scholarly journals Overview of Modern and Traditional Techniques of Permeation Enhancement for Topical Drug Deliver

2022 ◽  
pp. 44-54
Author(s):  
Manan Patel ◽  
Rigved Nagarkar ◽  
Srushti Sodha ◽  
Harshil M Parikh ◽  
Sowmya Kulal
Keyword(s):  
Permeation Enhancement

Gastrointestinal Region Specific Insulin Permeation Enhancement by Aloe vera Gel

2020 ◽  
Vol 10 (2) ◽  
pp. 117-122
Author(s):  
Elizca Pretorius ◽  
Clarissa Willers ◽  
Josias H. Hamman ◽  
Johan D. Steyn
Keyword(s):  
Gastrointestinal Tract ◽  
Ex Vivo ◽  
Aloe Vera ◽  
Diffusion Chamber ◽  
Proximal Jejunum ◽  
Absorption Enhancers ◽  
Permeation Enhancement ◽  
Insulin Transport ◽  
Aloe Vera Gel ◽  
Specific Insulin

Background: The oral administration route is still the most preferred by patients for drug treatment, but is unfortunately not suitable for all drug compounds. For example, protein and peptide drugs (e.g. insulin) are typically administered via injection seeing as they are unstable in the gastrointestinal luminal environment and have poor membrane permeation properties. To overcome this problem, functional excipients such as drug absorption enhancers can be co-administered. Although Aloe vera gel has the ability to improve the permeation of drugs across the intestinal epithelium, its drug permeation enhancing effect has not been investigated in the different regions of the gastrointestinal tract yet. Objective: The aim of this study was to investigate the insulin permeation enhancing effects of A. vera gel material across excised pig intestinal tissues from different regions of the gastrointestinal tract and to identify the gastrointestinal region where the highest insulin permeation enhancement was achieved. : Insulin transport across excised pig intestinal tissues from the duodenum, proximal jejunum, medial jejunum, distal jejunum, ileum and colon was measured in the absence and presence of A. vera gel (0.5% w/v) using both the Sweetana-Grass diffusion chamber and everted sac techniques. Results: The insulin permeation results obtained from both ex vivo techniques showed varied permeation enhancing effects of A. vera gel as a function of the different regions of the gastrointestinal tract. The colon was identified as the gastrointestinal region where A. vera gel was the most effective in terms of insulin permeation enhancement in the Sweetana-Grass diffusion chamber technique with a Papp value of 5.50 x 10-7 cm.s-1, whereas the ileum was the region where the highest permeation enhancement occurred in the everted sac technique with a Papp value of 5.45 x 10-7 cm.s-1. Conclusion: The gastrointestinal permeation enhancing effects of A. vera gel on insulin is region specific with the highest effect observed in the ileum and colon.

Flexible electro-responsive in-situ polymer acid doped polyaniline membranes for permeation enhancement and membrane fouling removal

2019 ◽  
Vol 578 ◽  
pp. 263-272 ◽  
Author(s):  
Li Li Xu ◽  
Salman Shahid ◽  
Darrell Alec Patterson ◽  
Emma Anna Carolina Emanuelsson
Keyword(s):  
Membrane Fouling ◽  
Permeation Enhancement ◽  
Doped Polyaniline

Passive Skin Permeation Enhancement

2012 ◽  
pp. 23-42 ◽  
Author(s):  
Majella E. Lane ◽  
Paulo Santos ◽  
Adam C. Watkinson ◽  
Jonathan Hadgraft
Keyword(s):  
Skin Permeation ◽  
Permeation Enhancement ◽  
Skin Permeation Enhancement

scholarly journals Cyclodextrin based nanosponge of norfloxacin: Intestinal permeation enhancement and improved antibacterial activity

2018 ◽  
Vol 195 ◽  
pp. 586-592 ◽  
Author(s):  
Cassiana Mendes ◽  
Gabriela C. Meirelles ◽  
Clarissa Germano Barp ◽  
Jamil Assreuy ◽  
Marcos A.S. Silva ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Permeation Enhancement ◽  
Intestinal Permeation

Abstract 5566: In vitro human skin permeation enhancement of endoxifen by oleic acid

2011 ◽  
Author(s):  
Oukseub Lee ◽  
David Ivancic ◽  
Robert T. Chatterton ◽  
Seema A. Khan
Keyword(s):  
Oleic Acid ◽  
Human Skin ◽  
Skin Permeation ◽  
Permeation Enhancement ◽  
Skin Permeation Enhancement

scholarly journals Microcontainers for oral insulin delivery – In vitro studies of permeation enhancement

2019 ◽  
Vol 143 ◽  
pp. 98-105 ◽  
Author(s):  
Jacob Rune Jørgensen ◽  
Morten Leth Jepsen ◽  
Line Hagner Nielsen ◽  
Martin Dufva ◽  
Hanne Mørck Nielsen ◽  
...  
Keyword(s):  
Insulin Delivery ◽  
In Vitro Studies ◽  
Oral Insulin ◽  
Permeation Enhancement
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