scholarly journals P.57 Acetylsalicylic Acid Reduces Passive Aortic Wall Stiffness and Cardiac Remodelling in a Mouse Model of Advanced Atherosclerosis

2020 ◽  
Vol 26 (Supplement 1) ◽  
pp. S79
Author(s):  
Lynn Roth ◽  
Wim Martinet ◽  
Guido R.Y. De Meyer
Keyword(s):  
Mouse Model ◽  
Acetylsalicylic Acid ◽  
Aortic Wall ◽  
Cardiac Remodelling ◽  
Wall Stiffness

Increased aortic wall stiffness is predictive of aortic dilation in adult patients following coarctation of the aorta repair

2019 ◽  
Vol 53 ◽  
pp. 15-20
Author(s):  
Abigail Starker ◽  
Benjamin Goot ◽  
Jennifer Gerardin ◽  
Salil Ginde ◽  
Michael G. Earing
Keyword(s):  
Aortic Wall ◽  
Coarctation Of The Aorta ◽  
Adult Patients ◽  
Aortic Dilation ◽  
Wall Stiffness

scholarly journals Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome

2019 ◽  
Vol 11 (490) ◽  
pp. eaat4822 ◽  
Author(s):  
Jennifer Pardo Habashi ◽  
Elena Gallo MacFarlane ◽  
Rustam Bagirzadeh ◽  
Caitlin Bowen ◽  
Nicholas Huso ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Mouse Model ◽  
Marfan Syndrome ◽  
Uterine Contraction ◽  
Aortic Wall ◽  
Erk Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Erk Phosphorylation ◽  
Extracellular Signal ◽  
Erk Kinase

Women with Marfan syndrome (MFS) are at high risk for pregnancy-associated aortic dissection. Pathogenic models that singularly invoke hemodynamic stress are difficult to reconcile with predominant postnatal occurrence of aortic tear, often occurring weeks to months after delivery. In consideration of events that peak at term, are sustained after delivery, and might synergize with previously defined signaling pathways implicated in aneurysm progression, we examined the hormone oxytocin, which initiates uterine contraction and milk letdown for the duration of lactation through phosphorylation of extracellular signal–regulated kinase (ERK). In a mouse model of MFS that shows highly penetrant postnatal aortic dissection, risk was strongly attenuated by preventing lactation or use of an oxytocin receptor antagonist. Survival correlated inversely with the extent of ERK activation in the aortic wall, and strong protection was observed upon attenuation of ERK phosphorylation using an inhibitor of ERK kinase (MEK) or the U.S. Food and Drug Administration–approved medication hydralazine, offering potential therapeutic strategies for pregnancy-associated vascular catastrophe in the setting of MFS.

In vivo angiotensin II receptor blockade and converting enzyme inhibition on canine aortic viscoelasticity

1997 ◽  
Vol 272 (2) ◽  
pp. H859-H868 ◽  
Author(s):  
J. G. Barra ◽  
J. Levenson ◽  
R. L. Armentano ◽  
E. I. Cabrera Fischer ◽  
R. H. Pichel ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Enzyme Inhibition ◽  
Aortic Wall ◽  
Early Stage ◽  
Viscosity Index ◽  
Pressure Curve ◽  
Converting Enzyme ◽  
Angiotensin Ii Receptor ◽  
Wall Stiffness ◽  
Converting Enzyme Inhibition

The influence of the renin-angiotensin system (RAS) on the aortic wall mechanical properties under angiotensin I converting enzyme inhibition (enalaprilat, 0.3 mg/kg iv) or angiotensin II receptor (AT1) blockade (E-3174, 1 mg/kg iv) was examined in eight normotensive and eight renovascular hypertensive conscious dogs. Aortic diameter (D; sonomicrometry)-pressure (P; microtransducer) hysteresis loops during steady state and during rapid distal aortic occlusion allowed (after hysteresis elimination) calculation of the aortic wall viscosity index, the purely elastic P-D relationship, and derivation into compliance-pressure curves. At the early stage ofrenovascular hypertension when activation of RAS is more pronounced, aortic wall stiffness and wall viscosity were increased as compared with normotensive states. Blood pressure remained unchanged in normotensive animals and was reduced during hypertension after antihypertensive treatments. In hypertensive animals, enalaprilat and E-3174 decreased viscosity index and shifted the compliance-pressure curve upward with respect to pretreatment conditions. In normotensive dogs, whereas E-3174 did not change the compliance-pressure curve and viscosity index, enalaprilat increased compliance and reduced viscosity index. We concluded that in normotensive dogs converting enzyme inhibition modifies arterial viscoelastic parameters by angiotensin-independent mechanisms that contribute to the modulation of the buffering function of large arteries.

scholarly journals The role of type I collagen in aortic wall strength with a homotrimeric [α1(I)]3 collagen mouse model

2001 ◽  
Vol 33 (6) ◽  
pp. 1263-1270 ◽  
Author(s):  
Angela G. Vouyouka ◽  
Brent J. Pfeiffer ◽  
Timothy K. Liem ◽  
Timothy A. Taylor ◽  
Junaid Mudaliar ◽  
...  
Keyword(s):  
Mouse Model ◽  
Type I Collagen ◽  
Aortic Wall ◽  
Type I ◽  
Wall Strength

scholarly journals Using MRI to predict future adverse cardiac remodelling in a male mouse model of myocardial infarction

2016 ◽  
Vol 11 ◽  
pp. 29-34 ◽  
Author(s):  
Rachael E. Redgrave ◽  
Simon Tual-Chalot ◽  
Benjamin J. Davison ◽  
Elizabeth Greally ◽  
Mauro Santibanez-Koref ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Mouse Model ◽  
Male Mouse ◽  
Cardiac Remodelling

scholarly journals IMPACT OF TOTAL ARTERIAL COMPLIANCE, ASCENDING AND DESCENDING AORTIC WALL STIFFNESS ON LEFT VENTRICULAR MASS AND GEOMETRY

2014 ◽  
Vol 63 (12) ◽  
pp. A1253
Author(s):  
Payman Zamani ◽  
Scott Akers ◽  
Prithvi Shiva Kumar ◽  
Sanjal Desai ◽  
Shivapriya Peddireddy ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Aortic Wall ◽  
Arterial Compliance ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Total Arterial Compliance ◽  
Wall Stiffness

Interventions affect aortic wall stiffness

The Lancet ◽  
1997 ◽  
Vol 350 (9083) ◽  
pp. 1008
Author(s):  
Eldon D Lehmann ◽  
Gustav G Belz
Keyword(s):  
Aortic Wall ◽  
Wall Stiffness

scholarly journals On the Impact of Vessel Wall Stiffness on Quantitative Flow Dynamics in a Synthetic Model of the Thoracic Aorta

2021 ◽  
Author(s):  
Judith Zimmermann ◽  
Michael Loecher ◽  
Fikunwa Kolawole ◽  
Kathrin Bäumler ◽  
Kyle Gifford ◽  
...  
Keyword(s):  
Thoracic Aorta ◽  
Temporal Resolution ◽  
Aortic Wall ◽  
Predictive Marker ◽  
Flow Dynamics ◽  
4D Flow ◽  
Cross Sectional ◽  
Wall Stiffness ◽  
The Impact

Abstract Aortic wall stiffening is a predictive marker for morbidity in hypertensive patients. Arterial pulse wave velocity (PWV) correlates with the level of stiffness and can be derived using non-invasive 4D-flow magnetic resonance imaging (MRI). The objectives of this study were twofold: to develop subject-specific thoracic aorta models embedded into an MRI-compatible flow circuit operating under controlled physiological conditions; and to evaluate how a range of aortic wall stiffness impacts 4D-flow-based quantification of hemodynamics, particularly PWV. Three aorta models were 3D-printed using a novel photopolymer material at two compliant and one nearly rigid stiffnesses and characterized via tensile testing. Luminal pressure and 4D-flow MRI data were acquired for each model and cross-sectional net flow, peak velocities, and PWV were measured. In addition, the confounding effect of temporal resolution on all metrics was evaluated. Stiffer models resulted in increased systolic pressures (112, 116, and 133 mmHg), variations in velocity patterns, and increased peak velocities, peak flow rate, and PWV (5.8 to 7.3 m/s). Lower temporal resolution (20 ms down to 62.5 ms per image frame) impacted estimates of peak velocity and PWV (7.31 down to 4.77 m/s). Using compliant aorta models is essential to produce realistic flow dynamics and conditions that recapitulated in vivo hemodynamics.

Sign in / Sign up

Export Citation Format

Share Document