Effects of PTEN inhibition on the regulation of Tau phosphorylation in rat cortical neuronal injury after oxygen and glucose deprivation

Brain Injury ◽  
2016 ◽  
Vol 30 (9) ◽  
pp. 1150-1159 ◽  
Author(s):  
Jing Zhao ◽  
Yurong Chen ◽  
Yuxia Xu ◽  
Guanghuan Pi
Keyword(s):  
Neuronal Injury ◽  
Glucose Deprivation ◽  
Tau Phosphorylation ◽  
Oxygen And Glucose Deprivation ◽  
Pten Inhibition

scholarly journals Somatic autophagy of axonal mitochondria in ischemic neurons

2019 ◽  
Vol 218 (6) ◽  
pp. 1891-1907 ◽  
Author(s):  
Yanrong Zheng ◽  
Xiangnan Zhang ◽  
Xiaoli Wu ◽  
Lei Jiang ◽  
Anil Ahsan ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Neuronal Injury ◽  
Glucose Deprivation ◽  
Retrograde Transport ◽  
Direct Link ◽  
Mitochondrial Content ◽  
Oxygen And Glucose Deprivation ◽  
Mitochondrial Movement ◽  
Mitochondrial Motility ◽  
Ischemic Neuronal Injury

Mitophagy protects against ischemic neuronal injury by eliminating damaged mitochondria, but it is unclear how mitochondria in distal axons are cleared. We find that oxygen and glucose deprivation-reperfusion reduces mitochondrial content in both cell bodies and axons. Axonal mitochondria elimination was not abolished in Atg7fl/fl;nes-Cre neurons, suggesting the absence of direct mitophagy in axons. Instead, axonal mitochondria were enwrapped by autophagosomes in soma and axon-derived mitochondria prioritized for elimination by autophagy. Intriguingly, axonal mitochondria showed prompt loss of anterograde motility but increased retrograde movement upon reperfusion. Anchoring of axonal mitochondria by syntaphilin blocked neuronal mitophagy and aggravated injury. Conversely, induced binding of mitochondria to dynein reinforced retrograde transport and enhanced mitophagy to prevent mitochondrial dysfunction and attenuate neuronal injury. Therefore, we reveal somatic autophagy of axonal mitochondria in ischemic neurons and establish a direct link of retrograde mitochondrial movement with mitophagy. Our findings may provide a new concept for reducing ischemic neuronal injury by correcting mitochondrial motility.

Protective effect of nicotinamide on neuronal cells under oxygen and glucose deprivation and hypoxia/reoxygenation

2004 ◽  
Vol 11 (4) ◽  
pp. 472-481 ◽  
Author(s):  
Chiung-Chyi Shen ◽  
Hsueh-Meei Huang ◽  
Hsiu-Chung Ou ◽  
Huan-Lian Chen ◽  
Wen-Chi Chen ◽  
...  
Keyword(s):  
Protective Effect ◽  
Neuronal Cells ◽  
Glucose Deprivation ◽  
Oxygen And Glucose Deprivation ◽  
Hypoxia Reoxygenation
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