Head and neck cancer in young people: a series of 52 SCCs of the oral tongue in patients aged 35 years or less

Purpose This article investigated the effects of increased oral lingual pressure on pharyngeal pressures during swallowing in patients who have undergone radiotherapy for head and neck cancer. It was hypothesized that increased oral lingual pressure would result in increased pharyngeal pressures. Method A within-subject experimental design was used with 20 participants who were status post external beam radiotherapy for head and neck cancer. Participants completed typical swallows and swallows with increased lingual force during manofluoroscopic swallow studies. The swallow condition order was randomized across participants. Results Manometric data revealed significant differences in swallow pressure by condition at the base of tongue and upper esophageal sphincter sensor locations without significant pressure differences in the lower pharynx. The effortful lingual swallows resulted in higher mean pressures at all locations. Conclusions The results of this study suggest that use of a maneuver designed to increase oral tongue effort can also increase pharyngeal tongue base pressure. Therefore, therapeutic activities used to generate greater pressure of the oral tongue may also alter pharyngeal response. Further research is needed to determine the direct clinical effect on swallow function for individuals with head and neck cancer.

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Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

Clinical Oral Investigations ◽

10.1007/s00784-020-03735-1 ◽

2021 ◽

Author(s):

Shih-Wei Yang ◽

Yun-Shien Lee ◽

Liang-Che Chang ◽

Cheng-Han Yang ◽

Cheng-Ming Luo ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Treatment Outcomes ◽

Malignant Transformation ◽

Neck Cancer ◽

Clinicopathological Characteristics ◽

Transformation Rate ◽

Oral Tongue ◽

Lesion Area ◽

History Of

Abstract Objectives The tongue is identified as a high-risk site for oral leukoplakia and malignant transformation. The purpose of this study is to investigate the clinicopathological characteristics and treatment outcomes of tongue leukoplakia and assess the factors related to recurrence and malignant transformation. Materials and methods One hundred and forty-four patients who received carbon dioxide laser surgery for tongue leukoplakia from 2002 to 2019 were analyzed statistically. Results The follow-up period was 54.90 ± 54.41 months. Thirty patients showed postoperative recurrence (20.83%), and 12 patients developed malignant transformation (8.33%). The annual transformation rate was 2.28%. Univariate analysis showed that a history of head and neck cancer, size of lesion area, clinical appearance, and pathology were significant factors for both recurrence and malignant transformation. In the multivariate logistic regression, a history of head and neck cancer and size of lesion area were independent prognostic factors for recurrence, and a history of head and neck cancer was the only independent factor for postoperative malignant change. Conclusions Clinicians should adopt more aggressive strategies for tongue leukoplakia patients with a history of head and neck cancer. Clinical relevance These results may help clinicians gain a better understanding of oral tongue leukoplakia.

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Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort

Cancers ◽

10.3390/cancers13102387 ◽

2021 ◽

Vol 13 (10) ◽

pp. 2387

Author(s):

Anna Maria Wirsing ◽

Inger-Heidi Bjerkli ◽

Sonja Eriksson Steigen ◽

Oddveig Rikardsen ◽

Synnøve Norvoll Magnussen ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Prognostic Value ◽

Prognostic Markers ◽

Multivariate Analyses ◽

Tongue Cancer ◽

Cancer Tissue ◽

Oral Tongue ◽

Protein Coding

The Pathology Atlas is an open-access database that reports the prognostic value of protein-coding transcripts in 17 cancers, including head and neck cancer. However, cancers of the various head and neck anatomical sites are specific biological entities. Thus, the aim of the present study was to validate promising prognostic markers for head and neck cancer reported in the Pathology Atlas in oral tongue squamous cell carcinoma (OTSCC). We selected three promising markers from the Pathology Atlas (CALML5, CD59, LIMA1), and analyzed their prognostic value in a Norwegian OTSCC cohort comprising 121 patients. We correlated target protein and mRNA expression in formalin-fixed, paraffin-embedded cancer tissue to five-year disease-specific survival (DSS) in univariate and multivariate analyses. Protein expression of CALML5 and LIMA1 were significantly associated with five-year DSS in the OTSCC cohort in univariate analyses (p = 0.016 and p = 0.043, respectively). In multivariate analyses, lymph node metastases, tumor differentiation, and CALML5 were independent prognosticators. The prognostic role of the other selected markers for head and neck cancer patients identified through unbiased approaches could not be validated in our OTSCC cohort. This underlines the need for subsite-specific analyses for head and neck cancer.

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Cardiac Metastasis in a Patient with Head and Neck Cancer: A Case Report and Review of the Literature

Case Reports in Otolaryngology ◽

10.1155/2019/9581259 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Joseph K. Kim ◽

Kunal Sindhu ◽

Richard L. Bakst

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Tongue Cancer ◽

Primary Diagnosis ◽

Cardiac Metastasis ◽

Review Of The Literature ◽

Oral Tongue ◽

Oral Tongue Cancer ◽

Cardiac Metastases

Cardiac metastasis from a primary head and neck cancer is a rare finding. Most patients with cardiac metastases have nonspecific symptoms that may vary depending on the severity and location of the lesion. Due to the infrequency of reported cases, there are no clear guidelines for the diagnosis or management of cardiac metastasis in head and neck cancer patients. In this report, we discuss the case of a patient with a primary diagnosis of oral tongue cancer who developed a cardiac metastasis that was detected antemortem.

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Head and neck cancer awareness: a survey of young people in international communities

International Journal of Adolescent Medicine and Health ◽

10.1515/ijamh-2018-0231 ◽

2019 ◽

Vol 0 (0) ◽

Cited By ~ 1

Author(s):

Kehinde Kazeem Kanmodi ◽

Nneamaka Nnebedum ◽

Mayowa Bello ◽

Miracle Adesina ◽

Omotayo Francis Fagbule ◽

...

Keyword(s):

Risk Factors ◽

Head And Neck Cancer ◽

Family History ◽

Young People ◽

Head And Neck ◽

Neck Cancer ◽

Significant Proportion ◽

Risky Behaviors ◽

Cancer Awareness ◽

History Of

Abstract Head and neck cancer (HNC) is killing young people yearly. The knowledge of HNC risk factors and its symptoms among this population group may go a long way in HNC prevention among them. This study aims to: determine the level of awareness of HNC; determine the prevalence of HNC risk factors; and explore the knowledge of HNC risk factors, HNC symptoms, as well as family history of HNC among youth in the international communities (with focus on the Canadian and Nigerian youth). Methods A sample of 801 youth were surveyed using an e-questionnaire. The questionnaire obtained information from each participant about their: socio-demographic information; knowledge of HNC, its risk factors, and its manifestations; and family history of HNC. Data obtained from the participants were analyzed using the Statistical Analysis Software (SAS Version 9.4 for Windows). Results The majority (73%) of the surveyed youth (n=801) were residing in Nigeria, seven-tenths of them were between the age 18 and 24 years, and 53% were females. Less than 10% had a history of smoking, 7% were active smokers, and 24% had history of oral sex (of which 57% (108/109) of them had a lifetime history of more than one oral sexual partner). Around half (51%) of the participants had never heard of HNC before. Only 4% knew of a family member who had suffered/is suffering from HNC. Half of the participants were not sure whether HNC can manifest without initial complaint, pain, or symptoms. Only 9% of the participants erroneously believed that HNC is a contagious disease. Comparative analyses among subgroups revealed that a higher proportion of those participants who were: from Canada; young adults; and males generally knew about HNC when compared with the proportions recorded among those in the adolescents; females, and Nigerian participants’ categories. Lastly, 76% of the participants showed interest in knowing more about HNC. Conclusion The majority of the surveyed youth demonstrated poor knowledge of HNC. Also, a significant proportion of them are at risk of developing HNC disease in future, if they keep indulging in HNC risky behaviors. There exists the need to conduct community health education programs on HNC among youth in these surveyed communities.

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