Statistical analysis of clinical breast cancer by computer

1978 ◽  
Vol 3 (2) ◽  
pp. 131-135
Author(s):  
L. Angelini ◽  
A. R. Antonaci ◽  
R. De Angelis ◽  
R. Maceratini ◽  
A. Daniele ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Statistical Analysis ◽  
Clinical Breast

Financial Anxiety is Associated With Cancer Screening Adherence in Women at High Risk of Breast Cancer

2021 ◽  
Author(s):  
Salene M W Jones ◽  
Tammy A Schuler ◽  
Tasleem J Padamsee ◽  
M Robyn Andersen
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Pap Smear ◽  
Clinical Breast Examination ◽  
Lower Odds ◽  
Breast Examination ◽  
Clinical Breast ◽  
Financial Anxiety ◽  
Screening Adherence

Abstract Background Previous studies have examined the impact of material financial hardship on cancer screening but without focusing on the psychological aspects of financial hardship. Purpose This study examined the effects of different types of financial anxiety on adherence to breast cancer screening in women at high risk of breast cancer. Adherence to cervical cancer screening was also examined to determine whether associations between financial anxiety and screening adherence were unique to breast cancer screening or more general. Methods Women (n = 324) aged 30–50 and at high risk for inherited breast cancer completed a survey on general financial anxiety, worry about affording healthcare, financial stigma due to cancer risk, and adherence to cancer screening. Multivariate analyses controlled for poverty, age, and race. Results More financial anxiety was associated with lower odds of mammogram adherence (odds ratio [OR] = 0.97, confidence interval [CI] = 0.94, 0.99), Pap smear adherence (OR = 0.98, CI = 0.96, 0.996), and clinical breast examination adherence (OR = 0.98, CI = 0.96, 0.995). More worry about affording healthcare was associated with lower odds of clinical breast examination adherence (OR = 0.95, CI = 0.91, 0.9992) but not mammogram or Pap smear adherence (p > .05). Financial stigma due to cancer risk was associated with lower odds of Pap smear adherence (OR = 0.87, CI = 0.77, 0.97) but no other cancer screenings (p > .07). Conclusions Financial anxiety may impede cancer screening, even for high-risk women aware of their risk status. Clinical interventions focused on social determinants of health may also need to address financial anxiety for women at high risk of breast cancer.

A possible divergent role for the oestrogen receptor alpha and beta subtypes in clinical breast cancer

2000 ◽  
Vol 89 (2) ◽  
pp. 209-212 ◽  
Author(s):  
Janice M. Knowlden ◽  
Julia M.W. Gee ◽  
John F.R. Robertson ◽  
Ian O. Ellis ◽  
Robert I. Nicholson
Keyword(s):  
Breast Cancer ◽  
Oestrogen Receptor ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha ◽  
Clinical Breast

scholarly journals Knowledge, Attitude and Practice toward Breast Cancer among Kurdish Women in Sulaimani Governorate/ Iraq

2017 ◽  
Vol 2 (2) ◽  
pp. 20-28
Author(s):  
Bekhal Abdalwahid Amin ◽  
Muhammed Babakir-Mina ◽  
Fadhil Ahmed Mohialdeen ◽  
Mohammed I. M. Gubari
Keyword(s):  
Breast Cancer ◽  
Clinical Breast Examination ◽  
Education Level ◽  
Breast Self Examination ◽  
Attitude And Practice ◽  
Breast Examination ◽  
Clinical Breast ◽  
The Right ◽  
Self Examination ◽  
Knowledge Attitude And Practice

Breast cancer is a devastating affliction, the frequency of which is gradually increasing all over the world. Cancer may be cured if properly intervened at the right time. The correct treatment, aided by professionals and the right technology can provide critical life support to breast cancer patients. This study was conducted to assessment knowledge, attitude and practice of breast cancer among Kurdish females visited Maternity Teaching Hospital in Sulaimani. A face-to-face interview through a question¬naire to assessment of knowledge and practices toward breast cancer of 500 non-breast cancer women visited Maternity Teaching Hospital was done. Data were computerized and analyzed using Statistical Package for the Social Science (SPSS, version 22). P-value of < 0.05 was considered as statistically significant. Out of 500 participants in the current study on knowledge and practices toward breast cancer among non-breast cancer women, consequently were 227 (45.4%) and 201 (40.2%) practiced breast self-examination(BSE) and clinical breast examination respectively. In this study the participants having no symptoms and lack of knowledge about how to do BSE where regarded as the barriers of not practicing BSE (44.7%, 55.3%) respectively. The most common reason for not doing clinical breast examination (CBE) is fear of the outcome and no sign & symptom of breast cancer (28.8%, 61.9%) respectively. The high education level showed significantly more knowledge of breast self-examination and mammography than Illiterate women P≤ 0.001 and P≤ 0.03 respectively. On the other hand, the high education level women showed significantly more practice of breast self-examination P≤ 0.001. In conclusion, the present study found the facts to the inadequate knowledge of female about breast cancer and recognized the negative influence of low knowledge on the practice of BSE, CBE and mammography and the breast cancer incidence. Therefore, more determinations are needed to develop a positive attitude toward BSE, CBE and mammography screening and practice in Sulaimani.

scholarly journals Investigation of olfactory receptor family 51 subfamily j member 1 (OR51J1) gene susceptibility as a potential breast cancer-associated biomarker

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246752
Author(s):  
Maryam Asadi ◽  
Nahid Ahmadi ◽  
Simin Ahmadvand ◽  
Ali Akbar Jafari ◽  
Akbar Safaei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Statistical Analysis ◽  
Protein Expression ◽  
Olfactory Receptor ◽  
Mrna Level ◽  
Expression Level ◽  
Pcr Analysis ◽  
Normal Tissues ◽  
Qrt Pcr ◽  
Human Protein Atlas

Among cancer treatment methods, targeted therapy using cancer-associated biomarkers has minimum side effects. Recently olfactory receptor (OR) family attracts the researcher’s attention as a favorable biomarker of cancer. Here, a statistical approach using complete data from the human protein atlas database was used to evaluate the potential of OR51J1 gene as a cancer-associated biomarker. To confirm the findings of statistical analysis, the OR51J1 mRNA and protein expression levels in breast tumor and normal tissue were measured using quantitative Real Time PCR (qRT-PCR) and immunohistochemistry (IHC) techniques. The association with clinicopathological factors was analyzed. Statistical analysis revealed that OR51J1 has a high expression level in more than 20 types of cancer tissues without any expression in 44 normal tissues. In 15 cancer types, including breast cancer, expression score was more than 90%. The qRT-PCR analysis in breast cancer showed OR51J1 have significantly higher expression level in tumors than normal tissues (2.91 fold). The IHC results showed OR51J1 expression on other cellular subtypes than tumor and normal cells, including myoepithelium, fibroblast, and lymphocytes. OR51J1 protein expression in invasive cells, as well as its overall score, showed a significant correlation with ER and PR expression and breast cancer (BC) subtypes. Results revealed the potential of OR51J1 as a cancer-associated biomarker for the diagnosis of breast cancer at the mRNA level.

scholarly journals Awareness, Attitudes and Practices of women related to breast cancer in Niamey and Zinder

2019 ◽  
Author(s):  
Abdou Aissami ◽  
Guido Van Hal ◽  
Dille Issimouha
Keyword(s):  
Breast Cancer ◽  
Clinical Breast Examination ◽  
Cancer Knowledge ◽  
Cancer Awareness ◽  
Cancer Symptoms ◽  
Attitudes And Practices ◽  
Breast Examination ◽  
Clinical Breast ◽  
History Of ◽  
Breast Cancer Knowledge

Abstract Background: In Niger, breast cancer is the first cancer related morbidity and mortality within the female population. While Breast cancer awareness can contribute to early diagnosis and disease mortality reduction, Niger women’s knowledge of breast cancer is not well documented. The objective of this study was to assess the knowledge, attitudes and practices of women related to breast cancer and have a look on the factors associated this knowledge. Methods: The study was conducted thought a cross sectional survey in women population in Zinder and Niamey regions. A random sampling was used to select women in households within health districts. We defined a breast cancer knowledge score and used a generalized linear model to assess factors associated with breast cancer knowledge. Results: A total of 675 women were included in the survey. Average age of women was 39.2 years (38.2-40.2) and 48.4% (44.7-52.2) of them were not educated. Overall women’s knowledge of breast cancer is relatively low, only 41.2% (37.5-45.0) were aware of breast cancer. An area where women demonstrated an awareness was breast cancer symptoms knowledge with 65.0% (61.3-68.7). Insufficient level of knowledge was observed on knowledge of risk and protection factors with only 27.4 % (24.0-31.0) level of awareness and breast cancer good practice with 16.9% (14.2-19.7). Younger age OR=0.98 (0.96-0.99) practicing clinical breast examination OR=2.25 (1.31–3.16), breastfeeding 3.34 (2.12-5.26), not having a history of participation to breast cancer 0.53 (0.34-0.82) and living in rural and peri-urban areas 0.34 (0.20–0.44) were factors related to awareness of breast cancer. Conclusion: Niger women had overall low level of breast cancer awareness. While they were not acquainted with breast self-examination and clinical breast examination, their knowledge of breast cancer symptoms was acceptable. Clinical breast examination, area of residence, age, breastfeeding and history of participation to breast cancer screening were found to be associated with breast cancer knowledge. Awareness programs can promote clinical breast examination as mammography is not common and target older women. Focus should be given to awareness of breast cancer risk factors and promoting early detection procedures.

scholarly journals Management of Breast Cancer in Nepal

2009 ◽  
Vol 48 (175) ◽  
Author(s):  
Yogendra P Singh ◽  
P Sayami
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Cancer Education ◽  
Tumor Biology ◽  
Metastatic Breast ◽  
Premenopausal Women ◽  
Clinical Breast Examination ◽  
Cancer Management ◽  
Breast Cancer Management ◽  
Clinical Breast

Breast cancer is the second most common malignancy among women in Nepal. It is more commonin young premenopausal women. Breast cancer continues to increase in incidence due to lifestylechanges in Nepalese women despite constant remarkable development in the management of thisdisease over the past three decades. Breast cancer was diagnosed solely clinically and surgery wasthe only treatment option until fi fty years ago. Multidisciplinary approach has been adopted fordiagnosis and treatment of breast cancer in Nepal. Imaging is required for the diagnosis, appropriatetreatment decision and proper follow up. Treatment modality depends upon the extent of thedisease and tumor biology. However, there is a strong need for standard guidelines for the propermanagement of breast cancer in Nepal so that surgeries, chemotherapy, hormone therapy andradiotherapy are standardized in the country. Palliative care has been initiated to provide to somepatients with metastatic breast cancer recently.The breast cancer management in Nepal is a little different when compared with the centers in thedeveloped countries. The reasons are socioeconomic status, lack of education and lack of facilities.Although cancer care is on the rise in Nepal, the optimal facility for centers managing breast cancerhas to be improved signifi cantly.Cancer education, screening and early detection are the keyelements to infl uence the diagnosis, treatment and prognosis of breast cancer in Nepal. Breast cancerawareness and clinical breast examination are important tools for early detection in our resourcelimited context. Breast cancer can be cured in majority of the cases if diagnosed in early stages.This review will focus on relevant patient data along with future recommendation regarding breastcancer treatment in Nepal.Key Words: Breast cancer, cancer education, chemotherapy, imaging, radiotherapy, surgery

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