Obsessive—Compulsive Disorder in Post-Streptococcal Infection

1998 ◽  
Vol 32 (4) ◽  
pp. 579-581
Author(s):  
Erik Monasterio ◽  
Roger T. Mulder ◽  
Thomas D. Marshall
Keyword(s):  
Streptococcal Infection ◽  
Past History ◽  
Sudden Onset ◽  
Autoimmune Response ◽  
Progressive Reduction ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
History Of ◽  
Peritoneal Infection

Objective: We describe the sudden onset of obsessive—compulsive symptoms fol lowing a peritoneal infection with α-haemolytic streptococci. Clinical picture: A 35–year-old woman with no past history or family history of obsessions or compulsions developed these symptoms 2 weeks after a peritoneal infection. Treatment: The patient received 80 mg fluoxetine daily. Outcome: She responded to treatment with a progressive reduction in symptoms. Conclusions: It is suggested that these obsessions and compulsions may be related to an autoimmune response to the streptococcal infection.

PROLACTIN IN CHILDHOOD OBSESSIVE-COMPULSIVE DISORDER: CLINICAL CORRELATES AND RESPONSE TO CLOMIPRAMINE

PEDIATRICS ◽  
1991 ◽  
Vol 88 (5) ◽  
pp. 992-992
Author(s):  
Gregory L. Hanna ◽  
James T. MCCracken ◽  
Dennis P. Cantwell
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Serotonergic Receptors ◽  
Duration Of Illness ◽  
Chronic Tic Disorder ◽  
History Of ◽  
Clomipramine Treatment

Basal prolactin concentrations were measured before treatment in 18 children and adolescents with obsessive-compulsive disorder as well as in 15 of these patients after 4 and 8 weeks of clomipramine treatment. Basal prolactin levels were influenced by a history of chronic tic disorder and by the duration and severity of obsessive-compulsive symptoms. Clomipramine administration significantly increased basal prolactin levels. A slight decline in prolactin levels during the last 4 weeks of clomipramine treatment was positively correlated with a favorable treatment response and negatively correlated with duration of illness. If the changes in prolactin levels observed during clomipramine treatment are due primarily to changes in serotonergic neurotransmission, these data suggest that clomipramine treatment of obsessive-compulsive disorder produces an adaptive decrease in the responsiveness of serotonergic receptors.

Obsessive compulsive disorder in adults with rheumatic heart disease

2007 ◽  
Vol 19 (2) ◽  
pp. 118-121 ◽  
Author(s):  
Ashfaq-U-Rahaman ◽  
Y. C Janardhan Reddy ◽  
Prabhavathi ◽  
Pramod Kumar Pal
Keyword(s):  
Heart Disease ◽  
General Population ◽  
Rheumatic Heart Disease ◽  
Obsessive Compulsive Disorder ◽  
Streptococcal Infection ◽  
Assessment Tools ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
History Of ◽  
Rheumatic Heart

Objective:There are considerable data on the possible association between streptococcal infection and obsessive compulsive disorder (OCD), particularly the relation between Sydenham’s chorea (SC) and OCD. However, neuropsychiatric sequelae related to streptococcal infection are mainly reported in children. In this preliminary study, we examined prevalence of OCD in a group of adult subjects with established rheumatic heart disease (RHD). We hypothesized that the rate of OCD would be higher than the known general population rates.Method:One hundred adult subjects with RHD were evaluated for OCD and other comorbid psychiatric disorders using well-known psychiatric assessment tools. A qualified psychiatrist conducted the assessments. The diagnoses were made according to DSM-IV criteria.Results:The rate of clinical OCD and subclinical OCD was 10% and 3%, respectively (n = 13), a rate much higher than the 1–3% rate reported in general population. Of the 13 subjects, only three had a history of SC (23%).Conclusions:OCD could be a long-term sequel in adults with a history of rheumatic fever in childhood, even in the absence of frank chorea. The findings call for systematic research in this little explored area.

Gender Differences in Obsessive Compulsive Disorder

1995 ◽  
Vol 29 (1) ◽  
pp. 114-117 ◽  
Author(s):  
David J. Castle ◽  
Alicia Deale ◽  
Isaac M. Marks
Keyword(s):  
Gender Differences ◽  
Eating Disorder ◽  
Anxiety Disorders ◽  
Obsessive Compulsive Disorder ◽  
Past History ◽  
Onset Age ◽  
Obsessive Compulsive ◽  
Behavioural Treatment ◽  
Compulsive Disorder ◽  
History Of

We investigated gender differences in 219 patients with obsessive compulsive disorder consecutively referred to a centre specialising in the behavioural treatment of anxiety disorders. Females had a later mean onset-age, and were more likely to be married and to have children; they were also marginally more likely to have a past history of an eating disorder or depression, while males were more likely to have a history of anxious or meticulous personality traits. Family loading for psychiatric disorders did not differ significantly between the sexes. The results are discussed in the context of the epidemiological literature on gender differences in OCD.

scholarly journals Comorbidity of Obsessive-Compulsive Disorder and Schizophrenia in an Adolescent

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Ahmad Nabil Md. Rosli ◽  
Wan Salwina Wan Ismail
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
History Of

We report a case of a girl with a history of obsessive-compulsive disorder (OCD) subsequently exhibiting psychosis. She never attained remission since the outset. Initially she seemed to be resistant to most antipsychotics, namely, risperidone, haloperidol, paliperidone, quetiapine, and clozapine. However, she later responded remarkably better to risperidone after it was reintroduced for the second time. Recognizing and understanding the various pathogenesis of OCD or obsessive-compulsive symptoms (OCS) in schizophrenia are vital in laying out plan to manage the patient effectively.

A Follow-Up of Adolescents with Obsessive-Compulsive Disorder

1989 ◽  
Vol 154 (6) ◽  
pp. 829-834 ◽  
Author(s):  
M. Allsopp ◽  
C. Verduyn
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Psychiatric Illness ◽  
Response To Therapy ◽  
Initial Contact ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Outcome Information ◽  
History Of

Twenty-six patients seen at a regional adolescent psychiatry unit between 1974 and 1979 with a discharge diagnosis of obsessive-compulsive disorder were followed up after an average of ten years. Of 24 subjects traced, outcome information was obtained from 20. At the point of follow-up, ten patients remained psychiatrically ill, six having persisting obsessive–compulsive symptoms. Poor outcome was associated with a family history of psychiatric illness and lack of response to therapy at initial contact. All patients who were asymptomatic at discharge had remained well.

Obsessional Symptoms Associated with Risperidone Treatment

1998 ◽  
Vol 32 (2) ◽  
pp. 299-301 ◽  
Author(s):  
Rathi Mahendran
Keyword(s):  
Side Effects ◽  
Antipsychotic Medication ◽  
Clinical Picture ◽  
Low Dose ◽  
Past History ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
History Of ◽  
Risperidone Treatment

Objective: The aim of this paper is to report the occurrence of obsessional symptoms with risperidone treatment in a patient with no past history of obsessive-compulsive symptoms. Clinical picture: A 26–year-old, single, Chinese lady with a chronic untreated schizophrenic illness was prescribed risperidone after she experienced side effects with other antipsychotic medication. After the second week on risperidone, she developed obsessional symptoms. Treatment and Outcome: The obsessional symptoms responded to treatment with low dose clomipramine. Conclusion: The potential for the newer antipsychotic medication to precipitate or exacerbate obsessive-compulsive symptoms during treatment for schizophrenia must be borne in mind.

scholarly journals Plasmapheresis, Rituximab, and Ceftriaxone Provided Lasting Improvement for a 27-Year-Old Adult Male with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Adam Krouse ◽  
Huihua Li ◽  
Joseph A. Krenzer ◽  
William Nicholas Rose
Keyword(s):  
Clinical Symptoms ◽  
Neuropsychiatric Symptoms ◽  
Neuropsychiatric Disorders ◽  
Sudden Onset ◽  
Autoimmune Response ◽  
Urine Drug Screen ◽  
Streptococcal Infections ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Old Adult

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a specific autoimmune response to group-A streptococcal (GAS) infections in children and adolescents with a sudden onset of neuropsychiatric disorders including obsessive-compulsive disorder (OCD) or tic-like symptoms. We present a case report of a 27-year-old male patient who had lasting improvement with plasmapheresis, rituximab, and ceftriaxone. Our patient first developed sudden psychosis and confusion after GAS infections at age 17. He had elevated anti-streptolysin O (ASO) titers, negative urine drug screen, no ETOH in blood, normal CBC, normal TSH, normal salicylate, normal acetaminophen, and a normal head CT. The tentative diagnosis of PANDAS was made, and the patient was thereafter treated with antipsychotics, antibiotics, tonsillectomy, and IVIG which resulted in remissions and relapses of his neuropsychiatric symptoms. Once he reached age 27, he received a trial of therapeutic plasma exchange (TPE), rituximab, and ceftriaxone. This eventually resulted in sustained benefit and minimal fluctuations of his clinical symptoms. Our report is noteworthy in three ways.One, he is a 27-year-old adult with PANDAS.Two, he improved after TPE, rituximab, and ceftriaxone. Our literature search yielded minimal data on the use of plasmapheresis for nonteenage adults with PANDAS. Three, he had unusual symptoms of PANDAS, as the typical OCD and/or tic-like symptoms were not observed.

scholarly journals The Evidence before One’s Eyes: A Case Report on Schizo-Obsessive Disorder

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Elliott B. Martin
Keyword(s):  
Low Dose ◽  
Psychotic Disorders ◽  
Sudden Onset ◽  
Obsessive Compulsive ◽  
Naive Patient ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Improved Outcomes ◽  
Underlying Disorder ◽  
Subtype A

Obsessive compulsive disorder is still considered primarily an anxiety disorder, though historically there has always been a question of whether obsessive-compulsive symptoms may be more properly considered psychotic in nature, the so-called schizo-obsessive disorder or subtype. A case is presented here of a middle-aged man with debilitating obsessive-compulsive symptoms of sudden onset in his late teens. Given the nature of onset and symptomatology, and the failure of prior therapies, the case was approached as a primary psychotic disorder. The neuroleptic-naive patient had remarkable response to low-dose antipsychotic medication, as well as to psychodynamic psychotherapy modeled along the lines of neuroplasticity. The case illustrates the blurred distinctions among anxiety, mood, and psychotic disorders and the improved outcomes when the proper underlying disorder is addressed.

scholarly journals Obsessive-Compulsive Disorder with Suicide Obsessions in a First Responder without Previous Diagnosis of OCD or History of Suicide Attempts

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Vivekananda Rachamallu ◽  
Michael M. Song ◽  
Haiying Liu ◽  
Charles L. Giles ◽  
Terry McMahon
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Suicide Attempts ◽  
Past History ◽  
Case Reports ◽  
First Responder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Prevention Therapy ◽  
Increased Risk ◽  
History Of

Obsessive-compulsive disorder (OCD) is a distressing and often debilitating disorder characterized by obsessions, compulsions, or both that are time-consuming and cause impairment in social, occupational, or other areas of functioning. There are many published studies reporting higher risk of suicidality in OCD patients, as well as studies describing increased risk of suicidality in OCD patients with other comorbid psychiatric conditions such as major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). Existing case reports on OCD with suicide as the obsessive component describe patients with long standing diagnosis of OCD with suicidal ideations or previous suicide attempts. This report describes the case of a 28-year-old male, who works as a first responder, who presented with new onset symptoms characteristic of MDD and PTSD, with no past history of OCD or suicidality who developed OCD with suicidal obsessions. Differentiating between suicidal ideation in the context of other psychiatric illnesses and suicidal obsessions in OCD is critical to ensuring accurate diagnosis and timely provision of most appropriate treatment. The combination of exposure and response prevention therapy and pharmacotherapy with sertraline and olanzapine was effective in helping the patient manage the anxiety and distress stemming from the patient’s OCD with suicidal obsession.

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