Shift work and cancer

2020 ◽  
pp. 838-838
Author(s):  
M. C. Turner
Keyword(s):  
General Population ◽  
Shift Work ◽  
Preventive Measures ◽  
Night Shift ◽  
Circadian Disruption ◽  
Light Spectrum ◽  
Light At Night ◽  
Epidemiological Evidence ◽  
Cardiometabolic Diseases ◽  
Breast And Prostate Cancer

Circadian disruption and night-shift work have been associated with a range of acute and chronic health effects including cardiometabolic diseases, obesity, as well as breast and prostate cancer. Circadian disruption may also affect the health of the general population because of widespread mistimed lifestyle practices including mistimed eating and sleep patterns and increasing exposure to light-at-night and particularly blue light spectrum through the use of e-readers, LEDs and smartphones. New epidemiological evidence on the effects of circadian disruption and light-at-night in workers and the general population will be presented, and mechanisms of disease and potential preventive measures discussed.

scholarly journals Rotating night shift work, exposure to light at night, and glomerular filtration rate: baseline results from a Chinese occupational cohort

2020 ◽  
Author(s):  
Shengkui Zhang ◽  
Yongbin Wang ◽  
Zhende Wang ◽  
Han Wang ◽  
Chao Xue ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Shift Work ◽  
Filtration Rate ◽  
Night Shift ◽  
Cumulative Number ◽  
Ambient Light ◽  
Light At Night ◽  
Night Shift Work ◽  
Night Shifts

Abstract Background The misalignment between the circadian clock and behavioral cycles has been implicated in pathogenesis of many diseases. However, whether the kidneys are also more prone to disease in the circumstances of chronic circadian rhythms disruption due to night shift work and light at night (LAN) is unclear. The main purpose of this study is to examine the association between rotating night shift work, exposure to light at night, and glomerular filtration rate among steelworkers in north China. Methods A total of 6869 participants, aged 22 to 60 years, were included in this study. Multivariable logistic regression was used to examine the association between night shift work, the brightness of bedroom ambient light at night (LAN), and estimated glomerular filtration rate (eGFR) with adjustment for potential confounders. The relationship between duration of night shift work (continuous), cumulative number of night shifts (continuous), and eGFR were also examined using restricted cubic spline models. Results Long duration of night shift work (≥29 years) had elevated odds of decreased eGFR (OR, 1.39, 95% CI 1.10–1.75) compared with day work after adjustment for potential confounders. Negative associations between duration of night shift work, cumulative number of night shifts, and eGFR (mL/min/1.73 m 2 ) were observed in RCS models. No significant associations were observed among the different brightness of bedroom ambient light levels: middle level (OR, 0.90, 95% CI 0.77–1.05), lightest level (OR, 0.94, 95% CI 0.75–1.17), and decreased eGFR compared with the darkest level. Conclusion The increased duration of night shift work and cumulative number of night shifts among night shift workers, but not the brightness of bedroom ambient LAN, are associated with a slight decline of renal function among steelworkers.

Insomnia, Sleepiness, and Fatigue Among Polish Nurses

2020 ◽  
Vol 68 (6) ◽  
pp. 272-278 ◽  
Author(s):  
Tomasz Zdanowicz ◽  
Krzysztof Turowski ◽  
Jolanta Celej-Szuster ◽  
Regina Lorencowicz ◽  
Elżbieta Przychodzka
Keyword(s):  
General Population ◽  
Occupational Health ◽  
Sleep Quality ◽  
Diagnostic Tests ◽  
Preventive Measures ◽  
Health Workers ◽  
Night Shift ◽  
Severity Scale ◽  
Athens Insomnia Scale ◽  
Fatigue Severity

Background: Sleep disorders can result in sleepiness, fatigue, and apathy, and may contribute to serious occupational consequences such as errors at work. The aim of the study was to examine the level of insomnia, sleepiness, and fatigue in a sample of Polish nurses. Methods: The research was conducted among nurses employed in the Lublin region of Poland. A sample of nurses were invited to participate in a survey in which we measured insomnia, sleepiness, and fatigue using the Athens Insomnia Scale (AIS), the Epworth Sleepiness Scale (ESS), and the Fatigue Severity Scale (FSS). Findings: Among the 200 nurses that were surveyed, 141 (70.5%) responded. The findings indicated that a total of 47.8% of the surveyed nurses reported insomnia. Half (50.0%) exceeded the threshold for fatigue relative to the general population. Although no differences in fatigue and sleepiness were observed by level of insomnia between those who did and did not work night shift, we observed an overall correlation between insomnia (AIS) and sleepiness (ESS), as well as between insomnia (AIS) and fatigue (FSS). Conclusions/Application to practice: This sample of Polish nurses displayed problems with sleep quality. The consequences of insomnia and fatigue challenge occupational health workers to go beyond traditional care and standard diagnostic tests. Undertaking preventive measures aimed at reducing health hazards, and the risk of making a mistake at work due to increased sleepiness and fatigue, in nurses are warranted.

Differential effects of light at night and shift rotation pattern on the circadian system in night workers.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1556-1556
Author(s):  
Pedram Razavi ◽  
Eva S Schernhammer ◽  
Keyword(s):  
Shift Work ◽  
Night Shift ◽  
Circadian System ◽  
Activity Level ◽  
Melatonin Level ◽  
Consecutive Night ◽  
Light At Night ◽  
Night Shift Work ◽  
Single Night ◽  
Night Shifts

1556 Background: Light at night as in shift work suppresses nocturnal secretion of melatonin, a pineal hormone with oncostatic properties. Several studies have associated night shift work with higher risk of cancer, leading WHO in 2007 to classify rotating night shift work as “probably carcinogenic”. We conducted one of the most comprehensive studies, to date, to evaluate the effects of light and night shift work on melatonin measurements in the field. Methods: Study participants were 130 active nurses (84 current rotating night shift workers and 46 day shift workers) participating in NHS2. Each nurse wore a head-mounted light- and accelerometer for a 3-day study period, during which each spontaneous urine was collected for repeated urinary 6-sulfatoxymelatonin (melatonin) measurements. In addition, nurses were asked to fill out paper questionnaires and diaries. We used mixed models to evaluate the influence of light, activity and night shift work on urinary melatonin level adjusting, for age, lifestyle, and occupational history. We log-transformed main variables and report geometric means (GM [standard deviation]). Results: Greater levels of light were associated with lower melatonin (P < 0.0001), independent of activity level. An increase in light intensity from 10 to 100 lux was associated with a 12% decrease in geometric mean of melatonin level; however, this inverse association was only significant at night (Ptrend = 0.01). At night, each hour increase in exposure to ≥ 20 lux light lowered melatonin level by 5.7% (Ptrend < 0.0001). A single night shift affected the circadian system by lowering melatonin peak by 22% (day shift: GM = 17.57 [2.73]; night shift: GM = 13.64 [2.54]) and induced a phase shift (PS) of 0.9 hours, -changes that reset to normal by the next day. Two consecutive night shifts had a similar effect as a single shift. However, the effect was worse after three consecutive night shifts (GM = 10.11 [2.77]; PS = 2.2 hours). Conclusions: We found significant inverse associations of intensity and duration of exposure to light at night with urinary melatonin, independent of activity level. Three consecutive night shifts affected the circadian system more strongly than two consecutive, or a single night shift.

scholarly journals Shift-work: is time of eating determining metabolic health? Evidence from animal models

2018 ◽  
Vol 77 (3) ◽  
pp. 199-215 ◽  
Author(s):  
Natalí N. Guerrero-Vargas ◽  
Estefania Espitia-Bautista ◽  
Ruud M. Buijs ◽  
Carolina Escobar
Keyword(s):  
Food Intake ◽  
Shift Work ◽  
Temporal Patterns ◽  
Experimental Models ◽  
Circadian Disruption ◽  
Metabolic Dysfunction ◽  
Light At Night ◽  
Shift Workers ◽  
Time Signals ◽  
Altered Metabolism

The circadian disruption in shift-workers is suggested to be a risk factor to develop overweight and metabolic dysfunction. The conflicting time signals given by shifted activity, shifted food intake and exposure to light at night occurring in the shift-worker are proposed to be the cause for the loss of internal synchrony and the consequent adverse effects on body weight and metabolism. Because food elicited signals have proven to be potent entraining signals for peripheral oscillations, here we review the findings from experimental models of shift-work and verify whether they provide evidence about the causal association between shifted feeding schedules, circadian disruption and altered metabolism. We found mainly four experimental models that mimic the conditions of shift-work: protocols of forced sleep deprivation, of forced activity during the normal rest phase, exposure to light at night and shifted food timing. A big variability in the intensity and duration of the protocols was observed, which led to a diversity of effects. A common result was the disruption of temporal patterns of activity; however, not all studies explored the temporal patterns of food intake. According to studies that evaluate time of food intake as an experimental model of shift-work and studies that evaluate shifted food consumption, time of food intake may be a determining factor for the loss of balance at the circadian and metabolic level.

scholarly journals Rotating Night Shift Work, Exposure to Light at Night, and Glomerular Filtration Rate: Baseline Results from a Chinese Occupational Cohort

2020 ◽  
Vol 17 (23) ◽  
pp. 9035
Author(s):  
Shengkui Zhang ◽  
Yongbin Wang ◽  
Ying Zhu ◽  
Xiaoming Li ◽  
Yang Song ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Shift Work ◽  
Filtration Rate ◽  
Night Shift ◽  
Mediation Effect ◽  
Ambient Light ◽  
Light At Night ◽  
Night Shift Work ◽  
Night Shifts

The misalignment between the circadian clock and behavioral cycles has been implicated in pathogenesis of many diseases. The main purpose of this study is to examine the association between rotating night shift work, exposure to light at night, and glomerular filtration rate among steelworkers in north China. A total of 6869 steelworkers, aged 22 to 60 years, were included in this study. Multivariable logistic regression was used to examine the association between night shift work, the brightness of bedroom ambient light at night (LAN), and estimated glomerular filtration rate (eGFR), with adjustment for potential confounders. Mediation analysis was performed to examine the mediation effect of potential mediators on the association of duration of night shifts and eGFR. Long duration of night shift work (≥29 years) had elevated odds of decreased eGFR (≤89 mL/min/1.73 m2) (odds ratio (OR), 1.37, 95% confidence interval (CI) 1.09–1.73) compared with day work after adjustment for potential confounders. The association between duration of night shifts and eGFR (continuous) was partially modified by diastolic blood pressure (average causal mediation effect (ACME), –0.077, 95% CI –0.134 to −0.030, p < 0.001). No significant associations were observed among the different brightness of bedroom ambient light levels: middle level (OR, 0.90, 95% CI 0.77–1.05), lightest level (OR, 0.94, 95% CI 0.75–1.18), and decreased eGFR compared with the darkest level. Long-term night-shift work, rather than the brightness of bedroom ambient LAN, is associated with early stage of renal dysfunction in steelworkers, and blood pressure may mediate the relationship between night shift work and decreased eGFR.

scholarly journals Night Shift Work, Light at Night, and Risk of Breast Cancer

2001 ◽  
Vol 93 (20) ◽  
pp. 1557-1562 ◽  
Author(s):  
S. Davis ◽  
D. K. Mirick ◽  
R. G. Stevens
Keyword(s):  
Breast Cancer ◽  
Shift Work ◽  
Night Shift ◽  
Light At Night ◽  
Night Shift Work
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