scholarly journals THORAX-ABDOMINAL VAGUS NERVES IN FETUSES. Nervios vagos toraco-abdominales en fetos

2016 ◽  
Vol 7 (3) ◽  
pp. 145-152
Author(s):  
Susana N Biasutto ◽  
Gabriel A F Ceccón ◽  
Matías De la Rosa ◽  
Paulina A Bortolín
Keyword(s):  
Vagus Nerve ◽  
Surgical Procedures ◽  
Carotid Arteries ◽  
Clinical Aspects ◽  
Esophageal Hiatus ◽  
Specific Information ◽  
Vagus Nerves ◽  
Clinical Procedures ◽  
Lower Neck ◽  
Upper Third

Los nervios vagos han sido exhaustivamente estudiados en los adultos pero no en los niños, y mayormente en el trayecto intracraneal, más que en la periferia. El objetivo de este estudio fue proveer información más específica sobre los nervios vagos toraco-abdominales, describirlos en fetos y asociarlos con la rotación gástrica, de modo que pueda ser aplicada a procedimientos clínicos, reduciendo la morbilidad. Se disecaron treinta fetos entre 12 y 23 semanas de gestación, mayormente varones (87%), desde la parte inferior del cuello hasta el cardias, identificando los troncos y ramas de los nervios vagos. Los nervios fueron descriptos en su ingreso en el tórax en relación con las arterias carótidas, en su posición en el tercio superior del esófago asociados con el origen de las ramas cardíacas y pulmonares, en el tercio inferior del esófago con muchas variaciones en su distribución, a nivel diafragmático en el hiato esofágico y, finalmente, en relación con la posición gástrica. La discusión involucró descripciones hechas por diferentes autores incluyendo algunos estudios recientes que proporcionan resultados electrofisio-lógicos y consideraciones de aspectos clínicos, principalmente representados por procedimientos quirúrgicos y su morbilidad, ambos asociados con la lesión de los nervios vagos. Vagus nerves have been extensively studied in adults but not in fetuses, and mostly in the intracranial pathway than the peripheral one. The objective of this study was to provide more specific information on the thorax-abdominal vagus nerves, to describe them in fetuses and to associate them with the gastric rotation, so it could be applied to clinical procedures, reducing morbidity. Thirty fetuses between 12 to 23 weeks of gestation, mainly male (87%), were dissected from the lower neck to the cardias, identifying vagus nerve trunks and braches. Vagus nerves were described at the entrance in the thorax in relation with the carotid arteries, in their position at the upper third of the esophagus associated with the origin of cardiac and pulmonary branches, in the lower third of the esophagus with many variations in their distribution, at the diaphragmatic level in the esophageal hiatus and, finally, in relation with the gastric position. The discussion involved descriptions made by different authors including some recent studies providing electrophysiological results and considerations on clinical aspects, mainly represented by surgical procedures and their morbidity associated, both to vagus nerve injury.

Endings of the vagus nerve fibers in the mammalian heart

1927 ◽  
Vol 23 (6-7) ◽  
pp. 622-623
Author(s):  
B. I. Lavrent'ev
Keyword(s):  
Methylene Blue ◽  
Vagus Nerve ◽  
Nerve Fibers ◽  
Nerve Cells ◽  
Vagus Nerves ◽  
Mammalian Heart ◽  
Cardiac Ganglia ◽  
Important Study ◽  
Spiral Fibers

In 1893, Prof. V.V. Nikolaev, having cut vagus nerves of a frog, saw under a microscope degeneration of so-called spiral fibers and pericellular apparatuses on nerve cells of intracardiac nodes. Later these observations were thoroughly verified by Prof. D.V. Polumordvinov and fully confirmed by him. I had a chance to look through amazing by technique preparations of the late Prof. Polumordvinov, obtained by methylene blue method, on which decay of pericellular apparatuses in cardiac ganglia of a frog was absolutely clearly visible. D. V-ch, who died untimely in 1919, unfortunately, did not have time to publish in detail his important study; the manuscript and drawings of his work also remained undiscovered.

scholarly journals THE INFLUENCE OF THE VAGUS NERVES UPON CONDUCTION BETWEEN AURICLES AND VENTRICLES IN THE DOG DURING AURICULAR FIBRILLATION

1916 ◽  
Vol 24 (5) ◽  
pp. 605-619 ◽  
Author(s):  
G. Canby Robinson
Keyword(s):  
Vagus Nerve ◽  
Vagus Nerves ◽  
The Right ◽  
Left Vagus ◽  
Stimulation Of

The experiments that have been reported indicate that stimulation of either the right vagus or the left vagus nerve is equally effectual in blocking impulses from the auricles to the ventricles when auricular fibrillation is present. Stimulation of the left vagus nerve is as effectual in blocking impulses from the normally beating auricles as from the auricles when in a state of fibrillation, and the type of auricular activity has apparently no influence on the effect which stimulation of the left vagus has on auriculoventricular conduction.

Aortic nerve-activated cardioinhibitory neurons and interneurons

1975 ◽  
Vol 229 (3) ◽  
pp. 783-789 ◽  
Author(s):  
J Schwaber ◽  
N Schneiderman
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Baroreceptor Reflex ◽  
Motor Nucleus ◽  
Vagus Nerves ◽  
Antidromic Activation ◽  
Medial Nucleus ◽  
Aortic Nerve ◽  
Dorsal Motor Nucleus ◽  
Stimulation Of

Unit activity evoked by electrical stimulation of the aortic and vagus nerves was recorded in the dorsal motor nucleus and nucleus solitarius of unanesthetized rabbits. Cardioinhibitory cells which showed antidromic activation to stimulation of the vagus nerve and synaptic activation to stimulation of the aortic nerve were localized in lateral dorsal motor nucleus 0.5-0.8 mm anterior of the obex. Additionally, units were found that appeared to be interneurons in the medullary pathway subserving baroreceptor reflex effects on cardioinhibitory neurons. These cells were activated by aortic, and usually vagus, nerve stimulation, appeared to be polysynaptically activated, and were located in medial nucleus solitarius rostral to the obex. Neurons reflecting a cardiac rhythm but not activated by aortic nerve stimulation were also observed.

Pancreatic bicarbonate response to HCl before and after cutting the extrinsic nerves of the pancreas in dogs

1988 ◽  
Vol 254 (3) ◽  
pp. G436-G443
Author(s):  
W. Niebel ◽  
C. Beglinger ◽  
M. V. Singer
Keyword(s):  
Surgical Procedures ◽  
Plasma Levels ◽  
Truncal Vagotomy ◽  
Vagus Nerves ◽  
Splanchnic Nerves ◽  
Before And After ◽  
Pancreatic Fistulas ◽  
Bicarbonate Output ◽  
Intravenous Atropine ◽  
Extrinsic Nerves

In two sets of dogs with gastric and pancreatic fistulas, we studied the effect of atropine on pancreatic bicarbonate output and release of secretin in response to intraduodenal HCl before and after stepwise removal of the extrinsic nerves of the pancreas, i.e., celiac and superior mesenteric ganglionectomy alone or truncal vagotomy alone and truncal vagotomy plus celiac and superior mesenteric ganglionectomy. Ganglionectomy alone did not alter the incremental bicarbonate response to HCl. Truncal vagotomy alone significantly (P less than 0.05) decreased the incremental bicarbonate response to low (1.5 and 3 mmol/h) but not high (6 to 24 mmol/h) loads of HCl. Additional ganglionectomy restored the bicarbonate response to prevagotomy levels. With the extrinsic nerves intact and after ganglionectomy, but not after truncal vagotomy and truncal vagotomy plus ganglionectomy, intravenous atropine (14 nmol.kg-1.h-1) significantly reduced the incremental bicarbonate response to low (1.5 and 3 mmol/h) but not high loads of HCl. Neither the different surgical procedures nor atropine significantly altered plasma levels of secretin basally and in response to intestinal HCl. We conclude that 1) cholinergic fibers within the vagus nerves but not the splanchnic nerves are important mediators of the pancreatic bicarbonate response to low loads of HCl and 2) release of secretin by intestinal HCl is not under cholinergic and splanchnic control.

Neurosarcoidosis Directly Involving the Cervical Vagus Nerve

2020 ◽  
pp. 000348942094254
Author(s):  
Jason R. Crossley ◽  
Nathan Aminpour ◽  
Jonathan P. Giurintano ◽  
Ann K. Jay ◽  
Brent T. Harris ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Vocal Fold ◽  
Granulomatous Inflammation ◽  
Nerve Biopsy ◽  
Jugular Foramen ◽  
Vagus Nerves ◽  
Vocal Fold Paresis ◽  
Nerve Tumor ◽  
Left Recurrent Laryngeal Nerve ◽  
Cranial Neuropathies

Objectives: To present a novel location in which neurosarcoidomatous inflammation is identified and its accompanying presentation. Methods: The authors present a case of bilateral vocal fold paresis associated with non-caseating granulomatous inflammation of the cervical and intra-axial portions of the vagus nerve masquerading as a cranial nerve tumor. Results: Examination revealed bilateral vocal fold paresis and asymmetric palate elevation. MRI demonstrated enhancing bilateral jugular foramen masses, and neck ultrasound demonstrated bilateral thickened appearance of the vagus nerves. Vagus nerve biopsy demonstrated non-caseating granulomas. Conclusions: Neurosarcoidosis may contribute to variable cranial neuropathies. Vocal fold paresis is usually thought to arise from mediastinal compression of the left recurrent laryngeal nerve. Rarely, though, lesions may arise in other parts of the vagus nerve. Failure of response to steroids does not rule out the diagnosis, making tissue diagnosis important in some cases.

Both CCK-A and CCK-B/gastrin receptors are present on rabbit vagus nerve

1992 ◽  
Vol 263 (3) ◽  
pp. R591-R595 ◽  
Author(s):  
C. W. Lin ◽  
T. R. Miller
Keyword(s):  
Vagus Nerve ◽  
Receptor Site ◽  
Vagal Afferents ◽  
Scatchard Analysis ◽  
Vagus Nerves ◽  
Binding Studies ◽  
Cck Receptors ◽  
High Affinity ◽  
Selective Agonists ◽  
Subtype Selective

Cholecystokinin (CCK) receptors on vagal afferents have been implicated in many of the actions of the brain-gut peptide CCK, including satiety. Autoradiographic studies in rats have demonstrated the presence of CCK-A-type receptors on vagus nerves. However, direct and detailed characterization of this important CCK receptor site has never been reported with membrane-binding techniques. Using 125I-Bolt-on-Hunter-CCK octapeptide (125I-BH-CCK-8) and the recently discovered selective agonists and antagonists of CCK receptors, we have delineated the properties of CCK receptors on rabbit vagus nerve. 125I-BH-CCK-8 binding sites appeared to be homogeneous by the Scatchard analysis, with a dissociation constant of 0.14 nM and a maximum binding of 72 fmol/mg protein. However, competition studies using selective CCK ligands showed that the vagal CCK receptors are heterogeneous. A71378, a selective CCK-A agonist, showed biphasic displacement curves, with the high-affinity portion (less than 10 nM) accounting for approximately 60% and the low-affinity portion for approximately 40%. Competitive binding studies using A63387, a selective CCK-B/gastrin receptor agonist, also showed biphasic displacement curves, with the high-affinity portion (less than 30 nM) at approximately 40% and the low-affinity portion at approximately 60%. Under conditions which selectively examined vagal CCK-A or CCK-B/gastrin receptors, we demonstrated that a number of CCK subtype selective agonists and antagonists possessed similar affinities for the vagal CCK-A and -B/gastrin receptors as those found on the guinea pig pancreas (CCK-A) and cerebral cortex (CCK-B), respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Right atrium mediates a vasomotor reflex

1981 ◽  
Vol 241 (3) ◽  
pp. R163-R166
Author(s):  
R. F. Munzner ◽  
D. G. Ward ◽  
D. S. Gann
Keyword(s):  
Right Atrium ◽  
Carotid Arteries ◽  
Right Atrial ◽  
Vagus Nerves ◽  
Vascular Responses ◽  
The Right ◽  
Vasomotor Reflex ◽  
Atrial Receptors ◽  
Volume Pulsation

To examine the role of right atrial receptors in mediating reflex vascular responses we measured, in cats anesthetized with chloralose/urethan, changes in mean arterial pressure (MAP) in response to volume pulsation of the right atrium (+/- 1 ml, 1 Hz). Changes in MAP were measured 1) with pressure in the carotid arteries normal and vagus nerves intact: right atrial pulsation led to a very small and transient fall in MAP; 2) with pressure in the carotid arteries at 75 mmHg and the vagus nerves intact: right atrial pulsation led to a larger and sustained fall in MAP; 3) with pressure in the carotid arteries at 75 mmHg and the vagus nerves cooled or sectioned bilaterally: right atrial pulsation of the right atrium led only to a very small and transient fall in MAP. These data suggest strongly that signals from right atrial receptors traveling in the vagus nerves mediate a reflex change in MAP that is normally masked by signals from carotid receptors.

scholarly journals Human organ donor-derived vagus nerve biopsies allow for well-preserved ultrastructure and high-resolution mapping of myelinated and unmyelinated fibers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Leif A. Havton ◽  
Natalia P. Biscola ◽  
Esther Stern ◽  
Plamen V. Mihaylov ◽  
Chandrashekhar A. Kubal ◽  
...  
Keyword(s):  
High Resolution ◽  
Vagus Nerve ◽  
Functional Organization ◽  
Adjunctive Treatment ◽  
Vagus Nerves ◽  
Human Organ ◽  
Ultrastructural Studies ◽  
Unmyelinated Fibers ◽  
Unmyelinated Axons ◽  
Myelinated And Unmyelinated Fibers

AbstractThe vagus nerve provides motor, sensory, and autonomic innervation of multiple organs, and electrical vagus nerve stimulation (VNS) provides an adjunctive treatment option for e.g. medication-refractory epilepsy and treatment-resistant depression. The mechanisms of action for VNS are not known, and high-resolution anatomical mapping of the human vagus nerve is needed to better understand its functional organization. Electron microscopy (EM) is required for the detection of both myelinated and unmyelinated axons, but access to well-preserved human vagus nerves for ultrastructural studies is sparse. Intact human vagus nerve samples were procured intra-operatively from deceased organ donors, and tissues were immediately immersion fixed and processed for EM. Ultrastructural studies of cervical and sub-diaphragmatic vagus nerve segments showed excellent preservation of the lamellated wall of myelin sheaths, and the axolemma of myelinated and unmyelinated fibers were intact. Microtubules, neurofilaments, and mitochondria were readily identified in the axoplasm, and the ultrastructural integrity of Schwann cell nuclei, Remak bundles, and basal lamina was also well preserved. Digital segmentation of myelinated and unmyelinated axons allowed for determination of fiber size and myelination. We propose a novel source of human vagus nerve tissues for detailed ultrastructural studies and mapping to support efforts to refine neuromodulation strategies, including VNS.

scholarly journals Further research in the area of the central endings of the X-th pair of cranial nerves

2020 ◽  
Vol VI (2) ◽  
pp. 155-168
Author(s):  
V. P. Osipov
Keyword(s):  
Vagus Nerve ◽  
Medulla Oblongata ◽  
Cranial Nerves ◽  
Vagus Nerves ◽  
The Way

In 1896, I published the research of the central endings of the vagus nerve. Continuing with the study in the indicated direction, I received, in addition to confirming the results of the first study, some results that were not devoid of interest; These results were not new for me, because on the microscopic preparations that served as materials for the first work, there are corresponding changes in the area of ​​the central endings of the vagus nerve; on the contrary, further research was undertaken by me with the aim of checking the constancy of some changes in the medulla oblongata, advancing every step of the way behind the overwhelming vagus nerves. Thus, the present work is, as it were, an addition to the first one, containing the results of research that were not included in the first work.

Optical Approaches to Functional Organization of Glossopharyngeal and Vagal Motor Nuclei in the Embryonic Chick Hindbrain

2002 ◽  
Vol 88 (1) ◽  
pp. 383-393 ◽  
Author(s):  
Katsushige Sato ◽  
Hiraku Mochida ◽  
Itaru Yazawa ◽  
Shinichi Sasaki ◽  
Yoko Momose-Sato
Keyword(s):  
Vagus Nerve ◽  
Developmental Stages ◽  
Functional Organization ◽  
Signal Amplitude ◽  
Optical Recording ◽  
Single Peak ◽  
Motor Nucleus ◽  
Vagus Nerves ◽  
Dorsal Motor Nucleus ◽  
Motor Nuclei

We investigated the functional organization of the glossopharyngeal and vagal motor nuclei during embryogenesis using multiple-site optical recording with a fast voltage-sensitive dye. Intact brain stem preparations with glossopharyngeal and vagus nerves were dissected from 4- to 8-day-old chick embryos. Electrical responses evoked by glossopharyngeal/vagus nerve stimulation were optically recorded from many loci of the stained preparations. In 4- to 6-day-old preparations, action potential-related fast spikelike signals were detected from the nucleus of the glossopharyngeal nerve and the dorsal motor nucleus of the vagus nerve. Contour line maps of the signal amplitude showed multiple-peak patterns, suggesting that the neurons and/or their activity were not uniformly distributed within the nuclei at early developmental stages. As development proceeded from 4 to 6 days, the peaks fused with each other and the number of peaks decreased gradually. In most 7- and 8-day-old preparations, only a single peak was identified in the nuclei, and the distribution of the signal amplitude formed a layered pattern surrounding the peak-signal area. These results suggest that functional organization of the motor nuclei in the embryonic hindbrain changes dynamically with development, resulting in a rearrangement of functional nuclear cores from multiple-peaks to a single peak.

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