Mean platelet volume is significantly associated with serum levels of thyroid-stimulating hormone in a cohort of older euthyroid subjects

We investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1βand IL6), and the serum levels of tumour necrosis factor-α(TNFα) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNFα, IL1β, and IL6 differed significantly (allpvalues < 0.05) between severely injured patients and controls. The mean platelet volume (MPV) did not correlate with the ISSs (p> 0.05). The TNFαand IL6 levels were useful for determining the severity of injury, and the CRP level was elevated in all trauma patients but did not correlate with the ISS. The IL1βlevel was higher in the study group but did not increase as the ISS increased. IL6 and TNFαlevels were higher in the study group and increased as the ISS increased. We found no significant difference between the trauma group and healthy individuals in terms of MPV values. IL6 and TNFαlevels can be used to assess trauma severity. However, neither the MPV nor the CRP or IL1βlevel is useful for this purpose.

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The Study on the Correlation between Serum Levels of Thyroid Stimulating Hormone and Metabolic Syndrome in Euthyroid Young Adults

Advances in Clinical Medicine ◽

10.12677/acm.2018.87101 ◽

2018 ◽

Vol 08 (07) ◽

pp. 603-609

Author(s):

晓晶吴

Keyword(s):

Metabolic Syndrome ◽

Young Adults ◽

Serum Levels ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS)This paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.

Biochemistry and Cell Biology ◽

10.1139/o10-022 ◽

2010 ◽

Vol 88 (4) ◽

pp. 723-730 ◽

Cited By ~ 13

Author(s):

Lan Wei ◽

Shen Sun ◽

Jing Zhang ◽

Hong Zhu ◽

Yun Xu ◽

...

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Endocrine Cells ◽

Peer Review Process ◽

Serum Levels ◽

Staining Intensity ◽

Thyroid Stimulating Hormone ◽

Human Organ ◽

Organ Systems ◽

Quantitative Image ◽

Stimulating Hormone

It is known that severe acute respiratory syndrome (SARS), a severe infectious illness, which caused an epidemic in Asia in 2003, has extensive and complex effects on human organ systems. It has been reported that the serum levels of prolactin (PRL), follicle stimulating hormone (FSH), and luteinizing hormone (LH) of SARS patients are significantly higher than those of control groups, while estradiol (E2), pregnancy hormone (P), and thyroid stimulating hormone (TSH) are considerably lower than those of normal controls. This phenomenon suggests that the adenohypophyseal endocrine cells in SARS patients may be damaged. However, up to now there has been no direct histological investigation on the endocrine cells of patients’ pituitary. Here we investigated the endocrine cells in the adenohypophysis obtained from autopsies of 5 SARS patients. The immunohistochemistry and quantitative image results showed that compared with control cases, both the number of positive cells and the staining intensity of immunoreactivity for growth hormone, TSH, and adrenocorticotrophic hormone in these cells were remarkably decreased, while that of PRL, FSH, and LH were significantly increased in all SARS cases studied. These findings indicated that alterations occurred in the patients’ adenohypophyseal endocrine cells, and these changes were consistent with the serum levels of relevant endocrine hormones reported previously. It appears that changes in these endocrine cells and their hormones are affected by the severity of this new infectious disease.

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