New self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymer methoxy poly (ethylene glycol)-block-poly (ϵ-caprolactone)

2013 ◽  
Vol 18 (3) ◽  
pp. 745-751 ◽  
Author(s):  
Fuzheng Ren ◽  
Yuan Gao ◽  
Jialei Chen ◽  
Qiufang Jing ◽  
Yan Yu
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diblock Copolymer ◽  
Poly Ethylene Glycol ◽  
Amphiphilic Diblock Copolymer ◽  
Poly Ethylene

A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (15) ◽  
pp. 2011-2025 ◽  
Author(s):  
Zhen Li ◽  
Jialong Fan ◽  
Chunyi Tong ◽  
Hongyan Zhou ◽  
Wenmiao Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Graphene Quantum Dots ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.

scholarly journals Blend Electrospinning of Poly(Ɛ-Caprolactone) and Poly(Ethylene Glycol-400) Nanofibers Loaded with Ibuprofen as a Potential Drug Delivery System for Wound Dressings

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tabinda Riaz ◽  
Nabyl Khenoussi ◽  
Delia Mihaela Rata ◽  
Leonard Ionut Atanase ◽  
Dominique C. Adolphe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Kinetics ◽  
Poly Ethylene Glycol ◽  
Vis Spectroscopy ◽  
Poly Ethylene ◽  
The Impact

Abstract Electrospinning (ES) is a versatile and diverse technique to fabricate nano and micro fibers that could be utilized as drug delivery systems. The aim of this research was the fabrication and characterization of drug loaded nanofibrous scaffold produced by single-needle ES using poly(Ɛ-caprolactone) (PCL) and poly(ethylene glycol-400) (PEG) and to investigate the potential of this material as a drug delivery system. A model drug, Ibuprofen (IBU), was used. Ibuprofen is a medicine that is a non-steroidal, anti-inflammatory drug (NSAID). Two concentrations of IBU, 5 wt% and 7 wt%, were incorporated for the ES of PCL and PCL/PEG nanofibers. Characterization of nanofibers was done by using Scanning Electron Microscopy (SEM), Differential Scanning Calorimeter (DSC), Thermogravimetric Analysis (TGA), and Water Contact Angle Measurements. The impact of IBU on nanofibers’ properties such as morphology, diameters, hydrophilicity, and tensile strength was investigated. Finally, the drug release kinetics of IBU from nanofibers was analyzed and their percentage release efficiency of IBU (RE%) was determined by UV-vis spectroscopy during 24 h.

Acid-labile poly(ethylene glycol) shell of hydrazone-containing biodegradable polymeric micelles facilitating anticancer drug delivery

2018 ◽  
Vol 33 (2) ◽  
pp. 119-133 ◽  
Author(s):  
Jing Xu ◽  
Benkai Qin ◽  
Shujuan Luan ◽  
Peilan Qi ◽  
Yingying Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Drug Formulation ◽  
Poly Ethylene Glycol ◽  
Block Polymer ◽  
Poly Ethylene

Biodegradable pH-sensitive amphiphilic block polymer (mPEG-Hyde-PLGA) was synthesized via ring-opening polymerization, initiated from a hydrazone-containing macro-initiator. In this way, a pH-sensitive hydrazone bond was inserted into the backbone of block copolymer, linking hydrophilic poly(ethylene glycol) segment and hydrophobic poly(lactic-co-glycolic acid) segment. The copolymer self-assembled to form stable micelles with mean diameters below 100 nm and served as a drug delivery system for doxorubicin, with drug loading content of 5.3%. pH sensitivity of the hydrazone-containing micelles was investigated by changes in diameter and size distribution observed by dynamic light scattering measurements when the micelles were encountered to acidic medium. Small pieces and larger aggregates were found by transmission electron microscopy resulting from the disassociation of the micelles in acidic conditions. It was also noted that doxorubicin release from the pH-sensitive micelles is significantly faster at pH 4.0 and pH 5.0 compared to pH 7.4, while almost no difference was detected in the case of pH non-sensitive micelles. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays on HepG-2 and MCF-7 cells revealed that doxorubicin-loaded pH-sensitive micelles had higher antitumor activity than pH-insensitive ones. This pH-sensitive drug delivery system based on hydrazone-containing block copolymer has been proved as a promising drug formulation for cancer therapy.

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