Introduction: The student stage is marked by many changes that will affect different aspects of young youth life, including changes in sleep patterns. Sleep is known to play an active role in the overall development of students, mainly because of its restorative functions and an insufficient number of hours of sleep can be associated with consequences on physical and mental health. Objectives: To analyze the factors that interfere with higher education students’ sleep quality. Methods: A systematic review of the literature was carried out drawing on a selection of articles published between 2012 and 2020, following the method proposed by the Joanna Briggs Institute and according to the Preferred reporting items for systematic reviews and meta-analyzes (PRISMA). This selection was carried out using PubMed, B-On and SCIELO search engines. The review was based on 5 articles whose methodological quality was found to be undeniable. Results: Results show that, on the whole, students suffer from a poor quality of sleep. This situation is commonly associated with factors such as being a higher education student worker, shift work, or caffeine, alcohol, and tobacco use, among others. Conclusions: In view of the outcomes, it became clear that higher education students need to be made more aware of the importance of sleep habits and daytime sleepiness, and to improve their health literacy. They need to be informed and trained in these areas so they may reduce or at least prevent certain risk behaviours that increasingly threaten their sleep quality and overall health.