High Serum Levels of Thyroid-Stimulating Hormone and Sustained Weight Gain in Patients with Thyroid Cancer Undergoing Radioiodine Therapy

Purpose: Fetuin-A is a hepatokine that is linked to lipid metabolism, obesity, insulin resistance, type 2 diabetes and cardiovascular disease. Elevated thyroid-stimulating hormone (TSH) levels are associated with metabolic and cardiovascular disturbances. Our aim was to determine if TSH can regulate fetuin-A levels. Methods: Fetuin-A serum levels were examined in 26 subjects (19 women; previous thyroidectomy and radioactive iodine ablation) undergoing recombinant human TSH (rhTSH) stimulation to screen for thyroid cancer recurrence. Their age was 49±10 years, and body mass index (BMI) was 28±6 (both expressed as mean±SD). The patients received two doses of rhTSH (0.9 mg), administered 24 hours apart on days 1 and 2, without discontinuation of ongoing L-thyroxine therapy. Morning blood samples were obtained on days 1 (prior to the first dose of rhTSH), 3 and 5. Results: The baseline value of fetuin-A (mean±SD) for all participants was 527±186 mg/L. Values of fetuin-A did not change in response to rhTSH administration. The lack of response was not dependent on gender, age, baseline free thyroxine level or BMI. Conclusion: Fetuin-A has been implicated in metabolic and inflammatory conditions, but there have been no reports on whether fetuin-A is influenced by TSH. Within the context of rhTSH administration for surveillance of thyroid cancer recurrence, there was no effect on serum levels of fetuin-A.

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Circulating Levels of Immunoreactive Peptides and Steroid Hormones in Bronchogenic Carcinoma

The International Journal of Biological Markers ◽

10.1177/172460088600100207 ◽

1986 ◽

Vol 1 (2) ◽

pp. 93-100 ◽

Cited By ~ 2

Author(s):

Guido Francini ◽

Pieraldo Inaudi ◽

Giuseppe Gotti ◽

Stefano Gonnelli ◽

Barbara Lucani ◽

...

Keyword(s):

Bronchogenic Carcinoma ◽

Adrenocorticotropic Hormone ◽

Human Growth ◽

Plasma Renin ◽

Serum Levels ◽

Thyroid Stimulating Hormone ◽

High Serum ◽

Response To Therapy ◽

Circulating Levels ◽

Stimulating Hormone

Plasma levels of immunoreactive parathormone (iPTH), immunoreactive calcitonin (iCT) and prostaglandins (PGE2) were measured by RIA in 115 patients with bronchogenic carcinoma. In 37 of these cases the following hormones were also assayed: adrenocorticotropic hormone (ACTH), cortisol, plasma renin activity (PRA), aldosterone, prolactin, human growth hormone (HGH), thyroid stimulating hormone (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH) human chorionic gonadotropin (HCG), progesterone (P), an-drostenedoone (A), testosterone (T), estradiol (E2) and dehydropiandrosterone sulphate (DHAS). High serum levels of many hormone-like substances and hormones were found and the levels of certain hormones varied in some cases according to the clinical evolution of the disease and the response to therapy.

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The association between soya consumption and serum thyroid-stimulating hormone concentrations in the Adventist Health Study-2

Public Health Nutrition ◽

10.1017/s1368980015002943 ◽

2015 ◽

Vol 19 (8) ◽

pp. 1464-1470 ◽

Cited By ~ 8

Author(s):

Serena Tonstad ◽

Karen Jaceldo-Siegl ◽

Mark Messina ◽

Ella Haddad ◽

Gary E Fraser

Keyword(s):

Urinary Iodine ◽

Thyroid Stimulating Hormone ◽

Soya Protein ◽

High Serum ◽

Health Study ◽

Animal Products ◽

White Ethnicity ◽

High Consumption ◽

Stimulating Hormone ◽

Adventist Health Study

AbstractObjectiveConsumers may choose soya foods as healthful alternatives to animal products, but concern has arisen that eating large amounts of soya may adversely affect thyroid function. The present study aimed to examine the association between soya food consumption and serum thyroid-stimulating hormone (TSH) concentrations in North American churchgoers belonging to the Seventh-day Adventist denomination that encourages vegetarianism.DesignParticipants completed six repeated 24 h dietary recalls within a 6-month period. Soya protein and soya isoflavone intakes were estimated, and their relationships to TSH concentrations measured at the end of 6 months were calculated using logistic regression analyses.SettingCalibration sub-study of the Adventist Health Study-2.SubjectsWomen (n 548) and men (n 295) who were not taking thyroid medications.ResultsIn men, age and urinary iodine concentrations were associated with high serum TSH concentrations (>5 mIU/l), while among women White ethnicity was associated with high TSH. In multivariate models adjusted for age, ethnicity and urinary iodine, soya isoflavone and protein intakes were not associated with high TSH in men. In women higher soya isoflavone consumption was associated with higher TSH, with an adjusted odds ratio (highest v. lowest quintile) of 4·17 (95 % CI 1·73, 10·06). Likewise, women with high consumption of soya protein (midpoint of highest quintile, 11 g/d) v. low consumption (midpoint of lowest quintile, 0 g/d) carried increased odds of high TSH (OR=2·69; 95 % CI 1·34, 5·30).ConclusionsIn women high consumption of soya was associated with elevated TSH concentrations. No associations between soya intake and TSH were found in men.

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