In vitro Bioactivity Assessment of Novel Composites Based on Calcium Aluminate Cement

Calcium aluminate cement (CAC) is a penitential candidate for bone replacements with good bioactivity but relative lower strength. In this study, biodegradable PGA fiber was incorporated into the CAC paste in order to improve the strength of the material. And MC3T3 cells were seeded on the surface of CAC and CAC/fiber to study their in vitro biocompatibility. The results indicate that the PGA fiber can improve the compressive strength of CAC without changing the crystalline phases and micromorphology. Calcium aluminate oxide hydrate, katoite and Gibbsite crystals were detected by XRD. Plate-like crystals can be observed under FESEM. The MC3T3 cells were attached well on both CAC and CAC/fiber composite, indicating their good in vitro biocompatibility. In summary, fiber reinforcement can be an effective way to improve the properties of calcium aluminate cement for orthopaedic application.

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Effects of a novel calcium aluminate cement on the early events of the progression of osteogenic cell cultures

Brazilian Dental Journal ◽

10.1590/s0103-64402011000200002 ◽

2011 ◽

Vol 22 (2) ◽

pp. 99-104 ◽

Cited By ~ 24

Author(s):

Larissa Moreira Spinola de Castro-Raucci ◽

Ivone Regina de Oliveira ◽

Lucas Novaes Teixeira ◽

Adalberto Luiz Rosa ◽

Paulo Tambasco de Oliveira ◽

...

Keyword(s):

Cell Cultures ◽

Calcium Aluminate ◽

Experimental Studies ◽

Cell Number ◽

Calcium Aluminate Cement ◽

Total Protein Content ◽

Osteogenic Cell ◽

Calvarial Bone ◽

Aluminate Cement

The present study evaluated the progression of osteogenic cell cultures exposed to a novel calcium aluminate cement (CAC+) in comparison with the gold standard mineral trioxide aggregate (MTA). Cells were enzimatically isolated from newborn rat calvarial bone, plated on glass coverslips containing either CAC+ or a control MTA samples in the center, and grown under standard osteogenic conditions. Over the 10-day culture period, roundening of sample edges was clearly noticed only for MTA group. Although both cements supported osteogenic cell adhesion, spreading, and proliferation, CAC+-exposed cultures showed significantly higher values in terms of total cell number at days 3 and 7, and total protein content and alkaline phosphatase activity at day 10. The present in vitro results indicate that the exposure to CAC+ supports a higher differentiation of osteogenic cells compared with the ones exposed to MTA. Further experimental studies should consider CAC+ as a potential alternative to MTA when the repair of mineralized tissues is one of the desired outcomes in endodontic therapy.

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Calcium chloride-enriched calcium aluminate cement promotes in vitro osteogenesis

International Endodontic Journal ◽

10.1111/iej.12883 ◽

2018 ◽

Vol 51 (6) ◽

pp. 674-683 ◽

Cited By ~ 3

Author(s):

L. M. S. Castro-Raucci ◽

L. N. Teixeira ◽

A. F. S. Barbosa ◽

R. R. Fernandes ◽

W. Raucci-Neto ◽

...

Keyword(s):

Calcium Chloride ◽

Calcium Aluminate ◽

Calcium Aluminate Cement ◽

Aluminate Cement

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Influence of Tricalcium Aluminate Phase on In Vitro Biocompatibility and Bioactivity of Calcium Aluminate Bone Cement

Journal of Materials Research ◽

10.1557/jmr.2004.0139 ◽

2004 ◽

Vol 19 (4) ◽

pp. 1062-1067 ◽

Cited By ~ 12

Author(s):

S.H. Oh ◽

R. Finones ◽

S. Jin ◽

S.Y. Choi ◽

K.N. Kim

Keyword(s):

Bone Cement ◽

Calcium Aluminate ◽

Setting Time ◽

Simulated Body Fluid Solution ◽

Compound Layer ◽

Calcium Aluminate Cement ◽

In Vitro Biocompatibility ◽

Tricalcium Aluminate ◽

Aluminate Cement

The influence of tricalcium aluminate (3CaO·Al2O3) phase doping on in vitro biocompatibility and bioactivity of calcium aluminate (CaO·Al2O3) based bone cement has been investigated. It is demonstrated that the presence of approximately 25% tricalcium aluminate in the bone cement remarkably improves the bioactivity, yet still retains desirable mechanical strength and biocompatibility. An intermediary compound layer such as Ca3Al2(OH)12 was formed on the surface of the doped sample onto which hydroxyapatite (HAp) began to form soon, after only 2 days of immersion in a simulated body fluid solution. This is about seven-fold acceleration in the HAp formation over undoped calcium aluminate cement on which it took approximately15 days to nucleate the HAp phase. The depth of the HAp-containing layer after60 days of soaking was as much as 85 μm, about an order of magnitude more than the undoped calcium aluminate cement. The dramatically accelerated nucleation and growth of hydroxyapatite caused by the presence of tricalcium aluminate is attributed to the occurrence of intermediate layer materials such as Ca3Al2(OH)12, which most likely acts as the nuclei for HAp formation. This doped bone cement can be useful for injectable orthopedic applications, as the setting time for hardening has also been significantly reduced (by a factor of at least 4) to a practical regime of tens of minutes.

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Physicochemical, Mineralogical, and Mechanical Properties of Calcium Aluminate Cement Concrete Exposed to Elevated Temperatures

Materials ◽

10.3390/ma14143855 ◽

2021 ◽

Vol 14 (14) ◽

pp. 3855

Author(s):

Amirmohamad Abolhasani ◽

Bijan Samali ◽

Fatemeh Aslani

Keyword(s):

Temperature Rise ◽

Calcium Aluminate ◽

Elevated Temperatures ◽

Ultrasonic Pulse Velocity ◽

Pulse Velocity ◽

Calcium Aluminate Cement ◽

Cement Concrete ◽

Sem Images ◽

Strength Deterioration ◽

Aluminate Cement

One commonly used cement type for thermal applications is CAC containing 38–40% alumina, although the postheated behavior of this cement subjected to elevated temperature has not been studied yet. Here, through extensive experimentation, the postheated mineralogical and physicochemical features of calcium aluminate cement concrete (CACC) were examined via DTA/TGA, X-ray diffraction (XRD), and scanning electron microscopy (SEM) imaging and the variation in the concrete physical features and the compressive strength deterioration with temperature rise were examined through ultrasonic pulse velocity (UPV) values. In addition, other mechanical features that were addressed were the residual tensile strength and elastic modulus. According to the XRD test results, with the temperature rise, the dehydration of the C3AH6 structure occurred, which, in turn, led to the crystallization of the monocalcium dialuminate (CA2) and alumina (Al2O3) structures. The SEM images indicated specific variations in morphology that corresponded to concrete deterioration due to heat.

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