scholarly journals Research on Influence of Clopidogrel on Life Quality in Patients with Transient Ischemic Attack and its Influencing Factors

2018 ◽  
Vol 1 (1) ◽  
pp. 16
Author(s):  
Lanbo Chen ◽  
Xiaohong Gu ◽  
Bo Dong
Keyword(s):  
Quality Of Life ◽  
Influencing Factors ◽  
Transient Ischemic Attack ◽  
Life Quality ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Ischemic Attack ◽  
Aspirin Group

Purpose: To analyze the basic situation and health related quality of life (HRQOL) results of patients with transient ischemic attack (TIA), and to study the influencing factors of health related quality of life in patients receiving clopidogrel. Method: Divide the TIA patients into clopidogrel group, aspirin group and untreated group. Measure HRQOL scores of TIA patients using the short form 36 questionnaire (SF-36) scale and analyze influencing factors of HRQOL with one-way ANOVA and multivariate stepwise linear regression statistical methods. Results: The differences of HRQOL scores among three groups are of statistical significance (F = 4.29, P = 0.00). There is no difference in HRQOL score between clopidogrel group and aspirin group (t = 5.35, P = 0.00), but HRQOL scores of clopidogrel group and aspirin group are higher than those of the untreated group (t = 6.14, P = 0.00; t = 5.16, P = 0.00). The HRQOL scores of clopidogrel group are positively correlated with diet, exercise, gender and family harmony (P < 0.05), but negatively correlated with diabetes, hypertension, smoking, drinking, hyperlipidemia, age, career and ABCD2 score (P < 0.05). Conclusion: TIA patients who received secondary prevention with clopidogrel and aspirin show better life quality results than those who did not. There were many factors influencing clopidogrel's treatment effect. Paying attention to middle-aged and elderly, the obese, mental workers and female TIA patients, teach TIA patients to quit smoking, drinking and eating low-salt and low-fat food, actively treating their hypertension, hyperlipidemia and diabetes and laying emphasis on psychological counseling and exercise can significantly improve the treatment effect of clopidogrel. 

scholarly journals Utility of the Hospital Frailty Risk Score Derived From Administrative Data and the Association With Stroke Outcomes

Stroke ◽  
2021 ◽  
Author(s):  
Monique F. Kilkenny ◽  
Hoang T. Phan ◽  
Richard I. Lindley ◽  
Joosup Kim ◽  
Derrick Lopez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Length Of Stay ◽  
Risk Score ◽  
Transient Ischemic Attack ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Ischemic Attack ◽  
Frailty Score

Background and Purpose: Conditions associated with frailty are common in people experiencing stroke and may explain differences in outcomes. We assessed associations between a published, generic frailty risk score, derived from administrative data, and patient outcomes following stroke/transient ischemic attack; and its accuracy for stroke in predicting mortality compared with other measures of clinical status using coded data. Methods: Patient-level data from the Australian Stroke Clinical Registry (2009–2013) were linked with hospital admissions data. We used International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes with a 5-year look-back period to calculate the Hospital Frailty Risk Score (termed Frailty Score hereafter) and summarized results into 4 groups: no-risk (0), low-risk (1–5), intermediate-risk (5–15), and high-risk (>15). Multilevel models, accounting for hospital clustering, were used to assess associations between the Frailty Score and outcomes, including mortality (Cox regression) and readmissions up to 90 days, prolonged acute length of stay (>20 days; logistic regression), and health-related quality of life at 90 to 180 days (quantile regression). The performance of the Frailty Score was then compared with the Charlson and Elixhauser Indices using multiple tests (eg, C statistics) for predicting 30-day mortality. Models were adjusted for covariates including sociodemographics and stroke-related factors. Results: Among 15 468 adult patients, 15% died ≤90 days. The frailty scores were 9% no risk; 23% low, 45% intermediate, and 22% high. A 1-point increase in frailty (continuous variable) was associated with greater length of stay (OR adjusted , 1.05 [95% CI, 1.04 to 1.06), 90-day mortality (HR adjusted , 1.04 [95% CI, 1.03 to 1.05]), readmissions (OR adjusted , 1.02 [95% CI, 1.02 to 1.03]; and worse health-related quality of life (median difference, −0.010 [95% CI −0.012 to −0.010]). Adjusting for the Frailty Score provided a slightly better explanation of 30-day mortality (eg, larger C statistics) compared with other indices. Conclusions: Greater frailty was associated with worse outcomes following stroke/transient ischemic attack. The Frailty Score provides equivalent precision compared with the Charlson and Elixhauser indices for assessing risk-adjusted outcomes following stroke/transient ischemic attack.

Health-Related Quality of Life and Fatigue After Transient Ischemic Attack and Minor Stroke

2019 ◽  
Vol 28 (2) ◽  
pp. 276-284 ◽  
Author(s):  
José M. Ramírez-Moreno ◽  
Pedro Muñoz-Vega ◽  
Sandra Bartolomé Alberca ◽  
Diego Peral-Pacheco
Keyword(s):  
Quality Of Life ◽  
Transient Ischemic Attack ◽  
Minor Stroke ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Ischemic Attack

Health related quality of life of rosacea patients in China assessed by DLQI and willingness to pay: Cross-Sectional Questionnaire Study (Preprint)

2020 ◽  
Author(s):  
Yaqun Huang ◽  
Sha Yan ◽  
Hongfu Xie ◽  
Ben Wang ◽  
Zhixiang Zhao ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Willingness To Pay ◽  
Disease Duration ◽  
Life Quality ◽  
Cross Sectional Study ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related

BACKGROUND Rosacea is a chronic inflammatory dermatosis with facial skin involved, leading to physical and emotional problems, which greatly affected quality of life (QoL) of patients. Dermatology Life Quality Index (DLQI) and willingness to pay (WTP) are well-established instruments assessing the health-related quality of life (HRQoL), while very few studies have been focused on this topic about rosacea in China. OBJECTIVE To investigate HRQoL in Chinese rosacea patients assessed by DLQI and WTP and investigate potential predictors for patients with HRQoL severely affected. METHODS This cross-sectional study was conducted on 973 patients with rosacea. Sociodemographic data, clinical features and DLQI were collected, and WTP was assessed by three standardized items. Multivariable logistic analysis was performed to investigate independent factors influencing QoL. RESULTS 921 questionnaires were accomplished by participants. The mean DLQI score was 11.6 (median 11). Patients were willing to pay an average of $1050.2 or € 896.2 (median $431.4 or € 368.1) for complete cure. 33.3% would like to pay more than 20% of their monthly income to achieve sustainable control. There were positive correlations between WTP with DLQI (P < .05). DLQI could be independently impacted by age (21-30 and 31-40, OR = 3.242 and 3.617, respectively), the occupational requirement of appearance (high, OR = 4.410), disease duration (< 2 years, OR = 1.582), oedema (OR = 1.844) and severity of flushing, burning, stinging and pruritus (severe, OR = 2.003, 1.981, 2.491, 2.249, respectively). There were no significant associations between WTP and most of the clinical factors. CONCLUSIONS The QoL was negatively affected and should not be ignored among rosacea patients in China. Patients aged 21-40y, having occupational requirement of appearance, with the disease duration less than 2 years, and suffering severe flushing and related symptoms were more likely to have severe or very severe limitation of QoL.

Health-related quality of life and its influencing factors in individuals with high cardiovascular disease risk: a cross-sectional study based on EQ-5D utility scores in Inner Mongolia, China

2021 ◽  
Author(s):  
Ning Cao ◽  
Yunfeng Xi ◽  
Yumin Gao ◽  
Hailing Li ◽  
Yanchao Liu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
High Risk ◽  
Influencing Factors ◽  
Inner Mongolia ◽  
Health Related Quality ◽  
Tobit Regression ◽  
Cvd Risk ◽  
Related Quality ◽  
Health Related

Abstract Background The high risk of cardiovascular disease (CVD) being associated with impaired Health-related quality of life (HRQoL). However, few studies have assessed the HRQoL of individuals with a high risk of CVD in Inner Mongolia, or even in China. We aimed to assess health-related quality of life (HRQoL) among individuals in Inner Mongolia with a high risk of CVD and its risk factors, to provide a reference to improve HRQoL in individuals with high CVD risk. Methods From 2015 to 2017, residents of six villages or communities in Inner Mongolia, selected using a multi-stage stratified cluster random sampling method, were invited to complete a questionnaire and undergo physical examination and laboratory testing. We selected participants whose predicted 10-year risk for CVD exceeded 10% as those with high CVD risk. HRQoL in individuals with high CVD risk was investigated based on the EuroQol-5 Dimension (EQ-5D) scale. The Chinese utility value integral system was used to calculate EQ-5D utility scores, and the Tobit regression model were used to analyze the influencing factors of HRQoL among individuals with high CVD risk. Results Of 13,359 participants with high CVD risk, 65.63% reported no problems in any of the five dimensions; the most frequently reported difficulty was pain/discomfort. The mean utility score was 1.000 (0.869, 1.000). Tobit regression analysis showed that sex, age, education level, residence area, household income, physical activity, hypertension, and dyslipidemia were influencing factors of HRQoL. Conclusion We found that female sex, older age, living in an urban area, lower education level, lower household income, and lower physical activity levels were associated with reduced HRQoL. People with a high risk of CVD should maintain their blood glucose and lipid levels within the normal range.

scholarly journals Dermatology life quality index in psoriasis patients attending a tertiary care hospital: a study from North India

2020 ◽  
Vol 8 (9) ◽  
pp. 3277
Author(s):  
Faizan Younus Shah ◽  
Ifrah Shafat Kitab ◽  
Aaqib Aslam Shah ◽  
Faisal Younis Shah ◽  
Mohd Younus Shah ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Severe Disease ◽  
Life Quality ◽  
Health Related Quality ◽  
Disease Group ◽  
Moderate Disease ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Background: Psoriasis affects nearly 1% of the world population. It can be a source of significant morbidity and psychological stress to the patient but is not lethal under ordinary circumstances. Patients suffering from the disease feel a lack of empathy on part of care-givers, family members, healthcare professionals as well as society in general. Dermatology life quality index (DLQI) is a questionnaire-based assessment of health related quality of life in patients suffering from skin disorders and has been seen to correlate well with the impact of the disease on a patient. This study was done to understand the impact of psoriasis on the overall well-being of patients using DLQI as the tool of assessment.Methods: The study included 40 cases of psoriasis that were assessed for the severity of the disease based on percentage body surface area involvement. The impact of disease severity and other factors on the quality of life of the patient was assessed using DLQI.Results: Out of 35 patients with BSA involvement <50% (mild and moderate disease), 28.6% (n=10/35) showed a very large or extremely large effect on the quality of life while no patient with a BSA involvement >50% (severe and very severe disease) reported the same. A small, moderate or no effect on the DLQI was seen in 71.4% (n=25/35) of cases from the mild and moderate disease group while 100% (n=5/5) of cases from severe and very severe disease group reported a similar effect. Thus, DLQI was not directly related to the extent of BSA involvement and was dependent on other factors as well.Conclusion: Age had a correlation with the effect of the disease on the quality of life of psoriasis cases. Patients who were younger were more likely to report stress and anxiety related to the recurrences seen with the disease. Patients with lesions on sites that are socially exposed like face, hands, scalp, etc. were more likely to feel embarrassed about their condition. Younger age, female gender, lesions on exposed sites and recently diagnosed patients (<12 months) were factors which had a significant impact on the health-related quality of life of patients. The severity of disease and extent of involvement were not always directly related to extent of impact on the quality of life.

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