neoplastic foci are similar to those of 57Co-bleomycin.

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Comparative Chemical, Biological and Clinical Studies of 99mTc-Glucoheptonate and 99mTc-Dimercaptosucci- nate as Used in Renal Scintigraphy

Nuklearmedizin ◽

10.1055/s-0037-1620873 ◽

1979 ◽

Vol 18 (01) ◽

pp. 40-45 ◽

Cited By ~ 1

Author(s):

M. Malešević ◽

Lj. Stefanović ◽

N. Vanlić-Razumenić

Keyword(s):

Clinical Studies ◽

Gamma Camera ◽

Radiochemical Purity ◽

Renal Cortex ◽

Renal Scintigraphy ◽

Time Intervals ◽

Experimental Animals ◽

Dynamic Studies

The renal radiopharmaceutical preparations 99mTc-DMS and 99mTc-GH were examined chemically, biologically and clinically. Both preparations are of high radiochemical purity. The biodistribution of both preparations was examined in experimental animals at different time intervals, from 15 min to 4 hr; the percentage of incorporation of 99mTc-DMS into kidneys is much higher (29.4% to 52.0%) than that of 99mTc-GH (12.80% to 22.20%). Both preparations accumulate to a greater extent in the renal cortex than in the medulla.The most suitable time for renal scintigraphy for "mTc-DMS is 90-150 min while for 99mTc-GH it is 60-90 min. It is concluded that 99mTc-DMS is more suitable for static scintigrams on the scanner and 99mTc-GH for dynamic studies with the gamma camera.

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Quantitative Radioisotope Measurement of Duodenogastric Reflux in Patients with Ulcer or Gastrectomized for Ulcer

Nuklearmedizin ◽

10.1055/s-0038-1624287 ◽

1985 ◽

Vol 24 (03) ◽

pp. 107-110

Author(s):

M. Pääkkönen ◽

S. Aukee ◽

K. Korhonen ◽

A. Pääkkönen ◽

E. Länsimies ◽

...

Keyword(s):

Gamma Camera ◽

Background Activity ◽

Bile Reflux ◽

Duodenogastric Reflux ◽

Upper Limit ◽

Visual Evidence ◽

Biochemical Measurement

SummaryIn this work the duodenogastric reflux was quantified as the amount of radioactivity entering the stomach after an i.v. administration of 99mmTc-HIDA in ulcer patients and in patients who had undergone BI gastrectomy. The results were compared with visual evidence of gastric activity in the gamma camera images and biochemical determination of gastric bile reflux. The method is useful in quantifying the reflux if the activity is above the background activity. It allows the determination of an upper limit for the reflux when the reflux is evident visually. Only two or three images are needed for the quantitation. No correlation was found between biochemical measurement of fasting bile reflux in the stomach and radioisotopic quantification.

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On the Determination of the Resolution Index of a Gamma Camera

Nuklearmedizin ◽

10.1055/s-0038-1624837 ◽

1973 ◽

Vol 12 (04) ◽

pp. 360-366

Author(s):

Barbara Gwiazdowska ◽

H. Mackiewicz ◽

J. Tolwinski

Keyword(s):

Gamma Camera

L’étude tâche d’interpréter les différences des indices de résolution de gamma caméra obtenues expérimentalement et calculées. Les erreurs de mesurage et les conditions de validité des formules utilisées dans les calcules sont discutées. On a pu obtenir un agréement des deux méthodes et une confirmation théorique. On suggert de déterminer quelque condition de mesurage ou de remplacer les méthodes de mesurage par de calcul.

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Dosimetry with 188Re-labelled monoclonal anti-CD66 antibodies

Nuklearmedizin ◽

10.1055/s-0038-1625927 ◽

2006 ◽

Vol 45 (03) ◽

pp. 134-138 ◽

Cited By ~ 6

Author(s):

T. Kull ◽

N. M. Blumstein ◽

D. Bunjes ◽

B. Neumaier ◽

A. K. Buck ◽

...

Keyword(s):

Monoclonal Antibody ◽

Bone Marrow ◽

Gamma Camera ◽

Absorbed Dose ◽

Correlation Coefficients ◽

Residence Times ◽

Reliable Prediction ◽

Red Bone Marrow ◽

Antibody Preparation ◽

Simplified Method

SummaryAim: For the therapeutic application of radiopharmaceuticals the activity is determined on an individual basis. Here we investigated the accuracy for a simplified assessment of the residence times for a 188Re-labelled anti-CD66 monoclonal antibody. Patients, methods: For 49 patients with high risk leukaemia (24 men, 25 women, age: 44 ± 12 years) the residence times were determined for the injected 188Re-labelled anti-CD66 antibodies (1.3 ± 0.4 GBq, 5–7 GBq/mg protein, >95% 188Re bound to the antibody) based on 5 measurements (1.5, 3, 20, 26, and 44 h p.i.) using planar conjugate view gamma camera images (complete method). In a simplified method the residence times were calculated based on a single measurement 3 h p.i. Results: The residence times for kidneys, liver, red bone marrow, spleen and remainder of body for the complete method were 0.4 ± 0.2 h, 1.9 ± 0.8 h, 7.8 ± 2.1 h, 0.6 ± 0.3 h and 8.6 ± 2.1 h, respectively. For all organs a linear correlation exists between the residence times of the complete method and the simplified method with the slopes (correlation coefficients R > 0.89) of 0.89, 0.99, 1.23, 1.13 and 1.09 for kidneys, liver, red bone marrow, spleen and remainder of body, respectively. Conclusion: The proposed approach allows reliable prediction of biokinetics of 188Re-labelled anti-CD66 monoclonal antibody biodistribution with a single study. Efficient pretherapeutic estimation of organ absorbed dose may be possible, provided that a more stable anti-CD66 antibody preparation is available.

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Rapid evaluation of FDG imaging alternatives using head-to-head comparisons of full ring and gamma camera based PET scanners –

Nuklearmedizin ◽

10.1055/s-0038-1625288 ◽

2002 ◽

Vol 41 (05) ◽

pp. 208-213 ◽

Cited By ~ 1

Author(s):

L. M. Haslinghuis-Bajan ◽

L. Hooft ◽

A. van Lingen ◽

M. van Tulder ◽

W. Devillé ◽

...

Keyword(s):

Methodological Quality ◽

Gamma Camera ◽

First Generation ◽

Prospective Evaluation ◽

First Approximation ◽

Variable Head ◽

Malignant Lesions ◽

The Impact ◽

Pet Scanners

SummaryAim: While FDG full ring PET (FRPET) has been gradually accepted in oncology, the role of the cheaper gamma camera based alternatives (GCPET) is less clear. Since technology is evolving rapidly, “tracker trials” would be most helpful to provide a first approximation of the relative merits of these alternatives. As difference in scanner sensitivity is the key variable, head-to-head comparison with FRPET is an attractive study design. This systematic review summarises such studies. Methods: Nine studies were identified until July 1, 2000. Two observers assessed the methodological quality (Cochrane criteria), and extracted data. Results: The studies comprised a variety of tumours and indications. The reported GC- and FRPET agreement for detection of malignant lesions ranged from 55 to 100%, but with methodological limitations (blinding, standardisation, limited patient spectrum). Mean lesion diameter was 2.9 cm (SD 1.8), with only about 20% <1.5 cm. The 3 studies with the highest quality reported concordances of 74-79%, for the studied lesion spectrum. Contrast at GCPET was lower than that of FRPET, contrast and detection agreement were positively related. Logistic regression analysis suggested that pre-test indicators might be used to predict FRPET-GCPET concordance. Conclusion: In spite of methodological limitations, “first generation” GCPET devices detected sufficient FRPET positive lesions to allow prospective evaluation in clinical situations where the impact of FRPET is not confined to detection of small lesions (<1.5 cm). The efficiency of head-to-head comparative studies would benefit from application in a clinically relevant patient spectrum, with proper blinding and standardisation of acquisition procedures.

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Comparison of Quantification Methods of111In-Labelled Platelet Deposition in Peripheral Bypass Grafts

Nuklearmedizin ◽

10.1055/s-0038-1628869 ◽

1987 ◽

Vol 26 (02) ◽

pp. 87-92 ◽

Cited By ~ 3

Author(s):

A. Verbruggen ◽

C. De Bakker ◽

A. Vandecruys ◽

J. Joosten ◽

A. Nevelsteen ◽

...

Keyword(s):

Gamma Camera ◽

Reliable Method ◽

Survival Curve ◽

Region Of Interest ◽

Reference Region ◽

Visual Interpretation ◽

Bypass Grafts ◽

Antithrombotic Drugs ◽

Exponential Regression ◽

Peripheral Bypass

The action of antithrombotic drugs can be evaluated by measuring the deposition of111In-labelled platelets on peripheral bypass grafts several days after injection. This evaluation can be performed qualitatively (visual interpretation on the daily images) or quantitatively. Four different methods which calculate the ratio of platelet uptake with a reference region are compared: two methods use a gamma camera and two a detector. A blood sample or the region under the sternal angle are used as reference. The daily ratio of the counts, recorded by a gamma camera in a region of interest covering the graft, and the blood radioactivity interpolated from a platelet survival curve appears to be the most reliable method. The information of all the ratios can be combined in a single thrombogenicity index which reflects the daily rise of a linear or exponential regression versus time.

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F-18-FDG Positron Imaging in Oncological Patients: Gamma Camera Coincidence Detection versus Dedicated PET

Nuklearmedizin ◽

10.1055/s-0038-1632201 ◽

1999 ◽

Vol 38 (04) ◽

pp. 108-114 ◽

Cited By ~ 3

Author(s):

H.-J. Kaiser ◽

U. Cremerius ◽

O. Sabri ◽

M. Schreckenberger ◽

P. Reinartz ◽

...

Keyword(s):

Attenuation Correction ◽

Spatial Resolution ◽

Gamma Camera ◽

Lesion Detection ◽

Coincidence Detection ◽

System Sensitivity ◽

Oncological Patients ◽

Phantom Studies ◽

Pet System ◽

Dedicated Pet

Summary Aim of the present study was to investigate the feasibility of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) imaging in oncological patients with a dual head gamma camera modified for coincidence detection (MCD). Methods: Phantom studies were done to determine lesion detection at various lesion-to-background ratios, system sensitivity and spatial resolution. Thirty-two patients with suspected or known malignant disease were first studied with a dedicated full-ring PET system (DPET) applying measured attenuation correction and subsequently with an MCD system without attenuation correction. MCD images were first interpreted without knowledge of the DPET findings. In a second reading, MCD and DPET were evaluated simultaneously. Results: The phantom studies revealed a comparable spatial resolution for DPET and MCD (5.9 × 6.3 × 4.2 mm vs. 5.9 × 6.5 × 6.0 mm). System sensitivity of MCD was less compared to DPET (91 cps/Bq/ml/cmF0V vs. 231 cps/ Bq/ml/cmFOv). At a lesion-to-background ratio of 4:1, DPET depicted a minimal phantom lesion of 1.0 cm in diameter, MCD a minimal lesion of 1.6 cm. With DPET, a total of 91 lesions in 27 patients were classified as malignant. MCD without knowledge of DPET results revealed increased FDG uptake in all patients with positive DPET findings. MCD detected 72 out of 91 DPET lesions (79.1 %). With knowledge of the DPET findings, 11 additional lesions were detected (+12%). MCD missed lesions in six patients with relevance for staging in two patients. All lesions with a diameter above 18 mm were detected. Conclusion: MCD FDG imaging yielded results comparable to dedicated PET in most patients. However, a considerable number of small lesions clearly detectable with DPET were not detected by MCD alone. Therefore, MCD cannot yet replace dedicated PET in all oncological FDG studies. Further technical refinement of this new method is needed to improve image quality (e.g. attenuation correction).

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