Hepatobiliary Function in Puerperium after Normal Pregnancy and Toxaemia of Late Pregnancy, with Special Reference to the Radioactive Rose Bengal Test

1967 ◽  
Vol 46 (4) ◽  
pp. 515-524 ◽  
Author(s):  
Pekka Ylostalo ◽  
Jaakko Jussila ◽  
Ahti Rekonen
2011 ◽  
Vol 5 (4) ◽  
pp. e950 ◽  
Author(s):  
Ramón Díaz ◽  
Aurora Casanova ◽  
Javier Ariza ◽  
Ignacio Moriyón

Author(s):  
DIVYA PAWAR ◽  
Dr Sameer Gholap

Motherhood is a divine blessing. Anti-natal care is a potential timely care of mother and foetus till delivery from first month of her pregnancy which is co-related with Garbhini Paricharya explained in Ayurveda, to get Shreyasi Praja which ensure normal pregnancy and uncomplicated labour with delivery of a healthy baby from healthy mother. Wellbeing of garbha can be achieved only through of the wellness of the garbhini thus Acharyas have given it under Garbhini Paricharya concept. In Ayurveda along with Trimester wise regimen, Garbhini Paricharya comprises Masanumasik Pathya (Month wise dietary regimen), Garbhopaghatakara Bhavas which are contraindicated Dietetics and mode of life for mother. Garbhasthapaka drugs which are useful for foetus.   AIMS AND OBJECTIVE To study Garbhini Paricharya and establish its Ayurveda co-ordination. To evaluate Trimester wise regimen. To give proper nutrition, equilibrium of doshas, welfare and contraindication of mother and Foetus.   METHODOLOGY Reviewing the modern science literature regarding Anti-natal care and Ayurvedic classics, commentaries also recently published books and Research journals, the Garbhini Paricharya collection done and attempt to get co-relation between Ayurveda and Modern Anti-natal care for healthy progeny.   CONCLUSION- Ayurvedic preconceptional measure help to achieve the goal of preconception to have healthy and good progeny. Ayurvedic remedy for getting healthy progeny emphasizes again preventive aspect of Ayurveda.   KEY WORDS: Garbhini Paricharya, Month wise dietary regimen, Garbhopaghatakara Bhavas, Garbhasthapaka drugs, Anti-natal care.


Author(s):  
Hiroaki Onishi ◽  
Kimiko Kaniyu ◽  
Mitsutoshi Iwashita ◽  
Asashi Tanaka ◽  
Takashi Watanabe

Background: Pregnancy represents a major risk factor for deep vein thrombosis (DVT). Most coagulation/fibrinolysis markers currently utilized change during pregnancy, and therefore they cannot accurately evaluate thrombotic events in pregnancy because the rate of false positive results is high. Fibrin monomer complex (FMC) has recently become widely available for diagnosing DVT. The present study examined whether FMC is suitable for evaluating thrombotic status in pregnancy. Methods: Concentrations of FMC and other haemostatic markers were investigated in 87 pregnant women without major complications at early, mid- or late pregnancy. FMC concentrations were also measured in 127 normal non-pregnant women, and in one woman who developed DVT after delivery. Results: In normal pregnant women, FMC concentrations were unchanged during early or mid-pregnancy and slightly elevated during late pregnancy. Concentrations were within reference range in most cases, and none exceeded the cut-off value for DVT. In contrast, thrombin-antithrombin complex (TAT) and D-dimer (DD) concentrations were significantly elevated in late pregnancy, and median values exceeded reference ranges. The DVT case displayed significantly elevated FMC concentrations. Conclusions: Changes in FMC concentrations during normal pregnancy are minimal compared with other haemostatic markers. Because the rate of false positivity is lower, FMC could be a potential marker of thrombotic status in pregnancy rather than TAT and DD.


1975 ◽  
Vol 152 (3) ◽  
pp. 433-443 ◽  
Author(s):  
R G Rodway ◽  
N J Kuhn

Treatment of pregnant rats with human chorionic gonadotrophin, luteotrophin (luteinizing hormone), luteotrophin-releasing hormone, prostaglandin F2α, aminoglutethimide, or by foetoplacental removal or hysterectomy achieved a common multiple-response pattern, namely increased activity of luteal 20α-hydroxy steroid dehydrogenase with decreased activity of delta5-3β-hydroxy steriod dehydrogenase and release of delta4-3-oxo steroids in vitro. 2. Similar effects of foetoplacental removal are noted in pregnant mice. 3. Gonadotrophin induced lower activities of 20α-hydroxy steroid dehydrogenase, except at the very end of pregnancy, and partly inhibited the induction caused by foetoplacental removal. 4. The results suggest that existence of a placental factor that restrains these changes until the end of normal pregnancy, which is produced in amounts proportional to the number of placentae and is conveyed to the ovary via the blood. 5. This factor was not replaced by prolactin. 6. It is argued that neither placental lactogen nor pituitary luteotrophin participate in the induction of 20α-hydroxy steroid dehydrogenase at late pregnancy in the rat. 7. Aminoglutethimide induced 20α-hydroxy steroid dehydrogenase only in late pregnancy. This was partly reversed by progesterone, wholly reversed by progesterone plus oestrogen, and did not involve the pituitary.


2010 ◽  
Vol 299 (5) ◽  
pp. R1326-R1332 ◽  
Author(s):  
Crystal West ◽  
Zheng Zhang ◽  
Geoffrey Ecker ◽  
Shyama M. E. Masilamani

Pregnancy-mediated sodium (Na) retention is required to provide an increase in plasma volume for the growing fetus. The mechanisms responsible for this Na retention are not clear. We first used a targeted proteomics approach and found that there were no changes in the protein abundance compared with virgin rats of the β or γ ENaC, type 3 Na+/H+ exchanger (NHE3), bumetanide-sensitive cotransporter (NKCC2), or NaCl cotransporter (NCC) in mid- or late pregnancy. In contrast, we observed marked increases in the abundance of the α-ENaC subunit. The plasma volume increased progressively during pregnancy with the greatest plasma volume being evident in late pregnancy. ENaC inhibition abolished the difference in plasma volume status between virgin and pregnant rats. To determine the in vivo activity of ENaC, we conducted in vivo studies of rats in late pregnancy ( days 18–20) and virgin rats to measure the natriuretic response to ENaC blockade (with benzamil). The in vivo activity of ENaC (UNaV postbenzamil-UNaV postvehicle) was markedly increased in late pregnancy, and this difference was abolished by pretreatment with the mineralocorticoid receptor antagonist, eplerenone. These findings demonstrate that the increased α-ENaC subunit of pregnancy is associated with an mineralocorticoid-dependent increase in ENaC activity. Further, we show that ENaC activity is a major contributor of plasma volume status in late pregnancy. These changes are likely to contribute to the renal sodium retention and plasma volume expansion required for an optimal pregnancy.


1996 ◽  
Vol 271 (1) ◽  
pp. F16-F20 ◽  
Author(s):  
S. N. Sturgiss ◽  
R. Wilkinson ◽  
J. M. Davison

Pregnancy in healthy women is associated with increments in glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). We hypothesized that the hyperfiltration of normal pregnancy attenuates or exhausts renal reserve. In 21 healthy females studied serially in early and late pregnancy and then on average 15 wk postpartum, GFR and ERPF were determined by inulin and p-aminohippurate clearances, respectively, before and during either an amino acid infusion (Vamin 9; Kabi Pharmacia) (n = 14) or a control infusion of Hartman's solution (n = 7), both infused at 4 ml/min for 210 min. In early and late pregnancy, GFR increased significantly in response to amino acid infusion [from 137 +/- 29 to 162 +/- 35 ml/min (P < 0.001) and from 134 +/- 29 to 148 +/- 40 ml/min (P < 0.01), respectively], with the increments (18 and 10%, respectively) not significantly different from postpartum (non-pregnant) when GFR increased by 12% from 94 +/- 22 to 105 +/- 23 ml/min (P < 0.002). Amino acid infusion significantly increased ERPF from 874 +/- 188 to 980 +/- 215 ml/min in early pregnancy (P < 0.01), from 684 +/- 135 to 773 +/- 181 ml/min in late pregnancy (P < 0.01), and from 507 +/- 121 to 560 +/- 141 ml/min postpartum (P < 0.006), increments of 12, 13, and 10%, respectively. GFR did not change in response to control infusion. We conclude that, despite gestational increments in renal hemodynamics of > 40%, pregnancy does not attenuate the renal response to amino acid infusion.


2011 ◽  
Vol 47 (2) ◽  
pp. 157-165 ◽  
Author(s):  
Lingyun Zhang ◽  
Takashi Sugiyama ◽  
Nao Murabayashi ◽  
Takashi Umekawa ◽  
Ning Ma ◽  
...  

The infiltration of classically activated macrophages (M1) and alternatively activated macrophages (M2) in subcutaneous adipose tissue (SAT) and parametrial adipose tissue (PAT) was analyzed to investigate whether local inflammatory change in adipose tissue occurs in late pregnancy. C57BL/6N female mice at 6 weeks of age were fed a normal chow diet for 4 weeks prior to mating at 10 weeks of age and were sampled on day 17 of pregnancy. The serum levels of adipokines and biochemical markers were measured using ELISA and enzymatic methods. The identification of M1 and M2 was analyzed by double immunofluorescence with anti-F4/80 and anti-CD11c antibodies. The gene expression of adipokines in adipose tissues was analyzed by quantitative RT-PCR. The pregnant group showed adipocyte hypertrophy, higher macrophage infiltration, and higher M1/M2 in both SAT and PAT compared with the non-pregnant (NP) group. Serum levels of free fatty acids, tumor necrosis factor α (TNFα), interleukin 6 (IL6), and IL10 were higher, and serum levels of adiponectin were lower in the pregnant group than those in the NP group. The gene expressions of CD68, Itgax, CCR2, TNFα, and PAI1 in SAT during pregnancy were significantly higher than those in the NP group, as were the gene expressions of CD68, Emrl, Itgax, MCP1, TNFα, IL6, PAI1, adiponectin, and IL10 in PAT. These results suggest that the low-grade inflammation of adipose tissue indicated by increased macrophage infiltration occurs in late normal pregnancy.


1933 ◽  
Vol 3 (1) ◽  
pp. 55-60 ◽  
Author(s):  
W. Parker Stowe ◽  
G. D. Delprat ◽  
Alanson Weeks

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